JP2024541910A5 - - Google Patents
Info
- Publication number
- JP2024541910A5 JP2024541910A5 JP2024524567A JP2024524567A JP2024541910A5 JP 2024541910 A5 JP2024541910 A5 JP 2024541910A5 JP 2024524567 A JP2024524567 A JP 2024524567A JP 2024524567 A JP2024524567 A JP 2024524567A JP 2024541910 A5 JP2024541910 A5 JP 2024541910A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- stereoisomer
- acceptable salt
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2021127023 | 2021-10-28 | ||
| CNPCT/CN2021/127023 | 2021-10-28 | ||
| CN2022112270 | 2022-08-12 | ||
| CNPCT/CN2022/112270 | 2022-08-12 | ||
| PCT/CN2022/128220 WO2023072240A1 (en) | 2021-10-28 | 2022-10-28 | Prolyl hydroxylase domain-containing protein (phd) inhibitors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024541910A JP2024541910A (ja) | 2024-11-13 |
| JP2024541910A5 true JP2024541910A5 (https=) | 2025-10-22 |
Family
ID=86159087
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024524568A Pending JP2024539946A (ja) | 2021-10-28 | 2022-10-28 | プロリルヒドロキシラーゼドメイン含有タンパク質（ｐｈｄ）阻害剤およびその使用方法 |
| JP2024524567A Pending JP2024541910A (ja) | 2021-10-28 | 2022-10-28 | プロリルヒドロキシラーゼドメイン含有タンパク質（ｐｈｄ）阻害剤およびその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024524568A Pending JP2024539946A (ja) | 2021-10-28 | 2022-10-28 | プロリルヒドロキシラーゼドメイン含有タンパク質（ｐｈｄ）阻害剤およびその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US20250034132A1 (https=) |
| EP (2) | EP4422623A4 (https=) |
| JP (2) | JP2024539946A (https=) |
| KR (2) | KR20240095274A (https=) |
| CN (2) | CN118488838A (https=) |
| AR (3) | AR127501A1 (https=) |
| AU (1) | AU2022378858A1 (https=) |
| CA (1) | CA3235718A1 (https=) |
| IL (1) | IL312220A (https=) |
| TW (3) | TW202334158A (https=) |
| WO (3) | WO2023072246A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240095274A (ko) | 2021-10-28 | 2024-06-25 | 인실리코 메디신 아이피 리미티드 | 프롤릴 히드록실라제 도메인-함유 단백질 (phd) 억제제 및 그의 용도 |
| GB202301059D0 (en) | 2023-01-25 | 2023-03-08 | Univ Oxford Innovation Ltd | PHD inhibitors |
| EP4702023A1 (en) * | 2023-04-28 | 2026-03-04 | Insilico Medicine IP Limited | Crystalline prolyl hydroxylase domain-containing protein (phd) inhibitor and uses thereof |
| AU2024261389A1 (en) * | 2023-04-28 | 2025-10-30 | Insilico Medicine Ip Limited | Prolyl hydroxylase domain-containing protein (phd) inhibitors, combinations and uses thereof |
| CN121057737A (zh) * | 2023-04-28 | 2025-12-02 | 英矽智能科技知识产权有限公司 | 含脯氨酰羟化酶结构域的蛋白质(phd)抑制剂结晶及其用途 |
| CN117402178B (zh) * | 2023-12-15 | 2024-03-08 | 英矽智能科技(上海)有限公司 | 作为jak抑制剂和phd抑制剂的嘧啶类化合物 |
| CN117603230B (zh) * | 2023-12-15 | 2025-03-21 | 英矽智能科技(上海)有限公司 | 作为jak抑制剂和phd抑制剂的三并环类化合物 |
| CN117756822B (zh) * | 2023-12-20 | 2025-04-18 | 英矽智能科技(上海)有限公司 | 作为jak抑制剂和phd抑制剂的嘧啶氨基类化合物 |
| CN117736227B (zh) * | 2023-12-20 | 2025-01-21 | 英矽智能科技(上海)有限公司 | 抑制jak和phd的一类化合物 |
| CN117924326B (zh) * | 2024-01-23 | 2025-01-21 | 英矽智能科技(上海)有限公司 | 一类抑制jak和phd的三并环类化合物 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6730682B2 (en) * | 2000-07-12 | 2004-05-04 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| AU2003262946A1 (en) * | 2002-08-30 | 2004-03-19 | Pharmacia And Upjohn Company | Method of preventing or treating atherosclerosis or restenosis |
| US8614204B2 (en) | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
| GB0505621D0 (en) * | 2005-03-18 | 2005-04-27 | Glaxo Group Ltd | Novel compounds |
| US8962530B2 (en) | 2007-06-27 | 2015-02-24 | Regents Of The University Of Colorado | Inflammatory bowel disease therapies |
| KR20100045480A (ko) * | 2007-08-10 | 2010-05-03 | 크리스탈지노믹스(주) | 피리딘 유도체 및 이들의 사용방법 |
| EP2536709A4 (en) | 2010-02-17 | 2013-11-27 | Univ Cornell | PROLYL HYDROXYLASE HEMMER AND USE METHOD THEREFOR |
| WO2013134660A1 (en) * | 2012-03-09 | 2013-09-12 | Fibrogen, Inc. | 4 -hydroxy- isoquinoline compounds as hif hydroxylase inhibitors |
| GB201504565D0 (en) | 2015-03-18 | 2015-05-06 | Takeda Pharmaceutical | Novel compounds |
| CN106146490B (zh) | 2015-03-27 | 2018-10-23 | 沈阳三生制药有限责任公司 | 被芳氧基或杂芳氧基取代的5-羟基-1,7-萘啶化合物、其制备方法及其制药用途 |
| CN106146491B (zh) * | 2015-03-27 | 2017-12-12 | 沈阳三生制药有限责任公司 | 被芳基或杂芳基取代的5‑羟基‑1,7‑萘啶化合物、其制备方法及其制药用途 |
| CN108341777A (zh) | 2017-01-23 | 2018-07-31 | 四川科伦博泰生物医药股份有限公司 | 异喹啉酮类化合物及其应用 |
| WO2018218042A1 (en) * | 2017-05-25 | 2018-11-29 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| TW201920108A (zh) * | 2017-09-25 | 2019-06-01 | 日商武田藥品工業有限公司 | N-(氰基取代之苄基或吡啶基甲基)-3-羥基吡啶醯胺衍生物 |
| AU2018340475B2 (en) * | 2017-09-28 | 2023-01-19 | Transthera Sciences (Nanjing), Inc. | PDE9 inhibitor and use thereof |
| CN110878096A (zh) | 2018-09-05 | 2020-03-13 | 石药集团中奇制药技术（石家庄）有限公司 | 一种1,7-萘啶类衍生物及其制备方法和用途 |
| CN112979541B (zh) | 2019-12-17 | 2022-11-11 | 浙江大学 | 一种基于n-(3-羟基吡啶-2-羰基)甘氨酸的抗肿瘤药物增敏剂及其应用 |
| WO2021163344A1 (en) * | 2020-02-12 | 2021-08-19 | Amgen Inc. | Novel prmt5 inhibitors |
| GB202004960D0 (en) * | 2020-04-03 | 2020-05-20 | Kinsenus Ltd | Inhibitor compounds |
| KR20240095274A (ko) | 2021-10-28 | 2024-06-25 | 인실리코 메디신 아이피 리미티드 | 프롤릴 히드록실라제 도메인-함유 단백질 (phd) 억제제 및 그의 용도 |
-
2022
- 2022-10-28 KR KR1020247017207A patent/KR20240095274A/ko active Pending
- 2022-10-28 EP EP22886115.9A patent/EP4422623A4/en active Pending
- 2022-10-28 WO PCT/CN2022/128237 patent/WO2023072246A1/en not_active Ceased
- 2022-10-28 JP JP2024524568A patent/JP2024539946A/ja active Pending
- 2022-10-28 CA CA3235718A patent/CA3235718A1/en active Pending
- 2022-10-28 AR ARP220102948A patent/AR127501A1/es unknown
- 2022-10-28 AR ARP220102935A patent/AR127488A1/es not_active Application Discontinuation
- 2022-10-28 IL IL312220A patent/IL312220A/en unknown
- 2022-10-28 US US18/704,366 patent/US20250034132A1/en active Pending
- 2022-10-28 KR KR1020247017209A patent/KR20240093899A/ko active Pending
- 2022-10-28 JP JP2024524567A patent/JP2024541910A/ja active Pending
- 2022-10-28 AR ARP220102947A patent/AR127500A1/es unknown
- 2022-10-28 TW TW111141254A patent/TW202334158A/zh unknown
- 2022-10-28 WO PCT/CN2022/128293 patent/WO2023072257A1/en not_active Ceased
- 2022-10-28 TW TW111141004A patent/TW202334134A/zh unknown
- 2022-10-28 US US18/704,371 patent/US20260015349A1/en active Pending
- 2022-10-28 CN CN202280086990.8A patent/CN118488838A/zh active Pending
- 2022-10-28 WO PCT/CN2022/128220 patent/WO2023072240A1/en not_active Ceased
- 2022-10-28 AU AU2022378858A patent/AU2022378858A1/en active Pending
- 2022-10-28 CN CN202280086996.5A patent/CN118591533A/zh active Pending
- 2022-10-28 EP EP22886132.4A patent/EP4423074A4/en active Pending
- 2022-10-28 TW TW111141238A patent/TW202332677A/zh unknown
-
2023
- 2023-02-15 US US18/110,259 patent/US11731987B2/en active Active
- 2023-02-15 US US18/110,261 patent/US11780854B2/en active Active
- 2023-06-22 US US18/339,362 patent/US12071443B2/en active Active
- 2023-08-31 US US18/240,886 patent/US12209101B2/en active Active