JP2022108241A5 - - Google Patents
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- JP2022108241A5 JP2022108241A5 JP2021055886A JP2021055886A JP2022108241A5 JP 2022108241 A5 JP2022108241 A5 JP 2022108241A5 JP 2021055886 A JP2021055886 A JP 2021055886A JP 2021055886 A JP2021055886 A JP 2021055886A JP 2022108241 A5 JP2022108241 A5 JP 2022108241A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- tautomer
- compound
- occurrence
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2021/071256 WO2022150962A1 (en) | 2021-01-12 | 2021-01-12 | Protease inhibitors, preparation, and uses thereof |
| CNPCT/CN2021/071256 | 2021-01-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022108241A JP2022108241A (ja) | 2022-07-25 |
| JP2022108241A5 true JP2022108241A5 (https=) | 2022-09-20 |
| JP7611045B2 JP7611045B2 (ja) | 2025-01-09 |
Family
ID=75277880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021055886A Active JP7611045B2 (ja) | 2021-01-12 | 2021-03-29 | プロテアーゼ阻害剤、その調製、および使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11958830B2 (https=) |
| EP (1) | EP4026830A1 (https=) |
| JP (1) | JP7611045B2 (https=) |
| CN (2) | CN116751164B (https=) |
| WO (1) | WO2022150962A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ766594A (en) | 2018-01-31 | 2025-12-19 | Heparegenix Gmbh | Protein kinase mkk4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| EP3810139A1 (en) | 2018-06-21 | 2021-04-28 | HepaRegeniX GmbH | Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| IL279641B2 (en) | 2018-07-16 | 2024-04-01 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| CA3164361A1 (en) | 2020-01-15 | 2021-07-22 | Heparegenix Gmbh | 3-benzoyl-1h-pyrrolo[2,3-b]pyridine derivatives as mkk4 inhibitors for treating liver diseases |
| JP2024178473A (ja) * | 2021-09-03 | 2024-12-25 | 塩野義製薬株式会社 | ウイルス増殖阻害活性を有する二環性含窒素複素環誘導体およびそれらを含有する医薬組成物 |
| CN118076593A (zh) | 2021-09-07 | 2024-05-24 | 上海齐鲁制药研究中心有限公司 | 3CLpro蛋白酶抑制剂 |
| WO2024031089A1 (en) | 2022-08-05 | 2024-02-08 | Gilead Sciences, Inc. | Sars-cov2 main protease inhibitors |
| WO2024081351A1 (en) | 2022-10-14 | 2024-04-18 | Abbvie Inc. | Pyrrolidine main protease inhibitors as antiviral agents |
| WO2024124287A1 (en) * | 2022-12-12 | 2024-06-20 | The Walter And Eliza Hall Institute Of Medical Research | Compounds for treating viral infection |
| WO2024183629A1 (zh) * | 2023-03-03 | 2024-09-12 | 齐鲁动物保健品有限公司 | 3CLpro蛋白酶抑制剂在制备治疗猫冠状病毒疾病药物中的用途 |
| EP4695230A1 (en) * | 2023-04-11 | 2026-02-18 | Westlake Pharmaceuticals (Hangzhou) Co., Ltd. | Protease inhibitors and uses thereof |
| EP4722196A1 (en) | 2023-05-31 | 2026-04-08 | Westlake Pharmaceuticals (Hangzhou) Co., Ltd. | Crystal of viral protease inhibitor and use |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK175069B1 (da) * | 1986-03-11 | 2004-05-24 | Hoffmann La Roche | Pyrocatecholderivater |
| US6335350B1 (en) | 1998-12-09 | 2002-01-01 | American Home Products Corporation | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
| IL143262A0 (en) * | 1998-12-09 | 2002-04-21 | American Home Prod | Thiourea inhibitors of herpes viruses |
| CZ20012060A3 (cs) * | 1998-12-09 | 2001-11-14 | American Home Products Corporation | Thiomočovinové sloučeniny obsahující acetamid a substituovaný acetamid jako inhibitory herpes virů |
| TW200306159A (en) | 2002-03-19 | 2003-11-16 | Du Pont | Bicyclic fused pyridinyl amides and advantageous compositions thereof for use as fungicides |
| DE10306250A1 (de) | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7067529B2 (en) | 2003-05-19 | 2006-06-27 | Hoffmann-La Roche Inc. | Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors |
| CN100475209C (zh) * | 2003-07-15 | 2009-04-08 | 阿利健制药有限公司 | 抗冠状病毒剂 |
| US7732446B1 (en) * | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| EP1845988A2 (en) * | 2005-02-11 | 2007-10-24 | 3M Innovative Properties Company | Substituted imidazoquinolines and imidazonaphthyridines |
| WO2008088744A1 (en) * | 2007-01-17 | 2008-07-24 | Merck & Co., Inc. | Decahydroquinoline analogs as cb2 receptor modulators |
| CN101519372B (zh) * | 2009-04-01 | 2011-07-20 | 深圳市盛捷生物技术有限公司 | 用作GSK3抑制剂的苯并[e]异吲哚-1,3-二酮化合物及其制备 |
| EP2576514A1 (en) | 2010-06-04 | 2013-04-10 | Exonhit Sa | Substituted isoquinolines and their use as tubulin polymerization inhibitors |
| WO2012090177A2 (en) * | 2010-12-30 | 2012-07-05 | Lupin Limited | Cannabinoid receptor modulators |
| EP2780014A4 (en) | 2011-11-18 | 2015-07-01 | Constellation Pharmaceuticals Inc | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF |
| US9051269B2 (en) | 2011-11-18 | 2015-06-09 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| WO2013078320A1 (en) | 2011-11-21 | 2013-05-30 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| EP2809652B1 (en) | 2012-01-30 | 2019-05-15 | F.Hoffmann-La Roche Ag | Isoquinoline and naphthyridine derivatives |
| JP5989805B2 (ja) | 2012-02-10 | 2016-09-07 | コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | メチル基変更酵素の調節物質、組成物及びその使用 |
| IN2014MN01982A (https=) | 2012-04-25 | 2015-07-10 | Raqualia Pharma Inc | |
| WO2014025651A1 (en) | 2012-08-06 | 2014-02-13 | Amgen Inc. | Chroman derivatives as trpm8 inhibitors |
| MA38341B1 (fr) | 2013-02-11 | 2018-11-30 | Constellation Pharmaceuticals Inc | Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées |
| US9745305B2 (en) | 2013-03-15 | 2017-08-29 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| US9969716B2 (en) | 2013-08-15 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
| KR101715090B1 (ko) * | 2013-08-28 | 2017-03-13 | 한국화학연구원 | 신규한 화합물 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 인플루엔자 바이러스 감염으로 인한 질환의 예방 또는 치료용 약학적 조성물 |
| KR20150027922A (ko) * | 2013-09-04 | 2015-03-13 | 주식회사 대웅제약 | 신규한 항진균성 피리디닐하이드라자이드 유도체 |
| WO2016036638A1 (en) * | 2014-09-05 | 2016-03-10 | Merck Sharp & Dohme Corp. | Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| WO2017053604A1 (en) | 2015-09-23 | 2017-03-30 | The Regents Of The University Of California | Potent antiviral pyrazolopyridine compounds |
| WO2017066763A1 (en) | 2015-10-15 | 2017-04-20 | Cornell University | Proteasome inhibitors and uses thereof |
| JP6936820B2 (ja) | 2016-06-30 | 2021-09-22 | ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド | ヒト免疫不全ウイルス複製の阻害剤としてのアザデカリン誘導体 |
| CN107674029A (zh) | 2016-08-02 | 2018-02-09 | 上海迪诺医药科技有限公司 | 多环化合物、其药物组合物及应用 |
| US11247970B2 (en) | 2017-03-22 | 2022-02-15 | Dana-Farber Cancer Institute, Inc. | Selective inhibition of gluconeogenic activity |
| EP3829719B1 (en) | 2018-07-27 | 2025-04-02 | Cocrystal Pharma, Inc. | Pyrrolo[2,3-b]pyridin derivatives as inhibitors of influenza virus replication |
| MY205440A (en) * | 2018-09-28 | 2024-10-21 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
| EP3982954A4 (en) * | 2019-06-14 | 2024-01-03 | The Trustees of Columbia University in the City of New York | NT5C2 INHIBITORS FOR THE TREATMENT OF CHEMOTHERAPY-RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA |
-
2021
- 2021-01-12 WO PCT/CN2021/071256 patent/WO2022150962A1/en not_active Ceased
- 2021-03-29 CN CN202310629540.5A patent/CN116751164B/zh active Active
- 2021-03-29 US US17/215,313 patent/US11958830B2/en active Active
- 2021-03-29 CN CN202110336891.8A patent/CN113072497B/zh active Active
- 2021-03-29 JP JP2021055886A patent/JP7611045B2/ja active Active
- 2021-03-29 EP EP21165625.1A patent/EP4026830A1/en active Pending
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