RU2004127128A - Фармацевтическая композиция для регенерации цирротической печени - Google Patents

Фармацевтическая композиция для регенерации цирротической печени Download PDF

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Publication number
RU2004127128A
RU2004127128A RU2004127128/15A RU2004127128A RU2004127128A RU 2004127128 A RU2004127128 A RU 2004127128A RU 2004127128/15 A RU2004127128/15 A RU 2004127128/15A RU 2004127128 A RU2004127128 A RU 2004127128A RU 2004127128 A RU2004127128 A RU 2004127128A
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RU
Russia
Prior art keywords
pharmaceutical composition
regeneration
liver
cirrotic
dithiol
Prior art date
Application number
RU2004127128/15A
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English (en)
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RU2291696C2 (ru
Inventor
Санг-Геон КИМ (KR)
Санг-Геон КИМ
Кеон-Вук КАНГ (KR)
Кеон-Вук КАНГ
Уон-Гуон КИМ (KR)
Уон-Гуон КИМ
Мин-Кунг ЧО (KR)
Мин-Кунг ЧО
Original Assignee
Санг-Геон КИМ (KR)
Санг-Геон КИМ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Санг-Геон КИМ (KR), Санг-Геон КИМ filed Critical Санг-Геон КИМ (KR)
Publication of RU2004127128A publication Critical patent/RU2004127128A/ru
Application granted granted Critical
Publication of RU2291696C2 publication Critical patent/RU2291696C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Claims (4)

1. Фармацевтическая композиция для регенерации тканей печени для лечения цирроза печени, содержащая 5-(2-пиразинил)-4-метил-1,2-дитиол-3-тион (олтипраз) и фармацевтически приемлемый наполнитель.
2. Фармацевтическая композиция по п.1, где эта композиция приготовлена в форме, выбранной из группы, состоящей из капсулы, таблетки, мягкой капсулы, суспензии, сиропа, инъекционного раствора и порошка.
3. Фармацевтическая композиция по п.1, где эта композиция приготовлена в форме для перорального введения.
4. Применение 5-(2-пиразинил)-4-метил-1,2-дитиол-3-тиона для приготовления лекарственного средства для лечения цирротической печени посредством регенерации тканей печени.
RU2004127128/15A 2002-02-09 2003-02-08 Фармацевтическая композиция для регенерации цирротической печени RU2291696C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020020007678A KR20030067935A (ko) 2002-02-09 2002-02-09 올티프라즈를 포함하는 간경화(간경변증) 치료를 위한 간 조직 재생용 제약 조성물
KR2002/7678 2002-02-09

Publications (2)

Publication Number Publication Date
RU2004127128A true RU2004127128A (ru) 2005-04-20
RU2291696C2 RU2291696C2 (ru) 2007-01-20

Family

ID=27725720

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2004127128/15A RU2291696C2 (ru) 2002-02-09 2003-02-08 Фармацевтическая композиция для регенерации цирротической печени

Country Status (15)

Country Link
US (2) US20030171382A1 (ru)
EP (1) EP1471914A4 (ru)
JP (1) JP2005519926A (ru)
KR (1) KR20030067935A (ru)
CN (1) CN1278687C (ru)
AU (1) AU2003206245B2 (ru)
BR (1) BR0306923A (ru)
CA (1) CA2473202C (ru)
MX (1) MXPA04007675A (ru)
NO (1) NO20042876L (ru)
PL (1) PL371245A1 (ru)
RU (1) RU2291696C2 (ru)
TW (1) TWI248931B (ru)
WO (1) WO2003066058A1 (ru)
ZA (1) ZA200406059B (ru)

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KR20060031956A (ko) * 2004-10-11 2006-04-14 재단법인서울대학교산학협력재단 ｐ90 리보솜 Ｓ6 키나제 1 (ＲＳＫ1)의 직접적인 키나제활성증진을 통한 간섬유화와 간경변증 예방 및 치료용약학조성물
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US8076311B2 (en) 2006-05-11 2011-12-13 Prendergast Patrick T Compositions and methods for modulating the immune system
GB0704718D0 (en) * 2007-03-12 2007-04-18 Prendergast Patrick T Compounds and methods for preventing and treating mucositis
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AP2011005681A0 (en) 2008-10-02 2011-04-30 George Zabrecky Methods and formulations for treating chronic liver disease.
EP2674159B1 (de) 2012-06-15 2016-04-27 Phrontier S.A.R.L. Pharmazeutische Zusammensetzung für die Leber-Regeneration
BR112018004518A2 (pt) 2015-09-08 2019-03-19 OP2 Drugs compostos para o tratamento de doenças ligadas à produção de espécies reativas de oxigênio (ros) mitocondriais
CN108348781B (zh) * 2015-09-08 2022-02-11 Op2药品公司 用于治疗与线粒体活性氧簇(ros)产生相关的疾病的化合物
CN114404595A (zh) * 2015-12-07 2022-04-29 国立大学法人京都大学 Pd-1信号抑制剂的并用疗法
CA3055122A1 (en) 2017-03-07 2018-09-13 OP2 Drugs Desmethylanethole trithione derivatives for the treatment of diseases linked to mitochondrial reactive oxygen species (ros) production
DK3811155T3 (da) * 2019-08-29 2022-08-29 Esko Graphics Imaging Gmbh Uv-led-strålingskilder til anvendelse i fotopolymerbelysning

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Also Published As

Publication number Publication date
WO2003066058A1 (en) 2003-08-14
TW200305570A (en) 2003-11-01
CA2473202A1 (en) 2003-08-14
ZA200406059B (en) 2005-06-21
CN1625399A (zh) 2005-06-08
AU2003206245A1 (en) 2003-09-02
RU2291696C2 (ru) 2007-01-20
PL371245A1 (en) 2005-06-13
CN1278687C (zh) 2006-10-11
EP1471914A1 (en) 2004-11-03
US20030171382A1 (en) 2003-09-11
MXPA04007675A (es) 2004-11-10
US20060063781A1 (en) 2006-03-23
JP2005519926A (ja) 2005-07-07
NO20042876L (no) 2004-09-01
CA2473202C (en) 2007-11-13
BR0306923A (pt) 2004-12-28
TWI248931B (en) 2006-02-11
EP1471914A4 (en) 2007-08-08
KR20030067935A (ko) 2003-08-19
AU2003206245B2 (en) 2006-07-20

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Effective date: 20150209