PA8586601A1 - Proceso para la preparacion de (s,s)-cis-2-benzhidril-3-bencilaminoquinuclidina - Google Patents

Proceso para la preparacion de (s,s)-cis-2-benzhidril-3-bencilaminoquinuclidina

Info

Publication number
PA8586601A1
PA8586601A1 PA20038586601A PA8586601A PA8586601A1 PA 8586601 A1 PA8586601 A1 PA 8586601A1 PA 20038586601 A PA20038586601 A PA 20038586601A PA 8586601 A PA8586601 A PA 8586601A PA 8586601 A1 PA8586601 A1 PA 8586601A1
Authority
PA
Panama
Prior art keywords
organic
acid
isomero
benzhidril
bencilaminoquinuclidina
Prior art date
Application number
PA20038586601A
Other languages
English (en)
Inventor
Thomas C Nugent
Robert Seemayer
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8586601A1 publication Critical patent/PA8586601A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCESO PARA PREPARAR (S,S)-CIS-2-BENZHIDRIL-3-BENCILAMINOQUINUCLIDINA. EL PROCESO INCLUYE LOS PASOS DE CONTACTAR UN COMPUESTO QUE CONTIENE UNA MEZCLA DE R- Y S-ISOMEROS Y QUE TIENE LA FORMULA CON UNA CANTIDAD EFECTIVA DE UN ACIDO ORGANICO QUIRAL EN PRESENCIA DE UN SOLVENTE ORGANICO Y UNA CANTIDAD EFECTIVA DE UN ACIDO CARBOXILICO PARA CONVERTIR EL R-ISOMERO EN UNA SAL ACIDA DEL S-ISOMERO, EN DONDE EL SOLVENTE ORGANICO ES CAPAZ DE SOLUBILIZAR EL COMPUESTO QUE CONTIENE LA MEZCLA DE R- Y S-ISOMEROS, MIENTRAS PRECIPITA LA SAL ACIDA Y EL ACIDO CARBOXILICO ORGANICO ES DIFERENTE DEL ACIDO ORGANICO QUIRAL; NEUTRALIZANDO LA SAL ACIDA CON UNA BASE PARA PROVEER UN S-ISOMERO DE UNA CETONA QUIRAL DE LA FORMULA Y HACIENDO REACCIONAR LA CETONA QUIRAL CON UNA AMINA ORGANICA EN PRESENCIA DE UN ACIDO LEWIS PARA PROVEER LA CORRESPONDIENTE IMINA Y REDUCIR LA IMINA.
PA20038586601A 2002-10-16 2003-10-16 Proceso para la preparacion de (s,s)-cis-2-benzhidril-3-bencilaminoquinuclidina PA8586601A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41905102P 2002-10-16 2002-10-16

Publications (1)

Publication Number Publication Date
PA8586601A1 true PA8586601A1 (es) 2005-02-04

Family

ID=32108014

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20038586601A PA8586601A1 (es) 2002-10-16 2003-10-16 Proceso para la preparacion de (s,s)-cis-2-benzhidril-3-bencilaminoquinuclidina

Country Status (22)

Country Link
US (2) US6861526B2 (es)
EP (1) EP1551833A4 (es)
JP (1) JP2006506368A (es)
KR (1) KR100739901B1 (es)
CN (1) CN100418964C (es)
AP (1) AP2005003288A0 (es)
AR (1) AR041587A1 (es)
AU (1) AU2003277353B2 (es)
BR (1) BR0315335A (es)
CA (1) CA2500635A1 (es)
EA (1) EA008192B1 (es)
HK (1) HK1078087A1 (es)
HR (1) HRP20050328A2 (es)
IS (1) IS7755A (es)
MX (1) MXPA05004058A (es)
PA (1) PA8586601A1 (es)
PE (1) PE20040777A1 (es)
PL (1) PL376218A1 (es)
TN (1) TNSN05111A1 (es)
UY (1) UY28024A1 (es)
WO (1) WO2004035575A1 (es)
ZA (1) ZA200502411B (es)

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US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
SI1713504T1 (sl) * 2004-01-30 2017-10-30 Zoetis Services Llc Protimikrobni konzervansi za dosego večodmerne formulacije z uporabo beta-ciklodekstrinov za tekoče odmerne oblike
AU2005210259A1 (en) * 2004-02-02 2005-08-18 Pfizer Products Inc. Process for preparation of 1-(2S,3S)-2-benzhydr yl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine
DE102004054054A1 (de) * 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
CN102838599A (zh) 2006-05-04 2012-12-26 贝林格尔.英格海姆国际有限公司 多晶型
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
AU2009331471B2 (en) 2008-12-23 2015-09-03 Boehringer Ingelheim International Gmbh Salt forms of organic compound
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
KR102668834B1 (ko) 2009-11-27 2024-05-24 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
ES2935300T3 (es) 2010-05-05 2023-03-03 Boehringer Ingelheim Int Combiterapia
KR20230051307A (ko) 2010-06-24 2023-04-17 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
EA030121B1 (ru) 2011-07-15 2018-06-29 Бёрингер Ингельхайм Интернациональ Гмбх Замещенные хиназолины, их получение и их применение в фармацевтических композициях
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
WO2013171167A1 (en) 2012-05-14 2013-11-21 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
EP4233840A3 (en) 2016-06-10 2023-10-18 Boehringer Ingelheim International GmbH Combinations of linagliptin and metformin
CN108341811A (zh) * 2017-01-23 2018-07-31 科贝源(北京)生物医药科技有限公司 马罗皮坦杂质的制备方法
CN108341812A (zh) * 2017-01-23 2018-07-31 科贝源(北京)生物医药科技有限公司 一种含奎宁环化合物的制备方法
CN106977512B (zh) * 2017-05-04 2019-01-01 海门慧聚药业有限公司 制备马罗匹坦游离碱的方法

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US4680283A (en) 1984-09-26 1987-07-14 Merck & Co., Inc. Analogs of substance P and eledoisin
MX18467A (es) * 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
US5138060A (en) 1991-01-03 1992-08-11 Pfizer Inc. Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines
DK0585328T3 (da) 1991-05-22 2002-02-11 Pfizer Substituerede 3-aminoquinuclidiner
RU2103269C1 (ru) 1991-05-31 1998-01-27 Пфайзер Инк. Производные хинуклидина или их фармацевтически приемлемые соли и фармацевтическая композиция
AU4224993A (en) 1992-08-19 1994-03-15 Pfizer Inc. Substituted benzylamino nitrogen containing non-aromatic heterocycles
JP2656699B2 (ja) 1992-10-21 1997-09-24 ファイザー製薬株式会社 置換ベンジルアミノキヌクリジン
US5604241A (en) * 1992-10-21 1997-02-18 Pfizer Inc. Substituted benzylaminoquinuclidines as substance P antagonists
JP2656700B2 (ja) 1992-10-28 1997-09-24 ファイザー製薬株式会社 置換キヌクリジン誘導体
KR950704311A (ko) * 1992-11-12 1995-11-17 알렌 제이. 스피겔 물질 p 길항체로서의 퀴누클리딘 유도체(quinuclidine derivative as substance p antagonist)
IL109646A0 (en) 1993-05-19 1994-08-26 Pfizer Heteroatom substituted alkyl benzylamino-quinuclidines
PE8798A1 (es) 1995-07-17 1998-03-02 Pfizer Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil]
MX9706944A (es) 1996-09-12 1998-08-30 Pfizer Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p.

Also Published As

Publication number Publication date
IS7755A (is) 2005-03-17
PL376218A1 (en) 2005-12-27
PE20040777A1 (es) 2004-11-20
WO2004035575A1 (en) 2004-04-29
EP1551833A4 (en) 2010-06-02
US20050085641A1 (en) 2005-04-21
TNSN05111A1 (en) 2007-05-14
EP1551833A1 (en) 2005-07-13
US20040116704A1 (en) 2004-06-17
CA2500635A1 (en) 2004-04-29
BR0315335A (pt) 2005-08-16
ZA200502411B (en) 2006-05-31
UY28024A1 (es) 2004-05-31
HK1078087A1 (en) 2006-03-03
AU2003277353B2 (en) 2007-08-09
AR041587A1 (es) 2005-05-26
AU2003277353A1 (en) 2004-05-04
KR20050083764A (ko) 2005-08-26
JP2006506368A (ja) 2006-02-23
US6861526B2 (en) 2005-03-01
AP2005003288A0 (en) 2005-06-30
MXPA05004058A (es) 2005-06-08
CN1705664A (zh) 2005-12-07
KR100739901B1 (ko) 2007-07-13
HRP20050328A2 (en) 2005-06-30
EA200500650A1 (ru) 2005-10-27
EA008192B1 (ru) 2007-04-27
WO2004035575A8 (en) 2005-05-12
CN100418964C (zh) 2008-09-17

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