JP2023523130A5 - - Google Patents
Info
- Publication number
- JP2023523130A5 JP2023523130A5 JP2022554565A JP2022554565A JP2023523130A5 JP 2023523130 A5 JP2023523130 A5 JP 2023523130A5 JP 2022554565 A JP2022554565 A JP 2022554565A JP 2022554565 A JP2022554565 A JP 2022554565A JP 2023523130 A5 JP2023523130 A5 JP 2023523130A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- independently
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025078734A JP2025122005A (ja) | 2020-04-30 | 2025-05-09 | Ｂｔｋ阻害因子とｅ３リガーゼリガンドとのコンジュゲーションによるブルトンチロシンキナーゼ（ｂｔｋ）の分解及び使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020088322 | 2020-04-30 | ||
| CNPCT/CN2020/088322 | 2020-04-30 | ||
| CN2021085369 | 2021-04-02 | ||
| CNPCT/CN2021/085369 | 2021-04-02 | ||
| PCT/CN2021/090898 WO2021219070A1 (en) | 2020-04-30 | 2021-04-29 | Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025078734A Division JP2025122005A (ja) | 2020-04-30 | 2025-05-09 | Ｂｔｋ阻害因子とｅ３リガーゼリガンドとのコンジュゲーションによるブルトンチロシンキナーゼ（ｂｔｋ）の分解及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023523130A JP2023523130A (ja) | 2023-06-02 |
| JP2023523130A5 true JP2023523130A5 (https=) | 2024-05-09 |
| JP7681038B2 JP7681038B2 (ja) | 2025-05-21 |
Family
ID=78374077
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022554565A Active JP7681038B2 (ja) | 2020-04-30 | 2021-04-29 | Ｂｔｋ阻害因子とｅ３リガーゼリガンドとのコンジュゲーションによるブルトンチロシンキナーゼ（ｂｔｋ）の分解及び使用方法 |
| JP2025078734A Pending JP2025122005A (ja) | 2020-04-30 | 2025-05-09 | Ｂｔｋ阻害因子とｅ３リガーゼリガンドとのコンジュゲーションによるブルトンチロシンキナーゼ（ｂｔｋ）の分解及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025078734A Pending JP2025122005A (ja) | 2020-04-30 | 2025-05-09 | Ｂｔｋ阻害因子とｅ３リガーゼリガンドとのコンジュゲーションによるブルトンチロシンキナーゼ（ｂｔｋ）の分解及び使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20230167118A1 (https=) |
| EP (1) | EP4146655A4 (https=) |
| JP (2) | JP7681038B2 (https=) |
| KR (1) | KR20230003161A (https=) |
| CN (4) | CN116589466B (https=) |
| AU (1) | AU2021264916A1 (https=) |
| BR (1) | BR112022019014A2 (https=) |
| CA (1) | CA3172498A1 (https=) |
| IL (1) | IL297664A (https=) |
| MX (1) | MX2022013407A (https=) |
| TW (1) | TWI902789B (https=) |
| WO (1) | WO2021219070A1 (https=) |
| ZA (1) | ZA202209962B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116589466B (zh) * | 2020-04-30 | 2025-08-15 | 百济神州有限公司 | 通过缀合btk抑制剂与e3连接酶配体降解布鲁顿氏酪氨酸激酶(btk)及其使用方法 |
| CN116981675A (zh) * | 2020-12-31 | 2023-10-31 | 百济神州有限公司 | 通过布鲁顿氏酪氨酸激酶（btk）抑制剂与e3连接酶配体的缀合降解btk和使用方法 |
| AU2022270089A1 (en) * | 2021-05-03 | 2023-11-16 | Nurix Therapeutics, Inc. | Compounds for inhibiting or degrading target proteins, compositions, comprising the same, methods of their making, and methods of their use |
| TW202309039A (zh) * | 2021-05-05 | 2023-03-01 | 美商百健Ｍａ公司 | 用於靶向布魯頓氏酪胺酸激酶降解之化合物 |
| KR20240020735A (ko) | 2021-05-07 | 2024-02-15 | 카이메라 쎄라퓨틱스 인코포레이티드 | Cdk2 분해제 및 그 용도 |
| JP2024525181A (ja) * | 2021-06-21 | 2024-07-10 | ベイジーン スウィッツァーランド ゲーエムベーハー | （ｒ）－グルタルイミドｃｒｂｎリガンド及び使用方法 |
| KR20240128831A (ko) | 2021-12-30 | 2024-08-27 | 베이진 스위찰랜드 게엠베하 | 브루톤 티로신 키나아제(btk) 억제제와 e3 리가아제 리간드의 접합에 의한 btk의 분해 및 사용 방법 |
| WO2023125907A1 (en) * | 2021-12-30 | 2023-07-06 | Beigene, Ltd. | Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use |
| JP7805983B2 (ja) | 2022-03-22 | 2026-01-26 | アッヴィ・インコーポレイテッド | ブルトン型チロシンキナーゼを分解するためのピリミジン |
| WO2024169871A1 (zh) * | 2023-02-17 | 2024-08-22 | 江苏威凯尔医药科技有限公司 | Btk抑制剂及其用途 |
| CN118946561A (zh) * | 2023-03-10 | 2024-11-12 | 标新生物医药科技(上海)有限公司 | 新颖的e3泛素连接酶配体、蛋白降解剂及其应用 |
| CN117126133A (zh) * | 2023-08-14 | 2023-11-28 | 中国海洋大学 | 一种化合物及其用途 |
| TW202532078A (zh) * | 2024-02-09 | 2025-08-16 | 瑞士商百濟神州瑞士有限責任公司 | 用嵌合降解活化化合物治療b細胞增殖性病症 |
| CN120623148A (zh) * | 2024-03-11 | 2025-09-12 | 北京深势科技有限公司 | 一种c-Myc降解剂及其制备方法和用途 |
| WO2025218772A1 (en) * | 2024-04-19 | 2025-10-23 | Beigene (Suzhou) Co., Ltd. | Solid forms comprising a bruton's tyrosine kinase degrader and uses therefor |
| WO2025232885A1 (en) * | 2024-05-10 | 2025-11-13 | Beigene (Suzhou) Co., Ltd. | Preparation method of a bruton's tyrosine kinase degrader thereof |
| WO2026012424A1 (zh) * | 2024-07-10 | 2026-01-15 | 江苏恒瑞医药股份有限公司 | 一种杂芳基类化合物、其制备方法及其在医药上的应用 |
| CN121405700A (zh) * | 2024-07-26 | 2026-01-27 | 苏州亚盛药业有限公司 | Btk降解剂及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013157021A1 (en) * | 2012-04-20 | 2013-10-24 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
| KR20150060839A (ko) * | 2012-10-26 | 2015-06-03 | 에프. 호프만-라 로슈 아게 | 브루톤 티로신 키나아제의 억제제 |
| EP3444251B1 (en) * | 2013-12-11 | 2023-06-07 | Biogen MA Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
| CN111936498B (zh) * | 2018-03-26 | 2024-04-16 | 诺华股份有限公司 | N-(3-(7H-吡咯并[2,3-d]嘧啶-4-基)苯基)苯甲酰胺衍生物 |
| EP3774808A1 (en) * | 2018-03-26 | 2021-02-17 | Novartis AG | 3-hydroxy-n-(3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)pyrrolidine-1-carboxamide derivatives |
| CN116589466B (zh) * | 2020-04-30 | 2025-08-15 | 百济神州有限公司 | 通过缀合btk抑制剂与e3连接酶配体降解布鲁顿氏酪氨酸激酶(btk)及其使用方法 |
-
2021
- 2021-04-29 CN CN202310380645.1A patent/CN116589466B/zh active Active
- 2021-04-29 EP EP21797070.6A patent/EP4146655A4/en active Pending
- 2021-04-29 IL IL297664A patent/IL297664A/en unknown
- 2021-04-29 TW TW110115475A patent/TWI902789B/zh active
- 2021-04-29 MX MX2022013407A patent/MX2022013407A/es unknown
- 2021-04-29 BR BR112022019014A patent/BR112022019014A2/pt unknown
- 2021-04-29 CN CN202180031447.3A patent/CN115485278A/zh active Pending
- 2021-04-29 WO PCT/CN2021/090898 patent/WO2021219070A1/en not_active Ceased
- 2021-04-29 CN CN202310380649.XA patent/CN116589467A/zh active Pending
- 2021-04-29 JP JP2022554565A patent/JP7681038B2/ja active Active
- 2021-04-29 KR KR1020227041734A patent/KR20230003161A/ko active Pending
- 2021-04-29 CN CN202511130551.4A patent/CN121159541A/zh active Pending
- 2021-04-29 CA CA3172498A patent/CA3172498A1/en active Pending
- 2021-04-29 US US17/919,847 patent/US20230167118A1/en active Pending
- 2021-04-29 AU AU2021264916A patent/AU2021264916A1/en active Pending
-
2022
- 2022-09-07 ZA ZA2022/09962A patent/ZA202209962B/en unknown
-
2025
- 2025-05-09 JP JP2025078734A patent/JP2025122005A/ja active Pending