JP2014508811A5 - - Google Patents
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- JP2014508811A5 JP2014508811A5 JP2014501273A JP2014501273A JP2014508811A5 JP 2014508811 A5 JP2014508811 A5 JP 2014508811A5 JP 2014501273 A JP2014501273 A JP 2014501273A JP 2014501273 A JP2014501273 A JP 2014501273A JP 2014508811 A5 JP2014508811 A5 JP 2014508811A5
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- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- optionally substituted
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 26
- 150000003839 salts Chemical class 0.000 claims 23
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 206010010774 Constipation Diseases 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000005233 alkylalcohol group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 229940121367 non-opioid analgesics Drugs 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 0 **N(*)CCC1(*)CC(*)(*)O*C1 Chemical compound **N(*)CCC1(*)CC(*)(*)O*C1 0.000 description 39
- SLUUUCZQJJRUEW-UHFFFAOYSA-N C=Cc1c[o]cn1 Chemical compound C=Cc1c[o]cn1 SLUUUCZQJJRUEW-UHFFFAOYSA-N 0.000 description 1
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N CCc1ccccc1 Chemical compound CCc1ccccc1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 1
- DMNOVGJWPASQDL-UHFFFAOYSA-N COc1c(CNCCC2(CC3(CCCC3)OCC2)c2ncccc2)[s]cc1 Chemical compound COc1c(CNCCC2(CC3(CCCC3)OCC2)c2ncccc2)[s]cc1 DMNOVGJWPASQDL-UHFFFAOYSA-N 0.000 description 1
- QIMMUPPBPVKWKM-UHFFFAOYSA-N Cc1cc2ccccc2cc1 Chemical compound Cc1cc2ccccc2cc1 QIMMUPPBPVKWKM-UHFFFAOYSA-N 0.000 description 1
- CRKVMJHROLSFMV-UHFFFAOYSA-N Fc1cncc(CNCCC2(CC3(CCCC3)OCC2)c2ncccc2)c1 Chemical compound Fc1cncc(CNCCC2(CC3(CCCC3)OCC2)c2ncccc2)c1 CRKVMJHROLSFMV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161466809P | 2011-03-23 | 2011-03-23 | |
| US61/466,809 | 2011-03-23 | ||
| US201261596808P | 2012-02-09 | 2012-02-09 | |
| US61/596,808 | 2012-02-09 | ||
| PCT/US2012/030327 WO2012129495A1 (en) | 2011-03-23 | 2012-03-23 | Opioid receptor ligands and methods of using and making same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016067208A Division JP6243949B2 (ja) | 2011-03-23 | 2016-03-30 | オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014508811A JP2014508811A (ja) | 2014-04-10 |
| JP2014508811A5 true JP2014508811A5 (https=) | 2015-05-07 |
| JP5912169B2 JP5912169B2 (ja) | 2016-04-27 |
Family
ID=46877853
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014501273A Active JP5912169B2 (ja) | 2011-03-23 | 2012-03-23 | オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 |
| JP2016067208A Expired - Fee Related JP6243949B2 (ja) | 2011-03-23 | 2016-03-30 | オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 |
| JP2017216012A Expired - Fee Related JP6649341B2 (ja) | 2011-03-23 | 2017-11-09 | オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 |
| JP2020004039A Active JP6923683B2 (ja) | 2011-03-23 | 2020-01-15 | オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 |
| JP2021122940A Active JP7248750B2 (ja) | 2011-03-23 | 2021-07-28 | オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 |
| JP2023040218A Pending JP2023075282A (ja) | 2011-03-23 | 2023-03-15 | オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016067208A Expired - Fee Related JP6243949B2 (ja) | 2011-03-23 | 2016-03-30 | オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 |
| JP2017216012A Expired - Fee Related JP6649341B2 (ja) | 2011-03-23 | 2017-11-09 | オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 |
| JP2020004039A Active JP6923683B2 (ja) | 2011-03-23 | 2020-01-15 | オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 |
| JP2021122940A Active JP7248750B2 (ja) | 2011-03-23 | 2021-07-28 | オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 |
| JP2023040218A Pending JP2023075282A (ja) | 2011-03-23 | 2023-03-15 | オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (8) | US8835488B2 (https=) |
| EP (3) | EP2688403B1 (https=) |
| JP (6) | JP5912169B2 (https=) |
| KR (3) | KR101991326B1 (https=) |
| CN (1) | CN103702561B (https=) |
| AU (2) | AU2012230761B2 (https=) |
| CA (1) | CA2830742C (https=) |
| CY (1) | CY1119057T1 (https=) |
| DK (2) | DK2688403T3 (https=) |
| EA (1) | EA025456B1 (https=) |
| ES (2) | ES2857549T3 (https=) |
| HR (1) | HRP20171021T1 (https=) |
| HU (2) | HUE054055T2 (https=) |
| IL (4) | IL228506A (https=) |
| LT (1) | LT2688403T (https=) |
| ME (1) | ME02754B (https=) |
| PL (2) | PL3290415T3 (https=) |
| PT (2) | PT2688403T (https=) |
| RS (1) | RS56111B1 (https=) |
| SI (1) | SI2688403T1 (https=) |
| SM (1) | SMT201700325T1 (https=) |
| WO (1) | WO2012129495A1 (https=) |
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| ME02754B (me) | 2011-03-23 | 2018-01-20 | Trevena Inc | Ligandi opioidnih receptora i postupci njihove upotrebe i pripreme |
| EP2729448B1 (en) | 2011-07-06 | 2015-09-09 | Gilead Sciences, Inc. | Compounds for the treatment of hiv |
| TWI694071B (zh) | 2013-03-01 | 2020-05-21 | 美商基利科學股份有限公司 | 治療反轉錄病毒科(Retroviridae)病毒感染之治療性化合物 |
| WO2015130964A1 (en) | 2014-02-28 | 2015-09-03 | Gilead Sciences, Inc. | Therapeutic compounds |
| US10703712B2 (en) | 2015-09-16 | 2020-07-07 | Metacrine, Inc. | Farnesoid X receptor agonists and uses thereof |
| US10626081B2 (en) | 2015-09-16 | 2020-04-21 | Metacrine, Inc. | Farnesoid X receptor agonists and uses thereof |
| WO2017049177A1 (en) | 2015-09-16 | 2017-03-23 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| CN106588899B (zh) * | 2015-10-15 | 2019-11-15 | 江苏恒瑞医药股份有限公司 | 吡啶基取代的6-氧杂螺[4.5]癸烷类衍生物、其制备方法及其在医药上的应用 |
| HUE048032T2 (hu) * | 2015-10-15 | 2020-05-28 | Jiangsu Hengrui Medicine Co | Oxaspiro-származék, elõállítási eljárása és alkalmazásai gyógyszerekben |
| EP3389657A4 (en) | 2015-12-14 | 2019-08-07 | Trevena, Inc. | METHOD FOR THE TREATMENT OF HYPERALGESIA |
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| CA3008637A1 (en) * | 2015-12-17 | 2017-06-22 | Trevena, Inc. | Combinations of opioid receptor ligands and cytochrome p450 inhibitors |
| CN107098876B (zh) * | 2016-02-23 | 2021-04-06 | 江苏恒瑞医药股份有限公司 | 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用 |
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| CN108727347B (zh) * | 2017-04-14 | 2020-06-16 | 江苏恒瑞医药股份有限公司 | 一种阿片样物质受体(mor)激动剂的晶型及其制备方法 |
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| US20090028873A1 (en) | 2007-07-27 | 2009-01-29 | Auspex Pharmaceuticals, Inc. | Substituted cyclohexanols |
| AU2009228647B2 (en) * | 2008-03-27 | 2013-07-04 | Grunenthal Gmbh | Substituted spirocyclic cyclohexane derivatives |
| FR2939136B1 (fr) * | 2008-12-02 | 2010-12-03 | Galderma Res & Dev | Nouveaux composes 4-(heterocycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| FR2967672B1 (fr) * | 2010-11-22 | 2012-12-28 | Sanofi Aventis | Derives de nitrobenzothiazoles, leur preparation et leurs applications therapeutiques |
| ME02754B (me) * | 2011-03-23 | 2018-01-20 | Trevena Inc | Ligandi opioidnih receptora i postupci njihove upotrebe i pripreme |
| EP3389657A4 (en) | 2015-12-14 | 2019-08-07 | Trevena, Inc. | METHOD FOR THE TREATMENT OF HYPERALGESIA |
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