EA200000629A1 - Стабилизированные растворы терипаратида - Google Patents

Стабилизированные растворы терипаратида

Info

Publication number
EA200000629A1
EA200000629A1 EA200000629A EA200000629A EA200000629A1 EA 200000629 A1 EA200000629 A1 EA 200000629A1 EA 200000629 A EA200000629 A EA 200000629A EA 200000629 A EA200000629 A EA 200000629A EA 200000629 A1 EA200000629 A1 EA 200000629A1
Authority
EA
Eurasian Patent Office
Prior art keywords
stabilized
teriparatid
solutions
cresol
preservative
Prior art date
Application number
EA200000629A
Other languages
English (en)
Other versions
EA004761B1 (ru
Inventor
Чин-Минг Чанг
Генри А. Хейвел
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22086574&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200000629(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200000629A1 publication Critical patent/EA200000629A1/ru
Publication of EA004761B1 publication Critical patent/EA004761B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)

Abstract

(57) Описана стабилизированная фармацевтическая композиция с паратиреоидным гормоном в виде раствора для парентерального введения, в которой терапевтически активный ингредиент стабилизирован буфером и полиолом. Предпочтительные препараты содержат в водном растворе РТН (1-34) человека, маннитол, ацетатный или тартратный буферный агент и м-крезол или бензиловый спирт в качестве консерванта.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000629A 1997-12-09 1998-12-08 Стабилизированная жидкая композиция паратиреоидного гормона, флакон с композицией и способы их получения EA004761B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6907597P 1997-12-09 1997-12-09
PCT/US1998/026043 WO1999029337A1 (en) 1997-12-09 1998-12-08 Stabilized teriparatide solutions

Publications (2)

Publication Number Publication Date
EA200000629A1 true EA200000629A1 (ru) 2000-12-25
EA004761B1 EA004761B1 (ru) 2004-08-26

Family

ID=22086574

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000629A EA004761B1 (ru) 1997-12-09 1998-12-08 Стабилизированная жидкая композиция паратиреоидного гормона, флакон с композицией и способы их получения

Country Status (32)

Country Link
EP (2) EP0920873B1 (ru)
JP (1) JP4405666B2 (ru)
KR (1) KR100482703B1 (ru)
CN (1) CN1198644C (ru)
AR (1) AR018526A1 (ru)
AT (1) ATE260113T1 (ru)
AU (1) AU759726B2 (ru)
BR (1) BR9813463A (ru)
CA (1) CA2314313C (ru)
CY (1) CY1114000T1 (ru)
CZ (1) CZ302401B6 (ru)
DE (1) DE69821872T2 (ru)
DK (2) DK0920873T3 (ru)
EA (1) EA004761B1 (ru)
EG (1) EG23675A (ru)
ES (2) ES2215268T3 (ru)
HK (1) HK1021798A1 (ru)
HU (1) HU230784B1 (ru)
ID (1) ID27741A (ru)
IL (1) IL136662A (ru)
MY (1) MY120063A (ru)
NO (1) NO327302B1 (ru)
NZ (1) NZ505222A (ru)
PE (1) PE20000001A1 (ru)
PL (1) PL194268B1 (ru)
PT (2) PT920873E (ru)
SK (1) SK288203B6 (ru)
TR (1) TR200002134T2 (ru)
TW (1) TW570811B (ru)
UA (1) UA72884C2 (ru)
WO (1) WO1999029337A1 (ru)
ZA (1) ZA9811127B (ru)

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Also Published As

Publication number Publication date
ATE260113T1 (de) 2004-03-15
DK1417972T3 (da) 2013-05-13
NO327302B1 (no) 2009-06-02
JP2001525372A (ja) 2001-12-11
EG23675A (en) 2007-04-15
MY120063A (en) 2005-08-30
EP0920873A3 (en) 1999-08-04
DK1417972T4 (en) 2018-10-22
NO20002945L (no) 2000-07-07
UA72884C2 (ru) 2005-05-16
SK288203B6 (sk) 2014-07-02
CZ302401B6 (cs) 2011-05-04
HUP0004447A3 (en) 2003-06-30
CZ20002115A3 (en) 2001-05-16
DE69821872D1 (de) 2004-04-01
NZ505222A (en) 2003-05-30
CA2314313C (en) 2005-02-08
WO1999029337A1 (en) 1999-06-17
EP0920873B1 (en) 2004-02-25
TW570811B (en) 2004-01-11
DE69821872T2 (de) 2005-01-05
KR20010032881A (ko) 2001-04-25
IL136662A0 (en) 2001-06-14
EA004761B1 (ru) 2004-08-26
PL194268B1 (pl) 2007-05-31
CN1198644C (zh) 2005-04-27
ES2405994T5 (es) 2019-01-30
EP1417972B1 (en) 2013-04-10
EP1417972B2 (en) 2018-08-22
ES2215268T3 (es) 2004-10-01
TR200002134T2 (tr) 2000-11-21
CA2314313A1 (en) 1999-06-17
AU1717799A (en) 2005-05-16
NO20002945D0 (no) 2000-06-08
AR018526A1 (es) 2001-11-28
PT920873E (pt) 2004-06-30
PT1417972E (pt) 2013-05-24
HUP0004447A2 (hu) 2001-04-28
SK15322000A3 (sk) 2001-05-10
EP1417972A1 (en) 2004-05-12
BR9813463A (pt) 2000-10-10
PE20000001A1 (es) 2000-01-17
ES2405994T3 (es) 2013-06-04
EP0920873A2 (en) 1999-06-09
HU230784B1 (en) 2018-05-02
AU759726B2 (en) 2003-04-17
IL136662A (en) 2004-09-27
CN1281370A (zh) 2001-01-24
CY1114000T1 (el) 2016-07-27
ZA9811127B (en) 2000-07-11
DK0920873T3 (da) 2004-06-28
ID27741A (id) 2001-04-26
JP4405666B2 (ja) 2010-01-27
HK1021798A1 (en) 2000-07-07
KR100482703B1 (ko) 2005-04-14
PL340902A1 (en) 2001-03-12

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