JP2007501859A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007501859A5 JP2007501859A5 JP2006532943A JP2006532943A JP2007501859A5 JP 2007501859 A5 JP2007501859 A5 JP 2007501859A5 JP 2006532943 A JP2006532943 A JP 2006532943A JP 2006532943 A JP2006532943 A JP 2006532943A JP 2007501859 A5 JP2007501859 A5 JP 2007501859A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- aryl
- cycloalkyl
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 37
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47014603P | 2003-05-13 | 2003-05-13 | |
| PCT/US2004/014671 WO2004101562A2 (en) | 2003-05-13 | 2004-05-11 | Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007501859A JP2007501859A (ja) | 2007-02-01 |
| JP2007501859A5 true JP2007501859A5 (https=) | 2007-06-28 |
Family
ID=33452372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006532943A Pending JP2007501859A (ja) | 2003-05-13 | 2004-05-11 | γ−セクレターゼ阻害剤としての架橋ｎ−アリールスルホニルピペリジン |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7368457B2 (https=) |
| EP (1) | EP1641801B9 (https=) |
| JP (1) | JP2007501859A (https=) |
| CN (1) | CN1820010A (https=) |
| AR (1) | AR044294A1 (https=) |
| AT (1) | ATE401328T1 (https=) |
| CA (1) | CA2525124A1 (https=) |
| CL (1) | CL2004001011A1 (https=) |
| DE (1) | DE602004015110D1 (https=) |
| ES (1) | ES2308206T3 (https=) |
| MX (1) | MXPA05012268A (https=) |
| PE (1) | PE20050555A1 (https=) |
| TW (1) | TW200510405A (https=) |
| WO (1) | WO2004101562A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4564713B2 (ja) | 2000-11-01 | 2010-10-20 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 窒素性複素環式化合物、ならびに窒素性複素環式化合物およびその中間体を作製するための方法 |
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| PE20060481A1 (es) | 2004-06-30 | 2006-06-19 | Schering Corp | N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas |
| AU2006279312A1 (en) * | 2005-08-19 | 2007-02-22 | Elan Pharmaceuticals, Inc. | Bridged N-cyclic sulfonamido inhibitors of gamma secretase |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| AR076936A1 (es) | 2009-06-02 | 2011-07-20 | Vitae Pharmaceuticals Inc | Inhibidores de carbamato y urea de la 11 beta hidroxiesteroide deshidrogenasa 1 |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| BR112014015197A8 (pt) | 2011-12-21 | 2017-06-13 | Novira Therapeutics Inc | agentes antivirais de hepatite b |
| KR102271574B1 (ko) | 2012-08-28 | 2021-07-01 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 설파모일-아릴아미드 및 b형 간염 치료제로서의 그 용도 |
| WO2014131847A1 (en) | 2013-02-28 | 2014-09-04 | Janssen R&D Ireland | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| MX353412B (es) | 2013-04-03 | 2018-01-10 | Janssen Sciences Ireland Uc | Derivados de n-fenil-carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| TWI733288B (zh) | 2013-05-17 | 2021-07-11 | 愛爾蘭商健生科學愛爾蘭無限公司 | 胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途 |
| DK2997019T3 (en) | 2013-05-17 | 2018-12-03 | Janssen Sciences Ireland Uc | SULFAMOYLTHIOPHENAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B |
| HRP20180791T1 (hr) | 2013-07-25 | 2018-09-07 | Janssen Sciences Ireland Uc | Glioksamid supstituirani derivati pirolamida i njihova uporaba kao lijekova za liječenje hepatitisa b |
| CA2923712C (en) | 2013-10-23 | 2021-11-02 | Janssen Sciences Ireland Uc | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| CA2936947A1 (en) | 2014-02-05 | 2015-08-13 | Novira Therapeutics, Inc. | Combination therapy for treatment of hbv infections |
| TW201620893A (zh) | 2014-02-06 | 2016-06-16 | 健生科學愛爾蘭無限公司 | 磺醯胺基吡咯醯胺衍生物及其用作治療ｂ型肝炎之醫藥品的用途 |
| SG11201607183PA (en) * | 2014-03-06 | 2016-10-28 | Shanghai Haiyan Pharmaceutical Technology Co Ltd | Piperidine derivatives as orexin receptor antagonist |
| JP2018510159A (ja) | 2015-03-19 | 2018-04-12 | ノヴィラ・セラピューティクス・インコーポレイテッド | アゾカン及びアゾナン誘導体及びｂ型肝炎感染症の治療法 |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| TW201718496A (zh) | 2015-09-29 | 2017-06-01 | 諾維拉治療公司 | B型肝炎抗病毒劑之晶型 |
| AU2017248828A1 (en) | 2016-04-15 | 2018-11-01 | Janssen Sciences Ireland Uc | Combinations and methods comprising a capsid assembly inhibitor |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| MX2020009531A (es) | 2018-03-14 | 2020-10-05 | Janssen Sciences Ireland Unlimited Co | Regimen posologico del modulador del ensamblaje de la capside. |
| WO2020169784A1 (en) | 2019-02-22 | 2020-08-27 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of hbv infection or hbv-induced diseases |
| AR119732A1 (es) | 2019-05-06 | 2022-01-05 | Janssen Sciences Ireland Unlimited Co | Derivados de amida útiles en el tratamiento de la infección por vhb o de enfermedades inducidas por vhb |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04247081A (ja) * | 1991-02-01 | 1992-09-03 | Takeda Chem Ind Ltd | ５員複素環酸アミド類 |
| NZ514453A (en) * | 1999-02-26 | 2003-04-29 | Merck & Co Inc | Novel sulfonamide compounds and uses thereof |
| US20060079533A1 (en) * | 2001-03-23 | 2006-04-13 | Nieman James A | Methods of treating alzheimer's disease |
-
2004
- 2004-05-11 WO PCT/US2004/014671 patent/WO2004101562A2/en not_active Ceased
- 2004-05-11 AT AT04751862T patent/ATE401328T1/de not_active IP Right Cessation
- 2004-05-11 CA CA002525124A patent/CA2525124A1/en not_active Abandoned
- 2004-05-11 JP JP2006532943A patent/JP2007501859A/ja active Pending
- 2004-05-11 AR ARP040101597A patent/AR044294A1/es not_active Application Discontinuation
- 2004-05-11 PE PE2004000484A patent/PE20050555A1/es not_active Application Discontinuation
- 2004-05-11 MX MXPA05012268A patent/MXPA05012268A/es not_active Application Discontinuation
- 2004-05-11 US US10/842,783 patent/US7368457B2/en not_active Expired - Fee Related
- 2004-05-11 TW TW093113229A patent/TW200510405A/zh unknown
- 2004-05-11 CL CL200401011A patent/CL2004001011A1/es unknown
- 2004-05-11 DE DE602004015110T patent/DE602004015110D1/de not_active Expired - Lifetime
- 2004-05-11 CN CNA200480019637XA patent/CN1820010A/zh active Pending
- 2004-05-11 ES ES04751862T patent/ES2308206T3/es not_active Expired - Lifetime
- 2004-05-11 EP EP04751862A patent/EP1641801B9/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007501859A5 (https=) | ||
| JP2012510523A5 (https=) | ||
| JP2022551185A5 (https=) | ||
| JP2004516314A5 (https=) | ||
| JP2020530487A5 (https=) | ||
| JP2018519357A5 (https=) | ||
| RU2003133448A (ru) | 3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс- хемокинового рецептора | |
| RU2013156074A (ru) | Диазакарбазолы и способы применения | |
| JP2010514786A5 (https=) | ||
| JP2017526726A5 (https=) | ||
| JP2008074862A5 (https=) | ||
| JP2009519218A5 (https=) | ||
| JP2005508905A5 (https=) | ||
| JP2021527051A5 (https=) | ||
| JP2006512313A5 (https=) | ||
| JP2008510691A5 (https=) | ||
| JP2009534404A5 (https=) | ||
| JP2014520898A5 (https=) | ||
| JP2006528205A5 (https=) | ||
| JP2009534407A5 (https=) | ||
| JP2007516180A5 (https=) | ||
| JP2009529540A5 (https=) | ||
| JP2008533191A5 (https=) | ||
| JP2009534405A5 (https=) | ||
| JP2014521625A5 (https=) |