JP2017132781A5 - - Google Patents
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- JP2017132781A5 JP2017132781A5 JP2017038701A JP2017038701A JP2017132781A5 JP 2017132781 A5 JP2017132781 A5 JP 2017132781A5 JP 2017038701 A JP2017038701 A JP 2017038701A JP 2017038701 A JP2017038701 A JP 2017038701A JP 2017132781 A5 JP2017132781 A5 JP 2017132781A5
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- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- formula
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 10
- 125000006239 protecting group Chemical group 0.000 claims 5
- -1 2- (1- (4-butoxyphenyl) -2-methylpropan-2-ylamino) -1-hydroxyethyl Chemical group 0.000 claims 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- FAIIOPGOQIHOGV-UHFFFAOYSA-N 1-(4-butoxyphenyl)-2-methylpropan-2-amine Chemical compound CCCCOC1=CC=C(CC(C)(C)N)C=C1 FAIIOPGOQIHOGV-UHFFFAOYSA-N 0.000 claims 1
- SCOJKGRNQDKFRP-UHFFFAOYSA-N 2-chloro-n-methoxy-n-methylacetamide Chemical compound CON(C)C(=O)CCl SCOJKGRNQDKFRP-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- AEMRFAOFKBGASW-UHFFFAOYSA-M Glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 claims 1
- 235000019445 benzyl alcohol Nutrition 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003444 phase transfer catalyst Substances 0.000 claims 1
- 238000011916 stereoselective reduction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2011/079379 | 2011-09-06 | ||
| CN2011079379 | 2011-09-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529113A Division JP6130835B2 (ja) | 2011-09-06 | 2012-09-05 | ベンゾチアゾロン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017132781A JP2017132781A (ja) | 2017-08-03 |
| JP2017132781A5 true JP2017132781A5 (https=) | 2017-10-19 |
| JP6340103B2 JP6340103B2 (ja) | 2018-06-06 |
Family
ID=47010668
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529113A Expired - Fee Related JP6130835B2 (ja) | 2011-09-06 | 2012-09-05 | ベンゾチアゾロン化合物 |
| JP2017038701A Expired - Fee Related JP6340103B2 (ja) | 2011-09-06 | 2017-03-01 | ベンゾチアゾロン化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529113A Expired - Fee Related JP6130835B2 (ja) | 2011-09-06 | 2012-09-05 | ベンゾチアゾロン化合物 |
Country Status (39)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3192B1 (ar) | 2011-09-06 | 2018-03-08 | Novartis Ag | مركب بنزوثيازولون |
| UA117092C2 (uk) | 2011-09-06 | 2018-06-25 | Байєр Інтеллектуал Проперті Гмбх | Амінозаміщені імідазопіридазини |
| DK2890687T3 (en) * | 2012-08-30 | 2017-10-09 | Novartis Ag | Salts of benzothiazolone compound as beta-2-adrenoceptor agonist |
| ES2646916T3 (es) | 2012-11-19 | 2017-12-18 | Bayer Pharma Aktiengesellschaft | Aminoimidazopiridazinas como inhibidores de MKNK1 cinasa |
| EP2961391B1 (en) * | 2013-02-28 | 2017-05-17 | Novartis AG | Formulation comprising benzothiazolone compound |
| US10967119B1 (en) | 2019-04-01 | 2021-04-06 | Azizi Bilal | Wearable medication injecting device |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0308157B1 (en) * | 1987-09-15 | 1997-02-26 | The Rowett Research Institute | Therapeutic applications of beta-adrenergic agonists |
| US20070082918A1 (en) * | 1993-11-02 | 2007-04-12 | Naftchi N E | Neurologically active compounds and compounds with multiple activities |
| GB9405019D0 (en) | 1994-03-15 | 1994-04-27 | Smithkline Beecham Plc | Novel compounds |
| ZA967892B (en) | 1995-09-21 | 1998-03-18 | Lilly Co Eli | Selective β3 adrenergic agonists. |
| WO1999009018A1 (en) | 1997-08-14 | 1999-02-25 | Kirin Beer Kabushiki Kaisha | BENZOTHIAZOLONE DERIVATIVES HAVING SELECTIVE β2 RECEPTOR AGONIST ACTIVITY |
| EP1144387A1 (en) | 1998-12-04 | 2001-10-17 | Neurosearch A/S | New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| US6872723B2 (en) * | 2002-01-28 | 2005-03-29 | Wyeth | Stabilized difloxacin injectable solution |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| US6743797B2 (en) * | 2002-02-22 | 2004-06-01 | Chantest, Inc. | Methods for treating cardiac arrhythmia |
| GB0217225D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicinal compounds |
| PE20050130A1 (es) | 2002-08-09 | 2005-03-29 | Novartis Ag | Compuestos organicos |
| GB0225540D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Medicinal compounds |
| JP2006521201A (ja) * | 2003-03-26 | 2006-09-21 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 鏡像異性体富化したアルコール類およびアミン類を製造する方法 |
| WO2004087142A1 (en) * | 2003-04-04 | 2004-10-14 | Novartis Ag | Quinoline-2-one-derivatives for the treatment of airways diseases |
| JP2007503472A (ja) * | 2003-06-10 | 2007-02-22 | カリプシス・インコーポレーテッド | 病気治療用のヒストン脱アセチル化酵素阻害剤としてのカルボニル化合物 |
| AU2004247136A1 (en) | 2003-06-10 | 2004-12-23 | Kalypsys, Inc. | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease |
| JP2009513531A (ja) | 2003-07-11 | 2009-04-02 | グラクソ グループ リミテッド | 糖エステルを含む吸入可能医薬製剤 |
| JP2009514779A (ja) | 2003-07-11 | 2009-04-09 | グラクソ グループ リミテッド | 医薬製剤 |
| US7345060B2 (en) | 2003-11-21 | 2008-03-18 | Theravance, Inc. | Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| GB0328490D0 (en) | 2003-12-09 | 2004-01-14 | Glaxo Group Ltd | Medicinal compounds |
| JP2005187357A (ja) | 2003-12-25 | 2005-07-14 | Nippon Suisan Kaisha Ltd | 選択的なβ２受容体アゴニスト活性を有するベンゾチアゾロン誘導体の製造方法 |
| GB0402797D0 (en) * | 2004-02-09 | 2004-03-10 | Novartis Ag | Organic compounds |
| CA2565243A1 (en) | 2004-05-13 | 2005-11-24 | Boehringer Ingelheim International Gmbh | Hydroxy-substituted benzo-condensed heterocycles for use as beta agonists in the treatment of respiratory diseases |
| EP1595873A1 (de) | 2004-05-13 | 2005-11-16 | Boehringer Ingelheim Pharma GmbH & Co.KG | Substituierte Cycloalkylderivate zur Behandlung von Atemswegerkrankungen |
| WO2006014704A1 (en) | 2004-07-21 | 2006-02-09 | Theravance, Inc. | DIARYL ETHER β2 ADRENERGIC RECEPTOR AGONISTS |
| DE102004045648A1 (de) | 2004-09-21 | 2006-03-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Betamimetika zur Behandlung von Atemwegserkrankungen |
| GB0426164D0 (en) * | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
| DE102005007654A1 (de) | 2005-02-19 | 2006-08-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue langwirksame Betamimetika zur Behandlung von Atemwegserkrankungen |
| TW200740781A (en) | 2005-08-29 | 2007-11-01 | Astrazeneca Ab | Novel compounds |
| TW200738659A (en) | 2005-08-29 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| WO2007086078A2 (en) | 2006-01-30 | 2007-08-02 | Panacea Biotec Ltd. | Novel pharmaceutical compositions and process of preparation thereof |
| MX2008010187A (es) | 2006-02-10 | 2008-10-31 | Summit Corp Plc | Tratamiento de distrofia muscular de duchenne. |
| TW200745084A (en) | 2006-03-08 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| GB0613154D0 (en) | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
| EP2064174B1 (en) * | 2006-08-10 | 2016-10-26 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Preparation of (r,r)- or (r,s)-fenoterol analogues and their use in treating congestive heart failure |
| TW200833670A (en) * | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| JP2010535708A (ja) | 2007-08-03 | 2010-11-25 | ビオマリン アイジーエー リミテッド | デュシェンヌ型筋ジストロフィーの治療のための薬物併用 |
| WO2010015792A1 (en) | 2008-08-06 | 2010-02-11 | Argenta Discovery Limited | Nitrogen containing heterocyclic compounds useful as bifunctional modulators of m3 receptors and beta-2 receptors |
| GB0814728D0 (en) | 2008-08-12 | 2008-09-17 | Argenta Discovery Ltd | New combination |
| GB0823140D0 (en) | 2008-12-18 | 2009-01-28 | Astrazeneca Ab | New combination |
| GB201009801D0 (en) | 2010-06-11 | 2010-07-21 | Astrazeneca Ab | Compounds 950 |
| GB201107985D0 (en) | 2011-05-13 | 2011-06-29 | Astrazeneca Ab | Process |
| JO3192B1 (ar) | 2011-09-06 | 2018-03-08 | Novartis Ag | مركب بنزوثيازولون |
| DK2890687T3 (en) * | 2012-08-30 | 2017-10-09 | Novartis Ag | Salts of benzothiazolone compound as beta-2-adrenoceptor agonist |
| EP2961391B1 (en) | 2013-02-28 | 2017-05-17 | Novartis AG | Formulation comprising benzothiazolone compound |
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2012
- 2012-09-04 JO JOP/2012/0250A patent/JO3192B1/ar active
- 2012-09-05 SI SI201230841A patent/SI2753609T1/sl unknown
- 2012-09-05 SG SG2014013114A patent/SG2014013114A/en unknown
- 2012-09-05 ES ES12770249.6T patent/ES2615052T3/es active Active
- 2012-09-05 PL PL12770249T patent/PL2753609T3/pl unknown
- 2012-09-05 PT PT127702496T patent/PT2753609T/pt unknown
- 2012-09-05 EA EA201490573A patent/EA022909B1/ru not_active IP Right Cessation
- 2012-09-05 CN CN201280043386.3A patent/CN103781771B/zh not_active Expired - Fee Related
- 2012-09-05 PE PE2014000312A patent/PE20141993A1/es not_active Application Discontinuation
- 2012-09-05 HR HRP20170075TT patent/HRP20170075T1/hr unknown
- 2012-09-05 WO PCT/IB2012/054580 patent/WO2013035047A1/en not_active Ceased
- 2012-09-05 DK DK12770249.6T patent/DK2753609T3/en active
- 2012-09-05 US US13/603,990 patent/US8933108B2/en not_active Expired - Fee Related
- 2012-09-05 CA CA2845766A patent/CA2845766A1/en not_active Abandoned
- 2012-09-05 MY MYPI2014000358A patent/MY163301A/en unknown
- 2012-09-05 KR KR1020167007782A patent/KR101800140B1/ko not_active Expired - Fee Related
- 2012-09-05 TW TW101132414A patent/TWI555738B/zh not_active IP Right Cessation
- 2012-09-05 AU AU2013200422A patent/AU2013200422C1/en not_active Ceased
- 2012-09-05 RS RS20161145A patent/RS55468B1/sr unknown
- 2012-09-05 UY UY0001034312A patent/UY34312A/es not_active Application Discontinuation
- 2012-09-05 CN CN201610536836.2A patent/CN106187942B/zh not_active Expired - Fee Related
- 2012-09-05 LT LTEP12770249.6T patent/LT2753609T/lt unknown
- 2012-09-05 KR KR1020147008777A patent/KR101628585B1/ko not_active Expired - Fee Related
- 2012-09-05 EP EP12770249.6A patent/EP2753609B1/en active Active
- 2012-09-05 MX MX2014002688A patent/MX345405B/es active IP Right Grant
- 2012-09-05 UA UAA201401193A patent/UA114295C2/uk unknown
- 2012-09-05 JP JP2014529113A patent/JP6130835B2/ja not_active Expired - Fee Related
- 2012-09-05 BR BR112014004732A patent/BR112014004732A2/pt not_active Application Discontinuation
- 2012-09-05 PH PH1/2014/500399A patent/PH12014500399A1/en unknown
- 2012-09-05 HU HUE12770249A patent/HUE030530T2/en unknown
- 2012-09-05 AP AP2014007462A patent/AP3830A/en active
- 2012-09-05 CU CUP2014000028A patent/CU24303B1/xx unknown
- 2012-09-06 AR ARP120103276A patent/AR087787A1/es unknown
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2014
- 2014-02-10 TN TNP2014000060A patent/TN2014000060A1/en unknown
- 2014-02-13 ZA ZA2014/01112A patent/ZA201401112B/en unknown
- 2014-02-27 IL IL231235A patent/IL231235A/en active IP Right Grant
- 2014-02-27 CL CL2014000493A patent/CL2014000493A1/es unknown
- 2014-03-04 GT GT201400042A patent/GT201400042A/es unknown
- 2014-03-06 CR CR20140114A patent/CR20140114A/es unknown
- 2014-03-06 CO CO14048375A patent/CO6900147A2/es not_active Application Discontinuation
- 2014-12-10 US US14/566,021 patent/US20150094346A1/en not_active Abandoned
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2015
- 2015-02-03 ZA ZA2015/00790A patent/ZA201500790B/en unknown
- 2015-08-03 US US14/817,175 patent/US20150336914A1/en not_active Abandoned
- 2015-11-20 US US14/947,458 patent/US20160075670A1/en not_active Abandoned
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2016
- 2016-06-10 US US15/178,579 patent/US9913828B2/en not_active Expired - Fee Related
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2017
- 2017-02-02 CY CY20171100153T patent/CY1118585T1/el unknown
- 2017-03-01 JP JP2017038701A patent/JP6340103B2/ja not_active Expired - Fee Related
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2018
- 2018-01-22 US US15/876,619 patent/US10251868B2/en not_active Expired - Fee Related