BR0215776A - Processo para a preparação de derivados de pename a partir de derivados de cefame - Google Patents

Processo para a preparação de derivados de pename a partir de derivados de cefame

Info

Publication number
BR0215776A
BR0215776A BR0215776-4A BR0215776A BR0215776A BR 0215776 A BR0215776 A BR 0215776A BR 0215776 A BR0215776 A BR 0215776A BR 0215776 A BR0215776 A BR 0215776A
Authority
BR
Brazil
Prior art keywords
formula
compound
derivatives
pename
cefame
Prior art date
Application number
BR0215776-4A
Other languages
English (en)
Inventor
Pandurang Balwant Deshpande
Udayampalayam Pa Sentthilkumar
G Andrew
Original Assignee
Orchid Chemicals & Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals & Pharm Ltd filed Critical Orchid Chemicals & Pharm Ltd
Publication of BR0215776A publication Critical patent/BR0215776A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/87—Compounds being unsubstituted in position 3 or with substituents other than only two methyl radicals attached in position 3, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

"PROCESSO PARA A PREPARAçãO DE DERIVADOS DE PENAME A PARTIR DE DERIVADOS DE CEFAME". A presente invenção refere-se a um processo para a preparação de derivados de 2<225>-heterociclil metil pename da fórmula (I) onde R~ 1~ representa hidrogênio, um grupo de proteção ácido carboxílico tal como um éster ou um sal farmaceuticamente aceitável; R~ 2~ e R~ 3~ podem ser os mesmos ou diferentes e representam, independentemente hidrogênio, halogênio, NH~ 2~, acilamino, ftalimido, contando que R~ 2~ e R~ 3~ não sejam ambos NH~ 2~, acilamino, ftalimido; Het representa um sistema de anel heterocíclico contendo NH de 5 ou 6 elementos contendo um ou mais heteroátomos selecionados de O, S ou N, o qual compreende: (i) reação de um composto da fórmula (VII) onde L representa um grupo de saída com um composto da fórmula (VIII), onde Het é conforme definido anteriormente, na presença de um solvente e uma base em uma temperatura na faixa de - 10 a 11O<198>C a fim de produzir um composto da fórmula (IX); (ii) oxidação do composto da fórmula (IX) usando-se agentes de oxidação convencionais na presença de um solvente miscível em água e um ácido orgânico a fim de produzir um composto da fórmula (I) e, se necessário (III) desesterificação do composto da fórmula (I), onde R~ 1~ representa um grupo de proteção carbóxi a um composto da fórmula (I) onde R~ 1~ representa hidrogênio, usando-se um catalisador de metal na presença de uma base e um solvente imiscível em água.
BR0215776-4A 2002-06-07 2002-06-12 Processo para a preparação de derivados de pename a partir de derivados de cefame BR0215776A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN434CH2002 2002-06-07
PCT/IB2002/002230 WO2003104241A1 (en) 2002-06-07 2002-06-12 Process for preparation of penam derivatives from cepham derivatives

Publications (1)

Publication Number Publication Date
BR0215776A true BR0215776A (pt) 2005-03-01

Family

ID=29727195

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0215776-4A BR0215776A (pt) 2002-06-07 2002-06-12 Processo para a preparação de derivados de pename a partir de derivados de cefame

Country Status (12)

Country Link
US (1) US6936711B2 (pt)
EP (1) EP1554287B1 (pt)
JP (1) JP2005534662A (pt)
KR (1) KR100671881B1 (pt)
CN (1) CN1285596C (pt)
AU (1) AU2002309162A1 (pt)
BR (1) BR0215776A (pt)
CA (1) CA2487883C (pt)
DE (1) DE60215867T2 (pt)
ES (1) ES2274978T3 (pt)
RU (1) RU2284329C2 (pt)
WO (1) WO2003104241A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100431052B1 (ko) * 2001-10-08 2004-05-12 주식회사 네오텍리서치 표면 굴곡에 의하여 형성된 다중 영역 효과를 가지는 액정표시 장치
US7417143B2 (en) * 2004-04-07 2008-08-26 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of Tazobactam in pure form
JP4716708B2 (ja) * 2004-10-28 2011-07-06 大塚化学株式会社 ペナム化合物の製造方法
US20060173177A1 (en) * 2005-01-28 2006-08-03 Gego Csaba L Process for preparation of penam derivatives
CN102304139B (zh) * 2011-07-12 2014-06-04 江西富祥药业股份有限公司 一种2β-三唑甲基青霉烷酸二苯甲酯二氧化物的制备方法
EP3616695A1 (en) 2011-09-09 2020-03-04 Merck Sharp & Dohme Corp. Methods for treating intrapulmonary infections
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US20140274989A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Manufacturing beta-lactam combination products
US20140274996A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Tazobactam and ceftolozane antibiotic compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
ES2800603T3 (es) 2013-09-09 2021-01-04 Merck Sharp & Dohme Tratamiento de infecciones con ceftolozano/tazobactam en sujetos con insuficiencia renal
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
CN115246844A (zh) * 2021-04-28 2022-10-28 苏州朗科生物技术股份有限公司 一种他唑巴坦中间体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU541028B2 (en) 1982-06-21 1984-12-13 Taiho Pharmaceutical Co., Ltd. 6-unsubstituted penicillin derivatives
JPS58225091A (ja) * 1982-06-21 1983-12-27 Taiho Yakuhin Kogyo Kk ペニシリン誘導体及びその製造法
CA1221358A (en) * 1982-12-08 1987-05-05 Erba Farmitalia 2-THIACEPHEM AND (5R)-PENEM DERIVATIVES
US4562073A (en) * 1982-12-24 1985-12-31 Taiho Pharmaceutical Company Limited Penicillin derivatives
CA1239392A (en) * 1983-10-13 1988-07-19 Shigeru Yamabe Penicillin derivatives and process for preparing the same
JPH067257B2 (ja) 1986-12-23 1994-01-26 富士写真フイルム株式会社 感光材料現像装置
JP2603082B2 (ja) 1987-09-07 1997-04-23 大塚化学株式会社 ペニシラン酸誘導体の製造法
JP2602685B2 (ja) * 1988-03-01 1997-04-23 大鵬薬品工業株式会社 ２α−メチル−２β―（１，２，３−トリアゾール−１−イル）メチルペナム−３α−カルボン酸誘導体の製造法

Also Published As

Publication number Publication date
EP1554287B1 (en) 2006-11-02
EP1554287A1 (en) 2005-07-20
DE60215867T2 (de) 2007-09-06
CN1649880A (zh) 2005-08-03
KR100671881B1 (ko) 2007-01-19
CA2487883A1 (en) 2003-12-18
US20030232983A1 (en) 2003-12-18
US6936711B2 (en) 2005-08-30
CN1285596C (zh) 2006-11-22
DE60215867D1 (de) 2006-12-14
AU2002309162A1 (en) 2003-12-22
ES2274978T3 (es) 2007-06-01
RU2004139100A (ru) 2005-06-10
JP2005534662A (ja) 2005-11-17
KR20050024318A (ko) 2005-03-10
WO2003104241A1 (en) 2003-12-18
CA2487883C (en) 2011-04-19
RU2284329C2 (ru) 2006-09-27

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA:INT.CI. C07D 499/06, C07D 499/87, A61P 31/00

Ipc: C07D 499/06 (2011.01), C07D 499/87 (2011.01), A61P

B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 11A E 12A ANUIDADES.

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2259 DE 22/04/2014 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 11A, 12A, 13A, 14A, 15A, 16A, 17A E 18A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.