JP2010506942A5 - - Google Patents

Info

Publication number

JP2010506942A5

JP2010506942A5 JP2009533425A JP2009533425A JP2010506942A5 JP 2010506942 A5 JP2010506942 A5 JP 2010506942A5 JP 2009533425 A JP2009533425 A JP 2009533425A JP 2009533425 A JP2009533425 A JP 2009533425A JP 2010506942 A5 JP2010506942 A5 JP 2010506942A5

Authority

JP

Japan

Prior art keywords

alkyl

cyclodextrin

composition

hydrogen

group

Prior art date

2007-10-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000000217 alkyl group Chemical group 0.000 claims 10
• 239000000203 mixture Substances 0.000 claims 10
• 229920000858 Cyclodextrin Polymers 0.000 claims 9
• -1 disubstituted urea compound Chemical class 0.000 claims 7
• 239000001116 FEMA 4028 Substances 0.000 claims 5
• 229960004853 betadex Drugs 0.000 claims 5
• 229910052739 hydrogen Inorganic materials 0.000 claims 5
• 239000001257 hydrogen Substances 0.000 claims 5
• 125000005843 halogen group Chemical group 0.000 claims 4
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 4
• 150000002431 hydrogen Chemical class 0.000 claims 3
• 101150006084 CHKB gene Proteins 0.000 claims 2
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
• 239000012190 activator Substances 0.000 claims 2
• 101150113535 chek1 gene Proteins 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 239000000651 prodrug Substances 0.000 claims 2
• 229940002612 prodrug Drugs 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 239000012453 solvate Substances 0.000 claims 2
• TURGQPDWYFJEDY-UHFFFAOYSA-N 1-hydroperoxypropane Chemical compound CCCOO TURGQPDWYFJEDY-UHFFFAOYSA-N 0.000 claims 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
• 230000002159 abnormal effect Effects 0.000 claims 1
• 239000007864 aqueous solution Substances 0.000 claims 1
• WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 1
• 235000011175 beta-cyclodextrine Nutrition 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 230000004663 cell proliferation Effects 0.000 claims 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
• 229960004316 cisplatin Drugs 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 1
• 229960005277 gemcitabine Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229960000485 methotrexate Drugs 0.000 claims 1
• 125000004430 oxygen atom Chemical group O* 0.000 claims 1
• 239000003002 pH adjusting agent Substances 0.000 claims 1
• 229960005079 pemetrexed Drugs 0.000 claims 1
• QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical group C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 claims 1
• 229920006395 saturated elastomer Polymers 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1
• 125000004434 sulfur atom Chemical group 0.000 claims 1
• NOYPYLRCIDNJJB-UHFFFAOYSA-N trimetrexate Chemical compound COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=NC(N)=NC3=CC=2)C)=C1 NOYPYLRCIDNJJB-UHFFFAOYSA-N 0.000 claims 1
• 229960001099 trimetrexate Drugs 0.000 claims 1
• 0 C[C@](*)Oc(c(*#I)c(*)c(*)c1)c1NC(Nc1ncc(C)nc1)=O Chemical compound C[C@](*)Oc(c(*#I)c(*)c(*)c1)c1NC(Nc1ncc(C)nc1)=O 0.000 description 1