NO331855B1 - CCR1-antagonister, farmasoytiske preparater omfattende slike, slike forbindelser for anvendelse i terapi eller diagnose samt anvendelse av slike for fremstilling av medikament for behandling av sykdom - Google Patents
CCR1-antagonister, farmasoytiske preparater omfattende slike, slike forbindelser for anvendelse i terapi eller diagnose samt anvendelse av slike for fremstilling av medikament for behandling av sykdom Download PDFInfo
- Publication number
- NO331855B1 NO331855B1 NO20052272A NO20052272A NO331855B1 NO 331855 B1 NO331855 B1 NO 331855B1 NO 20052272 A NO20052272 A NO 20052272A NO 20052272 A NO20052272 A NO 20052272A NO 331855 B1 NO331855 B1 NO 331855B1
- Authority
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- Norway
- Prior art keywords
- pharmaceutical preparation
- enantiomer
- physiologically acceptable
- dimethyl
- piperidin
- Prior art date
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Classifications
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2003/035817 WO2004043965A1 (en) | 2002-11-13 | 2003-11-12 | Ccr1 antagonists for the treatment of i.a. demyelinating inflammatory disease |
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| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TWI291467B (en) * | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| US7838522B2 (en) | 2004-11-17 | 2010-11-23 | Ares Trading S.A. | Benzothiazole formulations and use thereof |
| WO2006066200A2 (en) * | 2004-12-17 | 2006-06-22 | Millennium Pharmaceuticals, Inc. | Solid forms of a chemokine receptor antagonist and methods of use thereof |
| EA012266B1 (ru) | 2004-12-21 | 2009-08-28 | Лаборатуар Сероно С.А. | Сульфониламиноциклические соединения и их применение |
| JP4950070B2 (ja) | 2005-01-31 | 2012-06-13 | メルク セローノ ソシエテ アノニム | Ｎ−ヒドロキシアミド誘導体及びその使用 |
| KR20080044836A (ko) | 2005-07-15 | 2008-05-21 | 라보라뚜와르 세로노 에스. 에이. | 자궁내막증 치료용 ｊｎｋ 억제제 |
| BRPI0613042A2 (pt) | 2005-07-15 | 2010-12-14 | Serono Lab | inibidores de jnk para o tratamento de endometriose |
| EA013816B1 (ru) | 2005-09-01 | 2010-08-30 | Арес Трейдинг С.А. | Лечение неврита зрительного нерва |
| US7601844B2 (en) | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
| EA014695B1 (ru) * | 2006-07-14 | 2010-12-30 | Эли Лилли Энд Компани | Модулятор рецепторов глюкокортикостероидов и его применение |
| CN101808991A (zh) * | 2007-07-24 | 2010-08-18 | 百时美施贵宝公司 | 作为趋化因子受体活性调节剂的哌啶基衍生物 |
| US8288371B2 (en) * | 2007-10-05 | 2012-10-16 | Pharmacopeia, Llc | Ortho pyrrolidine, benzyl-substituted heterocycle CCR1 antagonists for autoimmune diseases and inflammation |
| JP2011505364A (ja) * | 2007-11-30 | 2011-02-24 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | ＴＭＥＤＡを用いた５−シクロプロピル−５，１１−ジヒドロ［１］ベンゾオキセピノ［３，４−ｂ］−ピリジン−５−オールの製造方法 |
| US20090286823A1 (en) * | 2007-12-17 | 2009-11-19 | Millennium Pharmaceuticals Inc. | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders |
| ATE522537T1 (de) | 2008-01-11 | 2011-09-15 | Lilly Co Eli | (e)-n-ä3-ä1-(8-fluor-11h-10-oxa-1-aza-dibenzo-ä , dü-cyclohepten-5-yliden)-propylü-phenylü- methylsulfon-amid als glucocorticoid- rezeptormodulator zur behandlung rheumatoider arthritis |
| TWI433838B (zh) | 2008-06-25 | 2014-04-11 | 必治妥美雅史谷比公司 | 作為趨化因子受體活性調節劑之六氫吡啶衍生物 |
| EP2771484A1 (en) | 2011-10-28 | 2014-09-03 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
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| GB1330966A (en) | 1970-12-22 | 1973-09-19 | Yoshitomi Pharmaceutical | N-substituted piperidine compounds methods for their production and pharmaceutical compositions containing them |
| GB1347935A (en) | 1971-04-10 | 1974-02-27 | Yoshitomi Pharmaceutical | Piperazine derivatives methods for their production and phar maceutical compositions containing them |
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| CA1237428A (en) * | 1983-06-24 | 1988-05-31 | Hiroshi Tanaka | ¬1| benzepino¬3,4-b|pyridine derivative |
| ES524680A0 (es) | 1983-08-02 | 1984-12-16 | Espanola Farma Therapeut | Procedimiento de obtencion de nuevos compuestos derivados de la difenil-metilen-etilamina. |
| DE3402060A1 (de) * | 1984-01-21 | 1985-08-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Substituierte 5,11-dihydro-6h-dibenz(b,e)azepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| CS236549B1 (cs) | 1984-02-02 | 1985-05-15 | Miroslav Protiva | Piperazinoalkanoly dibenzo(b,e)thiepinové řady a jejich soli s kyselinou maleinovou |
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| JPS6310784A (ja) * | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
| WO1988000049A1 (fr) | 1986-06-26 | 1988-01-14 | Kyowa Hakko Kogyo Co., Ltd. | Agent antiarythmique |
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