JP2006509715A5 - - Google Patents
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- JP2006509715A5 JP2006509715A5 JP2003569634A JP2003569634A JP2006509715A5 JP 2006509715 A5 JP2006509715 A5 JP 2006509715A5 JP 2003569634 A JP2003569634 A JP 2003569634A JP 2003569634 A JP2003569634 A JP 2003569634A JP 2006509715 A5 JP2006509715 A5 JP 2006509715A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- urea
- thiazol
- piperidin
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 C 1 -C 6 -alkyl Chemical group 0.000 claims 98
- 125000000623 heterocyclic group Chemical group 0.000 claims 16
- 239000004202 carbamide Substances 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000002757 morpholinyl group Chemical group 0.000 claims 12
- 125000003386 piperidinyl group Chemical group 0.000 claims 11
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 11
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000004193 piperazinyl group Chemical group 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 7
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 6
- 125000006264 diethylaminomethyl group Chemical group [H]C([H])([H])C([H])([H])N(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 4
- 125000004397 aminosulfonyl group Chemical class NS(=O)(=O)* 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 claims 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
- IEJANKDXAXHCGG-UHFFFAOYSA-N (2-phenyl-1,3-thiazol-4-yl)urea Chemical compound NC(=O)NC1=CSC(C=2C=CC=CC=2)=N1 IEJANKDXAXHCGG-UHFFFAOYSA-N 0.000 claims 2
- SLTYXVYQMFLHPK-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[6-(2-piperidin-4-ylethoxy)pyridin-2-yl]urea Chemical compound S1C(Br)=NC(NC(=O)NC=2N=C(OCCC3CCNCC3)C=CC=2)=C1 SLTYXVYQMFLHPK-UHFFFAOYSA-N 0.000 claims 2
- HWZCMNUJXAECNS-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[6-(3-hydroxypropylamino)pyridin-2-yl]urea Chemical compound OCCCNC1=CC=CC(NC(=O)NC=2N=C(Br)SC=2)=N1 HWZCMNUJXAECNS-UHFFFAOYSA-N 0.000 claims 2
- DSMUBPNMLFTCDI-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[6-[(1-methylpyrrolidin-2-yl)methoxy]pyridin-2-yl]urea Chemical compound CN1CCCC1COC1=CC=CC(NC(=O)NC=2N=C(Br)SC=2)=N1 DSMUBPNMLFTCDI-UHFFFAOYSA-N 0.000 claims 2
- JWKLQSUSVODONX-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[6-[(3-methylpiperidin-1-yl)methyl]pyridin-2-yl]urea Chemical compound C1C(C)CCCN1CC1=CC=CC(NC(=O)NC=2N=C(Br)SC=2)=N1 JWKLQSUSVODONX-UHFFFAOYSA-N 0.000 claims 2
- KXLVMMWTXTUXTK-UHFFFAOYSA-N 1-(2-chloro-1,3-thiazol-4-yl)-3-[6-(2-piperidin-4-ylethoxy)pyridin-2-yl]urea Chemical compound S1C(Cl)=NC(NC(=O)NC=2N=C(OCCC3CCNCC3)C=CC=2)=C1 KXLVMMWTXTUXTK-UHFFFAOYSA-N 0.000 claims 2
- LPOXYHGDUYOQNZ-UHFFFAOYSA-N 1-(2-chloro-1,3-thiazol-4-yl)-3-[6-(piperidin-1-ylmethyl)pyridin-2-yl]urea Chemical compound S1C(Cl)=NC(NC(=O)NC=2N=C(CN3CCCCC3)C=CC=2)=C1 LPOXYHGDUYOQNZ-UHFFFAOYSA-N 0.000 claims 2
- FFXYWEJGHJTSOI-UHFFFAOYSA-N 1-(2-chloro-1,3-thiazol-4-yl)-3-[6-(piperidin-4-ylmethoxy)pyridin-2-yl]urea Chemical compound S1C(Cl)=NC(NC(=O)NC=2N=C(OCC3CCNCC3)C=CC=2)=C1 FFXYWEJGHJTSOI-UHFFFAOYSA-N 0.000 claims 2
- KIZXTRYBMBRXFW-UHFFFAOYSA-N 1-(2-chloro-1,3-thiazol-4-yl)-3-[6-[(1-methylpyrrolidin-2-yl)methoxy]pyridin-2-yl]urea Chemical compound CN1CCCC1COC1=CC=CC(NC(=O)NC=2N=C(Cl)SC=2)=N1 KIZXTRYBMBRXFW-UHFFFAOYSA-N 0.000 claims 2
- DOPRSVFHJQVOTC-UHFFFAOYSA-N 1-(2-chloro-1,3-thiazol-4-yl)-3-[6-[(3-methylpiperidin-1-yl)methyl]pyridin-2-yl]urea Chemical compound C1C(C)CCCN1CC1=CC=CC(NC(=O)NC=2N=C(Cl)SC=2)=N1 DOPRSVFHJQVOTC-UHFFFAOYSA-N 0.000 claims 2
- QQPSZKJHHPRADH-UHFFFAOYSA-N 1-(2-phenyl-1,3-thiazol-4-yl)-3-[6-(2-piperidin-4-ylethoxy)pyridin-2-yl]urea Chemical compound C=1C=CC(OCCC2CCNCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=CC=C1 QQPSZKJHHPRADH-UHFFFAOYSA-N 0.000 claims 2
- HPUUYQVAMNKGNY-UHFFFAOYSA-N 1-(2-phenyl-1,3-thiazol-4-yl)-3-[6-(piperidin-4-ylmethoxy)pyridin-2-yl]urea Chemical compound C=1C=CC(OCC2CCNCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=CC=C1 HPUUYQVAMNKGNY-UHFFFAOYSA-N 0.000 claims 2
- KJNURJSIHRMSAP-UHFFFAOYSA-N 1-(2-phenyl-1,3-thiazol-4-yl)-3-[6-(pyrrolidin-1-ylmethyl)pyridin-2-yl]urea Chemical compound C=1C=CC(CN2CCCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=CC=C1 KJNURJSIHRMSAP-UHFFFAOYSA-N 0.000 claims 2
- ALAVWAINFQQTTB-UHFFFAOYSA-N 1-(2-phenyl-1,3-thiazol-4-yl)-3-[6-[(propan-2-ylamino)methyl]pyridin-2-yl]urea Chemical compound CC(C)NCC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 ALAVWAINFQQTTB-UHFFFAOYSA-N 0.000 claims 2
- GWHBHIFNZJPJPU-UHFFFAOYSA-N 1-(2-pyridin-4-yl-1,3-thiazol-4-yl)-3-[6-(1,2,3,6-tetrahydropyridin-4-yl)pyridin-2-yl]urea Chemical compound C=1C=CC(C=2CCNCC=2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 GWHBHIFNZJPJPU-UHFFFAOYSA-N 0.000 claims 2
- KJAMWKJQNWQDRV-UHFFFAOYSA-N 1-(2-pyridin-4-yl-1,3-thiazol-4-yl)-3-[6-(pyrrolidin-2-ylmethoxy)pyridin-2-yl]urea Chemical compound C=1C=CC(OCC2NCCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 KJAMWKJQNWQDRV-UHFFFAOYSA-N 0.000 claims 2
- QFFRNDMIERRDMZ-UHFFFAOYSA-N 1-(2-pyridin-4-yl-1,3-thiazol-4-yl)-3-[6-(pyrrolidin-3-ylmethoxy)pyridin-2-yl]urea Chemical compound C=1C=CC(OCC2CNCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 QFFRNDMIERRDMZ-UHFFFAOYSA-N 0.000 claims 2
- CUJKKZCQZNVMMK-UHFFFAOYSA-N 1-[2-(1h-indazol-5-yl)-1,3-thiazol-4-yl]-3-[6-(piperidin-1-ylmethyl)pyridin-2-yl]urea Chemical compound C=1SC(C=2C=C3C=NNC3=CC=2)=NC=1NC(=O)NC(N=1)=CC=CC=1CN1CCCCC1 CUJKKZCQZNVMMK-UHFFFAOYSA-N 0.000 claims 2
- RLRPCJOWGTXWIZ-UHFFFAOYSA-N 1-[2-(2-chloropyridin-4-yl)-1,3-thiazol-4-yl]-3-[6-(piperidin-1-ylmethyl)pyridin-2-yl]urea Chemical compound C1=NC(Cl)=CC(C=2SC=C(NC(=O)NC=3N=C(CN4CCCCC4)C=CC=3)N=2)=C1 RLRPCJOWGTXWIZ-UHFFFAOYSA-N 0.000 claims 2
- GRBSNCWHCWHCJE-UHFFFAOYSA-N 1-[2-(2-methoxypyridin-4-yl)-1,3-thiazol-4-yl]-3-[6-(piperidin-1-ylmethyl)pyridin-2-yl]urea Chemical compound C1=NC(OC)=CC(C=2SC=C(NC(=O)NC=3N=C(CN4CCCCC4)C=CC=3)N=2)=C1 GRBSNCWHCWHCJE-UHFFFAOYSA-N 0.000 claims 2
- VGNQPRZWLLRSEI-UHFFFAOYSA-N 1-[2-(2-methoxypyridin-4-yl)-1,3-thiazol-4-yl]-3-[6-[(1-methylpyrrolidin-2-yl)methoxy]pyridin-2-yl]urea Chemical compound C1=NC(OC)=CC(C=2SC=C(NC(=O)NC=3N=C(OCC4N(CCC4)C)C=CC=3)N=2)=C1 VGNQPRZWLLRSEI-UHFFFAOYSA-N 0.000 claims 2
- DBMVSKQVJPGMQP-UHFFFAOYSA-N 1-[4-(diethylaminomethyl)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound CCN(CC)CC1=CC=NC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=C1 DBMVSKQVJPGMQP-UHFFFAOYSA-N 0.000 claims 2
- PEJSESOMOHCUQP-UHFFFAOYSA-N 1-[4-(piperidine-1-carbonyl)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C(C(=O)N2CCCCC2)=CC=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 PEJSESOMOHCUQP-UHFFFAOYSA-N 0.000 claims 2
- TWRFTDFREDHKHH-UHFFFAOYSA-N 1-[6-(1-methylpiperidin-4-yl)oxypyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound C1CN(C)CCC1OC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 TWRFTDFREDHKHH-UHFFFAOYSA-N 0.000 claims 2
- BPDZREVVZIEUCZ-UHFFFAOYSA-N 1-[6-(1-methylpiperidin-4-yl)oxypyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C1CN(C)CCC1OC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 BPDZREVVZIEUCZ-UHFFFAOYSA-N 0.000 claims 2
- NNXOJRIQZFGDGC-UHFFFAOYSA-N 1-[6-(1-piperidin-1-ylethyl)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=NC=1C(C)N1CCCCC1 NNXOJRIQZFGDGC-UHFFFAOYSA-N 0.000 claims 2
- GTJRLXQLWKRRSK-UHFFFAOYSA-N 1-[6-(2-piperidin-4-ylethoxy)pyridin-2-yl]-3-(2-thiophen-2-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(OCCC2CCNCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=CS1 GTJRLXQLWKRRSK-UHFFFAOYSA-N 0.000 claims 2
- WYZQMGVLWMBISV-UHFFFAOYSA-N 1-[6-(3-hydroxypropylamino)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound OCCCNC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 WYZQMGVLWMBISV-UHFFFAOYSA-N 0.000 claims 2
- DBONYUFYBZLPJE-UHFFFAOYSA-N 1-[6-(4-ethylpiperazin-1-yl)pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound C1CN(CC)CCN1C1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 DBONYUFYBZLPJE-UHFFFAOYSA-N 0.000 claims 2
- BIYDCUBOPOIKRD-UHFFFAOYSA-N 1-[6-(azetidin-3-ylmethoxy)pyridin-2-yl]-3-(2-bromo-1,3-thiazol-4-yl)urea Chemical compound S1C(Br)=NC(NC(=O)NC=2N=C(OCC3CNC3)C=CC=2)=C1 BIYDCUBOPOIKRD-UHFFFAOYSA-N 0.000 claims 2
- FSESKXXUUGQRSX-UHFFFAOYSA-N 1-[6-(azetidin-3-ylmethoxy)pyridin-2-yl]-3-(2-chloro-1,3-thiazol-4-yl)urea Chemical compound S1C(Cl)=NC(NC(=O)NC=2N=C(OCC3CNC3)C=CC=2)=C1 FSESKXXUUGQRSX-UHFFFAOYSA-N 0.000 claims 2
- DQJUWPHMOYYKEF-UHFFFAOYSA-N 1-[6-(azetidin-3-ylmethoxy)pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(OCC2CNC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=CC=C1 DQJUWPHMOYYKEF-UHFFFAOYSA-N 0.000 claims 2
- AZZNKOCSCQDFQX-UHFFFAOYSA-N 1-[6-(diethylaminomethyl)pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound CCN(CC)CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 AZZNKOCSCQDFQX-UHFFFAOYSA-N 0.000 claims 2
- FBENHJKGNFJIJY-UHFFFAOYSA-N 1-[6-(diethylcarbamothioyl)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound CCN(CC)C(=S)C1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 FBENHJKGNFJIJY-UHFFFAOYSA-N 0.000 claims 2
- BVLQUUAQCAVKNY-UHFFFAOYSA-N 1-[6-(oxolan-3-ylmethoxy)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(OCC2COCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 BVLQUUAQCAVKNY-UHFFFAOYSA-N 0.000 claims 2
- FTRAJCMIWNGRHU-UHFFFAOYSA-N 1-[6-(oxolan-3-yloxy)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(OC2COCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 FTRAJCMIWNGRHU-UHFFFAOYSA-N 0.000 claims 2
- HWDNFJNJZDAYBC-UHFFFAOYSA-N 1-[6-(piperidin-2-ylmethylamino)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(NCC2NCCCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 HWDNFJNJZDAYBC-UHFFFAOYSA-N 0.000 claims 2
- FMWGSWOSIWGDLY-UHFFFAOYSA-N 1-[6-(piperidin-4-ylmethoxy)pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C=1C=CC(OCC2CCNCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=NC=C1 FMWGSWOSIWGDLY-UHFFFAOYSA-N 0.000 claims 2
- GYVYPFIYLAVURX-UHFFFAOYSA-N 1-[6-[(1-methylazetidin-3-yl)methoxy]pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound C1N(C)CC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 GYVYPFIYLAVURX-UHFFFAOYSA-N 0.000 claims 2
- QWKUDEFKJWXTNX-UHFFFAOYSA-N 1-[6-[(1-methylazetidin-3-yl)methoxy]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C1N(C)CC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 QWKUDEFKJWXTNX-UHFFFAOYSA-N 0.000 claims 2
- OIIDTSSKXKAXCW-UHFFFAOYSA-N 1-[6-[(1-methylpiperidin-4-yl)methoxy]pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound C1CN(C)CCC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 OIIDTSSKXKAXCW-UHFFFAOYSA-N 0.000 claims 2
- RACVMKFOBUIPAT-UHFFFAOYSA-N 1-[6-[(1-methylpiperidin-4-yl)methoxy]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C1CN(C)CCC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 RACVMKFOBUIPAT-UHFFFAOYSA-N 0.000 claims 2
- XJYDJVBUWZFERN-UHFFFAOYSA-N 1-[6-[(1-methylpyrrolidin-2-yl)methoxy]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound CN1CCCC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 XJYDJVBUWZFERN-UHFFFAOYSA-N 0.000 claims 2
- JHJZVKHAOGFOOI-UHFFFAOYSA-N 1-[6-[(1-methylpyrrolidin-2-yl)methoxy]pyridin-2-yl]-3-[2-(thiophen-2-ylsulfonylmethyl)-1,3-thiazol-4-yl]urea Chemical compound CN1CCCC1COC1=CC=CC(NC(=O)NC=2N=C(CS(=O)(=O)C=3SC=CC=3)SC=2)=N1 JHJZVKHAOGFOOI-UHFFFAOYSA-N 0.000 claims 2
- CTJAVOPVEAPWCL-UHFFFAOYSA-N 1-[6-[(2,6-dimethylpiperidin-1-yl)methyl]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound CC1CCCC(C)N1CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 CTJAVOPVEAPWCL-UHFFFAOYSA-N 0.000 claims 2
- KVSKMFBILRBMKJ-UHFFFAOYSA-N 1-[6-[(3-methylpiperidin-1-yl)methyl]pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound C1C(C)CCCN1CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 KVSKMFBILRBMKJ-UHFFFAOYSA-N 0.000 claims 2
- XEHKSCOHBUEMMC-UHFFFAOYSA-N 1-[6-[(propan-2-ylamino)methyl]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound CC(C)NCC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 XEHKSCOHBUEMMC-UHFFFAOYSA-N 0.000 claims 2
- JUILEWQVNWYLJL-UHFFFAOYSA-N 1-[6-[2-(dimethylamino)ethoxy]pyridin-2-yl]-3-[2-(2-methoxypyridin-4-yl)-1,3-thiazol-4-yl]urea Chemical compound C1=NC(OC)=CC(C=2SC=C(NC(=O)NC=3N=C(OCCN(C)C)C=CC=3)N=2)=C1 JUILEWQVNWYLJL-UHFFFAOYSA-N 0.000 claims 2
- XIUKUYBQSUQPBK-INIZCTEOSA-N 1-[6-[[(2s)-1-methylpyrrolidin-2-yl]methoxy]pyridin-2-yl]-3-(2-phenyl-1,3-thiazol-4-yl)urea Chemical compound CN1CCC[C@H]1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 XIUKUYBQSUQPBK-INIZCTEOSA-N 0.000 claims 2
- OMXRPPSIMAHWBU-OAHLLOKOSA-N 1-[6-[[(3r)-3-methylpiperidin-1-yl]methyl]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C1[C@H](C)CCCN1CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 OMXRPPSIMAHWBU-OAHLLOKOSA-N 0.000 claims 2
- OMXRPPSIMAHWBU-HNNXBMFYSA-N 1-[6-[[(3s)-3-methylpiperidin-1-yl]methyl]pyridin-2-yl]-3-(2-pyridin-4-yl-1,3-thiazol-4-yl)urea Chemical compound C1[C@@H](C)CCCN1CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 OMXRPPSIMAHWBU-HNNXBMFYSA-N 0.000 claims 2
- 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 claims 2
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- AOOWXVLNSQUELZ-UHFFFAOYSA-N n,n-diethyl-6-[(2-phenyl-1,3-thiazol-4-yl)carbamoylamino]pyridine-2-carboxamide Chemical compound CCN(CC)C(=O)C1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 AOOWXVLNSQUELZ-UHFFFAOYSA-N 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- MVXHZHFSJDOJPI-UHFFFAOYSA-N tert-butyl 2-[[6-[(2-pyridin-4-yl-1,3-thiazol-4-yl)carbamoylamino]pyridin-2-yl]oxymethyl]pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 MVXHZHFSJDOJPI-UHFFFAOYSA-N 0.000 claims 2
- YASDBTBEDJEUQP-UHFFFAOYSA-N tert-butyl 2-[[[6-[(2-pyridin-4-yl-1,3-thiazol-4-yl)carbamoylamino]pyridin-2-yl]amino]methyl]piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCCC1CNC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 YASDBTBEDJEUQP-UHFFFAOYSA-N 0.000 claims 2
- MIYPESNNYZVKQU-UHFFFAOYSA-N tert-butyl 3-[[6-[(2-pyridin-4-yl-1,3-thiazol-4-yl)carbamoylamino]pyridin-2-yl]oxymethyl]pyrrolidine-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 MIYPESNNYZVKQU-UHFFFAOYSA-N 0.000 claims 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- PYNKENWDVGFMQY-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[4-(piperidine-1-carbonyl)pyridin-2-yl]urea Chemical compound S1C(Br)=NC(NC(=O)NC=2N=CC=C(C=2)C(=O)N2CCCCC2)=C1 PYNKENWDVGFMQY-UHFFFAOYSA-N 0.000 claims 1
- DHTXAVKDVZVRPT-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[6-(piperidin-4-ylmethoxy)pyridin-2-yl]urea Chemical compound S1C(Br)=NC(NC(=O)NC=2N=C(OCC3CCNCC3)C=CC=2)=C1 DHTXAVKDVZVRPT-UHFFFAOYSA-N 0.000 claims 1
- ZFFOIDHFLFKHBI-UHFFFAOYSA-N 1-(2-bromo-1,3-thiazol-4-yl)-3-[6-[(propan-2-ylamino)methyl]pyridin-2-yl]urea Chemical compound CC(C)NCC1=CC=CC(NC(=O)NC=2N=C(Br)SC=2)=N1 ZFFOIDHFLFKHBI-UHFFFAOYSA-N 0.000 claims 1
- YZFRQCLJMBSIJK-UHFFFAOYSA-N 1-(2-chloro-1,3-thiazol-4-yl)-3-[4-(piperidine-1-carbonyl)pyridin-2-yl]urea Chemical compound S1C(Cl)=NC(NC(=O)NC=2N=CC=C(C=2)C(=O)N2CCCCC2)=C1 YZFRQCLJMBSIJK-UHFFFAOYSA-N 0.000 claims 1
- OOZDAVBSDIZTBO-UHFFFAOYSA-N 1-(2-cyclopropyl-1,3-thiazol-4-yl)-3-[6-(2-piperidin-4-ylethoxy)pyridin-2-yl]urea Chemical compound C=1C=CC(OCCC2CCNCC2)=NC=1NC(=O)NC(N=1)=CSC=1C1CC1 OOZDAVBSDIZTBO-UHFFFAOYSA-N 0.000 claims 1
- DWGQFABAMZZBFN-UHFFFAOYSA-N 1-(2-phenyl-1,3-thiazol-4-yl)-3-[4-(piperidine-1-carbonyl)pyridin-2-yl]urea Chemical compound C=1C(C(=O)N2CCCCC2)=CC=NC=1NC(=O)NC(N=1)=CSC=1C1=CC=CC=C1 DWGQFABAMZZBFN-UHFFFAOYSA-N 0.000 claims 1
- OTPDGNKMGMOSAV-UHFFFAOYSA-N 1-[6-[(1-methylpyrrolidin-2-yl)methoxy]pyridin-2-yl]-3-[2-(3-sulfamoylphenyl)-1,3-thiazol-4-yl]urea Chemical compound CN1CCCC1COC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=C(C=CC=2)S(N)(=O)=O)=N1 OTPDGNKMGMOSAV-UHFFFAOYSA-N 0.000 claims 1
- 125000004484 1-methylpiperidin-4-yl group Chemical group CN1CCC(CC1)* 0.000 claims 1
- ZINRZVULMXTYGZ-UHFFFAOYSA-N 2-[(2-bromo-1,3-thiazol-4-yl)carbamoylamino]-n,n-diethylpyridine-4-carboxamide Chemical compound CCN(CC)C(=O)C1=CC=NC(NC(=O)NC=2N=C(Br)SC=2)=C1 ZINRZVULMXTYGZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 125000004657 aryl sulfonyl amino group Chemical group 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000005357 cycloalkylalkynyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims 1
- 125000004531 indol-5-yl group Chemical group [H]N1C([H])=C([H])C2=C([H])C(*)=C([H])C([H])=C12 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
- QAFCNJYRJPTTPS-UHFFFAOYSA-N tert-butyl 4-[6-[(2-pyridin-4-yl-1,3-thiazol-4-yl)carbamoylamino]pyridin-2-yl]-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCC(C=2N=C(NC(=O)NC=3N=C(SC=3)C=3C=CN=CC=3)C=CC=2)=C1 QAFCNJYRJPTTPS-UHFFFAOYSA-N 0.000 claims 1
- PYIQZGPIWGGADX-UHFFFAOYSA-N tert-butyl n-[[6-[(2-phenyl-1,3-thiazol-4-yl)carbamoylamino]pyridin-2-yl]methyl]-n-propan-2-ylcarbamate Chemical compound CC(C)(C)OC(=O)N(C(C)C)CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CC=CC=2)=N1 PYIQZGPIWGGADX-UHFFFAOYSA-N 0.000 claims 1
- QAYURVVBRZRNMC-UHFFFAOYSA-N tert-butyl n-propan-2-yl-n-[[6-[(2-pyridin-4-yl-1,3-thiazol-4-yl)carbamoylamino]pyridin-2-yl]methyl]carbamate Chemical compound CC(C)(C)OC(=O)N(C(C)C)CC1=CC=CC(NC(=O)NC=2N=C(SC=2)C=2C=CN=CC=2)=N1 QAYURVVBRZRNMC-UHFFFAOYSA-N 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
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| PCT/US2003/004537 WO2003070727A1 (en) | 2002-02-15 | 2003-02-13 | Thiazolyl urea compounds for the treatment of cancer |
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