JP2006506368A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006506368A5 JP2006506368A5 JP2004544849A JP2004544849A JP2006506368A5 JP 2006506368 A5 JP2006506368 A5 JP 2006506368A5 JP 2004544849 A JP2004544849 A JP 2004544849A JP 2004544849 A JP2004544849 A JP 2004544849A JP 2006506368 A5 JP2006506368 A5 JP 2006506368A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- salt
- isomer
- benzhydryl
- organic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41905102P | 2002-10-16 | 2002-10-16 | |
| PCT/US2003/032275 WO2004035575A1 (en) | 2002-10-16 | 2003-10-10 | Process for the preparation of (s,s)-cis-2-benzhydryl-3-benzylaminoquinuclidine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006506368A JP2006506368A (ja) | 2006-02-23 |
| JP2006506368A5 true JP2006506368A5 (https=) | 2006-11-30 |
Family
ID=32108014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004544849A Pending JP2006506368A (ja) | 2002-10-16 | 2003-10-10 | （ｓ，ｓ）−シス−２−ベンズヒドリル−３−ベンジルアミノキヌクリジンの調製方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6861526B2 (https=) |
| EP (1) | EP1551833A4 (https=) |
| JP (1) | JP2006506368A (https=) |
| KR (1) | KR100739901B1 (https=) |
| CN (1) | CN100418964C (https=) |
| AP (1) | AP2005003288A0 (https=) |
| AR (1) | AR041587A1 (https=) |
| AU (1) | AU2003277353B2 (https=) |
| BR (1) | BR0315335A (https=) |
| CA (1) | CA2500635A1 (https=) |
| EA (1) | EA008192B1 (https=) |
| HR (1) | HRP20050328A2 (https=) |
| IS (1) | IS7755A (https=) |
| MX (1) | MXPA05004058A (https=) |
| PA (1) | PA8586601A1 (https=) |
| PE (1) | PE20040777A1 (https=) |
| PL (1) | PL376218A1 (https=) |
| TN (1) | TNSN05111A1 (https=) |
| UY (1) | UY28024A1 (https=) |
| WO (1) | WO2004035575A1 (https=) |
| ZA (1) | ZA200502411B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| LT1713504T (lt) * | 2004-01-30 | 2017-09-11 | Zoetis Services Llc | Antimikrobinis konservantas, skirtas multi-dozinėms kompozicijoms, panaudojant beta-ciklodekstrinus, skirtas skystoms vaisto formoms |
| SI1713801T1 (sl) * | 2004-02-02 | 2008-04-30 | Pfizer Prod Inc | Postopek priprave 1-(2S,3S)-2-benzhidril-N-(5-terc-butil-2-metoksibenzil)kinuklidin-3- amina |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| KR101452915B1 (ko) | 2006-05-04 | 2014-10-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 다형태 |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| JP2012512848A (ja) | 2008-12-23 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 有機化合物の塩の形態 |
| TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
| KR20240090632A (ko) | 2009-11-27 | 2024-06-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| CA3070513C (en) | 2010-05-05 | 2023-01-03 | Boehringer Ingelheim International Gmbh | A dpp-4 inhibitor for use in treatment of skin-alterations or necrosis |
| KR20130093012A (ko) | 2010-06-24 | 2013-08-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| DK2731947T3 (en) | 2011-07-15 | 2019-04-23 | Boehringer Ingelheim Int | SUBSTITUTED DIMERIC QUINAZOLINE DERIVATIVE, PREPARATION AND USE thereof IN PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF TYPE I AND TYPE II DIABETES |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| WO2013171167A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
| WO2013171166A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp-4 inhibitor for use in the treatment of sirs and/or sepsis |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| EP3110449B1 (en) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medical use of a dpp-4 inhibitor |
| EP4233840A3 (en) | 2016-06-10 | 2023-10-18 | Boehringer Ingelheim International GmbH | Combinations of linagliptin and metformin |
| CN108341812A (zh) * | 2017-01-23 | 2018-07-31 | 科贝源(北京)生物医药科技有限公司 | 一种含奎宁环化合物的制备方法 |
| CN108341811A (zh) * | 2017-01-23 | 2018-07-31 | 科贝源(北京)生物医药科技有限公司 | 马罗皮坦杂质的制备方法 |
| CN106977512B (zh) * | 2017-05-04 | 2019-01-01 | 海门慧聚药业有限公司 | 制备马罗匹坦游离碱的方法 |
| WO2025172911A1 (en) * | 2024-02-16 | 2025-08-21 | Teadus Pharmaceuticals Pvt. Ltd | A process for the preparation of (2s,3s)-2-benzhydryl- n-(5-tert-butyl-2-methoxybenzyl) quinuclidin-3-amine and pharmaceutically acceptable salts thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3560510A (en) * | 1969-03-05 | 1971-02-02 | Aldrich Chem Co Inc | 2-benzhydrylquinuclidines |
| US4680283A (en) | 1984-09-26 | 1987-07-14 | Merck & Co., Inc. | Analogs of substance P and eledoisin |
| MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
| US5138060A (en) | 1991-01-03 | 1992-08-11 | Pfizer Inc. | Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines |
| UA26401C2 (uk) * | 1991-05-22 | 1999-08-30 | Пфайзер Інк. | Заміщеhі 3-аміhохіhуклідиhи |
| AU657552B2 (en) | 1991-05-31 | 1995-03-16 | Pfizer Inc. | Quinuclidine as substance P antagonists |
| WO1994004496A1 (en) | 1992-08-19 | 1994-03-03 | Pfizer Inc. | Substituted benzylamino nitrogen containing non-aromatic heterocycles |
| US5604241A (en) * | 1992-10-21 | 1997-02-18 | Pfizer Inc. | Substituted benzylaminoquinuclidines as substance P antagonists |
| JP2656699B2 (ja) | 1992-10-21 | 1997-09-24 | ファイザー製薬株式会社 | 置換ベンジルアミノキヌクリジン |
| JP2656700B2 (ja) | 1992-10-28 | 1997-09-24 | ファイザー製薬株式会社 | 置換キヌクリジン誘導体 |
| CA2149242C (en) * | 1992-11-12 | 1998-08-04 | Fumitaka Ito | Quinuclidine derivative for treatment of inflammatory and gastrointestinal disorders |
| IL109646A0 (en) | 1993-05-19 | 1994-08-26 | Pfizer | Heteroatom substituted alkyl benzylamino-quinuclidines |
| PE8798A1 (es) * | 1995-07-17 | 1998-03-02 | Pfizer | Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil] |
| MX9706944A (es) | 1996-09-12 | 1998-08-30 | Pfizer | Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p. |
-
2003
- 2003-10-06 US US10/679,961 patent/US6861526B2/en not_active Expired - Fee Related
- 2003-10-10 HR HR20050328A patent/HRP20050328A2/xx not_active Application Discontinuation
- 2003-10-10 WO PCT/US2003/032275 patent/WO2004035575A1/en not_active Ceased
- 2003-10-10 AU AU2003277353A patent/AU2003277353B2/en not_active Ceased
- 2003-10-10 CN CNB200380101563XA patent/CN100418964C/zh not_active Expired - Fee Related
- 2003-10-10 EA EA200500650A patent/EA008192B1/ru not_active IP Right Cessation
- 2003-10-10 BR BR0315335-5A patent/BR0315335A/pt not_active IP Right Cessation
- 2003-10-10 EP EP03808986A patent/EP1551833A4/en not_active Withdrawn
- 2003-10-10 JP JP2004544849A patent/JP2006506368A/ja active Pending
- 2003-10-10 AP AP2005003288A patent/AP2005003288A0/xx unknown
- 2003-10-10 AR ARP030103709A patent/AR041587A1/es unknown
- 2003-10-10 CA CA002500635A patent/CA2500635A1/en not_active Abandoned
- 2003-10-10 MX MXPA05004058A patent/MXPA05004058A/es active IP Right Grant
- 2003-10-10 KR KR1020057006471A patent/KR100739901B1/ko not_active Expired - Fee Related
- 2003-10-10 PL PL03376218A patent/PL376218A1/xx not_active Application Discontinuation
- 2003-10-14 PE PE2003001050A patent/PE20040777A1/es not_active Application Discontinuation
- 2003-10-15 UY UY28024A patent/UY28024A1/es not_active Application Discontinuation
- 2003-10-16 PA PA20038586601A patent/PA8586601A1/es unknown
-
2004
- 2004-10-27 US US10/974,447 patent/US20050085641A1/en not_active Abandoned
-
2005
- 2005-03-17 IS IS7755A patent/IS7755A/is unknown
- 2005-03-23 ZA ZA200502411A patent/ZA200502411B/en unknown
- 2005-04-15 TN TNP2005000111A patent/TNSN05111A1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006506368A5 (https=) | ||
| KR100739901B1 (ko) | (ｓ,ｓ)-시스-2-벤즈하이드릴-3-벤질아미노퀴누클리딘의제조 방법 | |
| CN110035820A (zh) | 基于含氮生物聚合物的催化剂、其制备方法及其在氢化方法、还原脱卤和氧化中的用途 | |
| CN111233829A (zh) | 一种具有光学活性的尼古丁的制备方法 | |
| JP2002265444A (ja) | １−（３−ベンジルオキシプロピル）−５−（２−置換プロピル）インドリン誘導体およびその使用方法 | |
| CN103664677A (zh) | 一种(r,r)-福莫特罗酒石酸盐的不对称合成方法 | |
| TW200900376A (en) | Method for producing 4-aminomethylbenzoic acid | |
| CN101585798A (zh) | 光学活性化合物1-(3-苯甲酰氧基丙基)-5-(2-(1-苯基乙基胺)丙基)-7-氰基吲哚啉及其制备方法和用途 | |
| JP2013512276A5 (https=) | ||
| JP4079727B2 (ja) | 光学活性１−（フルオロ、トリフルオロメチルまたはトリフルオロメトキシ置換フェニル）アルキルアミンｎ−モノアルキル誘導体とその製造方法 | |
| EP1224161B1 (en) | Nitroxy derivatives of (r) and (s)-carnitine | |
| CN100422138C (zh) | 生产旋光活性1-烷基-取代的2,2,2-三氟乙基胺的方法 | |
| JP2002544252A5 (https=) | ||
| JP3982993B2 (ja) | 光学活性１−（トリフルオロメチルモノ置換フェニル）エチルアミンの精製方法 | |
| JP2005298334A (ja) | 新規な中間体化合物およびそれを用いる化合物の製造方法 | |
| WO2013058241A1 (ja) | （ｒ）－２－アミノ－２－エチルヘキサノールの製造法 | |
| CN102093254B (zh) | 一种二水合3-(2，2，2-三甲基肼)丙酸盐的制备方法 | |
| CN1058488C (zh) | １，３，６－三烷基六氢－１，３，６－三氮杂辛因－２－酮及其制备方法 | |
| CN113264839B (zh) | 一种使用手性辅基制备左旋特布他林的方法 | |
| JP7601462B2 (ja) | 不斉補助剤を使用してレボテルブタリンを調製する方法 | |
| JP2015166383A (ja) | ネラメキサン又はその塩を調製する方法 | |
| JP4904945B2 (ja) | 光学活性１−（フルオロ、トリフルオロメチルまたはトリフルオロメトキシ置換フェニル）アルキルアミンｎ−モノアルキル誘導体の製造方法 | |
| CN116693409A (zh) | 一种(2s)-[4-(3-氟苄氧基)苄胺基]丙酸甲酯的制备方法 | |
| JP2007532631A (ja) | 光学活性ｌ−エリトロ−２−アミノ−１−フェニル−１−プロパノールの製造方法 | |
| JP5749261B2 (ja) | ３，３，５，５−テトラメチルシクロヘキサノンを調製する方法 |