JP2022551185A5 - - Google Patents

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Publication number
JP2022551185A5
JP2022551185A5 JP2022521718A JP2022521718A JP2022551185A5 JP 2022551185 A5 JP2022551185 A5 JP 2022551185A5 JP 2022521718 A JP2022521718 A JP 2022521718A JP 2022521718 A JP2022521718 A JP 2022521718A JP 2022551185 A5 JP2022551185 A5 JP 2022551185A5
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JP
Japan
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JP2022521718A
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Japanese (ja)
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JPWO2021069705A5 (https=
JP7724394B2 (ja
JP2022551185A (ja
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Priority claimed from PCT/EP2020/078483 external-priority patent/WO2021069705A1/en
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Publication of JPWO2021069705A5 publication Critical patent/JPWO2021069705A5/ja
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JP2022521718A 2019-10-09 2020-10-09 イソインドリノン化合物 Active JP7724394B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH12812019 2019-10-09
CH01281/19 2019-10-09
PCT/EP2020/078483 WO2021069705A1 (en) 2019-10-09 2020-10-09 Isoindolinone compounds

Publications (4)

Publication Number Publication Date
JP2022551185A JP2022551185A (ja) 2022-12-07
JP2022551185A5 true JP2022551185A5 (https=) 2023-10-17
JPWO2021069705A5 JPWO2021069705A5 (https=) 2023-10-17
JP7724394B2 JP7724394B2 (ja) 2025-08-18

Family

ID=68242216

Family Applications (1)

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JP2022521718A Active JP7724394B2 (ja) 2019-10-09 2020-10-09 イソインドリノン化合物

Country Status (4)

Country Link
US (1) US20220242846A1 (https=)
EP (1) EP4041231A1 (https=)
JP (1) JP7724394B2 (https=)
WO (1) WO2021069705A1 (https=)

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JP2023507590A (ja) * 2019-12-17 2023-02-24 オリオニス バイオサイエンシズ,インコーポレイテッド タンパク質の動員および/または分解を調節する化合物
CN116583509A (zh) * 2020-10-07 2023-08-11 上海睿跃生物科技有限公司 治疗癌症的化合物和方法
JP2024504932A (ja) * 2021-01-13 2024-02-02 モンテ ローザ セラピューティクス, インコーポレイテッド イソインドリノン化合物
WO2022153220A1 (en) 2021-01-13 2022-07-21 Monte Rosa Therapeutics Ag Methods for the identification of degrons
CN117242060A (zh) * 2021-01-13 2023-12-15 蒙特罗萨医疗公司 异吲哚啉酮化合物
EP4278014A1 (en) 2021-01-13 2023-11-22 Monte Rosa Therapeutics, Inc. Treatment of myc-driven cancers with gspt1 degraders
WO2022200857A1 (en) * 2021-03-22 2022-09-29 Monte Rosa Therapeutics Ag Pharmaceutical compositions for use in the prevention and treatment of a disease or disorder caused by or associated with one or more premature termination codons
WO2022256623A1 (en) 2021-06-04 2022-12-08 Monte Rosa Therapeutics, Inc. E3 ligase fusion proteins for proximity detection
CN115504963A (zh) * 2021-06-22 2022-12-23 苏州开拓药业股份有限公司 一种c-Myc蛋白降解剂
WO2023001028A1 (zh) * 2021-07-19 2023-01-26 南京明德新药研发有限公司 杂芳-3-哌啶二酮类化合物及其应用
WO2023069708A1 (en) * 2021-10-22 2023-04-27 Monte Rosa Therapeutics, Inc. Compounds that mediate protein degradation and uses thereof
WO2023069700A1 (en) * 2021-10-22 2023-04-27 Monte Rosa Therapeutics, Inc. Compounds that mediate protein degradation and methods of use thereof
WO2023069720A1 (en) * 2021-10-22 2023-04-27 Monte Rosa Therapeutics, Inc. Compounds that mediate protein degradation and methods of use thereof
WO2023069731A1 (en) * 2021-10-22 2023-04-27 Monte Rosa Therapeutics, Inc. Compounds that mediate protein degradation and methods of use thereof
WO2023091567A1 (en) 2021-11-17 2023-05-25 Monte Rosa Therapeutics, Inc. Degron and neosubstrate identification
WO2023201282A1 (en) * 2022-04-14 2023-10-19 Bristol-Myers Squibb Company Novel gspt1 compounds and methods of use of the novel compounds
WO2024015855A1 (en) 2022-07-13 2024-01-18 Monte Rosa Therapeutics, Inc. COMBINATION THERAPY COMPRISING GSPT1-DIRECTED MOLECULAR GLUE DEGRADERS AND PI3K/AKT/mTOR PATHWAY INHIBITORS
CN119630648A (zh) * 2022-07-14 2025-03-14 蒙特罗莎治疗股份有限公司 异吲哚啉酮衍生物的制备方法及其晶形
WO2024027795A1 (zh) * 2022-08-04 2024-02-08 苏州开拓药业股份有限公司 包含Myc蛋白降解剂类生物活性化合物的抗体药物偶联物及其制备方法和用途
CN115636811A (zh) * 2022-08-17 2023-01-24 成都分迪药业有限公司 异吲哚啉苄胺衍生物的合成方法
CN120303264A (zh) 2022-09-09 2025-07-11 医诺康治疗公司 CK1α和双重CK1α/GSPT1降解化合物
WO2024201248A1 (en) * 2023-03-24 2024-10-03 Pin Therapeutics, Inc. Compounds and methods for degrading gspt1
CN121311477A (zh) * 2023-09-06 2026-01-09 上海超阳药业有限公司 内酰胺类衍生物及其应用
WO2025085416A1 (en) * 2023-10-16 2025-04-24 Bristol-Myers Squibb Company Gspt1 compounds and methods of use of the compounds
WO2025146112A1 (en) * 2024-01-05 2025-07-10 Primelink Biotherapeutics (Shenzhen) Co., Ltd. Gspt1 degrading compounds and compositions and uses thereof
WO2025179161A1 (en) 2024-02-21 2025-08-28 Innovo Therapeutics, Inc. Protein degrading compounds
WO2025259615A1 (en) * 2024-06-11 2025-12-18 Triana Biomedicines, Inc. Modulators of cdk2 and uses thereof
WO2026007898A1 (zh) * 2024-07-01 2026-01-08 上海海雁医药科技有限公司 含苯乙氧基亚烷基胺结构的异吲哚啉化合物、其药物组合物及应用

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TWI696615B (zh) 2016-05-05 2020-06-21 瑞士商伊蘭科動物健康公司 雜芳基-1,2,4-三唑及雜芳基-三唑化合物
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
WO2018071606A1 (en) 2016-10-11 2018-04-19 Arvinas, Inc. Compounds and methods for the targeted degradation of androgen receptor
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BR112022019532A2 (pt) * 2020-03-31 2022-12-06 Orum Therapeutics Inc Conjugados de neodegrader

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