KR960013384A - 글루카곤과 유사한 인슐린지향성 펩티드 유사체, 조성물 및 사용 방법 - Google Patents

글루카곤과 유사한 인슐린지향성 펩티드 유사체, 조성물 및 사용 방법 Download PDF

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KR960013384A
KR960013384A KR1019950035590A KR19950035590A KR960013384A KR 960013384 A KR960013384 A KR 960013384A KR 1019950035590 A KR1019950035590 A KR 1019950035590A KR 19950035590 A KR19950035590 A KR 19950035590A KR 960013384 A KR960013384 A KR 960013384A
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glucagon
insulin
compositions
methods
peptide analogs
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KR1019950035590A
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존 첸 빅터
데니스 디마르치 리챠드
블라다스 크리아우시우나스 아이다스
리 스밀리 데이비드
딘 스터키 러셀
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피터 지.스트링거
일라이 릴리 앤드 캄파니
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Publication of KR960013384A publication Critical patent/KR960013384A/ko

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Abstract

본 발명은 글루카곤과 유사한 인슐린지향성 펩티드(GLP-1(7-37)) 유사체 및 유도체에 관한 것이다. 이 유사체는 아미노산 치환반응, 아미노 및 카복실 말단의 변형반응 및 C6-C10아실화반응에 의한 것이다. 특허청구된 화합물은 작용불량성의 베타 세포내에서 인슐린으 분비 또는 생합성을 자극함으로써 Ⅱ형 당뇨병을 치료 하는 데 있어서 유용하다.

Description

글루카곤과 유사한 인슈린지향성 펩티드 유사체, 조성물 및 사용 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식(1) 의 화합물 또는 그의 약학적 허용가능한 염:
    상기 식에서,R1은 4-이미다조프피오닐, 4-이디다조아세틸. 또는 4-이미다조-α,α-디메틸-아세틸로 이루어진 그룹으로부터 선택되고;R2는 C6내지 C10의 비분지된 아실로 이루어진 그룹으로부터 선택되거나 또는 존재하지 않고; R3은 Gly-OH 또는 NH2로 이루어진 그룹으로부터 선택되며 ;Xaa는 Lys 또는 Arg이다.
  2. 제 2항에 있어서, R1이 4-이미다조프로피오닐이고, R2가 C8의 비분지된 아실이고, R3이 Gly-OH 이며M Xaa가 Arg인 화합물
  3. 활성 성분으로서 제 1항 또는 제 2항에 따른 일반식(1)의 화합물 또는 그의 약학적으로 허용가능한 염을 하나 이상의 약학적으로 허용가능한 담체와 함께 포함하는 약학 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950035590A 1994-10-18 1995-10-16 글루카곤과 유사한 인슐린지향성 펩티드 유사체, 조성물 및 사용 방법 KR960013384A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/324,960 US5512549A (en) 1994-10-18 1994-10-18 Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
US08/324,960 1994-10-18

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KR960013384A true KR960013384A (ko) 1996-05-22

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US (1) US5512549A (ko)
EP (2) EP0708179B1 (ko)
JP (1) JPH08245696A (ko)
KR (1) KR960013384A (ko)
CN (1) CN1129224A (ko)
AT (1) ATE285473T1 (ko)
AU (1) AU3432295A (ko)
BR (1) BR9504452A (ko)
CA (1) CA2160753A1 (ko)
CO (1) CO4480109A1 (ko)
CZ (1) CZ266695A3 (ko)
DE (1) DE69533868T2 (ko)
ES (1) ES2232820T3 (ko)
FI (1) FI954941A (ko)
HU (1) HUT73413A (ko)
IL (1) IL115583A0 (ko)
MX (1) MX9504380A (ko)
NO (1) NO954055L (ko)
PE (1) PE47096A1 (ko)
PL (1) PL310961A1 (ko)
ZA (1) ZA958723B (ko)

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HUT73413A (en) 1996-07-29
EP0708179A2 (en) 1996-04-24
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EP0708179B1 (en) 2004-12-22
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CO4480109A1 (es) 1997-07-09
ATE285473T1 (de) 2005-01-15
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CA2160753A1 (en) 1996-04-19
BR9504452A (pt) 1997-05-20
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AU3432295A (en) 1996-05-02
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