HUP0004447A2 - Stabilizált teriparatid oldatok - Google Patents

Stabilizált teriparatid oldatok

Info

Publication number
HUP0004447A2
HUP0004447A2 HU0004447A HUP0004447A HUP0004447A2 HU P0004447 A2 HUP0004447 A2 HU P0004447A2 HU 0004447 A HU0004447 A HU 0004447A HU P0004447 A HUP0004447 A HU P0004447A HU P0004447 A2 HUP0004447 A2 HU P0004447A2
Authority
HU
Hungary
Prior art keywords
stabilized
stabilized teriparatide
contain
solutions
teriparatide solutions
Prior art date
Application number
HU0004447A
Other languages
English (en)
Inventor
Chin-Ming Chang
Henry A. Havel
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22086574&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0004447(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of HUP0004447A2 publication Critical patent/HUP0004447A2/hu
Publication of HUP0004447A3 publication Critical patent/HUP0004447A3/hu
Publication of HU230784B1 publication Critical patent/HU230784B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Abstract

A találmány tárgya stabilizált gyógyászati készítmény oldat formában,egy paratiroid hormon parenterális beadása céljára, amiben aterápiásan hatékony aktív adalékanyagot egy puffer és egy poliolstabilizálja. Az előnyben részesített készítmények tartalmazzák ahumán PTH(1-34) vizes oldatát, tartalmaznak mannitot, egy acetát vagytartarát pufferelőágenst, valamint konzerválószerként m-krezolt vagybenzil-alkoholt. Ó
HU0004447A 1997-12-09 1998-12-08 Stabilized teriparatide solutions and process for producing HU230784B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6907597P 1997-12-09 1997-12-09
PCT/US1998/026043 WO1999029337A1 (en) 1997-12-09 1998-12-08 Stabilized teriparatide solutions

Publications (3)

Publication Number Publication Date
HUP0004447A2 true HUP0004447A2 (hu) 2001-04-28
HUP0004447A3 HUP0004447A3 (en) 2003-06-30
HU230784B1 HU230784B1 (en) 2018-05-02

Family

ID=22086574

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004447A HU230784B1 (en) 1997-12-09 1998-12-08 Stabilized teriparatide solutions and process for producing

Country Status (32)

Country Link
EP (2) EP1417972B2 (hu)
JP (1) JP4405666B2 (hu)
KR (1) KR100482703B1 (hu)
CN (1) CN1198644C (hu)
AR (1) AR018526A1 (hu)
AT (1) ATE260113T1 (hu)
AU (1) AU759726B2 (hu)
BR (1) BR9813463A (hu)
CA (1) CA2314313C (hu)
CY (1) CY1114000T1 (hu)
CZ (1) CZ302401B6 (hu)
DE (1) DE69821872T2 (hu)
DK (2) DK1417972T4 (hu)
EA (1) EA004761B1 (hu)
EG (1) EG23675A (hu)
ES (2) ES2405994T5 (hu)
HK (1) HK1021798A1 (hu)
HU (1) HU230784B1 (hu)
ID (1) ID27741A (hu)
IL (1) IL136662A (hu)
MY (1) MY120063A (hu)
NO (1) NO327302B1 (hu)
NZ (1) NZ505222A (hu)
PE (1) PE20000001A1 (hu)
PL (1) PL194268B1 (hu)
PT (2) PT920873E (hu)
SK (1) SK288203B6 (hu)
TR (1) TR200002134T2 (hu)
TW (1) TW570811B (hu)
UA (1) UA72884C2 (hu)
WO (1) WO1999029337A1 (hu)
ZA (1) ZA9811127B (hu)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL346127A1 (en) * 1998-07-23 2002-01-28 Lilly Co Eli Fsh and fsh variant formulations, products and methods
US20030166525A1 (en) 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
AR033639A1 (es) 1998-08-19 2004-01-07 Lilly Co Eli Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis
US7022674B2 (en) 1999-12-16 2006-04-04 Eli Lilly And Company Polypeptide compositions with improved stability
WO2001087322A2 (en) * 2000-05-17 2001-11-22 Bionebraska, Inc. Peptide pharmaceutical formulations
EP1301200A2 (en) * 2000-05-19 2003-04-16 Bionebraska, Inc. Peptide pharmaceutical formulations
EP1391209A4 (en) * 2001-05-30 2009-12-16 Chugai Pharmaceutical Co Ltd PROTEIN PREPARATION
EP1767213A3 (en) * 2001-11-05 2007-04-25 Eli Lilly & Company Method for improving stability of a bone-connecting implant
WO2003039331A2 (en) * 2001-11-05 2003-05-15 Eli Lilly And Company Method for improving stability of a bone-connecting implant
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
MXPA05010635A (es) 2003-04-02 2005-12-12 Ares Trading Sa Formulaciones farmaceuticas liquidas de hormona estimulante de foliculos y hormona luteinizante junto con un surfactante no ionico.
EP1638595B1 (en) 2003-06-20 2013-03-20 Ares Trading S.A. Freeze-dried fsh / lh formulations
US7329725B1 (en) 2003-10-29 2008-02-12 Nastech Pharmaceutical Company Inc. Phage displayed Trp cage ligands
SI1687019T1 (en) 2003-11-20 2018-04-30 Novo Nordisk A/S PROPILED GLIKO-CONTAINING PEPTIDAL FORMULATIONS OPTIMAL FOR MANUFACTURING AND FOR USE IN INJECTION DEVICES
US7282493B2 (en) 2003-12-23 2007-10-16 Infinity Pharmaceuticals, Inc. Analogs of benzoquinone-containing ansamycins and methods of use thereof
US8268791B2 (en) 2004-08-25 2012-09-18 Aegis Therapeutics, Llc. Alkylglycoside compositions for drug administration
US9114069B2 (en) 2004-08-25 2015-08-25 Aegis Therapeutics, Llc Antibacterial compositions for drug administration
EP2457580A1 (en) * 2004-08-25 2012-05-30 The UAB Research Foundation Absorption enhancers for drug administration
US8642564B2 (en) 2004-08-25 2014-02-04 Aegis Therapeutics, Llc Compositions for drug administration
US9895444B2 (en) 2004-08-25 2018-02-20 Aegis Therapeutics, Llc Compositions for drug administration
US20060046962A1 (en) 2004-08-25 2006-03-02 Aegis Therapeutics Llc Absorption enhancers for drug administration
US20140162965A1 (en) 2004-08-25 2014-06-12 Aegis Therapeutics, Inc. Compositions for oral drug administration
KR100700869B1 (ko) * 2005-06-03 2007-03-29 재단법인 목암생명공학연구소 Ｐｔｈ, 완충제 및 안정제를 포함하는 안정한 ｐｔｈ조성물
US7994129B2 (en) 2005-11-10 2011-08-09 Michigan Technological University Methods of using black bear parathyroid hormone
US8226949B2 (en) 2006-06-23 2012-07-24 Aegis Therapeutics Llc Stabilizing alkylglycoside compositions and methods thereof
CN101578093B (zh) * 2006-10-03 2011-09-14 半径健康公司 骨合成代谢蛋白质的药物递送方法
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
US7803770B2 (en) 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
EP1958618A1 (de) 2007-02-15 2008-08-20 Octapharma AG Verfahren zur Gefriertrocknung mit optimierter Rekonstitution von Biopolymeren
AU2008240179A1 (en) * 2007-04-12 2008-10-23 Infinity Discovery, Inc. Hydroquinone ansamycin formulations
WO2008150929A1 (en) * 2007-05-29 2008-12-11 Manhattan Pharmaceuticals, Inc. Topical compositions comprising a macromolecule and methods of using same
JP5513380B2 (ja) 2007-06-25 2014-06-04 アムジエン・インコーポレーテツド 肝細胞増殖因子に対する特異的結合剤の組成物
EP2271347B1 (en) 2008-03-28 2016-05-11 Hale Biopharma Ventures, Llc Administration of benzodiazepine compositions
EP2348845A4 (en) 2008-10-15 2013-01-23 Infinity Pharmaceuticals Inc ANSAMYCIN HYDROQUINONE COMPOSITIONS
US8440631B2 (en) 2008-12-22 2013-05-14 Aegis Therapeutics, Llc Compositions for drug administration
EP2682124B1 (en) * 2009-09-09 2018-02-28 Asahi Kasei Pharma Corporation Pth-containing therapeutic/prophylactic agent for osteoporosis, characterized in that pth is administered once a week at unit dose of 200 units
AU2009356227A1 (en) 2009-12-07 2012-06-21 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
WO2012174158A2 (en) 2011-06-14 2012-12-20 Hale Biopharma Ventures, Llc Administration of benzodiazepine
CN102731643A (zh) * 2012-06-26 2012-10-17 深圳翰宇药业股份有限公司 一种治疗骨质疏松多肽的制备方法
CN103301058A (zh) * 2013-06-17 2013-09-18 深圳翰宇药业股份有限公司 一种特立帕肽注射用组合物及其制备方法和制剂
BR112017023233A2 (pt) 2015-04-29 2018-11-06 Radius Pharmaceuticals Inc métodos para tratamento de câncer
CN106309358A (zh) * 2015-06-29 2017-01-11 成都金凯生物技术有限公司 含有人甲状旁腺激素的药物组合物及其制备方法与用途
JP6634758B2 (ja) * 2015-09-25 2020-01-22 ニプロ株式会社 液体組成物及び凍結乾燥製剤
MA45277A (fr) 2016-03-01 2019-01-09 Ascendis Pharma Bone Diseases As Promédicaments de pth
HRP20230383T1 (hr) 2016-09-29 2023-07-07 Ascendis Pharma Bone Diseases A/S Pth spojevi s malim omjerima maksimalne prema minimalnoj koncentraciji
HRP20231079T1 (hr) 2016-09-29 2023-12-22 Ascendis Pharma Bone Diseases A/S Režim za doziranje pth spoja s kontroliranim oslobađanjem
AU2018205285C1 (en) 2017-01-05 2023-08-24 Radius Pharmaceuticals, Inc. Polymorphic forms of RAD1901-2HCl
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
EP4360651A2 (en) 2017-08-24 2024-05-01 Novo Nordisk A/S Glp-1 compositions and uses thereof
WO2019059302A1 (ja) * 2017-09-22 2019-03-28 旭化成ファーマ株式会社 安定性に優れるテリパラチド含有液状医薬組成物
JP2019060866A (ja) * 2017-09-22 2019-04-18 旭化成ファーマ株式会社 液状医薬組成物の体内動態を予測する方法
CA3075984A1 (en) * 2017-09-22 2019-03-28 Asahi Kasei Pharma Corporation Teriparatide-containing liquid pharmaceutical composition having excellent pharmacokinetics and/or safety
CN108159404B (zh) * 2018-01-05 2019-08-27 北京博康健基因科技有限公司 重组人甲状旁腺激素制剂及其制备方法
WO2019220654A1 (ja) * 2018-05-17 2019-11-21 旭化成ファーマ株式会社 Ｎ－ホルミルピぺリジン含有量が低減されている、及び／又は、凍結乾燥ケーキの崩潰又は収縮が抑制されている、製剤
KR20210130751A (ko) * 2019-02-11 2021-11-01 아센디스 파마 본 디지즈 에이/에스 Pth 접합체의 액체 약학 제제
CN112439054B (zh) * 2019-08-28 2023-05-16 深圳翰宇药业股份有限公司 一种特立帕肽缓释凝胶注射液及其制备方法
EP4106724A1 (en) 2020-02-18 2022-12-28 Novo Nordisk A/S Glp-1 compositions and uses thereof
US20230190880A1 (en) * 2020-03-30 2023-06-22 Sichuan Luzhou Buchang Bio-Pharmaceutical Co., Ltd. Formulations of Human Parathyroid Hormone (PTH) and Methods for Producing Same
CN113967249A (zh) * 2021-12-10 2022-01-25 深圳先进技术研究院 甲状旁腺激素在制备治疗男性抑郁症的药物或保健品中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6360940A (ja) * 1986-09-01 1988-03-17 Toyo Jozo Co Ltd 白内障の予防または治療剤
JP2505812B2 (ja) * 1987-07-10 1996-06-12 旭化成工業株式会社 ｈ―ＰＴＨ（１―３４）凍結乾燥組成物
US5059587A (en) * 1987-08-03 1991-10-22 Toyo Jozo Company, Ltd. Physiologically active peptide composition for nasal administration
DE3935738A1 (de) * 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
GB9020544D0 (en) * 1990-09-20 1990-10-31 Sandoz Ltd Improvements in or relating to organic compounds
WO1993011785A1 (en) * 1991-12-09 1993-06-24 Asahi Kasei Kogyo Kabushiki Kaisha Stabilized parathyroid hormone composition
DK0679088T3 (da) 1992-09-29 2002-10-28 Inhale Therapeutic Syst Pulmonal levering af aktive fragmenter af parathyreoideaea hormon
IT1255723B (it) † 1992-10-09 1995-11-13 Uso di paratormone,suoi frammenti biologicamente attivi e peptidi correlati, per la preparazione di composizioni farmaceutiche utili nella prevenzione e terapia dell'aborto e del parto pretermine ed in generale per il trattamento della gestazione
US5496801A (en) * 1993-12-23 1996-03-05 Allelix Biopharmaceuticals Inc. Parathyroid hormone formulation
DE19538687A1 (de) † 1995-10-17 1997-04-24 Boehringer Mannheim Gmbh Stabile pharmazeutische Darreichungsformen enthaltend Parathormon

Also Published As

Publication number Publication date
IL136662A0 (en) 2001-06-14
PE20000001A1 (es) 2000-01-17
JP4405666B2 (ja) 2010-01-27
EP1417972B1 (en) 2013-04-10
DK1417972T4 (en) 2018-10-22
NO20002945L (no) 2000-07-07
PT920873E (pt) 2004-06-30
ZA9811127B (en) 2000-07-11
PL194268B1 (pl) 2007-05-31
IL136662A (en) 2004-09-27
NO327302B1 (no) 2009-06-02
CY1114000T1 (el) 2016-07-27
SK288203B6 (sk) 2014-07-02
EP1417972B2 (en) 2018-08-22
AU1717799A (en) 2005-05-16
ES2405994T5 (es) 2019-01-30
UA72884C2 (uk) 2005-05-16
TR200002134T2 (tr) 2000-11-21
DE69821872D1 (de) 2004-04-01
MY120063A (en) 2005-08-30
EP0920873B1 (en) 2004-02-25
EG23675A (en) 2007-04-15
EA200000629A1 (ru) 2000-12-25
CN1281370A (zh) 2001-01-24
KR100482703B1 (ko) 2005-04-14
DK0920873T3 (da) 2004-06-28
EP0920873A2 (en) 1999-06-09
ATE260113T1 (de) 2004-03-15
PT1417972E (pt) 2013-05-24
PL340902A1 (en) 2001-03-12
HU230784B1 (en) 2018-05-02
CN1198644C (zh) 2005-04-27
WO1999029337A1 (en) 1999-06-17
KR20010032881A (ko) 2001-04-25
TW570811B (en) 2004-01-11
CZ302401B6 (cs) 2011-05-04
ES2215268T3 (es) 2004-10-01
CZ20002115A3 (en) 2001-05-16
DK1417972T3 (da) 2013-05-13
EP1417972A1 (en) 2004-05-12
BR9813463A (pt) 2000-10-10
ES2405994T3 (es) 2013-06-04
HUP0004447A3 (en) 2003-06-30
CA2314313A1 (en) 1999-06-17
ID27741A (id) 2001-04-26
SK15322000A3 (sk) 2001-05-10
DE69821872T2 (de) 2005-01-05
NO20002945D0 (no) 2000-06-08
EA004761B1 (ru) 2004-08-26
JP2001525372A (ja) 2001-12-11
NZ505222A (en) 2003-05-30
CA2314313C (en) 2005-02-08
AR018526A1 (es) 2001-11-28
AU759726B2 (en) 2003-04-17
HK1021798A1 (en) 2000-07-07
EP0920873A3 (en) 1999-08-04

Similar Documents

Publication Publication Date Title
HUP0004447A2 (hu) Stabilizált teriparatid oldatok
PL329386A1 (en) Growth hormone, amino acid and non-ionic detergent containing pharmaceutic
DK1158959T3 (da) Sammensætninger og fremgangsmåder til forbedret indgift af hydrofobe terapeutiske midler
MY129417A (en) Zinc-free and low-zinc insulin preparations having improved stability
WO2002043750A8 (en) Method for the stabilizing of biomolecules (e.g. insulin) in liquid formulations
ES2110377T1 (es) Formulacion galenica de fenofibrato y aplicacion de la misma.
PT1035844E (pt) Utilizacao de poliois no combate a infeccoes por leveduras e preparacoes de poliol para a referida utilizacao
DE60233898D1 (de) Transdermales therapeutisches system für parkinson-krankheit mit hohen rotigotin-plasmaspiegeln
BR0013154A (pt) Vacina recombinante para o envelope contra infecção de flavivìrus
AR044147A1 (es) Formulaciones liquidas de interferon estabilizadas y libres de hsa
WO2000013662A3 (en) Medicated chewing gum delivery system for nicotine
MX9205384A (es) Dispositivo de administracion transdermica de un agente activo para uso veterinario.
DE69717293T2 (de) Pharmazeutische formulierungen aus corticotropin freisetzenden faktor mit verbesserter stabilitaet in fluessiger form
DK0641216T3 (da) Farmaceutisk præparat indeholdende IL-6
ATE353224T1 (de) Abgabeeinrichtung für eine zusammensetzung einer pharmazeutisch wirksamen substanz
DK1069912T3 (da) Injicerbare IGF-formuleringer, der indeholder succinat som puffermiddel
BG103958A (en) Pharmaceutical compositions of thioxanide and nitazoxanide
MX9207344A (es) Formulaciones mejoradas que tienen mejoradores hidrofobicos de penetracion transdermica y metodo para proveerla.
MY110074A (en) Pharmacuetical formulation.
ECSP982775A (es) Soluciones teriparatidas estabilizadas
TH20600A (th) เบนซิมิดาโซลที่ถูกแทนที่ (Substitued benzinidazole), กรรมวิธีสำหรับการเตรียมสารนั้นและการใช้ทางเภสัชศาสตร์ของสารนั้น
ITRM910038A1 (it) Composizioni farmaceutiche aventi come principio attivo calcitonina da somministrarsi per via intranasale.

Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished