JP2006508966A5 - - Google Patents

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Publication number
JP2006508966A5
JP2006508966A5 JP2004552003A JP2004552003A JP2006508966A5 JP 2006508966 A5 JP2006508966 A5 JP 2006508966A5 JP 2004552003 A JP2004552003 A JP 2004552003A JP 2004552003 A JP2004552003 A JP 2004552003A JP 2006508966 A5 JP2006508966 A5 JP 2006508966A5
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JP
Japan
Prior art keywords
disease
compound according
inflammatory
physiologically acceptable
medicament
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JP2004552003A
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English (en)
Japanese (ja)
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JP2006508966A (ja
JP4644491B2 (ja
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Priority claimed from PCT/US2003/035817 external-priority patent/WO2004043965A1/en
Publication of JP2006508966A publication Critical patent/JP2006508966A/ja
Publication of JP2006508966A5 publication Critical patent/JP2006508966A5/ja
Application granted granted Critical
Publication of JP4644491B2 publication Critical patent/JP4644491B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2004552003A 2002-11-13 2003-11-12 I.a.脱髄炎症疾患の処置のためのccr1アンタゴニスト Expired - Fee Related JP4644491B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42594702P 2002-11-13 2002-11-13
PCT/US2003/035817 WO2004043965A1 (en) 2002-11-13 2003-11-12 Ccr1 antagonists for the treatment of i.a. demyelinating inflammatory disease

Publications (3)

Publication Number Publication Date
JP2006508966A JP2006508966A (ja) 2006-03-16
JP2006508966A5 true JP2006508966A5 (enExample) 2006-11-02
JP4644491B2 JP4644491B2 (ja) 2011-03-02

Family

ID=32313083

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004552003A Expired - Fee Related JP4644491B2 (ja) 2002-11-13 2003-11-12 I.a.脱髄炎症疾患の処置のためのccr1アンタゴニスト

Country Status (24)

Country Link
US (7) US20040106639A1 (enExample)
EP (2) EP1669356B1 (enExample)
JP (1) JP4644491B2 (enExample)
KR (1) KR101109348B1 (enExample)
CN (1) CN100343257C (enExample)
AR (1) AR041942A1 (enExample)
AT (2) ATE468340T1 (enExample)
AU (2) AU2003291452A1 (enExample)
BR (1) BR0316261A (enExample)
CA (1) CA2505874C (enExample)
CY (1) CY1107985T1 (enExample)
DE (2) DE60305063T2 (enExample)
DK (1) DK1562954T3 (enExample)
EA (1) EA007748B1 (enExample)
ES (2) ES2261979T3 (enExample)
IL (2) IL168384A (enExample)
MX (1) MXPA05005105A (enExample)
NO (1) NO331855B1 (enExample)
PL (1) PL211022B1 (enExample)
PT (1) PT1562954E (enExample)
SI (1) SI1562954T1 (enExample)
TW (1) TWI291467B (enExample)
WO (1) WO2004043965A1 (enExample)
ZA (2) ZA200504144B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en) * 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
US7838522B2 (en) 2004-11-17 2010-11-23 Ares Trading S.A. Benzothiazole formulations and use thereof
EP1841429B1 (en) * 2004-12-17 2012-04-18 Millennium Pharmaceuticals, Inc. Solid forms of a chemokine receptor antagonist and methods of use thereof
MX2007007599A (es) 2004-12-21 2007-12-07 Serono Lab Dervivados ciclicos de sulfonilamino y uso de los mismos.
EA014238B1 (ru) 2005-01-31 2010-10-29 Мерк Сероно Са Производные n-гидроксиамида и их применение
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 jnk 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
EP1933860A2 (en) 2005-09-01 2008-06-25 Ares Trading S.A. Treatment of optic neuritis
US7601844B2 (en) 2006-01-27 2009-10-13 Bristol-Myers Squibb Company Piperidinyl derivatives as modulators of chemokine receptor activity
ES2384057T3 (es) 2006-07-14 2012-06-28 Eli Lilly And Company (E)-N-{3-(8-Cloro-11H-10-oxa-1-aza-dibenzo[a,d]ciclohepten-5-iliden)-propil]-fenil}-metanosulfonamida como modulador del receptor glucocorticoide y procedimientos de uso
EP2173713B1 (en) 2007-07-24 2016-02-17 Bristol-Myers Squibb Company Piperidinyl derivatives as modulators of chemokine receptor activity
US8288371B2 (en) * 2007-10-05 2012-10-16 Pharmacopeia, Llc Ortho pyrrolidine, benzyl-substituted heterocycle CCR1 antagonists for autoimmune diseases and inflammation
WO2009073462A1 (en) * 2007-11-30 2009-06-11 Millennium Pharmaceuticals, Inc. Process for the preparation of 5-cyclopropyl-5, 11-dihydro (1) benzoxepino (3, 4-b) -pyridin-5-ol using tmeda
US20090286823A1 (en) * 2007-12-17 2009-11-19 Millennium Pharmaceuticals Inc. CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders
WO2009089312A1 (en) 2008-01-11 2009-07-16 Eli Lilly And Company (e)-n-{3- [1-(8-fluoro-11h-10-oxa-1-aza-dibenzo [a,d] cycl0hepten-5ylidene)-propyl]-phenyl }-methynsulfon amide as glucocorticoid receptor modulator for the treatment of rheumatoid
TWI433838B (zh) 2008-06-25 2014-04-11 必治妥美雅史谷比公司 作為趨化因子受體活性調節劑之六氫吡啶衍生物
EP2771484A1 (en) 2011-10-28 2014-09-03 Galderma Research & Development New leukocyte infiltrate markers for rosacea and uses thereof

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD80449A (enExample)
DE80449C (enExample)
US377729A (en) * 1888-02-07 Half to phillips
GB1003292A (en) 1960-12-08 1965-09-02 Sandoz Ag Improvements in or relating to 4-azathiaxanthene derivatives
NL279409A (enExample) 1961-06-08
CH416624A (de) 1962-10-23 1966-07-15 Sandoz Ag Verfahren zur Herstellung von neuen heterocyclischen Verbindungen
NL132137C (enExample) 1963-04-24
FR88751E (enExample) 1963-07-09 1967-06-07
GB1085405A (en) 1963-10-14 1967-10-04 Pfizer & Co C Dibenzoxepins and dibenzthiepins
BE664609A (enExample) 1964-06-01
CH421138A (de) 1965-11-04 1966-09-30 Wander Ag Dr A Verfahren zur Herstellung von Thioxanthenderivaten
US3409621A (en) * 1966-04-01 1968-11-05 Schering Corp Piperazino-aza-dibenzo-[a, d]-cycloheptenes
US3625974A (en) 1967-04-28 1971-12-07 Fujisawa Pharmaceutical Co Dibenzothiazepine derivatives
GB1206216A (en) 1967-07-18 1970-09-23 Pfizer & Co C Aminopropylidene dibenzoxepine tranquilizers
NL6905642A (enExample) 1968-04-12 1969-10-14
JPS4830064B1 (enExample) 1968-12-23 1973-09-17
DE2163657A1 (de) * 1970-12-22 1972-07-13 Yoshitomi Pharmaceutical Industries Ltd., Osaka (Japan) N-substituierte Piperidinverbindungen
GB1330966A (en) 1970-12-22 1973-09-19 Yoshitomi Pharmaceutical N-substituted piperidine compounds methods for their production and pharmaceutical compositions containing them
GB1347935A (en) 1971-04-10 1974-02-27 Yoshitomi Pharmaceutical Piperazine derivatives methods for their production and phar maceutical compositions containing them
CA1010870A (en) * 1972-12-08 1977-05-24 Niels Lassen Thiaxanthene derivative and method
US4250176A (en) * 1976-12-21 1981-02-10 Janssen Pharmaceutica N.V. Piperazine derivatives
US4335122A (en) * 1981-03-18 1982-06-15 Hoechst-Roussel Pharmaceuticals Inc. Dihydro-dibenzoxepines-thiepines and -morphanthridones, compositions and use
DE3326641A1 (de) 1982-07-27 1984-02-02 Basf Ag, 6700 Ludwigshafen 5,6-dihydro-11-h-morphantridin-6-one, ihre herstellung und diese enthaltende arzneimittel
CA1237428A (en) * 1983-06-24 1988-05-31 Hiroshi Tanaka ¬1| benzepino¬3,4-b|pyridine derivative
ES8502099A1 (es) 1983-08-02 1984-12-16 Espanola Farma Therapeut Procedimiento de obtencion de nuevos compuestos derivados de la difenil-metilen-etilamina.
DE3402060A1 (de) * 1984-01-21 1985-08-01 Dr. Karl Thomae Gmbh, 7950 Biberach Substituierte 5,11-dihydro-6h-dibenz(b,e)azepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
CS236550B1 (cs) 1984-02-02 1985-05-15 Miroslav Protiva Způsob přípravy esterů piperazinoalkanolů dibenzo(b,e)thiepinové řady a jejich solí s kyselinou maleinovou
CS236549B1 (cs) 1984-02-02 1985-05-15 Miroslav Protiva Piperazinoalkanoly dibenzo(b,e)thiepinové řady a jejich soli s kyselinou maleinovou
CS240698B1 (cs) 1984-10-12 1986-02-13 Miroslav Protiva Substituované ll-(piperidinoalkyl)-6,ll-dihydrodibenzo (b,e)thiepin-ll-karbonitrily
JPH0665664B2 (ja) 1985-01-18 1994-08-24 大塚製薬株式会社 モルフアントリジン誘導体
SE8500273D0 (sv) * 1985-01-22 1985-01-22 Leo Ab Nya tricykliska foreningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder
JPS6310784A (ja) * 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd 抗アレルギー剤
EP0270692A4 (en) 1986-06-26 1990-12-12 Kyowa Hakko Kogyo Co., Ltd. Antiarrhythmic agent
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
IT8721978A0 (it) 1987-09-21 1987-09-21 Angeli Inst Spa Nuovi derivati ammidinici triciclici.
US4882351A (en) * 1987-10-14 1989-11-21 Roussel Uclaf Tricyclic compounds
US4994463A (en) 1987-12-14 1991-02-19 Kyowa Hakko Kogyo Co., Ltd. Tricyclic thromboxane A2 antagonists
ATE108453T1 (de) 1988-04-28 1994-07-15 Schering Corp Benzopyridopiperidin, -piperidyliden und - piperazin-verbindungen, zusammensetzungen, methoden zur herstellung und verwendung.
US5242931A (en) * 1988-06-09 1993-09-07 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds as TXA2 antagonists
CA1338625C (en) * 1988-06-09 1996-10-01 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
DE3827093A1 (de) 1988-08-10 1990-02-15 Nattermann A & Cie Verfahren zur herstellung von hochreinem ebselen
DE3838912A1 (de) * 1988-11-17 1990-05-23 Thomae Gmbh Dr K Mittel zur behandlung von akuten und chronischen obstruktiven atemwegserkrankungen
JPH0694464B2 (ja) * 1991-01-23 1994-11-24 協和醗酵工業株式会社 三環式化合物およびその中間体
CA2062587A1 (en) * 1991-03-11 1992-09-12 Toshiaki Kumazawa Indole derivatives
WO1992016226A1 (en) 1991-03-19 1992-10-01 Smithkline Beecham Corporation Il-1 inhibitors
EP0586560A1 (en) 1991-05-23 1994-03-16 Schering Corporation Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use
EP0595989A1 (en) 1991-07-23 1994-05-11 Schering Corporation Benzopyrido piperylidene compounds, compositions, methods of manufacture and methods of use
US5378701A (en) * 1991-12-27 1995-01-03 Kyowa Hakko Kogyo Tricyclic compounds
US5679703A (en) * 1992-09-16 1997-10-21 Kyowa Hakko Kogyo, Co., Ltd. Tricyclic compounds having ACAT inhibiting activity
EP0669979B1 (en) 1992-11-10 2005-10-12 Genentech, Inc. C-c ckr-1, c-c chemokine receptor
US5538986A (en) * 1993-12-06 1996-07-23 Schering Corporation Tricyclic derivatives, compositions and methods of use
MY113463A (en) * 1994-01-04 2002-03-30 Novo Nordisk As Novel heterocyclic compounds
US5801175A (en) * 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
WO1996031470A1 (en) 1995-04-07 1996-10-10 Novo Nordisk A/S Novel heterocyclic compounds
AU5270796A (en) 1995-04-07 1996-10-23 Novo Nordisk A/S N-substituted azaheterocyclic carboxylic acids and esters th ereof
UA54385C2 (uk) 1995-04-07 2003-03-17 Ново Нордіск А/С N-заміщені азагетероциклічні карбонові кислоти та їх ефіри, спосіб їх одержання, фармацевтична композиція та спосіб лікування
JPH0940662A (ja) 1995-05-24 1997-02-10 Kyowa Hakko Kogyo Co Ltd 三環式化合物
CA2231773A1 (en) * 1995-09-13 1997-03-20 Shigeru Aono Phenylpiperidine derivative
AU1208397A (en) 1995-12-28 1997-07-28 Takeda Chemical Industries Ltd. Diphenylmethane derivatives as mip-1alpha/rantes receptor antagonists
DE29602088U1 (de) 1996-02-07 1996-04-04 Bümach Engineering International B.V., Emmen Verschraubbarer druckmittelbetätigter Arbeitszylinder mit Verschlußteilen zur Kopplung des Zylinderrohres
ATE209192T1 (de) 1996-05-20 2001-12-15 Teijin Ltd Cyclischer diarylalkyl diaminederivate als antogoniste von chemokinerezeptoren
JP2000516210A (ja) * 1996-07-12 2000-12-05 ロイコサイト,インコーポレーテッド ケモカインレセプターアンタゴニストとその使用方法
US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO1998004554A1 (en) 1996-07-29 1998-02-05 Banyu Pharmaceutical Co., Ltd. Chemokine receptor antagonists
EP0927181A1 (en) 1996-09-13 1999-07-07 Schering Corporation Tricyclic compounds useful as fpt inhibitors
ATE294172T1 (de) 1996-09-13 2005-05-15 Schering Corp Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren
DE69709774T2 (de) 1996-09-13 2002-08-08 Schering Corp., Kenilworth Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren
AU4801197A (en) 1996-09-13 1998-04-02 Schering Corporation Tricyclic antitumor compounds being farnesyl protein transferase inhibit ors
CZ83499A3 (cs) 1996-09-13 1999-07-14 Schering Corporation Tricyklické sloučeniny, farmaceutický prostředek je obsahující a jejich použití
ES2235252T3 (es) 1996-09-13 2005-07-01 Schering Corporation Inhibidores triciclicos de la farnesil proteina transferasa.
ID21218A (id) 1996-09-13 1999-05-06 Schering Corp Senyawa trisiklik piperidinil baru yang berguna sebagai penghambat transferase farnesil protein
BR9712202A (pt) 1996-10-04 1999-08-31 Novo Nordisk As Composto, processo para preparar o mesmo, composicão farmacêutica, processo para o tratamento de inflamacão neurogênica em um indivíduo em necessidade deste tratamento, e, uso do composto.
KR20000048899A (ko) 1996-10-04 2000-07-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 1,4-디치환 피페라진
ZA978792B (en) 1996-10-04 1998-04-06 Novo Nordisk As N-substituted azaheterocyclic compounds.
AU5604998A (en) 1996-12-13 1998-07-03 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
WO1998025605A1 (en) 1996-12-13 1998-06-18 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
AU5522498A (en) 1996-12-13 1998-07-03 Merck & Co., Inc. Substituted aryl piperazines as modulators of chemokine receptor activity
US5919776A (en) * 1996-12-20 1999-07-06 Merck & Co., Inc. Substituted aminoquinolines as modulators of chemokine receptor activity
WO1998027815A1 (en) 1996-12-20 1998-07-02 Merck & Co., Inc. Substituted aminoquinolines as modulators of chemokine receptor activity
AU6517398A (en) 1997-03-27 1998-10-22 Kyowa Hakko Kogyo Co. Ltd. Therapeutic agent for autoimmune diseases
KR100447674B1 (ko) 1997-04-15 2004-09-08 교와 핫꼬 고교 가부시끼가이샤 삼환식 화합물
US5877177A (en) * 1997-06-17 1999-03-02 Schering Corporation Carboxy piperidylacetamide tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
JP2002515914A (ja) 1997-06-25 2002-05-28 ノボ ノルディスク アクティーゼルスカブ 新規へテロ環式化合物
US6040318A (en) 1997-06-25 2000-03-21 Novo Nordisk A/S Tricycle substituted with azaheterocyclic carboxylic acids
US6048856A (en) * 1997-12-17 2000-04-11 Novo Nordisk A/S Heterocyclic compounds
CA2318088A1 (en) 1998-01-21 1999-07-29 Yoshisuke Nakasato Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en) * 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CN1289336A (zh) * 1998-01-21 2001-03-28 千禧药品公司 趋化因子受体拮抗剂和其使用方法
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
AU2331199A (en) 1998-09-04 2000-03-27 Kyowa Hakko Kogyo Co. Ltd. Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
MXPA04004826A (es) 1998-09-04 2004-08-11 Millenium Pharmaceuticals Inc Antagonista del receptor de quimioquinas y metodos para su uso.
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US20020169155A1 (en) * 1998-09-04 2002-11-14 Millennium Pharmaceuticals, Inc. Chemokine receptor anagonists and methods of use therefor
WO2000032193A1 (en) 1998-12-02 2000-06-08 Novo Nordisk A/S Use of n-substituted azaheterocyclic compounds for the manufacture of a pharmaceutical composition for the treatment of indications related to angiogenesis
WO2001009094A2 (en) 1999-07-28 2001-02-08 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
AU6503900A (en) * 1999-07-28 2001-02-19 Kyowa Hakko Kogyo Co. Ltd. Chemokine receptor antagonists and methods of use therefor
KR101001092B1 (ko) * 2001-11-21 2010-12-14 교와 학꼬 고교 가부시키가이샤 케모카인 수용체 길항제 및 이의 사용 방법
TWI291467B (en) * 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
US7639107B2 (en) 2005-04-20 2009-12-29 Mitsubishi Denki Kabushiki Kaisha Overcurrent relay
JP4715952B2 (ja) 2009-02-18 2011-07-06 村田機械株式会社 フロッグレッグ型移載装置

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