JP2019519593A5 - - Google Patents
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- JP2019519593A5 JP2019519593A5 JP2018568930A JP2018568930A JP2019519593A5 JP 2019519593 A5 JP2019519593 A5 JP 2019519593A5 JP 2018568930 A JP2018568930 A JP 2018568930A JP 2018568930 A JP2018568930 A JP 2018568930A JP 2019519593 A5 JP2019519593 A5 JP 2019519593A5
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- JP
- Japan
- Prior art keywords
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- aryl
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- Prior art date
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- 125000000217 alkyl group Chemical group 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 229940124647 MEK inhibitor Drugs 0.000 claims 2
- 239000012828 PI3K inhibitor Substances 0.000 claims 2
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 2
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims 1
- UCYLROVJSUACAD-UHFFFAOYSA-N 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol Chemical compound OCCOCC(OCCO)COCCO UCYLROVJSUACAD-UHFFFAOYSA-N 0.000 claims 1
- 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 claims 1
- 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091007960 PI3Ks Proteins 0.000 claims 1
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 0 *c(cc1)cc(F)c1Nc(c(C(N*N(CC1)CCN1c1nc(cc(cc2)-c3cnc(*)c(NS(c(cc4)ccc4F)(=O)=O)c3)c2nc1)=O)ccc1F)c1F Chemical compound *c(cc1)cc(F)c1Nc(c(C(N*N(CC1)CCN1c1nc(cc(cc2)-c3cnc(*)c(NS(c(cc4)ccc4F)(=O)=O)c3)c2nc1)=O)ccc1F)c1F 0.000 description 16
- KAQSIIOCRZVCIQ-UHFFFAOYSA-N CC(C)(C)OC(NOCCOCCN(C)CCOCCC(O)=O)=O Chemical compound CC(C)(C)OC(NOCCOCCN(C)CCOCCC(O)=O)=O KAQSIIOCRZVCIQ-UHFFFAOYSA-N 0.000 description 1
- MRQVNRJCIOXFLB-UHFFFAOYSA-N CC(C)(C)OC(NOCCOCCN(C)CCOCCOCCC(O)=O)=O Chemical compound CC(C)(C)OC(NOCCOCCN(C)CCOCCOCCC(O)=O)=O MRQVNRJCIOXFLB-UHFFFAOYSA-N 0.000 description 1
- BQULJZSOTNNVMI-UHFFFAOYSA-N CC(C)(C)OC(NOCCOCCOCCCN(C)CCOCCOCCC(O)=O)=O Chemical compound CC(C)(C)OC(NOCCOCCOCCCN(C)CCOCCOCCC(O)=O)=O BQULJZSOTNNVMI-UHFFFAOYSA-N 0.000 description 1
- TVSMLBGFGKLKOO-UHFFFAOYSA-N CC1CCN(C)CC1 Chemical compound CC1CCN(C)CC1 TVSMLBGFGKLKOO-UHFFFAOYSA-N 0.000 description 1
- WRWPPGUCZBJXKX-UHFFFAOYSA-N Cc(cc1)ccc1F Chemical compound Cc(cc1)ccc1F WRWPPGUCZBJXKX-UHFFFAOYSA-N 0.000 description 1
- YXJKFEHSDJWXFA-UHFFFAOYSA-N NC(c(c(Nc(c(F)c1)ccc1I)c1F)ccc1F)=O Chemical compound NC(c(c(Nc(c(F)c1)ccc1I)c1F)ccc1F)=O YXJKFEHSDJWXFA-UHFFFAOYSA-N 0.000 description 1
- VVIJTFDWBOPSTL-UHFFFAOYSA-N O=C(c(c(Nc(c(F)c1)ccc1I)c1F)ccc1F)NOCCOCCOCCOCCNC/[O]=S/N(CC1)CCN1c1nc(cc(cc2)-c(cc3NS(c(cc4)ccc4F)(=O)=O)cnc3Cl)c2nc1 Chemical compound O=C(c(c(Nc(c(F)c1)ccc1I)c1F)ccc1F)NOCCOCCOCCOCCNC/[O]=S/N(CC1)CCN1c1nc(cc(cc2)-c(cc3NS(c(cc4)ccc4F)(=O)=O)cnc3Cl)c2nc1 VVIJTFDWBOPSTL-UHFFFAOYSA-N 0.000 description 1
- CABWOSCBGMOHCF-UHFFFAOYSA-N O=CN(CC1)CCN1c1nc(cc(cc2)-c(cc3NS(c(cc4)ccc4F)(=O)=O)cnc3Cl)c2nc1 Chemical compound O=CN(CC1)CCN1c1nc(cc(cc2)-c(cc3NS(c(cc4)ccc4F)(=O)=O)cnc3Cl)c2nc1 CABWOSCBGMOHCF-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021190205A JP7475062B2 (ja) | 2016-07-06 | 2021-11-24 | ＭＥＫ／ＰＩ３Ｋ及びｍＴＯＲ／ＭＥＫ／ＰＩ３Ｋ生物学的経路の多官能性阻害剤、並びに同多官能性阻害剤を用いた治療方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359001P | 2016-07-06 | 2016-07-06 | |
| US62/359,001 | 2016-07-06 | ||
| US201762454163P | 2017-02-03 | 2017-02-03 | |
| US62/454,163 | 2017-02-03 | ||
| PCT/US2017/040866 WO2018009638A1 (en) | 2016-07-06 | 2017-07-06 | MULTIFUNCTIONAL INHIBITORS OF MEK/PI3K AND mTOR/MEK/PI3K BIOLOGICAL PATHWAYS AND THERAPEUTIC METHODS USING THE SAME |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021190205A Division JP7475062B2 (ja) | 2016-07-06 | 2021-11-24 | ＭＥＫ／ＰＩ３Ｋ及びｍＴＯＲ／ＭＥＫ／ＰＩ３Ｋ生物学的経路の多官能性阻害剤、並びに同多官能性阻害剤を用いた治療方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019519593A JP2019519593A (ja) | 2019-07-11 |
| JP2019519593A5 true JP2019519593A5 (https=) | 2020-08-13 |
Family
ID=59363277
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568930A Pending JP2019519593A (ja) | 2016-07-06 | 2017-07-06 | ＭＥＫ／ＰＩ３Ｋ及びｍＴＯＲ／ＭＥＫ／ＰＩ３Ｋ生物学的経路の多官能性阻害剤、並びに同多官能性阻害剤を用いた治療方法 |
| JP2021190205A Active JP7475062B2 (ja) | 2016-07-06 | 2021-11-24 | ＭＥＫ／ＰＩ３Ｋ及びｍＴＯＲ／ＭＥＫ／ＰＩ３Ｋ生物学的経路の多官能性阻害剤、並びに同多官能性阻害剤を用いた治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021190205A Active JP7475062B2 (ja) | 2016-07-06 | 2021-11-24 | ＭＥＫ／ＰＩ３Ｋ及びｍＴＯＲ／ＭＥＫ／ＰＩ３Ｋ生物学的経路の多官能性阻害剤、並びに同多官能性阻害剤を用いた治療方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10919877B2 (https=) |
| EP (2) | EP4086250B1 (https=) |
| JP (2) | JP2019519593A (https=) |
| CN (1) | CN109563088B (https=) |
| AU (2) | AU2017291838B2 (https=) |
| CA (1) | CA3029875C (https=) |
| ES (2) | ES2922898T3 (https=) |
| WO (1) | WO2018009638A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018316175B2 (en) | 2017-08-11 | 2023-02-23 | The Regents Of The University Of Michigan | Inhibitors of MEK/PI3K, JAK/MEK, JAK/PI3K/mTOR and MEK/PI3K3k/mTOR biological pathways and methods for improving lymphatic uptake, bioavailability, and solubility of therapeutic compounds |
| CN112143700B (zh) * | 2019-06-26 | 2024-07-19 | 上海细胞治疗集团股份有限公司 | 制备过表达外源基因的免疫效应细胞的方法 |
| KR20240008312A (ko) * | 2021-04-09 | 2024-01-18 | 유니버시타트 바셀 | Pi3k의 가역적 및 비가역적 공유 억제제로서의 트리아진 유도체 |
| CN117396470A (zh) * | 2021-04-09 | 2024-01-12 | 巴塞尔大学 | 作为pi3k的可逆和不可逆共价抑制剂的三嗪衍生物 |
| WO2023170107A1 (en) | 2022-03-07 | 2023-09-14 | Centre Hospitalier Universitaire Vaudois (Chuv) | Pi3k/akt/mtor inhibitor for improving the cellular uptake of a radiopharmaceutical |
| JP2023180347A (ja) * | 2022-06-09 | 2023-12-21 | 国立大学法人金沢大学 | ハイブリッド型化合物又はその塩 |
| WO2025072796A1 (en) * | 2023-09-27 | 2025-04-03 | Totus Medicines Inc. | Pharmaceutical compositions and methods of use thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA197701A (en) | 1920-03-02 | Mcgoldrick Timothy | Arm cushion for crutches | |
| CA85878A (en) | 1903-08-19 | 1904-03-08 | George W. Peyton | Carpenter's gauge |
| US5608110A (en) | 1993-06-15 | 1997-03-04 | Bracco International B.V. | Heteroatom-bearing ligands and metal complexes thereof |
| JP3811775B2 (ja) | 2000-07-19 | 2006-08-23 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | ４−ヨードフェニルアミノベンズヒドロキサム酸の酸素化エステル |
| TW200505834A (en) | 2003-03-18 | 2005-02-16 | Sankyo Co | Sulfamide derivative and the pharmaceutical composition thereof |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| AR059339A1 (es) | 2006-02-09 | 2008-03-26 | Chugai Pharmaceutical Co Ltd | Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene |
| PT2074122E (pt) | 2006-09-15 | 2011-08-24 | Pfizer Prod Inc | Compostos de pirido(2,3-d)-pirimidinona e sua utilização como inibidores de pi3 |
| US8569378B2 (en) | 2007-07-20 | 2013-10-29 | Toshiyuki Sakai | p27 protein inducer |
| JP2011515462A (ja) | 2008-03-27 | 2011-05-19 | アウククランド ウニセルビセス リミテッド | 置換されたピリミジン、及びトリアジン、並びに癌療法におけるこれらの使用 |
| CA2725014C (en) * | 2008-05-30 | 2014-06-17 | Amgen Inc. | Inhibitors of pi3 kinase |
| EP2143819A1 (de) | 2008-07-11 | 2010-01-13 | Siemens Aktiengesellschaft | Beschichtungsverfahren und Korrosionsschutzbeschichtung für Turbinen-Komponenten |
| TW201038567A (en) | 2009-03-27 | 2010-11-01 | Pathway Therapeutics Ltd | Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy |
| CA2767008C (en) | 2009-07-07 | 2018-01-30 | Pathway Therapeutics, Inc. | Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy |
| US20110166191A1 (en) | 2010-01-07 | 2011-07-07 | Shijun Zhang | 3-(2-amino-ethyl)-5-(3-cyclohexyl-propylidene)-thiazolidine-2,4-dione and its derivatives as multiple signaling pathway inhibitors and for the treatment of cancer |
| GB201007227D0 (en) | 2010-04-30 | 2010-06-16 | Univ Basel | Piperazinotriazines |
| EP2604601B1 (en) * | 2010-08-10 | 2016-02-24 | Astellas Pharma Inc. | Hetero ring compound |
| WO2012068106A2 (en) | 2010-11-15 | 2012-05-24 | Exelixis, Inc. | Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture |
| PL2710018T3 (pl) * | 2011-05-19 | 2022-04-04 | Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) | Związki makrocykliczne jako inhibitory kinaz białkowych |
| WO2013071698A1 (zh) | 2011-11-17 | 2013-05-23 | 山东轩竹医药科技有限公司 | 三环类PI3K和/或mTOR抑制剂 |
| WO2014164942A1 (en) | 2013-03-13 | 2014-10-09 | The Regents Of The University Of Michigan | Dual mek/pi3k inhibitors and therapeutic methods using the same |
| RU2015148359A (ru) * | 2013-04-12 | 2017-05-15 | Асана Биосайенсис, Ллк | Хиназолины и азахиназолины - двойные ингибиторы путей ras/raf/mek/erk и pi3k/akt/pten/mtor |
| CN105130960B (zh) * | 2015-07-31 | 2018-07-06 | 沈阳药科大学 | 1,3,5-三嗪类衍生物及其应用 |
-
2017
- 2017-07-06 EP EP22179630.3A patent/EP4086250B1/en active Active
- 2017-07-06 EP EP17740578.4A patent/EP3481822B1/en active Active
- 2017-07-06 US US16/313,923 patent/US10919877B2/en active Active
- 2017-07-06 CN CN201780049835.8A patent/CN109563088B/zh active Active
- 2017-07-06 WO PCT/US2017/040866 patent/WO2018009638A1/en not_active Ceased
- 2017-07-06 ES ES17740578T patent/ES2922898T3/es active Active
- 2017-07-06 ES ES22179630T patent/ES3002745T3/es active Active
- 2017-07-06 JP JP2018568930A patent/JP2019519593A/ja active Pending
- 2017-07-06 AU AU2017291838A patent/AU2017291838B2/en active Active
- 2017-07-06 CA CA3029875A patent/CA3029875C/en active Active
-
2021
- 2021-04-28 AU AU2021202619A patent/AU2021202619B2/en active Active
- 2021-11-24 JP JP2021190205A patent/JP7475062B2/ja active Active
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