JP2005539012A5 - - Google Patents
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- JP2005539012A5 JP2005539012A5 JP2004526255A JP2004526255A JP2005539012A5 JP 2005539012 A5 JP2005539012 A5 JP 2005539012A5 JP 2004526255 A JP2004526255 A JP 2004526255A JP 2004526255 A JP2004526255 A JP 2004526255A JP 2005539012 A5 JP2005539012 A5 JP 2005539012A5
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 25
- 239000000203 mixture Substances 0.000 claims description 25
- 150000001875 compounds Chemical class 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 13
- 208000035475 disorder Diseases 0.000 claims description 11
- 201000006417 multiple sclerosis Diseases 0.000 claims description 10
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- 238000000034 method Methods 0.000 claims description 7
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- 208000024172 Cardiovascular disease Diseases 0.000 claims description 6
- 208000012902 Nervous system disease Diseases 0.000 claims description 6
- 230000003676 hair loss Effects 0.000 claims description 6
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 6
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- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 5
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- 125000001931 aliphatic group Chemical group 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 229910052717 sulfur Chemical group 0.000 claims 3
- 239000011593 sulfur Chemical group 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 102000001267 GSK3 Human genes 0.000 claims 2
- 108060006662 GSK3 Proteins 0.000 claims 2
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 2
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- 230000003110 anti-inflammatory effect Effects 0.000 claims 2
- 239000000935 antidepressant agent Substances 0.000 claims 2
- 229940005513 antidepressants Drugs 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000003900 neurotrophic factor Substances 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
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- 239000002671 adjuvant Substances 0.000 claims 1
- 230000001430 anti-depressive effect Effects 0.000 claims 1
- 230000000561 anti-psychotic effect Effects 0.000 claims 1
- 239000000164 antipsychotic agent Substances 0.000 claims 1
- 229940005529 antipsychotics Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 150000002926 oxygen Chemical class 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 230000019100 sperm motility Effects 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 230000000982 vasogenic effect Effects 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 0 *c1cc(*C2NNC3=C2C=C(*)C=C*3)nc(-c2c(C(F)(F)F)cccc2)n1 Chemical compound *c1cc(*C2NNC3=C2C=C(*)C=C*3)nc(-c2c(C(F)(F)F)cccc2)n1 0.000 description 4
- 230000004770 neurodegeneration Effects 0.000 description 3
- 230000000926 neurological effect Effects 0.000 description 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 description 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 description 2
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 description 2
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 description 2
- 208000034799 Tauopathies Diseases 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 description 2
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 208000033808 peripheral neuropathy Diseases 0.000 description 2
- FLZGOKYWHQKDDA-UHFFFAOYSA-N CN(C)CCCc1cc(Nc2n[nH]c3c2C=CCN3C)nc(-c2ccccc2C(F)(F)F)n1 Chemical compound CN(C)CCCc1cc(Nc2n[nH]c3c2C=CCN3C)nc(-c2ccccc2C(F)(F)F)n1 FLZGOKYWHQKDDA-UHFFFAOYSA-N 0.000 description 1
- GOXYECCEIJZLDT-UHFFFAOYSA-N CN(C)CCNCCCc1cc(Nc2n[nH]c3c2cccn3)nc(-c2ccccc2C(F)(F)F)n1 Chemical compound CN(C)CCNCCCc1cc(Nc2n[nH]c3c2cccn3)nc(-c2ccccc2C(F)(F)F)n1 GOXYECCEIJZLDT-UHFFFAOYSA-N 0.000 description 1
- AQHAJNPKECDVLW-UHFFFAOYSA-N CN(CCCc1cc(Nc2n[nH]c3ncccc23)nc(-c2ccccc2C(F)(F)F)n1)CCN1CCOCC1 Chemical compound CN(CCCc1cc(Nc2n[nH]c3ncccc23)nc(-c2ccccc2C(F)(F)F)n1)CCN1CCOCC1 AQHAJNPKECDVLW-UHFFFAOYSA-N 0.000 description 1
- VXUZPNCRQMAOSN-UHFFFAOYSA-N CNCCCc1cc(Nc2n[nH]c3ncccc23)nc(-c2ccccc2C(F)(F)F)n1 Chemical compound CNCCCc1cc(Nc2n[nH]c3ncccc23)nc(-c2ccccc2C(F)(F)F)n1 VXUZPNCRQMAOSN-UHFFFAOYSA-N 0.000 description 1
- WRVWHILNJVMKCM-UHFFFAOYSA-N Cc1cc(Nc(c2c3)n[nH]c2ccc3F)nc(-c2ccccc2C(F)(F)F)n1 Chemical compound Cc1cc(Nc(c2c3)n[nH]c2ccc3F)nc(-c2ccccc2C(F)(F)F)n1 WRVWHILNJVMKCM-UHFFFAOYSA-N 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- AIVIDAHSSPJVRI-UHFFFAOYSA-N FC(c(cccc1)c1-c1nc(C2CC2)cc(NC2=NNC3N=CC=CC23)n1)(F)F Chemical compound FC(c(cccc1)c1-c1nc(C2CC2)cc(NC2=NNC3N=CC=CC23)n1)(F)F AIVIDAHSSPJVRI-UHFFFAOYSA-N 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- KIAZTGTVDUSYMD-UHFFFAOYSA-N OCCNCCCc1cc(Nc2n[nH]c3ncccc23)nc(-c2ccccc2C(F)(F)F)n1 Chemical compound OCCNCCCc1cc(Nc2n[nH]c3ncccc23)nc(-c2ccccc2C(F)(F)F)n1 KIAZTGTVDUSYMD-UHFFFAOYSA-N 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 description 1
- 208000028683 bipolar I disease Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 239000003909 protein kinase inhibitor Substances 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40096702P | 2002-08-02 | 2002-08-02 | |
| US60/400,967 | 2002-08-02 | ||
| PCT/US2003/023950 WO2004013140A1 (en) | 2002-08-02 | 2003-07-31 | Pyrazole compositions useful as inhibitors of gsk-3 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006188629A Division JP2006273872A (ja) | 2002-08-02 | 2006-07-07 | Ｇｓｋ−３のインヒビターとして有用なピラゾール組成物 |
| JP2010211448A Division JP2010280729A (ja) | 2002-08-02 | 2010-09-21 | Ｇｓｋ−３のインヒビターとして有用なピラゾール組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005539012A JP2005539012A (ja) | 2005-12-22 |
| JP2005539012A5 true JP2005539012A5 (enExample) | 2006-08-24 |
| JP4733388B2 JP4733388B2 (ja) | 2011-07-27 |
Family
ID=31495907
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004526255A Expired - Fee Related JP4733388B2 (ja) | 2002-08-02 | 2003-07-31 | Ｇｓｋ−３のインヒビターとして有用なピラゾール組成物 |
| JP2006188629A Withdrawn JP2006273872A (ja) | 2002-08-02 | 2006-07-07 | Ｇｓｋ−３のインヒビターとして有用なピラゾール組成物 |
| JP2010211448A Pending JP2010280729A (ja) | 2002-08-02 | 2010-09-21 | Ｇｓｋ−３のインヒビターとして有用なピラゾール組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006188629A Withdrawn JP2006273872A (ja) | 2002-08-02 | 2006-07-07 | Ｇｓｋ−３のインヒビターとして有用なピラゾール組成物 |
| JP2010211448A Pending JP2010280729A (ja) | 2002-08-02 | 2010-09-21 | Ｇｓｋ−３のインヒビターとして有用なピラゾール組成物 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7491730B2 (enExample) |
| EP (1) | EP1532145B1 (enExample) |
| JP (3) | JP4733388B2 (enExample) |
| KR (1) | KR20050032105A (enExample) |
| CN (2) | CN1319968C (enExample) |
| AR (1) | AR040773A1 (enExample) |
| AT (1) | ATE339419T1 (enExample) |
| AU (2) | AU2003257078B2 (enExample) |
| BR (1) | BR0313176A (enExample) |
| CA (1) | CA2494100C (enExample) |
| CO (1) | CO5700772A2 (enExample) |
| DE (1) | DE60308387T2 (enExample) |
| DK (1) | DK1532145T3 (enExample) |
| EA (1) | EA200500299A1 (enExample) |
| EC (1) | ECSP055640A (enExample) |
| ES (1) | ES2273043T3 (enExample) |
| IL (1) | IL166620A (enExample) |
| MX (1) | MXPA05001367A (enExample) |
| NO (1) | NO20051100L (enExample) |
| NZ (2) | NZ538426A (enExample) |
| PL (1) | PL374967A1 (enExample) |
| PT (1) | PT1532145E (enExample) |
| TW (1) | TWI324157B (enExample) |
| WO (1) | WO2004013140A1 (enExample) |
| ZA (1) | ZA200501124B (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001290912A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US7473691B2 (en) | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| BR0116493A (pt) | 2000-12-21 | 2003-09-30 | Vertex Pharma | Compostos de pirazol úteis como inibidores de proteìna cinase |
| US20040009981A1 (en) | 2002-03-15 | 2004-01-15 | David Bebbington | Compositions useful as inhibitors of protein kinases |
| MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| MXPA05001367A (es) | 2002-08-02 | 2005-04-28 | Vertex Pharma | Composiciones de pirazol utiles como inhibidores de gsk-3. |
| WO2004072029A2 (en) | 2003-02-06 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridazines useful as inhibitors of protein kinases |
| WO2006007864A1 (en) * | 2004-07-17 | 2006-01-26 | Max Planck Geselllschaft Zur Förderung Der Wissenschaft | Treating neurodegenerative conditions |
| WO2006031852A1 (en) | 2004-09-13 | 2006-03-23 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| WO2006034207A2 (en) * | 2004-09-17 | 2006-03-30 | Vanderbilt University | Use of gsk3 inhibitors in combination with radiation therapies |
| US7737151B2 (en) | 2005-08-18 | 2010-06-15 | Vertex Pharmaceuticals Incorporated | Pyrazine kinase inhibitors |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP2275096A3 (en) | 2005-08-26 | 2011-07-13 | Braincells, Inc. | Neurogenesis via modulation of the muscarinic receptors |
| WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| JP5249770B2 (ja) | 2005-11-03 | 2013-07-31 | バーテックス ファーマシューティカルズ インコーポレイテッド | キナーゼインヒビターとして有用なアミノピリジン |
| NZ592968A (en) | 2006-01-17 | 2012-08-31 | Vertex Pharma | Azaindoles substituted with either triazine or pyrimidine useful as inhibitors of janus kinases consisting of JAK1, JAK2, JAK3, and TYK2 |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| ES2375877T3 (es) | 2006-10-31 | 2012-03-07 | Pfizer Products Inc. | Compuestos de pirazolina como antagonistas de receptores de mineralocorticoides. |
| CA2668429A1 (en) * | 2006-11-02 | 2008-05-15 | Vertex Pharmaceuticals Incorporated | Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases |
| NZ577768A (en) | 2006-12-19 | 2012-01-12 | Vertex Pharma | Aminopyrimidines useful as inhibitors of protein kinases |
| WO2008079346A1 (en) | 2006-12-21 | 2008-07-03 | Vertex Pharmaceuticals Incorporated | 5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
| US8802638B1 (en) | 2007-01-25 | 2014-08-12 | University Of South Florida | Flavonoid treatment of glycogen synthase kinase-based disease |
| EP2121613A2 (en) * | 2007-01-31 | 2009-11-25 | Vertex Pharmaceuticals, Inc. | 2-aminopyridine derivatives useful as kinase inhibitors |
| CN101663295B (zh) | 2007-03-09 | 2014-11-05 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的氨基嘧啶类化合物 |
| NZ579483A (en) | 2007-03-09 | 2012-07-27 | Vertex Pharma | Aminopyridines useful as inhibitors of protein kinases |
| JP5393489B2 (ja) * | 2007-03-09 | 2014-01-22 | バーテックス ファーマシューティカルズ インコーポレイテッド | 蛋白キナーゼの阻害剤として有用なアミノピリミジン |
| MX2009011059A (es) | 2007-04-13 | 2009-11-26 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de cinasas. |
| AU2008247594A1 (en) | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
| WO2008137619A2 (en) | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Thiazoles and pyrazoles useful as kinase inhibitors |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| CN101790526A (zh) * | 2007-06-08 | 2010-07-28 | 雅培制药有限公司 | 用作激酶抑制剂的5-杂芳基取代的吲唑化合物 |
| WO2009018415A1 (en) * | 2007-07-31 | 2009-02-05 | Vertex Pharmaceuticals Incorporated | Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof |
| KR20090031122A (ko) * | 2007-09-21 | 2009-03-25 | 주식회사 중외제약 | 인다졸 골격을 함유하는 화합물, 이의 제조방법 및 상기화합물을 함유하는 약제학적 조성물 |
| RU2010129928A (ru) | 2007-12-19 | 2012-01-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Пиразоло[1, 5-а]пиримидины, используемые в качестве ингибиторов jak2 |
| EP2262498A2 (en) * | 2008-03-10 | 2010-12-22 | Vertex Pharmceuticals Incorporated | Pyrimidines and pyridines useful as inhibitors of protein kinases |
| US8263547B2 (en) | 2008-05-28 | 2012-09-11 | Massachusetts Institute Of Technology | DISC-1 pathway activators in the control of neurogenesis |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2010098888A1 (en) * | 2009-02-27 | 2010-09-02 | Massachusetts Institute Of Technology | Uses of chemicals to modulate gsk-3 signaling for treatment of bipolar disorder and other brain disorders |
| WO2010104306A2 (ko) * | 2009-03-07 | 2010-09-16 | 주식회사 메디젠텍 | 세포핵에서 세포질로의 ｇｓｋ３의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 ｇｓｋ３ 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물 |
| GEP20207129B (en) | 2009-06-17 | 2020-07-10 | Vertex Pharma | Inhibitors of influenza viruses replication |
| UY33027A (es) * | 2009-11-13 | 2011-06-30 | Astrazeneca Ab | Pirazina sustituida con oxazolo[4,5-c]piridina |
| US8592485B2 (en) * | 2010-06-17 | 2013-11-26 | Healthpartners Research Foundation | Methods and pharmaceutical compositions for treating the animal central nervous system for psychiatric disorders |
| KR20120063283A (ko) * | 2010-12-07 | 2012-06-15 | 제일약품주식회사 | 신규한 피라졸로 피리딘 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 약학적 조성물 |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| EP2671885A1 (en) | 2012-06-05 | 2013-12-11 | Ares Trading S.A. | Imidazo-oxadiazole and Imidazo-thiadiazole derivatives |
| US8992951B2 (en) | 2013-01-09 | 2015-03-31 | Sapna Life Sciences Corporation | Formulations, procedures, methods and combinations thereof for reducing or preventing the development, or the risk of development, of neuropathology as a result of trauma |
| BR112015023261A2 (pt) | 2013-03-14 | 2017-07-18 | Massachusetts Inst Technology | composições e métodos para expansão e cultura de células-tronco epiteliais |
| PT3068776T (pt) | 2013-11-13 | 2019-08-26 | Vertex Pharma | Inibidores da replicação de vírus da gripe |
| HUE038820T2 (hu) | 2013-11-13 | 2018-11-28 | Vertex Pharma | Eljárás influenzavírusok replikációjának inhibitorai elõállítására |
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2003
- 2003-07-31 MX MXPA05001367A patent/MXPA05001367A/es active IP Right Grant
- 2003-07-31 ES ES03767010T patent/ES2273043T3/es not_active Expired - Lifetime
- 2003-07-31 PL PL03374967A patent/PL374967A1/xx not_active Application Discontinuation
- 2003-07-31 DK DK03767010T patent/DK1532145T3/da active
- 2003-07-31 DE DE60308387T patent/DE60308387T2/de not_active Expired - Lifetime
- 2003-07-31 KR KR1020057001908A patent/KR20050032105A/ko not_active Abandoned
- 2003-07-31 EP EP03767010A patent/EP1532145B1/en not_active Expired - Lifetime
- 2003-07-31 ZA ZA200501124A patent/ZA200501124B/en unknown
- 2003-07-31 CA CA2494100A patent/CA2494100C/en not_active Expired - Fee Related
- 2003-07-31 CN CNB038219859A patent/CN1319968C/zh not_active Expired - Fee Related
- 2003-07-31 AU AU2003257078A patent/AU2003257078B2/en not_active Ceased
- 2003-07-31 CN CNA2007100961579A patent/CN101037438A/zh active Pending
- 2003-07-31 EA EA200500299A patent/EA200500299A1/ru unknown
- 2003-07-31 AT AT03767010T patent/ATE339419T1/de active
- 2003-07-31 WO PCT/US2003/023950 patent/WO2004013140A1/en not_active Ceased
- 2003-07-31 JP JP2004526255A patent/JP4733388B2/ja not_active Expired - Fee Related
- 2003-07-31 NZ NZ538426A patent/NZ538426A/en not_active IP Right Cessation
- 2003-07-31 NZ NZ550883A patent/NZ550883A/en unknown
- 2003-07-31 PT PT03767010T patent/PT1532145E/pt unknown
- 2003-07-31 BR BR0313176-9A patent/BR0313176A/pt not_active IP Right Cessation
- 2003-08-01 US US10/632,340 patent/US7491730B2/en not_active Expired - Fee Related
- 2003-08-01 TW TW092121162A patent/TWI324157B/zh not_active IP Right Cessation
- 2003-08-01 AR AR20030102785A patent/AR040773A1/es unknown
-
2005
- 2005-02-01 IL IL166620A patent/IL166620A/en not_active IP Right Cessation
- 2005-02-25 CO CO05017965A patent/CO5700772A2/es not_active Application Discontinuation
- 2005-03-01 NO NO20051100A patent/NO20051100L/no not_active Application Discontinuation
- 2005-03-02 EC EC2005005640A patent/ECSP055640A/es unknown
-
2006
- 2006-07-07 JP JP2006188629A patent/JP2006273872A/ja not_active Withdrawn
-
2008
- 2008-12-18 US US12/338,129 patent/US7872129B2/en not_active Expired - Fee Related
-
2010
- 2010-07-01 AU AU2010202787A patent/AU2010202787A1/en not_active Abandoned
- 2010-09-21 JP JP2010211448A patent/JP2010280729A/ja active Pending
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