|
US3740412A
(en)
*
|
1970-04-08 |
1973-06-19 |
Synvar Ass |
Imidazoline-3-oxide-1-oxyl derivatives
|
|
US3997223A
(en)
*
|
1975-04-30 |
1976-12-14 |
Dynascan Corporation |
Apparatus and method for rejuvenating cathode ray tubes
|
|
US4166452A
(en)
*
|
1976-05-03 |
1979-09-04 |
Generales Constantine D J Jr |
Apparatus for testing human responses to stimuli
|
|
US4256108A
(en)
*
|
1977-04-07 |
1981-03-17 |
Alza Corporation |
Microporous-semipermeable laminated osmotic system
|
|
US4267333A
(en)
*
|
1979-09-26 |
1981-05-12 |
Union Carbide Agricultural Products Company, Inc. |
Preparation of 2-trifluoromethyl cinchoninic acids
|
|
US4265874A
(en)
*
|
1980-04-25 |
1981-05-05 |
Alza Corporation |
Method of delivering drug with aid of effervescent activity generated in environment of use
|
|
US4435419A
(en)
*
|
1981-07-01 |
1984-03-06 |
American Cyanamid Company |
Method of treating depression using azabicyclohexanes
|
|
US4431661A
(en)
*
|
1981-08-20 |
1984-02-14 |
American Cyanamid Company |
5-Aryl-3-azabicyclo[3.2.0]heptan-6-one acetals, and analgesic use therefor
|
|
AU534404B2
(en)
|
1981-09-01 |
1984-01-26 |
American Cyanamid Company |
Cyclopropane derivatives
|
|
US4490055A
(en)
|
1982-06-30 |
1984-12-25 |
International Business Machines Corporation |
Automatically adjustable delay function for timed typamatic
|
|
US4544665A
(en)
*
|
1983-11-21 |
1985-10-01 |
American Cyanamid Company |
1-Aryl-3-azabicyclo[3.2.0]heptanes
|
|
GB2200628A
(en)
|
1987-02-06 |
1988-08-10 |
Shell Int Research |
Diphenyl ether herbicides
|
|
US5089633A
(en)
*
|
1987-04-28 |
1992-02-18 |
Georgia Tech Research Corporation |
Substituted isocoumarins
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
JPH032797A
(ja)
|
1989-05-30 |
1991-01-09 |
Meidensha Corp |
音声合成装置の抑揚制御方式
|
|
US5120752A
(en)
*
|
1989-12-28 |
1992-06-09 |
Abbott Laboratories |
Cyclopropyl derivative lipoxygenase inhibitors
|
|
US5037853A
(en)
*
|
1989-12-28 |
1991-08-06 |
Abbott Laboratories |
Cyclopropyl derivative lipoxygenase inhibitors
|
|
US5114953A
(en)
*
|
1990-11-21 |
1992-05-19 |
University Of Florida |
Treatment for tissue ulceration
|
|
GB9102635D0
(en)
|
1991-02-07 |
1991-03-27 |
British Bio Technology |
Compounds
|
|
US5256657A
(en)
*
|
1991-08-19 |
1993-10-26 |
Sterling Winthrop, Inc. |
Succinamide derivative matrix-metalloprotease inhibitors
|
|
JP3333510B2
(ja)
|
1991-10-02 |
2002-10-15 |
スミスクライン・ビーチャム・コーポレイション |
抗アレルギー、抗炎症および腫瘍壊死因子抑制活性を有するシクロペンタンおよびシクロペンテン誘導体
|
|
JPH05262698A
(ja)
|
1992-03-24 |
1993-10-12 |
Dainippon Ink & Chem Inc |
光学活性トリフルオロメチルシクロプロパン誘導体、その合成中間体、それを含む液晶組成物及び液晶表示素子
|
|
US5525629A
(en)
|
1992-04-07 |
1996-06-11 |
British Bio-Technology Limited |
Inhibition of cytokine production
|
|
US5674901A
(en)
*
|
1995-06-01 |
1997-10-07 |
Wisconsin Alumni Research Foundation |
Methods of treating animals to maintain or increase CD-4 and CD-8 cell populations
|
|
US5318964A
(en)
|
1992-06-11 |
1994-06-07 |
Hoffmann-La Roche Inc. |
Hydroxamic derivatives and pharmaceutical compositions
|
|
EP0648225A1
(en)
|
1992-06-25 |
1995-04-19 |
Chiron Corporation |
Compositions for the inhibition of protein hormone formation and uses thereof
|
|
GB9215665D0
(en)
|
1992-07-23 |
1992-09-09 |
British Bio Technology |
Compounds
|
|
GB9223904D0
(en)
|
1992-11-13 |
1993-01-06 |
British Bio Technology |
Inhibition of cytokine production
|
|
US5455258A
(en)
*
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
US5646167A
(en)
*
|
1993-01-06 |
1997-07-08 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamix acids
|
|
US5552419A
(en)
*
|
1993-01-06 |
1996-09-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
US5506242A
(en)
*
|
1993-01-06 |
1996-04-09 |
Ciba-Geigy Corporation |
Arylsufonamido-substituted hydroxamic acids
|
|
CN1105799A
(zh)
|
1993-03-18 |
1995-07-26 |
大制药株式会社 |
作为基质金属蛋白酶抑制剂的喹诺酮衍生物
|
|
GB9307956D0
(en)
|
1993-04-17 |
1993-06-02 |
Walls Alan J |
Hydroxamic acid derivatives
|
|
JPH072797A
(ja)
|
1993-04-19 |
1995-01-06 |
Sankyo Co Ltd |
コラゲナーゼ阻害剤
|
|
GB9311282D0
(en)
*
|
1993-06-01 |
1993-07-21 |
Rhone Poulenc Rorer Ltd |
New compositions of matter
|
|
FI960803A7
(fi)
|
1993-08-23 |
1996-04-22 |
Immunex Corp |
TNF-alfa-sekreetion inhibiittoreita
|
|
US5594106A
(en)
*
|
1993-08-23 |
1997-01-14 |
Immunex Corporation |
Inhibitors of TNF-α secretion
|
|
GB9320660D0
(en)
|
1993-10-07 |
1993-11-24 |
British Bio Technology |
Inhibition of cytokine production
|
|
DE69502378T2
(de)
|
1994-01-20 |
1998-10-01 |
British Biotech Pharm |
Metalloproteinaseinhibitoren
|
|
GB9401129D0
(en)
|
1994-01-21 |
1994-03-16 |
British Bio Technology |
Hydroxamic acid derivatives as metalloproteinase inhibitors
|
|
FI962905A0
(fi)
|
1994-01-22 |
1996-07-19 |
British Biotech Pharm |
Metalloproteinaasi-inhibiittoreita
|
|
US5514716A
(en)
*
|
1994-02-25 |
1996-05-07 |
Sterling Winthrop, Inc. |
Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof
|
|
CA2185162A1
(en)
|
1994-03-07 |
1995-09-14 |
Robert F. Halenback (Deceased) |
Compositions for the inhibition of tnf formation and uses thereof
|
|
GB9501737D0
(en)
|
1994-04-25 |
1995-03-22 |
Hoffmann La Roche |
Hydroxamic acid derivatives
|
|
AU2394795A
(en)
|
1994-04-28 |
1995-11-29 |
Du Pont Merck Pharmaceutical Company, The |
Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents
|
|
US5817822A
(en)
*
|
1994-06-24 |
1998-10-06 |
Novartis Corporation |
Certain alpha-azacycloalkyl substituted arylsulfonamido acetohydroxamic acids
|
|
US5840698A
(en)
|
1994-10-27 |
1998-11-24 |
Affymax Technologies N.V. |
Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
|
|
JP2902318B2
(ja)
|
1994-12-28 |
1999-06-07 |
呉羽化学工業株式会社 |
エスクレチン誘導体、その製造方法及びマトリックスメタロプロテアーゼ阻害剤
|
|
US5691381A
(en)
|
1995-04-18 |
1997-11-25 |
The Dupont Merck Pharmaceutical Company |
Hydroxamic and carbocyclic acids as metalloprotease inhibitors
|
|
US5703092A
(en)
*
|
1995-04-18 |
1997-12-30 |
The Dupont Merck Pharmaceutical Company |
Hydroxamic acid compounds as metalloprotease and TNF inhibitors
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
GB2303130A
(en)
|
1995-07-10 |
1997-02-12 |
Secr Defence |
Cyclic oligomers of substituted cyclic ethers
|
|
GB9514867D0
(en)
*
|
1995-07-20 |
1995-09-20 |
British Biotech Pharm |
Metalloproteinase inhibitors
|
|
KR980009238A
(ko)
|
1995-07-28 |
1998-04-30 |
우에노 도시오 |
설포닐아미노산 유도체
|
|
WO1997009066A1
(en)
|
1995-09-08 |
1997-03-13 |
Kanebo, Ltd. |
Fas LIGAND SOLUBILIZATION INHIBITOR
|
|
HUP0003760A3
(en)
|
1995-10-05 |
2001-05-28 |
Darwin Discovery Ltd Cambridge |
Thio-substituted peptides as inhibitors for metalloproteinases and tnf liberation, process for production thereof and their use
|
|
EE9800115A
(et)
|
1995-11-14 |
1998-10-15 |
The Du Pont Merck Pharmaceutical Company |
Uudsed makrotsüklilised ühendid kui metalloproteaasi inhibiitorid
|
|
US5665777A
(en)
|
1995-11-14 |
1997-09-09 |
Abbott Laboratories |
Biphenyl hydroxamate inhibitors of matrix metalloproteinases
|
|
ES2164264T3
(es)
|
1995-11-23 |
2002-02-16 |
British Biotech Pharm |
Inhibidores de metaloproteinasas.
|
|
US5753653A
(en)
*
|
1995-12-08 |
1998-05-19 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
|
|
CA2238306A1
(en)
*
|
1995-12-08 |
1997-06-12 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
|
|
TW453995B
(en)
|
1995-12-15 |
2001-09-11 |
Novartis Ag |
Certain alpha-substituted arylsulfonamido acetohydroxamic acids
|
|
DE69624081T2
(de)
|
1995-12-20 |
2003-06-12 |
Agouron Pharmaceuticals, Inc. |
Matrix-metalloprotease Inhibitoren
|
|
JP4358908B2
(ja)
|
1996-01-02 |
2009-11-04 |
アヴェンティス ファーマシューティカルズ インコーポレイテッド |
置換（アリール、ヘテロアリール、アリールメチル又はヘテロアリールメチル）ヒドロキサム酸化合物
|
|
JPH09202774A
(ja)
*
|
1996-01-25 |
1997-08-05 |
Green Cross Corp:The |
２−アリールキノリン類およびその製造方法
|
|
TW448172B
(en)
*
|
1996-03-08 |
2001-08-01 |
Pharmacia & Upjohn Co Llc |
Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation
|
|
PT900211E
(pt)
|
1996-04-23 |
2003-10-31 |
Upjohn Co |
Tiadiazolil(tio)ureias uteis como inibidores de metaloproteases com matriz
|
|
AU2645497A
(en)
|
1996-05-06 |
1997-11-26 |
Zeneca Limited |
Thio derivatives of hydroxamic acids
|
|
IT1283637B1
(it)
*
|
1996-05-14 |
1998-04-23 |
Italfarmaco Spa |
Composti ad attivita' antinfiammatoria ed immunosoppressiva
|
|
US5853977A
(en)
*
|
1996-07-12 |
1998-12-29 |
Schering Corporation |
Mammalian TNF-α convertases
|
|
EP0912746A2
(en)
|
1996-07-12 |
1999-05-06 |
Schering Corporation |
MAMMALIAN TNF-$g(a) CONVERTASES
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
EP0923585B1
(en)
|
1996-07-18 |
2002-05-08 |
Pfizer Inc. |
Phosphinate based inhibitors of matrix metalloproteases
|
|
ES2194209T3
(es)
|
1996-07-22 |
2003-11-16 |
Monsanto Co |
Inhibidores de metaloproteasa de tiol sulfona.
|
|
WO1998007697A1
(en)
|
1996-08-23 |
1998-02-26 |
Pfizer Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
TR199900399T2
(xx)
*
|
1996-08-28 |
1999-06-21 |
The Procter & Gamble Company |
Matris metaloproteaz inhibit�rleri olarak fosfinik asit amidleri.
|
|
CZ62799A3
(cs)
|
1996-08-28 |
1999-07-14 |
The Procter & Gamble Company |
Heterocyklické metaloproteázové inhibitory
|
|
EP0923561B1
(en)
|
1996-08-28 |
2002-10-23 |
The Procter & Gamble Company |
Heterocyclic metalloprotease inhibitors
|
|
JP3347330B2
(ja)
|
1996-08-28 |
2002-11-20 |
ザ プロクター アンド ギャンブル カンパニー |
１，３―ジヘテロ環式メタロプロテアーゼ阻害剤類
|
|
US6262040B1
(en)
|
1996-09-04 |
2001-07-17 |
Pfizer Inc |
Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF)
|
|
CA2256631A1
(en)
|
1996-09-04 |
1998-03-12 |
Warner-Lambert Company |
Compounds for and a method of inhibiting matrix metalloproteinases
|
|
AU718055B2
(en)
|
1996-09-19 |
2000-04-06 |
Aventisub Ii Inc. |
3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
|
|
WO1998013340A1
(en)
|
1996-09-27 |
1998-04-02 |
Pharmacia & Upjohn Company |
β-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS
|
|
WO1998015525A1
(en)
|
1996-10-07 |
1998-04-16 |
Sumitomo Pharmaceuticals Co., Ltd. |
Hydroxamic acids
|
|
AU743901B2
(en)
|
1996-10-16 |
2002-02-07 |
Wyeth Holdings Corporation |
Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloprote inase and tace inhibitors
|
|
JP2001502326A
(ja)
|
1996-10-16 |
2001-02-20 |
アメリカン・サイアナミド・カンパニー |
マトリクス金属プロテナイーゼおよびＴＡＣＥに対する阻害薬としてのβ―スルホンアミドヒドロキサム酸
|
|
US5962481A
(en)
*
|
1996-10-16 |
1999-10-05 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
|
US6548524B2
(en)
*
|
1996-10-16 |
2003-04-15 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
|
US5977408A
(en)
*
|
1996-10-16 |
1999-11-02 |
American Cyanamid Company |
Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
|
AU731737B2
(en)
|
1996-10-16 |
2001-04-05 |
Wyeth Holdings Corporation |
The preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
|
WO1998016520A1
(en)
|
1996-10-16 |
1998-04-23 |
American Cyanamid Company |
The preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
|
GB9621814D0
(en)
|
1996-10-19 |
1996-12-11 |
British Biotech Pharm |
Metalloproteinase inhibitors
|
|
US6008243A
(en)
|
1996-10-24 |
1999-12-28 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
|
|
MY117687A
(en)
|
1996-10-31 |
2004-07-31 |
Bayer Corp |
Substituted 4-biphenyl-4-hydroxybutric acid derivatives as matrix metalloprotease inhibitors
|
|
JPH10130217A
(ja)
|
1996-11-01 |
1998-05-19 |
Kotobuki Seiyaku Kk |
カルボン酸及びその誘導体及びその製造法並びにこれを含有する医薬組成物
|
|
GB9624817D0
(en)
|
1996-11-28 |
1997-01-15 |
British Biotech Pharm |
Metalloproteinase inhibitors
|
|
US5840974A
(en)
|
1996-12-04 |
1998-11-24 |
Britisch Biotech Pharmaceuticals, Ltd. |
Metalloproteinase inhibitors
|
|
WO1998027069A1
(en)
|
1996-12-17 |
1998-06-25 |
Fujisawa Pharmaceutical Co., Ltd. |
Piperazine compounds as inhibitors of mmp or tnf
|
|
WO1998030566A1
(en)
|
1997-01-06 |
1998-07-16 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
ZA9820B
(en)
|
1997-01-07 |
1998-07-02 |
Abbott Lab |
Macrocyclic inhibitors of matrix metalloproteinases and tnf x secretion
|
|
ZA9818B
(en)
|
1997-01-07 |
1998-07-02 |
Abbott Lab |
C-terminal ketone inhibitors of matrix metalloproteinases and tnf alpha secretion
|
|
US5837696A
(en)
*
|
1997-01-15 |
1998-11-17 |
The Research Foundation Of State University Of New York |
Method of inhibiting cancer growth
|
|
JPH10204054A
(ja)
|
1997-01-21 |
1998-08-04 |
Ono Pharmaceut Co Ltd |
フェニルスルホンアミド誘導体
|
|
JPH10204059A
(ja)
|
1997-01-22 |
1998-08-04 |
Ono Pharmaceut Co Ltd |
フェニルスルホンアミド誘導体
|
|
ID22849A
(id)
|
1997-01-23 |
1999-12-09 |
Hoffmann La Roche |
Penghambat-penghambat sulmafida-metaloprotease
|
|
GB9702088D0
(en)
|
1997-01-31 |
1997-03-19 |
Pharmacia & Upjohn Spa |
Matrix metalloproteinase inhibitors
|
|
KR100447553B1
(ko)
|
1997-02-26 |
2004-09-08 |
화이자 인코포레이티드 |
헤테로아릴-헥사노산 아미드 유도체, 그의 제조 방법 및 ｍｉｐ-1 알파의 ｃｃｒ1 수용체로의 결합에 대한 선택적 저해제로서의 용도
|
|
TR199902063T2
(xx)
|
1997-02-26 |
1999-12-21 |
Glaxo Group Limited |
Metalloproteaz inhibitörleri olarak ters hidroksamat türevleri.
|
|
PT973512E
(pt)
|
1997-02-27 |
2004-07-30 |
Wyeth Corp |
N-hidroxi-2-(alquil, aril ou heteroaril sulfanil, sulfinilou sulfonil)-alquil, aril ou heteroarilamidas substituidas na posicao 3 como inibidores de metaloproteinases da matriz
|
|
US6172057B1
(en)
*
|
1997-02-27 |
2001-01-09 |
American Cyanamid Company |
N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
|
|
US6197791B1
(en)
*
|
1997-02-27 |
2001-03-06 |
American Cyanamid Company |
N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
|
|
NZ337376A
(en)
|
1997-03-11 |
2002-02-01 |
Aeterna Lab Inc |
Compositions for treating tumors containing shark cartilage extracts and anti-neoplastic agents
|
|
US6034136A
(en)
|
1997-03-20 |
2000-03-07 |
Novartis Ag |
Certain cyclic thio substituted acylaminoacid amide derivatives
|
|
AU6843298A
(en)
|
1997-03-28 |
1998-10-22 |
Zeneca Limited |
Hydroxamic acids substituted by heterocycles useful for inhibition of tumor necrosis factor
|
|
AU747280B2
(en)
|
1997-04-01 |
2002-05-09 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
|
|
US5985900A
(en)
*
|
1997-04-01 |
1999-11-16 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
|
|
AT404904B
(de)
|
1997-04-03 |
1999-03-25 |
Prior Eng Ag |
Vorrichtung zur kontinuierlichen annularen chromatographie
|
|
GB9707333D0
(en)
|
1997-04-11 |
1997-05-28 |
British Biotech Pharm |
Metalloproteinase inhibitors
|
|
DE59802394D1
(de)
|
1997-05-09 |
2002-01-24 |
Hoechst Ag |
Substituierte Diaminocarbonsäuren
|
|
AU7294098A
(en)
|
1997-05-09 |
1998-11-27 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
|
|
DE19719621A1
(de)
|
1997-05-09 |
1998-11-12 |
Hoechst Ag |
Sulfonylaminocarbonsäuren
|
|
US5804581A
(en)
*
|
1997-05-15 |
1998-09-08 |
Bayer Corporation |
Inhibition of matrix metalloproteases by substituted phenalkyl compounds
|
|
GB9710490D0
(en)
|
1997-05-21 |
1997-07-16 |
British Biotech Pharm |
Metalloproteinase inhibitors
|
|
EP0887077A1
(de)
|
1997-06-27 |
1998-12-30 |
Boehringer Mannheim Gmbh |
Verwendung von Azulenderivaten als Metalloproteaseinhibitoren
|
|
AU8858398A
(en)
|
1997-07-10 |
1999-02-08 |
Pharmacia & Upjohn S.P.A. |
Matrix metalloproteinase inhibitors
|
|
AU8766498A
(en)
|
1997-08-04 |
1999-02-22 |
Amgen, Inc. |
Hydroxamic acid substituted fused heterocyclic metalloproteinase inhibitors
|
|
PT895988E
(pt)
|
1997-08-08 |
2002-09-30 |
Pfizer Prod Inc |
Derivados do acido arilsulfonilamino-hidroxamico
|
|
ZA988967B
(en)
*
|
1997-10-03 |
2000-04-03 |
Du Pont Pharm Co |
Lactam metalloprotease inhibitors.
|
|
AU9663798A
(en)
|
1997-10-06 |
1999-04-27 |
Warner-Lambert Company |
Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
|
|
HUP0003880A3
(en)
|
1997-10-06 |
2001-11-28 |
American Cyanamid Co Madison |
Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors, pharmaceutical compositions thereof and process for the preparation of the same
|
|
EP1024134A4
(en)
|
1997-10-09 |
2003-05-14 |
Ono Pharmaceutical Co |
DERIVATIVES OF AMINOBUTANIC ACID
|
|
US6455528B1
(en)
*
|
1997-10-14 |
2002-09-24 |
Mitsubishi Pharma Corporation |
Piperazine compounds and medicinal use thereof
|
|
WO1999024419A1
(en)
|
1997-11-12 |
1999-05-20 |
Darwin Discovery Limited |
Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
|
|
DE69811111T2
(de)
|
1997-11-12 |
2003-07-24 |
Darwin Discovery Ltd., Cambridge |
Hydroxamsäure- und carbonsäurederivate mit mmp und tnf hemmender wirkung
|
|
GB9723905D0
(en)
|
1997-11-12 |
1998-01-07 |
Chiroscience Ltd |
Heterocyclic compounds having MMP and TNF inhibitory activity
|
|
PT1030842E
(pt)
|
1997-11-13 |
2003-07-31 |
British Biotech Pharm |
Inibidores da metaloproteinase
|
|
FR2771095B1
(fr)
*
|
1997-11-14 |
1999-12-17 |
Adir |
Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
BR9813554A
(pt)
|
1997-12-12 |
2001-07-24 |
Fuji Yakuhin Kogyo Kk |
Composto, uso do mesmo, processo para produzi-lo, composição farmacêutica ou veterinária, e, inibidor de metaloproteinase
|
|
EP0922702A1
(de)
|
1997-12-13 |
1999-06-16 |
Roche Diagnostics GmbH |
Neue Azulenderivate und diese enthaltende Arzneimittel
|
|
US6335329B1
(en)
|
1997-12-19 |
2002-01-01 |
Amgen Inc. |
Carboxylic acid substituted heterocycles, derivatives thereof and methods of use
|
|
US6107291A
(en)
|
1997-12-19 |
2000-08-22 |
Amgen Inc. |
Azepine or larger medium ring derivatives and methods of use
|
|
JP3887769B2
(ja)
|
1997-12-22 |
2007-02-28 |
バイエル コーポレイション |
対称および非対称ジフェニル尿素を用いるｐ３８キナーゼの阻害
|
|
WO1999032413A1
(en)
|
1997-12-23 |
1999-07-01 |
Spectran Corporation |
Method of making large scale optical fiber preforms with improved properties
|
|
US6071903A
(en)
*
|
1998-01-27 |
2000-06-06 |
American Cyanamid Company |
2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids
|
|
CN1293663A
(zh)
|
1998-01-27 |
2001-05-02 |
美国氰胺公司 |
为基质金属蛋白酶抑制剂的2,3,4,5－四氢－1h－[1,4]苯并二氮杂䓬－3－异羟肟酸
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
PL200418B1
(pl)
|
1998-01-30 |
2009-01-30 |
Darwin Discovery Ltd |
Pochodna N-hydroksyformamidu, zawierający ją środek farmaceutyczny i jej zastosowanie
|
|
RU2208609C2
(ru)
|
1998-02-04 |
2003-07-20 |
Новартис Аг |
Сульфониламинопроизводные, которые ингибируют разлагающие матрикс металлопротеиназы
|
|
CN1290260A
(zh)
|
1998-02-06 |
2001-04-04 |
达尔文发现有限公司 |
异羟肟酸和羧酸衍生物
|
|
ID25639A
(id)
|
1998-02-19 |
2000-10-19 |
American Cyanamid Co |
Alkil, aril atau heteroarilamida tersubstitusi n-hidroksi-2-(alkil, aril, atau heteroaril sulfanil, sulfinil atau sulfonil)-3 sebagai inhibitor matriks mataloproteinase
|
|
PT952148E
(pt)
|
1998-04-10 |
2004-09-30 |
Pfizer Prod Inc |
Derivados de acido ciclobutil-ariloxiarilsulfonilamino-hidroxamico
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
EP1077974A1
(en)
|
1998-05-14 |
2001-02-28 |
Du Pont Pharmaceuticals Company |
Substituted aryl hydroxamic acids as metalloproteinase inhibitors
|
|
JP2002514647A
(ja)
|
1998-05-14 |
2002-05-21 |
デュポン ファーマシューティカルズ カンパニー |
メタロプロテイナーゼ阻害薬としての新規な置換アリールヒドロキサム酸
|
|
US6288063B1
(en)
|
1998-05-27 |
2001-09-11 |
Bayer Corporation |
Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
|
|
AU4692399A
(en)
|
1998-06-17 |
2000-01-05 |
Du Pont Pharmaceuticals Company |
Cyclic hydroxamic acids as metalloproteinase inhibitors
|
|
FR2780402B1
(fr)
|
1998-06-30 |
2001-04-27 |
Adir |
Nouveaux composes acides carboxyliques et hydroxamiques inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
DE19831980A1
(de)
|
1998-07-16 |
2000-01-20 |
Hoechst Marion Roussel De Gmbh |
Sulfonylaminophosphin- und phosphonsäurederivate
|
|
WO2000006560A1
(en)
|
1998-07-30 |
2000-02-10 |
Warner-Lambert Company |
Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases
|
|
ATE261954T1
(de)
|
1998-07-30 |
2004-04-15 |
Warner Lambert Co |
Tricyclische sulfonamide und ihre derivate als inhibitoren von matrix-metalloproteinasen
|
|
UA59453C2
(uk)
|
1998-08-12 |
2003-09-15 |
Пфайзер Продактс Інк. |
Похідні гідроксипіпеколат гідроксамової кислоти як інгібітори матричних металопротеїназ
|
|
WO2000012082A1
(en)
|
1998-08-26 |
2000-03-09 |
Glaxo Group Limited |
Formamide compounds as therapeutic agents
|
|
AU5582899A
(en)
|
1998-08-26 |
2000-03-21 |
Glaxo Group Limited |
Formamides as therapeutic agents
|
|
AU5688999A
(en)
|
1998-08-26 |
2000-03-21 |
Glaxo Group Limited |
Formamide compounds as therapeutic agents
|
|
EP1107953A1
(en)
|
1998-08-29 |
2001-06-20 |
British Biotech Pharmaceuticals Limited |
Hydroxamic acid derivatives as proteinase inhibitors
|
|
GB9919776D0
(en)
|
1998-08-31 |
1999-10-27 |
Zeneca Ltd |
Compoujnds
|
|
KR20010079782A
(ko)
|
1998-09-11 |
2001-08-22 |
에가시라 구니오 |
벤젠 유도체 및 이의 의약 용도
|
|
US6451792B1
(en)
|
1998-09-22 |
2002-09-17 |
Ishihara Sangyo Kaisha Ltd. |
Medical composition containing nitroetheneamine derivative or salt thereof as active constituent
|
|
WO2000024720A1
(en)
|
1998-10-23 |
2000-05-04 |
Dow Agrosciences Llc |
3-(substituted phenyl)-5-(substituted cyclopropyl)-1,2,4-triazole compounds
|
|
DK1004578T3
(da)
*
|
1998-11-05 |
2004-06-28 |
Pfizer Prod Inc |
5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater
|
|
GB9826153D0
(en)
|
1998-11-27 |
1999-01-20 |
Hoffmann La Roche |
Hydrazine derivatives
|
|
ES2249055T3
(es)
|
1998-12-11 |
2006-03-16 |
F. Hoffmann-La Roche Ag |
Derivados de hidrazina.
|
|
WO2000037433A1
(en)
|
1998-12-18 |
2000-06-29 |
Abbott Laboratories |
Inhibitors of matrix metalloproteinases
|
|
US6372747B1
(en)
*
|
1998-12-18 |
2002-04-16 |
Schering Corporation |
Farnesyl protein transferase inhibitors
|
|
CA2355836A1
(en)
|
1998-12-22 |
2000-06-29 |
Ppd Development, Lp |
Genetic suppressor elements against human immunodeficiency virus
|
|
WO2000040564A1
(en)
|
1998-12-31 |
2000-07-13 |
Aventis Pharmaceuticals Inc. |
N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase
|
|
AU1926700A
(en)
|
1998-12-31 |
2000-07-24 |
Aventis Pharmaceuticals Inc. |
3-(thio-substituted amido)-lactams useful as inhibitors of matrix metalloproteinase
|
|
HK1045312A1
(zh)
|
1999-01-07 |
2002-11-22 |
藤泽药品工业株式会社 |
環狀化合物
|
|
DE60012688T2
(de)
|
1999-01-14 |
2005-07-28 |
Ca*Tx, Inc. |
Immunoassays zum nachweis von krankheiten oder krankheitsanfälligkeitsmerkmalen
|
|
FR2788525B1
(fr)
|
1999-01-19 |
2002-11-29 |
Commissariat Energie Atomique |
Pseudo-peptides phosphiniques, utilisables comme inhibiteurs des metalloproteases a zinc matricielles
|
|
US6294539B1
(en)
*
|
1999-01-19 |
2001-09-25 |
Advanced Syntech, Llc |
Heterocyclic hydroxamic acid derivatives as MMP inhibitors
|
|
AR022424A1
(es)
|
1999-01-27 |
2002-09-04 |
American Cyanamid Co |
Compuestos derivados de acidos ortosulfonamido acetilenico e hidroxamico biciclico heteroarilo amido de acido fosfinico como inhibidores tace, composicionfarmaceutica que los comprende y el uso de los mismos para la manufactura de un medicamento
|
|
US6225311B1
(en)
*
|
1999-01-27 |
2001-05-01 |
American Cyanamid Company |
Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
|
|
AR035311A1
(es)
|
1999-01-27 |
2004-05-12 |
Wyeth Corp |
Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento
|
|
AR022423A1
(es)
|
1999-01-27 |
2002-09-04 |
American Cyanamid Co |
Compuestos derivados de acidos 2,3,4,5-tetrahidro-1h-[1,4]benzodiazepina-3-hidroxamicos, composicion farmaceutica que los comprenden, y el uso de losmismos para la manufactura de un medicamento
|
|
IL144347A0
(en)
|
1999-01-27 |
2002-05-23 |
American Cyanamid Co |
Acetylenic sulfonamide thiol tace inhibitors
|
|
US6326516B1
(en)
*
|
1999-01-27 |
2001-12-04 |
American Cyanamid Company |
Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
|
|
AR022422A1
(es)
|
1999-01-27 |
2002-09-04 |
American Cyanamid Co |
Inhibidores de tace acetilenicos de acido hidroxamico de heteroarilfulfonamida y amida del acido fosfinico
|
|
AR035313A1
(es)
|
1999-01-27 |
2004-05-12 |
Wyeth Corp |
Inhibidores de tace acetilenicos de acido hidroxamico de sulfonamida a base de alfa-aminoacidos, composiciones farmaceuticas y el uso de los mismos para la manufactura de medicamentos.
|
|
BR0007784A
(pt)
|
1999-01-27 |
2002-02-05 |
American Cyanamid Co |
Composto, método para inibir mudanças patológicas mediadas pela enzima que converte o tnf-alfa (tace) em um mamìfero, composição farmacêutica, e, processo para preparar um composto
|
|
US6200996B1
(en)
*
|
1999-01-27 |
2001-03-13 |
American Cyanamid Company |
Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors
|
|
AR035478A1
(es)
|
1999-01-27 |
2004-06-02 |
Wyeth Corp |
Acido amida-hidroxamico, acido acetilenico, beta-sulfonamido y fosfinico como inhibidores de la tace, uso de los mismos para la manufactura de un medicamento y composicion farmaceutica que los contiene
|
|
US6277885B1
(en)
*
|
1999-01-27 |
2001-08-21 |
American Cyanamid Company |
Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
|
|
US6313123B1
(en)
*
|
1999-01-27 |
2001-11-06 |
American Cyanamid Company |
Acetylenic sulfonamide thiol tace inhibitors
|
|
AU2320500A
(en)
|
1999-02-02 |
2000-08-25 |
Shionogi & Co., Ltd. |
Sulfonamide derivatives having cyclic structures
|
|
AP2001002240A0
(en)
|
1999-02-08 |
2001-09-30 |
Searle & Co |
Sufamato hydroxamic acid metalloprotease inhibitor.
|
|
US6177077B1
(en)
*
|
1999-02-24 |
2001-01-23 |
Edward L. Tobinick |
TNT inhibitors for the treatment of neurological disorders
|
|
WO2000050391A1
(en)
|
1999-02-26 |
2000-08-31 |
Merck & Co., Inc. |
Novel sulfonamide compounds and uses thereof
|
|
WO2000058304A1
(en)
|
1999-03-26 |
2000-10-05 |
Shionogi & Co., Ltd. |
Heterocyclic sulfonamide derivatives
|
|
AU3196300A
(en)
|
1999-03-26 |
2000-10-16 |
Shionogi & Co., Ltd. |
Carbocyclic sulfonamide derivatives
|
|
WO2000058278A1
(fr)
|
1999-03-26 |
2000-10-05 |
Shionogi & Co., Ltd. |
Derives d'acides amines $g(b)
|
|
EP1041072B1
(en)
|
1999-03-31 |
2003-07-16 |
Pfizer Products Inc. |
Dioxocyclopentyl hydroxamic acids
|
|
EP1165500A1
(en)
|
1999-04-02 |
2002-01-02 |
Du Pont Pharmaceuticals Company |
Amide derivatives as inhibitors of matrix metalloproteinases,tnf-alpha,and aggrecanase
|
|
AU4249700A
(en)
|
1999-04-19 |
2000-11-02 |
Sumitomo Pharmaceuticals Company, Limited |
Hydroxamic acid derivative
|
|
AUPP982399A0
(en)
|
1999-04-19 |
1999-05-13 |
Fujisawa Pharmaceutical Co., Ltd. |
Mmp inhibitor
|
|
CN1347411A
(zh)
|
1999-04-19 |
2002-05-01 |
盐野义制药株式会社 |
含有噁二唑环的磺酰胺衍生物
|
|
GB9911071D0
(en)
|
1999-05-12 |
1999-07-14 |
Darwin Discovery Ltd |
Hydroxamic and carboxylic acid derivatives
|
|
RU2001133740A
(ru)
|
1999-05-17 |
2003-09-27 |
Дайити Файн Кемикал Ко., Лтд. (Jp) |
Новые производные гидроксамовой кислоты
|
|
EP1081137A1
(en)
|
1999-08-12 |
2001-03-07 |
Pfizer Products Inc. |
Selective inhibitors of aggrecanase in osteoarthritis treatment
|
|
GB9922825D0
(en)
|
1999-09-25 |
1999-11-24 |
Smithkline Beecham Biolog |
Medical use
|
|
US6632667B1
(en)
|
1999-10-28 |
2003-10-14 |
Isis Pharmaceuticals, Inc. |
Modulation of L-selectin shedding via inhibition of tumor necrosis factor-α converting enzyme (TACE)
|
|
GB0004153D0
(en)
|
2000-02-23 |
2000-04-12 |
Astrazeneca Uk Ltd |
Novel use
|
|
JP4798921B2
(ja)
|
2000-03-06 |
2011-10-19 |
バイオシーク インコーポレーティッド |
機能相同性スクリーニング
|
|
JP2003528097A
(ja)
|
2000-03-17 |
2003-09-24 |
ブリストル−マイヤーズ スクイブ ファーマ カンパニー |
マトリックスメタロプロテアーゼおよびＴＮＦ−α阻害剤としてのβ−アミノ酸誘導体
|
|
JP2003528072A
(ja)
|
2000-03-17 |
2003-09-24 |
ブリストル−マイヤーズ スクイブ ファーマ カンパニー |
マトリックスメタロプロテアーゼおよびＴＮＦ−αの阻害剤としての環状β−アミノ酸誘導体
|
|
AU778368B2
(en)
|
2000-05-15 |
2004-12-02 |
Darwin Discovery Limited |
Hydroxamic acid derivatives
|
|
US6620823B2
(en)
|
2000-07-11 |
2003-09-16 |
Bristol-Myers Squibb Pharme Company |
Lactam metalloprotease inhibitors
|
|
US20040029928A1
(en)
|
2000-08-31 |
2004-02-12 |
Terukage Hirata |
Novel propenohydroxamic acid derivatives
|
|
US6890915B2
(en)
|
2001-05-25 |
2005-05-10 |
Bristol-Myers Squibb Pharma Company |
Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)
|
|
SE519050C2
(sv)
|
2001-05-28 |
2003-01-07 |
Fazer Ab Oy Karl |
Påfyllnadsanordning för varor
|
|
WO2003016248A2
(en)
|
2001-08-17 |
2003-02-27 |
Bristol-Myers Squibb Company Patent Department |
Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or tnf-$g(a) converting enzyme (tace)
|
|
AU2002341715A1
(en)
|
2001-09-17 |
2003-04-01 |
Bristol-Myers Squibb Company |
Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace)
|