JP2008536825A5 - - Google Patents
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- Publication number
- JP2008536825A5 JP2008536825A5 JP2008504368A JP2008504368A JP2008536825A5 JP 2008536825 A5 JP2008536825 A5 JP 2008536825A5 JP 2008504368 A JP2008504368 A JP 2008504368A JP 2008504368 A JP2008504368 A JP 2008504368A JP 2008536825 A5 JP2008536825 A5 JP 2008536825A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- alkyl
- piperidin
- ethyl
- ethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66719905P | 2005-03-31 | 2005-03-31 | |
| PCT/US2006/011663 WO2006105304A2 (en) | 2005-03-31 | 2006-03-30 | Phenyl and pyridyl lta4h modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008536825A JP2008536825A (ja) | 2008-09-11 |
| JP2008536825A5 true JP2008536825A5 (https=) | 2009-05-14 |
Family
ID=36950133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008504368A Withdrawn JP2008536825A (ja) | 2005-03-31 | 2006-03-30 | フェニルおよびピリジルｌｔａ４ｈモジュレータ |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20060223792A1 (https=) |
| EP (1) | EP1868605A2 (https=) |
| JP (1) | JP2008536825A (https=) |
| KR (1) | KR20080003385A (https=) |
| CN (1) | CN101189012A (https=) |
| AU (1) | AU2006230379A1 (https=) |
| BR (1) | BRPI0607742A2 (https=) |
| CA (1) | CA2603122A1 (https=) |
| CO (1) | CO6382173A2 (https=) |
| CR (1) | CR9480A (https=) |
| EA (1) | EA200702128A1 (https=) |
| IL (1) | IL186432A0 (https=) |
| MX (1) | MX2007012235A (https=) |
| NI (1) | NI200700250A (https=) |
| NO (1) | NO20075429L (https=) |
| WO (1) | WO2006105304A2 (https=) |
| ZA (1) | ZA200709346B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT1976828T (lt) | 2005-12-29 | 2017-04-25 | Celtaxsys, Inc. | Diamino dariniai, kaip leukotrieno a4 hidrolazės inhibitoriai |
| JP2009269819A (ja) * | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
| MY157597A (en) * | 2008-04-11 | 2016-06-30 | Janssen Pharmaceutica Nv | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase |
| US8399465B2 (en) * | 2009-05-14 | 2013-03-19 | Janssen Pharmaceutica Nv | Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase |
| CN103415513B (zh) | 2011-03-14 | 2016-01-20 | 勃林格殷格翰国际有限公司 | 白三烯产物的苯并二氧杂环己烷抑制剂 |
| WO2013012844A1 (en) | 2011-07-19 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase |
| FR2984730A1 (fr) * | 2011-12-22 | 2013-06-28 | Diverchim | Nouvelles compositions cosmetiques anti-age et depigmentantes |
| JP6080227B2 (ja) | 2012-03-06 | 2017-02-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成を阻害するためのベンゾジオキサン |
| US9662339B2 (en) | 2012-03-06 | 2017-05-30 | Boehringer Ingelheim International Gmbh | Benzodioxane inhibitors of leukotriene production for combination therapy |
| AR091786A1 (es) | 2012-07-17 | 2015-02-25 | Boehringer Ingelheim Int | Inhibidores de la produccion de leucotrienos |
| AU2014249168B2 (en) | 2013-03-12 | 2018-07-12 | Celltaxis, Llc | Methods of inhibiting leukotriene A4 hydrolase |
| CA2906035A1 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
| BR112015022864A8 (pt) | 2013-03-14 | 2019-11-26 | Celtaxsys Inc | composto, composição farmacêutica e uso dos mesmos |
| WO2014152536A2 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
| WO2015009611A1 (en) | 2013-07-15 | 2015-01-22 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
| WO2015009609A1 (en) | 2013-07-15 | 2015-01-22 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
| BR102013020313B1 (pt) * | 2013-08-09 | 2021-07-06 | Fundação Oswaldo Cruz | derivados bifeniloxi-alquil-aminas e ariloxi-alquil-aminas, e, composição farmacêutica |
| US20160318866A1 (en) | 2013-12-19 | 2016-11-03 | Bayer Pharma Aktiengesellschaft | Substituted bipiperidinyl derivatives |
| EP3083610A1 (de) | 2013-12-19 | 2016-10-26 | Bayer Pharma Aktiengesellschaft | Substituierte bipiperidinyl-derivate als adrenrezeptor alpha 2c antagonisten |
| CR20160276A (es) | 2013-12-19 | 2016-10-20 | Bayer Pharma AG | "piperidiniltetrahidroquinolinas sustituidas y su uso como antagonistas de los adenoreceptores alpha-2c" |
| KR20160098424A (ko) | 2013-12-19 | 2016-08-18 | 바이엘 파마 악티엔게젤샤프트 | 치환된 피페리디닐-테트라히드로퀴놀린 |
| KR101499007B1 (ko) * | 2014-04-24 | 2015-03-05 | 고려대학교 산학협력단 | 염증성 질환의 예방 또는 치료용 약학 조성물 |
| ES2751698T3 (es) | 2014-11-03 | 2020-04-01 | Olon Spa | Procedimiento para la preparación del éster etílico del ácido 1-(2-halogen-etil)-4-piperidina-carboxílico |
| PT109740B (pt) | 2016-11-14 | 2020-07-30 | Hovione Farmaciencia Sa | Processo para a preparação de brometo de umeclidínio |
| HRP20220790T1 (hr) | 2017-05-04 | 2022-09-16 | Bayer Cropscience Aktiengesellschaft | Derivati 2-{[2-(feniloksimetil)piridin-5-il]oksi}etanamina i srodni spojevi kao pesticidi, primjerice namijenjeni zaštiti bilja |
| ES3014615T3 (en) | 2018-05-31 | 2025-04-23 | Celltaxis Llc | Method of reducing pulmonary exacerbations in respiratory disease patients |
| CN112513026B (zh) * | 2018-07-31 | 2025-02-25 | 诺华股份有限公司 | Lta4h抑制剂的晶型 |
| CN113784713A (zh) * | 2019-01-11 | 2021-12-10 | 纳吉斯制药股份有限公司 | 白三烯合成抑制剂 |
| CN110229091B (zh) * | 2019-06-21 | 2022-11-22 | 天津科技大学 | 具有白三烯a4水解酶抑制作用的1，5-二取代吲哚衍生物及应用 |
| CN113683491A (zh) * | 2021-09-01 | 2021-11-23 | 王传良 | 一种4-(2-溴乙基)苯酚的制备方法 |
| AU2022376563A1 (en) | 2021-11-01 | 2023-12-07 | Alkahest, Inc. | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4038412A (en) * | 1975-08-25 | 1977-07-26 | Richardson-Merrell Inc. | N-(phenylether-substituted benzyl)alkanediamines |
| JPH0696532B2 (ja) * | 1988-08-11 | 1994-11-30 | 山之内製薬株式会社 | 血小板活性化因子拮抗剤 |
| ES2125906T3 (es) * | 1991-10-04 | 1999-03-16 | Taisho Pharmaceutical Co Ltd | Derivado de alcoxifenilalquilamina. |
| US5585492A (en) * | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
| US6506876B1 (en) * | 1994-10-11 | 2003-01-14 | G.D. Searle & Co. | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use |
| US5925654A (en) * | 1997-03-12 | 1999-07-20 | G.D. Searle & Co. | LTA4 , hydrolase inhibitors |
| US6110944A (en) * | 1997-03-12 | 2000-08-29 | G. D. Searle & Co. | LTA4, hydrolase inhibitors |
| WO2002044130A1 (fr) * | 2000-11-29 | 2002-06-06 | Kyorin Pharmaceutical Co., Ltd. | Dérivés d'acide carboxylique substitués |
| ATE403654T1 (de) * | 2003-07-28 | 2008-08-15 | Janssen Pharmaceutica Nv | Benzimidazol-, benzothiazol- und benzoxazolderivate und deren verwendung als lta4h-modulatoren |
| US7825109B2 (en) * | 2003-08-29 | 2010-11-02 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding S1P receptor and pharmaceutical use thereof |
-
2006
- 2006-03-30 CA CA002603122A patent/CA2603122A1/en not_active Abandoned
- 2006-03-30 KR KR1020077025142A patent/KR20080003385A/ko not_active Withdrawn
- 2006-03-30 JP JP2008504368A patent/JP2008536825A/ja not_active Withdrawn
- 2006-03-30 US US11/393,532 patent/US20060223792A1/en not_active Abandoned
- 2006-03-30 MX MX2007012235A patent/MX2007012235A/es unknown
- 2006-03-30 CN CNA2006800193012A patent/CN101189012A/zh active Pending
- 2006-03-30 AU AU2006230379A patent/AU2006230379A1/en not_active Abandoned
- 2006-03-30 BR BRPI0607742-0A patent/BRPI0607742A2/pt not_active IP Right Cessation
- 2006-03-30 EA EA200702128A patent/EA200702128A1/ru unknown
- 2006-03-30 WO PCT/US2006/011663 patent/WO2006105304A2/en not_active Ceased
- 2006-03-30 EP EP06740056A patent/EP1868605A2/en not_active Withdrawn
-
2007
- 2007-09-28 NI NI200700250A patent/NI200700250A/es unknown
- 2007-10-07 IL IL186432A patent/IL186432A0/en unknown
- 2007-10-16 CO CO07108538A patent/CO6382173A2/es not_active Application Discontinuation
- 2007-10-25 NO NO20075429A patent/NO20075429L/no not_active Application Discontinuation
- 2007-10-29 CR CR9480A patent/CR9480A/es unknown
- 2007-10-30 ZA ZA200709346A patent/ZA200709346B/xx unknown
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