JP2008536825A5 - - Google Patents
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- Publication number
- JP2008536825A5 JP2008536825A5 JP2008504368A JP2008504368A JP2008536825A5 JP 2008536825 A5 JP2008536825 A5 JP 2008536825A5 JP 2008504368 A JP2008504368 A JP 2008504368A JP 2008504368 A JP2008504368 A JP 2008504368A JP 2008536825 A5 JP2008536825 A5 JP 2008536825A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- alkyl
- piperidin
- ethyl
- ethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66719905P | 2005-03-31 | 2005-03-31 | |
| PCT/US2006/011663 WO2006105304A2 (en) | 2005-03-31 | 2006-03-30 | Phenyl and pyridyl lta4h modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008536825A JP2008536825A (ja) | 2008-09-11 |
| JP2008536825A5 true JP2008536825A5 (https=) | 2009-05-14 |
Family
ID=36950133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008504368A Withdrawn JP2008536825A (ja) | 2005-03-31 | 2006-03-30 | フェニルおよびピリジルｌｔａ４ｈモジュレータ |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20060223792A1 (https=) |
| EP (1) | EP1868605A2 (https=) |
| JP (1) | JP2008536825A (https=) |
| KR (1) | KR20080003385A (https=) |
| CN (1) | CN101189012A (https=) |
| AU (1) | AU2006230379A1 (https=) |
| BR (1) | BRPI0607742A2 (https=) |
| CA (1) | CA2603122A1 (https=) |
| CO (1) | CO6382173A2 (https=) |
| CR (1) | CR9480A (https=) |
| EA (1) | EA200702128A1 (https=) |
| IL (1) | IL186432A0 (https=) |
| MX (1) | MX2007012235A (https=) |
| NI (1) | NI200700250A (https=) |
| NO (1) | NO20075429L (https=) |
| WO (1) | WO2006105304A2 (https=) |
| ZA (1) | ZA200709346B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007079078A1 (en) | 2005-12-29 | 2007-07-12 | Bayer Schering Pharma Aktiengesellschaft | Diamine derivatives as inhibitors of leukotriene a4 hydrolase |
| JP2009269819A (ja) * | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
| SI2336125T1 (sl) * | 2008-04-11 | 2013-04-30 | Janssen Pharmaceutica N.V. | Tiazolopiridin-2-iloksi-fenil in tiazolopirazin-2-iloksi-fenil amini kot modulatorji levkotrien a4 hidrolaze |
| CN102459251B (zh) * | 2009-05-14 | 2015-05-20 | 詹森药业有限公司 | 作为白三烯a4水解酶的调节剂的具有两个稠合双环杂芳基部分的化合物 |
| CA2835617C (en) | 2011-03-14 | 2020-07-21 | Boehringer Ingelheim International Gmbh | Benzodioxane inhibitors of leukotriene production |
| EP2734516B1 (en) | 2011-07-19 | 2015-06-17 | Boehringer Ingelheim International GmbH | Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase |
| FR2984730A1 (fr) * | 2011-12-22 | 2013-06-28 | Diverchim | Nouvelles compositions cosmetiques anti-age et depigmentantes |
| TW201350474A (zh) | 2012-03-06 | 2013-12-16 | Boehringer Ingelheim Int | 白三烯素生成之苯并二噁烷抑制劑 |
| NZ628587A (en) | 2012-03-06 | 2016-07-29 | Boehringer Ingelheim Int | Benzodioxanes in combination with other actives for inhibiting leukotriene production |
| US9403830B2 (en) | 2012-07-17 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
| ES2864862T3 (es) | 2013-03-12 | 2021-10-14 | Celltaxis Llc | Métodos de inhibición de la leucotrieno A4 hidrolasa |
| WO2014152536A2 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
| MX2015011677A (es) | 2013-03-14 | 2016-07-08 | Celtaxsys Inc | Inhibidores de leucotrieno a4 hidrolasa. |
| RU2678196C2 (ru) | 2013-03-14 | 2019-01-24 | Селтакссис, Инк. | Производные 2-фениламино-3-цианопиразоло[1,5-а]пиримидина, полезные в качестве ингибитора лейкотриен-a4-гидролазы |
| JP6353899B2 (ja) | 2013-07-15 | 2018-07-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害剤 |
| JP2016523982A (ja) | 2013-07-15 | 2016-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害剤 |
| BR102013020313B1 (pt) * | 2013-08-09 | 2021-07-06 | Fundação Oswaldo Cruz | derivados bifeniloxi-alquil-aminas e ariloxi-alquil-aminas, e, composição farmacêutica |
| CN106029648A (zh) * | 2013-12-19 | 2016-10-12 | 拜耳制药股份公司 | 作为肾上腺素能受体α2C拮抗剂的取代的联哌啶基衍生物 |
| WO2015091420A1 (de) * | 2013-12-19 | 2015-06-25 | Bayer Pharma Aktiengesellschaft | Substituierte bipiperidinyl-derivate als adrenrezeptor alpha 2c antagonisten |
| SG11201604949XA (en) | 2013-12-19 | 2016-07-28 | Bayer Pharma AG | Substituted piperidinyl-tetrahydroquinolines |
| AP2016009276A0 (en) | 2013-12-19 | 2016-06-30 | Bayer Pharma AG | Substituted piperidinyl-tetrahydroquinolines and their use as alpha-2c adrenoreceptor antagonists |
| KR101499007B1 (ko) * | 2014-04-24 | 2015-03-05 | 고려대학교 산학협력단 | 염증성 질환의 예방 또는 치료용 약학 조성물 |
| US10023535B2 (en) | 2014-11-03 | 2018-07-17 | Olon S.P.A. | Method for the preparation of 1-(2-halogen-ethyl)-4 piperidine-carboxylic acid ethyl esters |
| PT109740B (pt) | 2016-11-14 | 2020-07-30 | Hovione Farmaciencia Sa | Processo para a preparação de brometo de umeclidínio |
| EP3619196B1 (de) | 2017-05-04 | 2022-03-30 | Bayer CropScience Aktiengesellschaft | 2-{[2-(phenyloxymethyl)pyridin-5-yl]oxy}-ethanamin-derivate und verwandte verbindungen als schädlingsbekämpfungsmittel z.b. für den pflanzenschutz |
| EP3801559B1 (en) | 2018-05-31 | 2025-01-01 | Celltaxis, LLC | Method of reducing pulmonary exacerbations in respiratory disease patients |
| ES2984584T3 (es) * | 2018-07-31 | 2024-10-30 | Novartis Ag | Formas cristalinas de un inhibidor de LTA4H |
| EP3908278A4 (en) * | 2019-01-11 | 2022-09-28 | Naegis Pharmaceuticals Inc. | INHIBITORS OF LEUKOTRIEN SYNTHESIS |
| CN110229091B (zh) * | 2019-06-21 | 2022-11-22 | 天津科技大学 | 具有白三烯a4水解酶抑制作用的1，5-二取代吲哚衍生物及应用 |
| CN113683491A (zh) * | 2021-09-01 | 2021-11-23 | 王传良 | 一种4-(2-溴乙基)苯酚的制备方法 |
| AU2022376563A1 (en) | 2021-11-01 | 2023-12-07 | Alkahest, Inc. | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4038412A (en) * | 1975-08-25 | 1977-07-26 | Richardson-Merrell Inc. | N-(phenylether-substituted benzyl)alkanediamines |
| JPH0696532B2 (ja) * | 1988-08-11 | 1994-11-30 | 山之内製薬株式会社 | 血小板活性化因子拮抗剤 |
| EP0641766B1 (en) * | 1991-10-04 | 1998-11-11 | Taisho Pharmaceutical Co. Ltd | Alkoxyphenylalkylamine derivative |
| US6506876B1 (en) * | 1994-10-11 | 2003-01-14 | G.D. Searle & Co. | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use |
| US5585492A (en) * | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
| US5925654A (en) * | 1997-03-12 | 1999-07-20 | G.D. Searle & Co. | LTA4 , hydrolase inhibitors |
| US6110944A (en) * | 1997-03-12 | 2000-08-29 | G. D. Searle & Co. | LTA4, hydrolase inhibitors |
| AU2002222550A1 (en) * | 2000-11-29 | 2002-06-11 | Kyorin Pharmaceutical Co. Ltd. | Substituted carboxylic acid derivatives |
| CN1856490A (zh) * | 2003-07-28 | 2006-11-01 | 詹森药业有限公司 | 苯并咪唑、苯并噻唑和苯并噁唑衍生物及其作为lta4h调节剂的应用 |
| CN1874991A (zh) * | 2003-08-29 | 2006-12-06 | 小野药品工业株式会社 | 能够结合s1p受体的化合物及其药物用途 |
| EP1661881B1 (en) * | 2003-08-29 | 2014-12-17 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding s1p receptor and pharmaceutical use thereof |
-
2006
- 2006-03-30 US US11/393,532 patent/US20060223792A1/en not_active Abandoned
- 2006-03-30 EA EA200702128A patent/EA200702128A1/ru unknown
- 2006-03-30 WO PCT/US2006/011663 patent/WO2006105304A2/en not_active Ceased
- 2006-03-30 KR KR1020077025142A patent/KR20080003385A/ko not_active Withdrawn
- 2006-03-30 MX MX2007012235A patent/MX2007012235A/es unknown
- 2006-03-30 CN CNA2006800193012A patent/CN101189012A/zh active Pending
- 2006-03-30 CA CA002603122A patent/CA2603122A1/en not_active Abandoned
- 2006-03-30 EP EP06740056A patent/EP1868605A2/en not_active Withdrawn
- 2006-03-30 BR BRPI0607742-0A patent/BRPI0607742A2/pt not_active IP Right Cessation
- 2006-03-30 AU AU2006230379A patent/AU2006230379A1/en not_active Abandoned
- 2006-03-30 JP JP2008504368A patent/JP2008536825A/ja not_active Withdrawn
-
2007
- 2007-09-28 NI NI200700250A patent/NI200700250A/es unknown
- 2007-10-07 IL IL186432A patent/IL186432A0/en unknown
- 2007-10-16 CO CO07108538A patent/CO6382173A2/es not_active Application Discontinuation
- 2007-10-25 NO NO20075429A patent/NO20075429L/no not_active Application Discontinuation
- 2007-10-29 CR CR9480A patent/CR9480A/es unknown
- 2007-10-30 ZA ZA200709346A patent/ZA200709346B/xx unknown
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