JP2002508372A5 - - Google Patents
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- Publication number
- JP2002508372A5 JP2002508372A5 JP2000539018A JP2000539018A JP2002508372A5 JP 2002508372 A5 JP2002508372 A5 JP 2002508372A5 JP 2000539018 A JP2000539018 A JP 2000539018A JP 2000539018 A JP2000539018 A JP 2000539018A JP 2002508372 A5 JP2002508372 A5 JP 2002508372A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrate
- hydrate according
- diabetes
- prevention
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 206010012601 diabetes mellitus Diseases 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000000634 powder X-ray diffraction Methods 0.000 description 4
- 230000002265 prevention Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- NQLCBKFSQDRLKI-UAIGNFCESA-N O.C(\C=C/C(=O)O)(=O)O.S1C(NC(C1)=O)=O Chemical compound O.C(\C=C/C(=O)O)(=O)O.S1C(NC(C1)=O)=O NQLCBKFSQDRLKI-UAIGNFCESA-N 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- SUFUKZSWUHZXAV-BTJKTKAUSA-N rosiglitazone maleate Chemical compound [H+].[H+].[O-]C(=O)\C=C/C([O-])=O.C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O SUFUKZSWUHZXAV-BTJKTKAUSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9726568.0 | 1997-12-16 | ||
| GBGB9726568.0A GB9726568D0 (en) | 1997-12-16 | 1997-12-16 | Novel pharmaceutical |
| PCT/EP1998/008154 WO1999031094A1 (en) | 1997-12-16 | 1998-12-14 | Hydrate of 5-[4-[2- (n-methyl-n- (2-pyridil)amino) ethoxy]benzyl] thiazolidine-2, 4-dione maleic acid salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002508372A JP2002508372A (ja) | 2002-03-19 |
| JP2002508372A5 true JP2002508372A5 (enExample) | 2006-02-09 |
Family
ID=10823694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000539018A Withdrawn JP2002508372A (ja) | 1997-12-16 | 1998-12-14 | ５−［４−［２−（ｎ−メチル−ｎ−（２−ピリジル）アミノ）エトキシ］ベンジル］チアゾリジン−２，４−ジオン・マレイン酸塩の水和物 |
Country Status (37)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9909041D0 (en) * | 1999-04-20 | 1999-06-16 | Smithkline Beecham Plc | Novel pharmaceutical |
| US20040248945A1 (en) | 1999-04-23 | 2004-12-09 | Smithkline Beecham P.L.C. | Thiazolidinedione derivative and its use as antidiabetic |
| EA003031B1 (ru) * | 1999-04-23 | 2002-12-26 | Смитклайн Бичам Плс | Новый фармацевтический препарат |
| RS50114B (sr) | 1999-04-23 | 2009-03-25 | Smithkline Beecham P.L.C., | Novi polimorfni oblik 5-/4-/2-(n-metil- n-(2-piridil)amino/ etoksi/benzil/ tiazolidin-2,4-dion, soli maleinske kiseline |
| GB0014005D0 (en) * | 2000-06-08 | 2000-08-02 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB0021784D0 (en) * | 2000-09-05 | 2000-10-18 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB0021978D0 (en) * | 2000-09-07 | 2000-10-25 | Smithkline Beecham Plc | Novel pharmaceutical |
| AU2002350965A1 (en) * | 2001-12-13 | 2003-06-23 | Smithkline Beecham Plc | Toluenesulfonate hydrates of a thiazolidinedione derivative |
| GB0129876D0 (en) * | 2001-12-13 | 2002-02-06 | Smithkline Beecham Plc | Novel pharmaceutical |
| WO2003050116A1 (en) * | 2001-12-13 | 2003-06-19 | Smithkline Beecham Plc | A 5(-4-(2-(n-methyl-n-(2-pyridil)amino)ethoxy)benzyl)thiazolidine-2,4-dione (i) 10-camphorsulphonic acid salt and use against diabetes mellitus |
| GB0130511D0 (en) * | 2001-12-20 | 2002-02-06 | Smithkline Beecham Plc | Novel pharmaceutical |
| WO2003053962A1 (en) * | 2001-12-20 | 2003-07-03 | Smithkline Beecham Plc | 5- (4- (2- (n-methyl-n- (2-pyridyl) amino) ethoxy) benzyl) thiazolidine-2, 4-dione malic acid salt and use against diabetes mellitus |
| GB2405403A (en) * | 2003-08-29 | 2005-03-02 | Cipla Ltd | Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base |
| ITMI20041537A1 (it) * | 2004-07-28 | 2004-10-28 | Chemi Spa | Nuova forma polimorfa del rosiglitazone maleato |
| CZ298424B6 (cs) * | 2005-05-24 | 2007-09-26 | Zentiva, A. S. | Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel |
| EP2184055A1 (en) | 2008-11-07 | 2010-05-12 | LEK Pharmaceuticals d.d. | Process for preparing solid dosage forms of rosiglitazone maleate |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| US4812570A (en) * | 1986-07-24 | 1989-03-14 | Takeda Chemical Industries, Ltd. | Method for producing thiazolidinedione derivatives |
| EP0842925A1 (en) | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| GB8820389D0 (en) * | 1988-08-26 | 1988-09-28 | Beecham Group Plc | Novel compounds |
| GB9124513D0 (en) | 1991-11-19 | 1992-01-08 | Smithkline Beecham Plc | Novel process |
| JPH08500835A (ja) | 1992-08-28 | 1996-01-30 | メルク エンド カンパニー インコーポレーテッド | 陽イオン性−２−ヘテロアリールフェニル−カルバペネム抗菌剤 |
| US5741803A (en) | 1992-09-05 | 1998-04-21 | Smithkline Beecham Plc | Substituted thiazolidinedionle derivatives |
| GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| TW245716B (enExample) * | 1992-12-28 | 1995-04-21 | Takeda Pharm Industry Co | |
| DE4404198A1 (de) | 1994-02-10 | 1995-08-17 | Henkel Kgaa | 2-Fluor-6-nitroaniline |
| US20020137940A1 (en) | 1997-12-16 | 2002-09-26 | Smithkline Beecham P.L.C. | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
| US6664278B2 (en) * | 1997-12-16 | 2003-12-16 | Smithkline Beecham P.L.C. | Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt |
| GB9726566D0 (en) | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB9726563D0 (en) | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
| CZ432299A3 (cs) * | 1998-06-02 | 2000-08-16 | Smithkline Beecham Plc | Kompozice obsahující 5-[4-[2-(N-methyl-N-(2- pyridyI)amino)ethoxy]benzyl]thiazolidin-2,4-dion |
| EA003031B1 (ru) | 1999-04-23 | 2002-12-26 | Смитклайн Бичам Плс | Новый фармацевтический препарат |
| CN1167702C (zh) | 1999-04-23 | 2004-09-22 | 史密丝克莱恩比彻姆有限公司 | 5-[4-[2-n-甲基-n-(2-吡啶基)氨基]乙氧基]苄基]噻唑烷-2,4-二酮马来酸盐的多晶型物 |
| RS50114B (sr) | 1999-04-23 | 2009-03-25 | Smithkline Beecham P.L.C., | Novi polimorfni oblik 5-/4-/2-(n-metil- n-(2-piridil)amino/ etoksi/benzil/ tiazolidin-2,4-dion, soli maleinske kiseline |
-
1997
- 1997-12-16 GB GBGB9726568.0A patent/GB9726568D0/en not_active Ceased
-
1998
- 1998-12-14 CN CNA2008100930575A patent/CN101412714A/zh active Pending
- 1998-12-14 HR HR20000405A patent/HRP20000405A2/hr not_active Application Discontinuation
- 1998-12-14 IL IL13638198A patent/IL136381A/xx unknown
- 1998-12-14 WO PCT/EP1998/008154 patent/WO1999031094A1/en not_active Ceased
- 1998-12-14 RS YUP-362/00A patent/RS50079B/sr unknown
- 1998-12-14 EA EA200000655A patent/EA002355B1/ru not_active IP Right Cessation
- 1998-12-14 MA MA25392A patent/MA26582A1/fr unknown
- 1998-12-14 KR KR1020007006517A patent/KR100549143B1/ko not_active Expired - Fee Related
- 1998-12-14 SK SK910-2000A patent/SK286197B6/sk not_active IP Right Cessation
- 1998-12-14 CN CN98812092A patent/CN1281454A/zh active Pending
- 1998-12-14 PL PL98341147A patent/PL341147A1/xx not_active Application Discontinuation
- 1998-12-14 CA CA002314965A patent/CA2314965A1/en not_active Abandoned
- 1998-12-14 CZ CZ20002205A patent/CZ299970B6/cs not_active IP Right Cessation
- 1998-12-14 EP EP98966321A patent/EP1045847A1/en not_active Ceased
- 1998-12-14 ID IDW20001126A patent/ID24744A/id unknown
- 1998-12-14 UA UA2000063484A patent/UA63980C2/uk unknown
- 1998-12-14 CN CNA2008100930560A patent/CN101412713A/zh active Pending
- 1998-12-14 AP APAP/P/2000/001830A patent/AP1441A/en active
- 1998-12-14 AU AU22723/99A patent/AU2272399A/en not_active Abandoned
- 1998-12-14 NZ NZ504704A patent/NZ504704A/xx unknown
- 1998-12-14 TR TR2000/01798T patent/TR200001798T2/xx unknown
- 1998-12-14 BR BR9813604-6A patent/BR9813604A/pt not_active Application Discontinuation
- 1998-12-14 HU HU0100500A patent/HUP0100500A3/hu unknown
- 1998-12-14 OA OA1200000179A patent/OA11634A/en unknown
- 1998-12-14 JP JP2000539018A patent/JP2002508372A/ja not_active Withdrawn
- 1998-12-15 ZA ZA9811505A patent/ZA9811505B/xx unknown
- 1998-12-15 AR ARP980106365A patent/AR017430A1/es not_active Application Discontinuation
- 1998-12-15 DZ DZ980290A patent/DZ2680A1/xx active
- 1998-12-15 AR ARP980106369A patent/AR017213A1/es not_active Application Discontinuation
- 1998-12-15 EG EG155498A patent/EG21417A/xx active
- 1998-12-15 UY UY25310A patent/UY25310A1/es not_active IP Right Cessation
- 1998-12-15 UY UY25305A patent/UY25305A1/es not_active IP Right Cessation
- 1998-12-15 EG EG155098A patent/EG23694A/xx active
- 1998-12-15 MY MYPI98005675A patent/MY135770A/en unknown
- 1998-12-16 PE PE1998001232A patent/PE20000057A1/es not_active Application Discontinuation
- 1998-12-16 IN IN3770DE1998 patent/IN190821B/en unknown
- 1998-12-16 TW TW087121122A patent/TW467913B/zh not_active IP Right Cessation
- 1998-12-16 CO CO98074830A patent/CO4990927A1/es unknown
- 1998-12-16 TR TR1998/02626A patent/TR199802626A2/xx unknown
-
2000
- 2000-06-15 NO NO20003068A patent/NO317253B1/no not_active IP Right Cessation
- 2000-07-11 BG BG104595A patent/BG64905B1/bg unknown
-
2003
- 2003-10-24 US US10/692,544 patent/US7045633B2/en not_active Expired - Fee Related
-
2006
- 2006-03-16 US US11/377,470 patent/US20060189659A1/en not_active Abandoned
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