HUE054055T2 - Opoid receptor ligandumok és eljárás azok alkalmazására és elõállítására - Google Patents
Opoid receptor ligandumok és eljárás azok alkalmazására és elõállításáraInfo
- Publication number
- HUE054055T2 HUE054055T2 HUE17173483A HUE17173483A HUE054055T2 HU E054055 T2 HUE054055 T2 HU E054055T2 HU E17173483 A HUE17173483 A HU E17173483A HU E17173483 A HUE17173483 A HU E17173483A HU E054055 T2 HUE054055 T2 HU E054055T2
- Authority
- HU
- Hungary
- Prior art keywords
- preparation
- methods
- receptor ligands
- opoid receptor
- opoid
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161466809P | 2011-03-23 | 2011-03-23 | |
| US201261596808P | 2012-02-09 | 2012-02-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE054055T2 true HUE054055T2 (hu) | 2021-08-30 |
Family
ID=46877853
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE17173483A HUE054055T2 (hu) | 2011-03-23 | 2012-03-23 | Opoid receptor ligandumok és eljárás azok alkalmazására és elõállítására |
| HUE12760456A HUE032948T2 (en) | 2011-03-23 | 2012-03-23 | Opioid receptor ligands and methods of using and making same |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12760456A HUE032948T2 (en) | 2011-03-23 | 2012-03-23 | Opioid receptor ligands and methods of using and making same |
Country Status (22)
| Country | Link |
|---|---|
| US (8) | US8835488B2 (https=) |
| EP (3) | EP3290415B1 (https=) |
| JP (6) | JP5912169B2 (https=) |
| KR (3) | KR101991327B1 (https=) |
| CN (1) | CN103702561B (https=) |
| AU (2) | AU2012230761B2 (https=) |
| CA (1) | CA2830742C (https=) |
| CY (1) | CY1119057T1 (https=) |
| DK (2) | DK3290415T3 (https=) |
| EA (1) | EA025456B1 (https=) |
| ES (2) | ES2857549T3 (https=) |
| HR (1) | HRP20171021T1 (https=) |
| HU (2) | HUE054055T2 (https=) |
| IL (4) | IL228506A (https=) |
| LT (1) | LT2688403T (https=) |
| ME (1) | ME02754B (https=) |
| PL (2) | PL2688403T3 (https=) |
| PT (2) | PT2688403T (https=) |
| RS (1) | RS56111B1 (https=) |
| SI (1) | SI2688403T1 (https=) |
| SM (1) | SMT201700325T1 (https=) |
| WO (1) | WO2012129495A1 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2688403T1 (sl) | 2011-03-23 | 2017-08-31 | Trevena, Inc. | Ligandi opioidnih receptorjev in metode uporabe in izdelave istega |
| AU2012278976B2 (en) | 2011-07-06 | 2017-05-11 | Gilead Sciences, Inc. | Compounds for the treatment of HIV |
| TWI694071B (zh) | 2013-03-01 | 2020-05-21 | 美商基利科學股份有限公司 | 治療反轉錄病毒科(Retroviridae)病毒感染之治療性化合物 |
| US10202353B2 (en) | 2014-02-28 | 2019-02-12 | Gilead Sciences, Inc. | Therapeutic compounds |
| EP3350166A4 (en) | 2015-09-16 | 2019-05-01 | Metacrine, Inc. | FARNESOID-X RECEPTOR AGONISTS AND USES THEREOF |
| EP3350158A4 (en) | 2015-09-16 | 2019-05-08 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| WO2017049173A1 (en) | 2015-09-16 | 2017-03-23 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| CN106588899B (zh) * | 2015-10-15 | 2019-11-15 | 江苏恒瑞医药股份有限公司 | 吡啶基取代的6-氧杂螺[4.5]癸烷类衍生物、其制备方法及其在医药上的应用 |
| WO2017063509A1 (zh) * | 2015-10-15 | 2017-04-20 | 江苏恒瑞医药股份有限公司 | 氧杂螺环类衍生物、其制备方法及其在医药上的应用 |
| KR20180093930A (ko) * | 2015-12-14 | 2018-08-22 | 트레베나, 인코포레이티드. | 통각과민증을 치료하는 방법 |
| WO2017105881A1 (en) * | 2015-12-15 | 2017-06-22 | NeuForm Pharmaceuticals, Inc. | Deuterated compounds for treating pain |
| JP2019503351A (ja) * | 2015-12-17 | 2019-02-07 | トレベナ・インコーポレイテッドＴｒｅｖｅｎａ， Ｉｎｃ． | オピオイド受容体リガンドおよびシトクロムｐ４５０阻害剤の組合せ |
| CN107098876B (zh) * | 2016-02-23 | 2021-04-06 | 江苏恒瑞医药股份有限公司 | 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用 |
| EP3472155B1 (en) * | 2016-07-01 | 2022-03-16 | Neuform Pharmaceuticals, Inc. | Deuterated compounds for treating pain |
| CN119462611A (zh) | 2016-08-19 | 2025-02-18 | 吉利德科学公司 | 用于预防性或治疗性治疗hiv病毒感染的治疗性化合物 |
| US20200010457A1 (en) * | 2016-12-16 | 2020-01-09 | Esteve Pharmaceuticals, S.A. | Tetrahydropyran and tetrahydrothiopyran amide derivatives having multimodal activity against pain |
| CN110446495B (zh) * | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| AU2018221148B2 (en) | 2017-02-17 | 2022-05-05 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| IL269068B (en) | 2017-03-15 | 2022-09-01 | Metacrine Inc | Paranoid x receptor agonists and uses thereof |
| LT3609888T (lt) | 2017-03-15 | 2025-11-10 | Farnezoidinio x receptoriaus agonistai ir jų panaudojimas | |
| MX388643B (es) * | 2017-04-14 | 2025-03-20 | Jiangsu Hengrui Medicine Co | Composicion farmaceutica que contiene agonista de mor y agonista de kor, y sus usos |
| CN108727347B (zh) * | 2017-04-14 | 2020-06-16 | 江苏恒瑞医药股份有限公司 | 一种阿片样物质受体(mor)激动剂的晶型及其制备方法 |
| EP3610875B1 (en) * | 2017-04-14 | 2020-10-07 | Jiangsu Hengrui Medicine Co., Ltd. | Opioid receptor (mor) agonist salt, fumarate salt i crystal form thereof and preparation method thereof |
| CN109206417B (zh) * | 2017-07-04 | 2023-01-03 | 四川海思科制药有限公司 | 阿片受体激动剂及其应用 |
| AR112412A1 (es) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas de sal de colina de un inhibidor de la cápside del vih |
| TWI687415B (zh) | 2017-08-17 | 2020-03-11 | 美商基利科學股份有限公司 | Hiv蛋白質膜抑制劑之固體形式 |
| US11072601B2 (en) * | 2017-09-18 | 2021-07-27 | Shanghai Synergy Pharmaceutical Sciences Co., Ltd. | μ-opioid receptor agonist and preparation method therefor and use thereof in field of medicine |
| WO2019062804A1 (zh) | 2017-09-28 | 2019-04-04 | 江苏恒瑞医药股份有限公司 | 一种氧杂螺环类衍生物的制备方法及其中间体 |
| AU2018349930A1 (en) | 2017-10-13 | 2020-04-16 | Shandong Luye Pharmaceutical Co., Ltd. | 2,6-dioxaspiro (4,5) decane derivatives and preparation method therefor and pharmaceutical applications thereof |
| JP2021505547A (ja) * | 2017-12-06 | 2021-02-18 | 江蘇恒瑞医薬股▲ふん▼有限公司 | 疼痛を治療するための薬物の製造におけるｍｏｒアゴニストと組み合わせたｋｏｒアゴニストの使用 |
| SG11202007422QA (en) | 2018-02-05 | 2020-09-29 | Alkermes Inc | Compounds for the treatment of pain |
| JP7083398B2 (ja) | 2018-02-15 | 2022-06-10 | ギリアード サイエンシーズ， インコーポレイテッド | ピリジン誘導体およびｈｉｖ感染を処置するためのその使用 |
| EP3752496B1 (en) | 2018-02-16 | 2023-07-05 | Gilead Sciences, Inc. | Methods and intermediates for preparing a therapeutic compound useful in the treatment of retroviridae viral infection |
| CN111836807A (zh) * | 2018-04-28 | 2020-10-27 | 四川科伦博泰生物医药股份有限公司 | 氧杂螺环类化合物及其制备方法和用途 |
| CN111163778B (zh) * | 2018-05-14 | 2023-01-24 | 江苏恒瑞医药股份有限公司 | 一种mor受体激动剂药物组合物 |
| KR20210033492A (ko) | 2018-07-16 | 2021-03-26 | 길리애드 사이언시즈, 인코포레이티드 | Hiv의 치료를 위한 캡시드 억제제 |
| CN113056271B (zh) | 2018-09-18 | 2024-10-29 | 奥加诺沃公司 | 法尼醇x受体激动剂及其用途 |
| WO2020073985A1 (zh) * | 2018-10-12 | 2020-04-16 | 江苏恒瑞医药股份有限公司 | 一种阿片样物质受体(mor)激动剂的结晶形式及制备方法 |
| WO2020073984A1 (zh) * | 2018-10-12 | 2020-04-16 | 江苏恒瑞医药股份有限公司 | 一种阿片样物质受体(mor)激动剂的结晶形式及制备方法 |
| CN112334465B (zh) * | 2019-01-17 | 2024-06-11 | 上海海雁医药科技有限公司 | 三环取代的氧杂螺环衍生物、其制法与医药上的用途 |
| CN111662284B (zh) * | 2019-03-06 | 2021-08-10 | 上海海雁医药科技有限公司 | 双杂环取代的氧杂螺环衍生物、其制法与医药上的用途 |
| CA3157275C (en) | 2019-11-26 | 2026-02-10 | Gilead Sciences, Inc. | Capsid inhibitors for the prevention of hiv |
| EP4092031A4 (en) | 2020-01-17 | 2024-02-21 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | AZABICYCLIC SUBSTITUTED OXASPIRO DERIVATIVE, METHOD FOR THE PRODUCTION THEREOF AND ITS MEDICAL USE |
| CN118221680A (zh) | 2020-01-17 | 2024-06-21 | 上海海雁医药科技有限公司 | 光学纯的氧杂螺环取代的吡咯并吡唑衍生物、其制法与医药上的用途 |
| CN113214264B (zh) * | 2020-01-21 | 2022-08-09 | 上海海雁医药科技有限公司 | 二氢吡咯并五元杂芳基取代的氧杂螺环衍生物、其制法与医药上的用途 |
| WO2021188695A1 (en) | 2020-03-18 | 2021-09-23 | Metacrine, Inc. | Formulations of a farnesoid x receptor agonist |
| IL296532A (en) | 2020-03-18 | 2022-11-01 | Metacrine Inc | Crystal forms of farnesoid x receptor agonist |
| TWI858267B (zh) | 2020-06-25 | 2024-10-11 | 美商基利科學股份有限公司 | 用於治療hiv之蛋白殼抑制劑 |
| US20230096978A1 (en) * | 2020-08-10 | 2023-03-30 | Chengdu Easton Biopharmaceuticals Co., Ltd. | Mor receptor agonist compound, preparation method therefor, and use thereof |
| CN112694485B (zh) * | 2020-09-10 | 2023-04-07 | 四川海品信医药科技有限公司 | 一种阿片受体激动剂噻吩类化合物及其制备方法 |
| JP7751645B2 (ja) | 2020-12-29 | 2025-10-08 | 上海海雁医薬科技有限公司 | オキシスピロ環置換ピロロピラゾール誘導体及びその中間体並びにその調製方法 |
| WO2023284788A1 (zh) | 2021-07-13 | 2023-01-19 | 上海海雁医药科技有限公司 | Mor受体激动剂的药学上可接受的盐、其多晶型物及其用途 |
| CN115677675B (zh) * | 2021-07-21 | 2025-09-12 | 成都苑东生物制药股份有限公司 | 一种6-氧杂螺[4,5]癸烷类化合物的盐、制备方法及用途 |
| WO2023011422A1 (zh) * | 2021-08-02 | 2023-02-09 | 上海枢境生物科技有限公司 | 氧杂螺环类衍生物、制备方法及其用途 |
| WO2023030319A1 (zh) * | 2021-08-31 | 2023-03-09 | 天地恒一制药股份有限公司 | 阿片受体激动剂及其制备方法和用途 |
| US12084467B2 (en) | 2021-12-03 | 2024-09-10 | Gilead Sciences, Inc. | Therapeutic compounds for HIV virus infection |
| US12404262B2 (en) | 2021-12-03 | 2025-09-02 | Gilead Sciences, Inc. | Therapeutic compounds for HIV virus infection |
| CR20240223A (es) | 2021-12-03 | 2024-07-08 | Gilead Sciences Inc | Compuestos terapéuticos para la infección por el virus del vih |
| CN116041336B (zh) * | 2022-01-21 | 2024-07-09 | 成都硕德药业有限公司 | 一种6-氧杂螺[4,5]癸烷类化合物的新晶型、用途及其制备方法 |
| CN116589451B (zh) * | 2022-02-11 | 2024-07-09 | 成都硕德药业有限公司 | 一种6-氧杂螺[4,5]癸烷类化合物的新晶型、用途及其制备方法 |
| TW202530189A (zh) | 2023-09-29 | 2025-08-01 | 日商第一三共股份有限公司 | ３－苯基丙基胺衍生物 |
| CN118638109B (zh) * | 2024-04-30 | 2025-10-28 | 中山大学 | 一种阿片类药物-奥赛利定的制备方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5825980B2 (ja) | 1976-02-12 | 1983-05-31 | ヤマサ醤油株式会社 | サイクリックヌクレオチドの定量法 |
| US4602035A (en) * | 1983-12-07 | 1986-07-22 | Hoechst-Roussel Pharmaceuticals Inc. | Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines |
| US5223530A (en) | 1990-07-31 | 1993-06-29 | Sri, International | Arylcycloalkanepolyalkylamine ligands |
| US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
| WO1996005166A1 (en) * | 1994-08-11 | 1996-02-22 | Yamanouchi Pharmaceutical Co., Ltd. | Substituted amine derivative and medicinal composition containing the same |
| ES2247604T3 (es) | 1995-06-12 | 2006-03-01 | G.D. SEARLE & CO. | Composiciones que comprenden un inhibidor de ciclooxigenasa-2 y un inhibidor de 5-lipoxigenasa. |
| US6071918A (en) | 1999-07-21 | 2000-06-06 | Dupont Pharmaceuticals Company | Combination of an opioid antagonist and a selective serotonin reuptake inhibitor for treatment of alcoholism and alcohol dependence |
| GB0130261D0 (en) * | 2001-12-18 | 2002-02-06 | Pfizer Ltd | Lactams as tachykinin antagonists |
| TW200307539A (en) * | 2002-02-01 | 2003-12-16 | Bristol Myers Squibb Co | Cycloalkyl inhibitors of potassium channel function |
| KR101025633B1 (ko) * | 2002-09-19 | 2011-03-30 | 일라이 릴리 앤드 캄파니 | 오피오이드 수용체 안타고니스트로서의 디아릴 에테르 |
| NZ546834A (en) | 2003-10-01 | 2010-03-26 | Adolor Corp | Spirocyclic heterocyclic derivatives and methods of their use |
| US20100022637A1 (en) * | 2005-09-29 | 2010-01-28 | The Trustees Of Columbia University In The City Of New York | Identification of anti-cancer compounds and compounds for treating huntington's disease and methods of treatment thereof |
| WO2007081966A2 (en) * | 2006-01-09 | 2007-07-19 | University Of Southern California | Small molecules for treating cancer and abnormal cell proliferation disorders |
| US7645767B2 (en) | 2006-08-31 | 2010-01-12 | Trinity Laboratories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
| WO2008057857A1 (en) * | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF |
| WO2008057856A2 (en) * | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, ap-1 and/or nf-kappab activity and use thereof |
| US20090028873A1 (en) | 2007-07-27 | 2009-01-29 | Auspex Pharmaceuticals, Inc. | Substituted cyclohexanols |
| PT2260042E (pt) * | 2008-03-27 | 2011-12-06 | Gruenenthal Gmbh | Derivados de ciclo-hexano espirocíclicos substituídos |
| FR2939136B1 (fr) * | 2008-12-02 | 2010-12-03 | Galderma Res & Dev | Nouveaux composes 4-(heterocycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| FR2967672B1 (fr) * | 2010-11-22 | 2012-12-28 | Sanofi Aventis | Derives de nitrobenzothiazoles, leur preparation et leurs applications therapeutiques |
| SI2688403T1 (sl) * | 2011-03-23 | 2017-08-31 | Trevena, Inc. | Ligandi opioidnih receptorjev in metode uporabe in izdelave istega |
| KR20180093930A (ko) | 2015-12-14 | 2018-08-22 | 트레베나, 인코포레이티드. | 통각과민증을 치료하는 방법 |
-
2012
- 2012-03-23 SI SI201231000T patent/SI2688403T1/sl unknown
- 2012-03-23 SM SM20170325T patent/SMT201700325T1/it unknown
- 2012-03-23 CA CA2830742A patent/CA2830742C/en active Active
- 2012-03-23 EP EP17173483.3A patent/EP3290415B1/en active Active
- 2012-03-23 EA EA201391332A patent/EA025456B1/ru unknown
- 2012-03-23 KR KR1020137027288A patent/KR101991327B1/ko active Active
- 2012-03-23 WO PCT/US2012/030327 patent/WO2012129495A1/en not_active Ceased
- 2012-03-23 HR HRP20171021TT patent/HRP20171021T1/hr unknown
- 2012-03-23 EP EP12760456.9A patent/EP2688403B1/en active Active
- 2012-03-23 ES ES17173483T patent/ES2857549T3/es active Active
- 2012-03-23 KR KR1020187025108A patent/KR101991326B1/ko active Active
- 2012-03-23 PT PT127604569T patent/PT2688403T/pt unknown
- 2012-03-23 JP JP2014501273A patent/JP5912169B2/ja active Active
- 2012-03-23 US US13/428,849 patent/US8835488B2/en active Active
- 2012-03-23 KR KR1020197016977A patent/KR102129247B1/ko active Active
- 2012-03-23 ME MEP-2017-129A patent/ME02754B/me unknown
- 2012-03-23 PT PT171734833T patent/PT3290415T/pt unknown
- 2012-03-23 PL PL12760456T patent/PL2688403T3/pl unknown
- 2012-03-23 LT LTEP12760456.9T patent/LT2688403T/lt unknown
- 2012-03-23 DK DK17173483.3T patent/DK3290415T3/da active
- 2012-03-23 CN CN201280021050.7A patent/CN103702561B/zh active Active
- 2012-03-23 HU HUE17173483A patent/HUE054055T2/hu unknown
- 2012-03-23 DK DK12760456.9T patent/DK2688403T3/en active
- 2012-03-23 ES ES12760456.9T patent/ES2632009T3/es active Active
- 2012-03-23 HU HUE12760456A patent/HUE032948T2/en unknown
- 2012-03-23 AU AU2012230761A patent/AU2012230761B2/en not_active Ceased
- 2012-03-23 EP EP20217112.0A patent/EP3872076A1/en not_active Withdrawn
- 2012-03-23 PL PL17173483T patent/PL3290415T3/pl unknown
- 2012-03-23 RS RS20170630A patent/RS56111B1/sr unknown
-
2013
- 2013-08-12 US US13/964,505 patent/US9044469B2/en active Active
- 2013-09-17 IL IL228506A patent/IL228506A/en active IP Right Grant
-
2015
- 2015-05-15 US US14/712,974 patent/US9309234B2/en active Active
- 2015-12-27 IL IL243318A patent/IL243318B/en active IP Right Grant
-
2016
- 2016-03-30 JP JP2016067208A patent/JP6243949B2/ja not_active Expired - Fee Related
- 2016-04-07 US US15/093,315 patent/US9642842B2/en active Active
-
2017
- 2017-02-03 AU AU2017200745A patent/AU2017200745B2/en not_active Ceased
- 2017-03-29 US US15/472,345 patent/US9849119B2/en active Active
- 2017-07-04 CY CY20171100716T patent/CY1119057T1/el unknown
- 2017-11-09 JP JP2017216012A patent/JP6649341B2/ja not_active Expired - Fee Related
- 2017-12-01 US US15/828,695 patent/US11077098B2/en active Active
-
2019
- 2019-07-25 US US16/522,008 patent/US10588898B2/en active Active
-
2020
- 2020-01-15 JP JP2020004039A patent/JP6923683B2/ja active Active
- 2020-01-21 IL IL272165A patent/IL272165B/en unknown
-
2021
- 2021-06-27 IL IL284407A patent/IL284407B2/en unknown
- 2021-07-02 US US17/367,021 patent/US11931350B2/en active Active
- 2021-07-28 JP JP2021122940A patent/JP7248750B2/ja active Active
-
2023
- 2023-03-15 JP JP2023040218A patent/JP2023075282A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUE054055T2 (hu) | Opoid receptor ligandumok és eljárás azok alkalmazására és elõállítására | |
| HUE052485T2 (hu) | RNA készítmény immunterápiára | |
| DK2661266T3 (da) | Kemosensoriske receptorligandbaserede terapier | |
| HUE036663T2 (hu) | Készítmény anti-alfa4béta7 antitesthez | |
| HUE036664T2 (hu) | Készítmény anti-alfa4béta7 antitesthez | |
| HUE036929T2 (hu) | Alfa-folátreceptor elleni ellenanyagok és alkalmazásuk | |
| HUE037048T2 (hu) | Eljárások 4-cikloalkiloxibenzolszulfonamidok elõállítására | |
| DK3275892T3 (da) | Præfusions-rsv-f-antigener | |
| HRP20190576T1 (hr) | Postupci pripreme konjugata | |
| CO6890099A2 (es) | Nuevos derivados dihidroquinolina-2-ona | |
| BR112013033308A2 (pt) | assento | |
| EP2665707A4 (en) | ANTAGONISTS OF THE MINERALOCORTICOID RECEPTOR | |
| IL229963A0 (en) | Substituted quinolines and their use as medicaments | |
| EP2752333A4 (en) | SEAT DEVICE | |
| DK3246339T3 (da) | Antistoffer mod bradykinin-b1-receptorligander | |
| EP2665431C0 (en) | Drug delivery technology | |
| EP2785798C0 (en) | ANTHOCYANIN-BASED DYE | |
| EP2710925A4 (en) | SEAT | |
| HUE052855T2 (hu) | Kolonoszkópiás készítmény | |
| GB201120991D0 (en) | Microsensor | |
| BR112014015885A2 (pt) | preparação farmacêutica | |
| IL231660A0 (en) | Composition | |
| CO6960544A2 (es) | Preparación de liberación sostenida | |
| LT2742068T (lt) | Nauji antikūnai prieš fosforilcholiną | |
| HRP20181667T1 (hr) | Pripravak |