JP2022137237A5 - - Google Patents
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- Publication number
- JP2022137237A5 JP2022137237A5 JP2022113736A JP2022113736A JP2022137237A5 JP 2022137237 A5 JP2022137237 A5 JP 2022137237A5 JP 2022113736 A JP2022113736 A JP 2022113736A JP 2022113736 A JP2022113736 A JP 2022113736A JP 2022137237 A5 JP2022137237 A5 JP 2022137237A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- salt
- salt according
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 31
- 150000001875 compounds Chemical class 0.000 claims 30
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 125000001424 substituent group Chemical group 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 208000017667 Chronic Disease Diseases 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- -1 C 1-6 alkyl-R 30 Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 102000008135 Mechanistic Target of Rapamycin Complex 1 Human genes 0.000 claims 1
- 108010035196 Mechanistic Target of Rapamycin Complex 1 Proteins 0.000 claims 1
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023086862A JP7525693B2 (ja) | 2019-01-22 | 2023-05-26 | Ｍｔｏｒｃモジュレーターおよびその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962795482P | 2019-01-22 | 2019-01-22 | |
| US62/795,482 | 2019-01-22 | ||
| JP2021543495A JP7061236B2 (ja) | 2019-01-22 | 2020-01-22 | Ｍｔｏｒｃモジュレーターおよびその使用 |
| PCT/US2020/014671 WO2020154447A1 (en) | 2019-01-22 | 2020-01-22 | Mtorc modulators and uses thereof |
| JP2022067435A JP7108804B2 (ja) | 2019-01-22 | 2022-04-15 | Ｍｔｏｒｃモジュレーターおよびその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022067435A Division JP7108804B2 (ja) | 2019-01-22 | 2022-04-15 | Ｍｔｏｒｃモジュレーターおよびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023086862A Division JP7525693B2 (ja) | 2019-01-22 | 2023-05-26 | Ｍｔｏｒｃモジュレーターおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022137237A JP2022137237A (ja) | 2022-09-21 |
| JP2022137237A5 true JP2022137237A5 (https=) | 2023-01-20 |
| JP7288540B2 JP7288540B2 (ja) | 2023-06-07 |
Family
ID=71737003
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021543495A Active JP7061236B2 (ja) | 2019-01-22 | 2020-01-22 | Ｍｔｏｒｃモジュレーターおよびその使用 |
| JP2022067435A Active JP7108804B2 (ja) | 2019-01-22 | 2022-04-15 | Ｍｔｏｒｃモジュレーターおよびその使用 |
| JP2022113736A Active JP7288540B2 (ja) | 2019-01-22 | 2022-07-15 | Ｍｔｏｒｃモジュレーターおよびその使用 |
| JP2023086862A Active JP7525693B2 (ja) | 2019-01-22 | 2023-05-26 | Ｍｔｏｒｃモジュレーターおよびその使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021543495A Active JP7061236B2 (ja) | 2019-01-22 | 2020-01-22 | Ｍｔｏｒｃモジュレーターおよびその使用 |
| JP2022067435A Active JP7108804B2 (ja) | 2019-01-22 | 2022-04-15 | Ｍｔｏｒｃモジュレーターおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023086862A Active JP7525693B2 (ja) | 2019-01-22 | 2023-05-26 | Ｍｔｏｒｃモジュレーターおよびその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US11021492B2 (https=) |
| EP (2) | EP3914245A4 (https=) |
| JP (4) | JP7061236B2 (https=) |
| KR (2) | KR102705165B1 (https=) |
| CN (3) | CN118184678A (https=) |
| AU (3) | AU2020210921B2 (https=) |
| BR (1) | BR112021014479A2 (https=) |
| CA (2) | CA3236782A1 (https=) |
| EA (1) | EA202191983A1 (https=) |
| GB (3) | GB2586427B (https=) |
| IL (2) | IL285067B2 (https=) |
| MX (2) | MX2021008777A (https=) |
| WO (1) | WO2020154447A1 (https=) |
| ZA (3) | ZA202105847B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019241789A1 (en) | 2018-06-15 | 2019-12-19 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
| IL285067B2 (en) | 2019-01-22 | 2025-02-01 | Aeovian Pharmaceuticals Inc | MTORC Modulators and Their Uses |
| AU2020397938A1 (en) * | 2019-12-05 | 2022-06-23 | Janssen Pharmaceutica Nv | Rapamycin analogs and uses thereof |
| CN115776907B (zh) | 2020-03-27 | 2025-02-25 | 艾奥维安制药公司 | Mtorc1调节剂及其用途 |
| CN121426814A (zh) * | 2020-07-21 | 2026-01-30 | 艾奥维安制药公司 | Mtorc1调节剂及其用途 |
| US20220267352A1 (en) * | 2021-01-22 | 2022-08-25 | Anakuria Therapeutics, Inc. | Rapamycin analogs and uses thereof |
| CN116917294A (zh) * | 2021-01-22 | 2023-10-20 | 詹森药业有限公司 | 雷帕霉素类似物及其用途 |
| US20260102380A1 (en) * | 2022-09-30 | 2026-04-16 | Biotronik Ag | Synthesis and Characterization of Cyclic Hydrocarbon Esters of Everolimus |
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| AU2020397938A1 (en) | 2019-12-05 | 2022-06-23 | Janssen Pharmaceutica Nv | Rapamycin analogs and uses thereof |
| CN115776907B (zh) | 2020-03-27 | 2025-02-25 | 艾奥维安制药公司 | Mtorc1调节剂及其用途 |
| CN121426814A (zh) | 2020-07-21 | 2026-01-30 | 艾奥维安制药公司 | Mtorc1调节剂及其用途 |
| US20220267352A1 (en) | 2021-01-22 | 2022-08-25 | Anakuria Therapeutics, Inc. | Rapamycin analogs and uses thereof |
-
2020
- 2020-01-22 IL IL285067A patent/IL285067B2/en unknown
- 2020-01-22 CN CN202410308122.0A patent/CN118184678A/zh active Pending
- 2020-01-22 CN CN202310696207.6A patent/CN116947884B/zh active Active
- 2020-01-22 GB GB2018417.2A patent/GB2586427B/en active Active
- 2020-01-22 EP EP20745587.4A patent/EP3914245A4/en active Pending
- 2020-01-22 GB GB2018418.0A patent/GB2586764B/en active Active
- 2020-01-22 KR KR1020247006930A patent/KR102705165B1/ko active Active
- 2020-01-22 EP EP23198457.6A patent/EP4272825A3/en active Pending
- 2020-01-22 KR KR1020217026628A patent/KR102643707B1/ko active Active
- 2020-01-22 CA CA3236782A patent/CA3236782A1/en active Pending
- 2020-01-22 CN CN202080023208.9A patent/CN113766916B/zh active Active
- 2020-01-22 JP JP2021543495A patent/JP7061236B2/ja active Active
- 2020-01-22 CA CA3127448A patent/CA3127448C/en active Active
- 2020-01-22 BR BR112021014479-0A patent/BR112021014479A2/pt not_active Application Discontinuation
- 2020-01-22 MX MX2021008777A patent/MX2021008777A/es unknown
- 2020-01-22 IL IL315399A patent/IL315399A/en unknown
- 2020-01-22 AU AU2020210921A patent/AU2020210921B2/en active Active
- 2020-01-22 WO PCT/US2020/014671 patent/WO2020154447A1/en not_active Ceased
- 2020-01-22 GB GB2018342.2A patent/GB2586113B/en active Active
- 2020-01-22 EA EA202191983A patent/EA202191983A1/ru unknown
- 2020-09-17 US US17/024,470 patent/US11021492B2/en active Active
- 2020-09-17 US US17/024,486 patent/US11230557B2/en active Active
-
2021
- 2021-05-21 US US17/326,633 patent/US11702429B2/en active Active
- 2021-07-21 MX MX2023008859A patent/MX2023008859A/es unknown
- 2021-08-16 ZA ZA2021/05847A patent/ZA202105847B/en unknown
- 2021-12-16 US US17/553,409 patent/US12565505B2/en active Active
-
2022
- 2022-04-04 AU AU2022202241A patent/AU2022202241B1/en active Active
- 2022-04-15 JP JP2022067435A patent/JP7108804B2/ja active Active
- 2022-07-15 JP JP2022113736A patent/JP7288540B2/ja active Active
- 2022-07-27 AU AU2022209289A patent/AU2022209289B2/en active Active
- 2022-08-16 ZA ZA2022/09159A patent/ZA202209159B/en unknown
-
2023
- 2023-05-26 JP JP2023086862A patent/JP7525693B2/ja active Active
- 2023-07-18 ZA ZA2023/07174A patent/ZA202307174B/en unknown
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