JP2006506340A - 代謝調節型グルタミン酸受容体５のモジュレーターとしてのオキサジアゾール - Google Patents

代謝調節型グルタミン酸受容体５のモジュレーターとしてのオキサジアゾール Download PDF

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JP2006506340A
JP2006506340A JP2004527912A JP2004527912A JP2006506340A JP 2006506340 A JP2006506340 A JP 2006506340A JP 2004527912 A JP2004527912 A JP 2004527912A JP 2004527912 A JP2004527912 A JP 2004527912A JP 2006506340 A JP2006506340 A JP 2006506340A
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Prior art keywords
alkyl
piperazine
phenyl
carboxylic acid
methyl
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JP2004527912A
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Japanese (ja)
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JP2006506340A5 (enExample
Inventor
デイビッド、ウェンズボー
タオ、シン
トミスラブ、ステファナック
ジャラジ、アローラ
ドナルド、エイ．マクレオド
アニカ、カーズ
ヨハン、マルムベルク
カリン、オスカルソン
ルイーズ、エドワーズ
メスビン、イサック
アブデルマリク、スラッシ
トーマス、エム．ストーマン
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Shire NPS Pharmaceuticals Inc
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NPS Pharmaceuticals Inc
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Publication of JP2006506340A publication Critical patent/JP2006506340A/ja
Publication of JP2006506340A5 publication Critical patent/JP2006506340A5/ja
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    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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  • Organic Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2004527912A 2002-08-09 2003-08-08 代謝調節型グルタミン酸受容体５のモジュレーターとしてのオキサジアゾール Pending JP2006506340A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40203902P 2002-08-09 2002-08-09
PCT/US2003/024912 WO2004014370A2 (en) 2002-08-09 2003-08-08 Oxadiazoles as modulators of metabotropic glutamate receptor-5

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JP2006506340A true JP2006506340A (ja) 2006-02-23
JP2006506340A5 JP2006506340A5 (enExample) 2006-12-07

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JP2004527912A Pending JP2006506340A (ja) 2002-08-09 2003-08-08 代謝調節型グルタミン酸受容体５のモジュレーターとしてのオキサジアゾール

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US (2) US20040132726A1 (enExample)
EP (1) EP1536790A2 (enExample)
JP (1) JP2006506340A (enExample)
KR (1) KR20050039846A (enExample)
CN (1) CN1691944A (enExample)
AR (1) AR041508A1 (enExample)
AU (1) AU2003268064A1 (enExample)
BR (1) BR0313266A (enExample)
CA (1) CA2495120A1 (enExample)
IL (1) IL166650A0 (enExample)
MX (1) MXPA05001592A (enExample)
NO (1) NO20051223L (enExample)
NZ (1) NZ538339A (enExample)
TW (2) TW200424183A (enExample)
WO (1) WO2004014370A2 (enExample)
ZA (1) ZA200501101B (enExample)

Cited By (5)

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JP2010529052A (ja) * 2007-06-05 2010-08-26 サノフィ−アベンティス ジ（ヘテロ）アリールシクロヘキサン誘導体、それらの製造、それらの使用及びそれらを含む薬剤組成物
WO2013015203A1 (ja) * 2011-07-28 2013-01-31 日本軽金属株式会社 3-クロロ-4-メチル安息香酸イソプロピル及びその製造方法
JP2017528486A (ja) * 2014-09-17 2017-09-28 ヴァーセオン コーポレイション セリンプロテアーゼ阻害剤としてのピラゾリル置換ピリドン化合物
US10532995B2 (en) 2015-02-27 2020-01-14 Verseon Corporation Substituted pyrazole compounds as serine protease inhibitors
US10653674B2 (en) 2010-03-30 2020-05-19 Verseon Corporation Multisubstituted aromatic compounds as inhibitors of thrombin

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TR201706226T4 (tr) 2003-04-11 2018-06-21 Ptc Therapeutics Inc 1,2,4-oksadiazol benzoik asit bileşikleri ve bunların anlamsız baskılama ve hastalıkların tedavisinde kullanımı.
JP4795022B2 (ja) 2003-09-30 2011-10-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環化合物を含有する新規な抗真菌剤
WO2005077373A2 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
KR20070026382A (ko) * 2004-02-18 2007-03-08 아스트라제네카 아베 아세틸린성 피페라진 화합물 및 대사성 글루타메이트수용체 길항제로서 이들의 용도
US7585881B2 (en) 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
TW200538108A (en) 2004-02-19 2005-12-01 Astrazeneca Ab Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
EP1740559B1 (en) * 2004-04-20 2014-10-15 Merck Sharp & Dohme Corp. 1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
US7858800B2 (en) * 2004-06-30 2010-12-28 Banyu Pharmaceutical Co., Ltd. Biaryl derivatives
JP4557685B2 (ja) 2004-11-15 2010-10-06 独立行政法人理化学研究所 蛍光蛋白質
WO2006089076A2 (en) 2005-02-18 2006-08-24 Neurogen Corporation Thiazole amides, imidazole amides and related analogues
CA2603701A1 (en) * 2005-04-06 2006-10-19 Banyu Pharmaceutical Co., Ltd. 1,4-substituted piperazine derivative
MX2007012206A (es) * 2005-04-08 2007-12-05 Ptc Therapeutics Inc Composiciones de 1,2,4-oxadiazol activo por via oral para terapia de supresion de mutacion interruptora.
JP3789465B1 (ja) 2005-04-28 2006-06-21 学校法人立教学院 イソオキサゾール誘導体又はジヒドロイソオキサゾール誘導体の製造方法
GB0510139D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
EP1893606A2 (en) * 2005-05-18 2008-03-05 Addex Pharma SA Substituted oxadiazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
GB0510140D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B2
TW200800204A (en) * 2005-08-15 2008-01-01 Astrazeneca Ab Bicyclic piperazines as metabotropic glutatmate receptor antagonists
TW200800946A (en) * 2005-08-15 2008-01-01 Astrazeneca Ab Substituted piperazines as metabotropic glutamate receptor antagonists
UY29796A1 (es) 2005-09-29 2007-04-30 Astrazeneca Ab Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
MX2008012515A (es) 2006-03-30 2008-11-19 Ptc Therapeutics Inc Metodos para la produccion de proteina funcional a partir de adn que tiene una mutacion sin sentido y el tratamiento de trastornos asociados con la misma.
TW200808800A (en) * 2006-05-05 2008-02-16 Astrazeneca Ab MGluR5 modulators V
TW200811179A (en) * 2006-05-05 2008-03-01 Astrazeneca Ab mGluR5 modulators VI
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