BR9704117A - Derivados de insulina com maior ligação com zinco - Google Patents
Derivados de insulina com maior ligação com zincoInfo
- Publication number
- BR9704117A BR9704117A BR9704117A BR9704117A BR9704117A BR 9704117 A BR9704117 A BR 9704117A BR 9704117 A BR9704117 A BR 9704117A BR 9704117 A BR9704117 A BR 9704117A BR 9704117 A BR9704117 A BR 9704117A
- Authority
- BR
- Brazil
- Prior art keywords
- insulin derivatives
- zinc binding
- greater zinc
- binding
- insulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19630242 | 1996-07-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9704117A true BR9704117A (pt) | 1998-12-29 |
BR9704117B1 BR9704117B1 (pt) | 2009-08-11 |
Family
ID=7800962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9704117-3A BR9704117B1 (pt) | 1996-07-26 | 1997-07-28 | derivados de insulina com maior ligação com zinco. |
Country Status (25)
Country | Link |
---|---|
US (1) | US6221837B1 (pt) |
EP (1) | EP0821006B1 (pt) |
JP (1) | JP4046388B2 (pt) |
KR (1) | KR100547922B1 (pt) |
CN (2) | CN1158305C (pt) |
AR (1) | AR008269A1 (pt) |
AT (1) | ATE264871T1 (pt) |
AU (1) | AU725201B2 (pt) |
BR (1) | BR9704117B1 (pt) |
CA (1) | CA2207078C (pt) |
CZ (1) | CZ292274B6 (pt) |
DE (1) | DE59711533D1 (pt) |
DK (1) | DK0821006T3 (pt) |
ES (1) | ES2218622T3 (pt) |
HK (1) | HK1048125A1 (pt) |
HU (1) | HU224591B1 (pt) |
IL (2) | IL121382A0 (pt) |
NO (1) | NO317666B1 (pt) |
NZ (1) | NZ328421A (pt) |
PL (1) | PL188617B1 (pt) |
PT (1) | PT821006E (pt) |
RU (1) | RU2176646C2 (pt) |
TR (1) | TR199700685A3 (pt) |
TW (1) | TW474944B (pt) |
ZA (1) | ZA976645B (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19825447A1 (de) * | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
DE19838097A1 (de) | 1998-08-24 | 2000-03-02 | Hoechst Marion Roussel De Gmbh | Verfahren zur chromatographischen Reinigung von Insulinen |
DE19947456A1 (de) * | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga |
US7238663B2 (en) * | 2001-08-28 | 2007-07-03 | Eli Lilly And Company | Pre-mixes of GLP-1 and basal insulin |
MXPA04003569A (es) * | 2001-10-19 | 2004-07-23 | Lilly Co Eli | Mezclas bifasicas de glp-1 e insulina. |
KR100769183B1 (ko) * | 2001-12-28 | 2007-10-23 | 엘지.필립스 엘시디 주식회사 | 면발광 램프 |
CA2518776A1 (en) * | 2003-04-29 | 2004-11-11 | Eli Lilly And Company | Insulin analogs having protracted time action |
KR101159559B1 (ko) * | 2003-08-05 | 2012-06-26 | 노보 노르디스크 에이/에스 | 신규의 인슐린 유도체 |
NZ553263A (en) | 2004-07-19 | 2010-06-25 | Biocon Ltd | Insulin-oligomer conjugates, formulations and uses thereof |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
EP1969004B1 (en) | 2005-12-28 | 2011-08-10 | Novo Nordisk A/S | Compositions comprising an acylated insulin and zinc and method of making the said compositions |
JP5550338B2 (ja) | 2006-07-31 | 2014-07-16 | ノボ・ノルデイスク・エー/エス | ペグ化持続型インスリン |
US9018161B2 (en) * | 2006-09-22 | 2015-04-28 | Novo Nordisk A/S | Protease resistant insulin analogues |
JP5496082B2 (ja) * | 2007-04-30 | 2014-05-21 | ノボ・ノルデイスク・エー/エス | タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物 |
WO2008145730A1 (en) * | 2007-06-01 | 2008-12-04 | Novo Nordisk A/S | Stable non-aqueous pharmaceutical compositions |
JP5552046B2 (ja) * | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー/エス | インスリン誘導体を含有する薬学的製剤 |
WO2009050738A2 (en) * | 2007-10-16 | 2009-04-23 | Biocon Limited | An orally administerable solid pharmaceutical composition and a process thereof |
WO2009112583A2 (en) * | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
PL2254906T3 (pl) | 2008-03-18 | 2017-04-28 | Novo Nordisk A/S | Stabilizowane względem proteaz, acylowane analogi insuliny |
RU2540922C2 (ru) * | 2008-10-30 | 2015-02-10 | Ново Нордиск А/С | Лечение сахарного диабета с использованием инъекций инсулина с частотой менее одного раза в день |
BR112013010345A2 (pt) | 2010-10-27 | 2017-07-25 | Novo Nordisk As | tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção |
MX2014012096A (es) | 2012-04-11 | 2014-11-21 | Novo Nordisk As | Formulaciones de insulina. |
EP2991672A1 (en) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Novel administration regime |
SI3055325T1 (en) | 2013-10-07 | 2018-05-31 | Novo Nordisk A/S | NEW DERIVATIVE ANALOGUE INSULINE |
FR3013049B1 (fr) | 2013-11-14 | 2015-11-13 | You-Ping Chan | Analogue de l'insuline glargine |
TWI700091B (zh) | 2016-12-16 | 2020-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 含胰島素醫藥組成物 |
US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI78616C (fi) * | 1982-02-05 | 1989-09-11 | Novo Industri As | Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt. |
DE3326472A1 (de) | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
DE3440988A1 (de) | 1984-11-09 | 1986-07-10 | Hoechst Ag, 6230 Frankfurt | Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung |
US4569794A (en) | 1984-12-05 | 1986-02-11 | Eli Lilly And Company | Process for purifying proteins and compounds useful in such process |
US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
DE3526995A1 (de) | 1985-07-27 | 1987-02-05 | Hoechst Ag | Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung |
DE3636903A1 (de) | 1985-12-21 | 1987-07-02 | Hoechst Ag | Fusionsproteine mit eukaryotischem ballastanteil |
DE3541856A1 (de) | 1985-11-27 | 1987-06-04 | Hoechst Ag | Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens |
CA1340522C (en) | 1987-03-10 | 1999-05-04 | Heinz Dobeli | Fusion proteins containing neighbouring histidines for improved purification |
DE3805150A1 (de) | 1987-04-11 | 1988-10-20 | Hoechst Ag | Gentechnologisches verfahren zur herstellung von polypeptiden |
DE4012818A1 (de) | 1990-04-21 | 1991-10-24 | Hoechst Ag | Verfahren zur herstellung von fremdproteinen in streptomyceten |
DE3726655A1 (de) | 1987-08-11 | 1989-02-23 | Hoechst Ag | Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten |
DE3739347A1 (de) | 1987-11-20 | 1989-06-01 | Hoechst Ag | Verfahren zur selektiven spaltung von fusionsproteinen |
EP0347781B1 (de) | 1988-06-23 | 1994-02-16 | Hoechst Aktiengesellschaft | Mini-Proinsulin, seine Herstellung und Verwendung |
DE3827533A1 (de) * | 1988-08-13 | 1990-02-15 | Hoechst Ag | Pharmazeutische zubereitung zur behandlung des diabetes mellitus |
DE3837825A1 (de) | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
NZ232375A (en) * | 1989-02-09 | 1992-04-28 | Lilly Co Eli | Insulin analogues modified at b29 |
DE3921447A1 (de) * | 1989-06-30 | 1991-01-17 | Hoechst Ag | Verfahren zur herstellung von n-alkyl-halogenanilinen |
US5227293A (en) | 1989-08-29 | 1993-07-13 | The General Hospital Corporation | Fusion proteins, their preparation and use |
IL95495A (en) | 1989-08-29 | 1996-10-16 | Hoechst Ag | Fusion proteins their preparation and use |
US5358857A (en) | 1989-08-29 | 1994-10-25 | The General Hospital Corp. | Method of preparing fusion proteins |
CZ342492A3 (en) * | 1991-11-26 | 1993-06-16 | Lilly Co Eli | Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised |
EP0600372B1 (de) | 1992-12-02 | 1997-02-05 | Hoechst Aktiengesellschaft | Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken |
DE4405179A1 (de) | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
WO1996004925A1 (en) * | 1994-08-12 | 1996-02-22 | Immunomedics, Inc. | Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells |
-
1997
- 1997-07-17 PT PT97112197T patent/PT821006E/pt unknown
- 1997-07-17 DE DE59711533T patent/DE59711533D1/de not_active Expired - Lifetime
- 1997-07-17 ES ES97112197T patent/ES2218622T3/es not_active Expired - Lifetime
- 1997-07-17 DK DK97112197T patent/DK0821006T3/da active
- 1997-07-17 EP EP97112197A patent/EP0821006B1/de not_active Expired - Lifetime
- 1997-07-17 AT AT97112197T patent/ATE264871T1/de active
- 1997-07-24 RU RU97112742/04A patent/RU2176646C2/ru not_active IP Right Cessation
- 1997-07-24 IL IL12138297A patent/IL121382A0/xx unknown
- 1997-07-24 AR ARP970103352A patent/AR008269A1/es active IP Right Grant
- 1997-07-24 TW TW086110516A patent/TW474944B/zh not_active IP Right Cessation
- 1997-07-24 IL IL12138197A patent/IL121381A/en not_active IP Right Cessation
- 1997-07-24 NZ NZ328421A patent/NZ328421A/xx not_active IP Right Cessation
- 1997-07-24 CZ CZ19972370A patent/CZ292274B6/cs not_active IP Right Cessation
- 1997-07-24 TR TR97/00685A patent/TR199700685A3/tr unknown
- 1997-07-24 AU AU30171/97A patent/AU725201B2/en not_active Ceased
- 1997-07-25 HU HU9701299A patent/HU224591B1/hu not_active IP Right Cessation
- 1997-07-25 PL PL97321343A patent/PL188617B1/pl not_active IP Right Cessation
- 1997-07-25 NO NO19973438A patent/NO317666B1/no not_active IP Right Cessation
- 1997-07-25 JP JP20000297A patent/JP4046388B2/ja not_active Expired - Fee Related
- 1997-07-25 KR KR1019970034958A patent/KR100547922B1/ko not_active IP Right Cessation
- 1997-07-25 US US08/900,574 patent/US6221837B1/en not_active Expired - Lifetime
- 1997-07-25 CA CA002207078A patent/CA2207078C/en not_active Expired - Fee Related
- 1997-07-25 ZA ZA9706645A patent/ZA976645B/xx unknown
- 1997-07-25 CN CNB971046751A patent/CN1158305C/zh not_active Expired - Fee Related
- 1997-07-28 BR BRPI9704117-3A patent/BR9704117B1/pt not_active IP Right Cessation
-
2001
- 2001-12-17 CN CN01143664A patent/CN1362417A/zh active Pending
-
2003
- 2003-01-07 HK HK03100149.7A patent/HK1048125A1/zh unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
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FB34 | Technical and formal requirements: requirement - article 34 of industrial property law | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 03/11/2009, OBSERVADAS AS CONDICOES LEGAIS. |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 18A ANUIDADE. |
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B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2316 DE 26-05-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |