JP2006514626A5 - - Google Patents
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- Publication number
- JP2006514626A5 JP2006514626A5 JP2004552854A JP2004552854A JP2006514626A5 JP 2006514626 A5 JP2006514626 A5 JP 2006514626A5 JP 2004552854 A JP2004552854 A JP 2004552854A JP 2004552854 A JP2004552854 A JP 2004552854A JP 2006514626 A5 JP2006514626 A5 JP 2006514626A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- compound
- substituted
- carbamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000003545 alkoxy group Chemical group 0.000 claims description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 125000004452 carbocyclyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- -1 carbocyclyloxy Chemical group 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 claims 2
- HDMMWSNTZNGSBX-UHFFFAOYSA-N 2-[(2-butan-2-yloxyquinoline-4-carbonyl)amino]-1,3-thiazole-5-carboxylic acid Chemical compound C=12C=CC=CC2=NC(OC(C)CC)=CC=1C(=O)NC1=NC=C(C(O)=O)S1 HDMMWSNTZNGSBX-UHFFFAOYSA-N 0.000 claims 1
- UFNAMURUPUJLQM-UHFFFAOYSA-N 2-[[2-[(2-chlorophenyl)methoxy]-6-methylquinoline-4-carbonyl]amino]-1,3-thiazole-5-carboxylic acid Chemical compound C1=C(C(=O)NC=2SC(=CN=2)C(O)=O)C2=CC(C)=CC=C2N=C1OCC1=CC=CC=C1Cl UFNAMURUPUJLQM-UHFFFAOYSA-N 0.000 claims 1
- XECBYHDEIIBBJP-UHFFFAOYSA-N 2-[[2-[(2-chlorophenyl)methoxy]quinoline-4-carbonyl]amino]-1,3-thiazole-5-carboxylic acid Chemical compound S1C(C(=O)O)=CN=C1NC(=O)C1=CC(OCC=2C(=CC=CC=2)Cl)=NC2=CC=CC=C12 XECBYHDEIIBBJP-UHFFFAOYSA-N 0.000 claims 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- PYMSEHFAUFQANC-UHFFFAOYSA-N 6-[[2-[(2-chlorophenyl)methoxy]-6-methylquinoline-4-carbonyl]amino]pyridine-3-carboxylic acid Chemical compound C1=C(C(=O)NC=2N=CC(=CC=2)C(O)=O)C2=CC(C)=CC=C2N=C1OCC1=CC=CC=C1Cl PYMSEHFAUFQANC-UHFFFAOYSA-N 0.000 claims 1
- QGYKSBSGPZJCPA-UHFFFAOYSA-N 6-[[2-[(2-chlorophenyl)methoxy]quinoline-4-carbonyl]amino]pyridine-3-carboxylic acid Chemical compound N1=CC(C(=O)O)=CC=C1NC(=O)C1=CC(OCC=2C(=CC=CC=2)Cl)=NC2=CC=CC=C12 QGYKSBSGPZJCPA-UHFFFAOYSA-N 0.000 claims 1
- IDWNZTWUCYIQKP-UHFFFAOYSA-N 6-[[4-[(2-methylphenyl)methoxy]quinoline-2-carbonyl]amino]pyridine-3-carboxylic acid Chemical compound CC1=CC=CC=C1COC1=CC(C(=O)NC=2N=CC(=CC=2)C(O)=O)=NC2=CC=CC=C12 IDWNZTWUCYIQKP-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 0 C*OC(C1=CC=CC=CCC(NC(c2c(cc(*)c(C)c3)c3nc(*)c2)=O)=C1)=O Chemical compound C*OC(C1=CC=CC=CCC(NC(c2c(cc(*)c(C)c3)c3nc(*)c2)=O)=C1)=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0226931.4A GB0226931D0 (en) | 2002-11-19 | 2002-11-19 | Chemical compounds |
| PCT/GB2003/004915 WO2004045614A1 (en) | 2002-11-19 | 2003-11-13 | Quinoline derivatives as glucokinase ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006514626A JP2006514626A (ja) | 2006-05-11 |
| JP2006514626A5 true JP2006514626A5 (https=) | 2006-10-19 |
Family
ID=9948090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004552854A Withdrawn JP2006514626A (ja) | 2002-11-19 | 2003-11-13 | グルコキナーゼリガンドとしてのキノリン誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7230108B2 (https=) |
| EP (1) | EP1583532B1 (https=) |
| JP (1) | JP2006514626A (https=) |
| AT (1) | ATE401076T1 (https=) |
| AU (1) | AU2003282233A1 (https=) |
| DE (1) | DE60322267D1 (https=) |
| ES (1) | ES2307992T3 (https=) |
| GB (1) | GB0226931D0 (https=) |
| WO (1) | WO2004045614A1 (https=) |
Families Citing this family (49)
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| SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| GB0328178D0 (en) * | 2003-12-05 | 2004-01-07 | Astrazeneca Ab | Compounds |
| FR2864535B1 (fr) | 2003-12-24 | 2006-12-22 | Merck Sante Sas | Derives acides de quinoline et leurs applications en therapeutique |
| KR20070007104A (ko) * | 2004-02-18 | 2007-01-12 | 아스트라제네카 아베 | 화합물 |
| BRPI0507746A (pt) * | 2004-02-18 | 2007-07-10 | Astrazeneca Ab | composto ou um sal, pró-droga ou solvato do mesmo, composição farmacêutica, método de tratar doenças mediadas por glk, e, processo para a preparação de um composto |
| TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| KR20070085371A (ko) * | 2004-10-16 | 2007-08-27 | 아스트라제네카 아베 | 페녹시 벤즈아미드 화합물의 제조 방법 |
| GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| EP1891069A1 (en) * | 2005-05-24 | 2008-02-27 | AstraZeneca AB | 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators |
| TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
| JP2009500442A (ja) * | 2005-07-09 | 2009-01-08 | アストラゼネカ アクチボラグ | ２型糖尿病を処置するためのグルコキナーゼのモジュレーターとしての２−ヘテロシクリルオキシベンゾイルアミノヘテロシクリル化合物 |
| KR101346902B1 (ko) * | 2005-07-09 | 2014-01-02 | 아스트라제네카 아베 | 당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체 |
| JP2009504621A (ja) * | 2005-08-09 | 2009-02-05 | アストラゼネカ アクチボラグ | 糖尿病の処置のためのヘテロアリールカルバモイルベンゼン誘導体 |
| US9202182B2 (en) * | 2005-08-11 | 2015-12-01 | International Business Machines Corporation | Method and system for analyzing business architecture |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| CA2624102A1 (en) | 2005-09-29 | 2007-04-12 | Sanofi-Aventis | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
| NZ567858A (en) * | 2005-11-01 | 2011-08-26 | Array Biopharma Inc | Pyridine compounds useful as Glucokinase activators |
| TW200738621A (en) * | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
| EP2001875A2 (en) | 2006-03-08 | 2008-12-17 | Takeda San Diego, Inc. | Glucokinase activators |
| EP2010520B1 (en) * | 2006-04-20 | 2012-09-12 | Pfizer Products Inc. | Heterobicyclic amides for the prevention and treatment of glucokinase-mediated diseases |
| EP2049518B1 (en) | 2006-05-31 | 2011-08-31 | Takeda San Diego, Inc. | Indazole and isoindole derivatives as glucokinase activating agents. |
| TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
| TW200825060A (en) * | 2006-10-26 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
| US8163779B2 (en) | 2006-12-20 | 2012-04-24 | Takeda San Diego, Inc. | Glucokinase activators |
| KR20090090390A (ko) | 2006-12-21 | 2009-08-25 | 아스트라제네카 아베 | Ｇｌｋ 활성제로서 유용한 신규 결정 화합물 |
| US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
| EP2324028A2 (en) | 2008-08-04 | 2011-05-25 | AstraZeneca AB | Therapeutic agents 414 |
| EP2348857B1 (en) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
| GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
| AR076221A1 (es) * | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad |
| WO2010116177A1 (en) | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity |
| AU2010241564B2 (en) | 2009-04-30 | 2014-07-31 | Midwestern University | Novel therapeutic treatments using centhaquin |
| JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| SG192941A1 (en) | 2011-02-25 | 2013-09-30 | Merck Sharp & Dohme | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| WO2012158474A1 (en) * | 2011-05-17 | 2012-11-22 | Merck Sharp & Dohme Corp. | N-linked quinolineamide m1 receptor positive allosteric modulators |
| RU2015106909A (ru) | 2012-08-02 | 2016-09-27 | Мерк Шарп И Доум Корп. | Антидиабетические трициклические соединения |
| KR20150118158A (ko) | 2013-02-22 | 2015-10-21 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨병 비시클릭 화합물 |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| EP3191452A1 (de) | 2014-09-09 | 2017-07-19 | Bayer Pharma Aktiengesellschaft | Substituierte n,2-diarylchinolin-4-carboxamide und ihre anti-inflammatorische verwendung |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| EP3558298B1 (en) | 2016-12-20 | 2026-03-11 | Merck Sharp & Dohme LLC | Antidiabetic spirochroman compounds |
| US11136296B2 (en) | 2017-04-10 | 2021-10-05 | Bayer Aktiengesellschaft | Substituted N-arylethyl-2-arylquinoline-4-carboxamides and use thereof |
| TWI770157B (zh) | 2017-04-10 | 2022-07-11 | 德商拜耳廠股份有限公司 | 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途 |
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| TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| US20080026987A1 (en) | 2004-06-17 | 2008-01-31 | Novo Nordisk A/S | Use of Liver-Selective Glucokinase Activators |
| GB0418046D0 (en) | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Eantioselective process |
| KR100890695B1 (ko) | 2004-08-12 | 2009-03-26 | 프로시디온 리미티드 | 치환된 페닐아세트아미드 및 글루코키나제 활성화제로서의그의 용도 |
| GB0418058D0 (en) | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Fluorination process |
| GB0423044D0 (en) | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| GB0423043D0 (en) | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| KR20070085371A (ko) | 2004-10-16 | 2007-08-27 | 아스트라제네카 아베 | 페녹시 벤즈아미드 화합물의 제조 방법 |
-
2002
- 2002-11-19 GB GBGB0226931.4A patent/GB0226931D0/en not_active Ceased
-
2003
- 2003-11-13 AT AT03773851T patent/ATE401076T1/de not_active IP Right Cessation
- 2003-11-13 JP JP2004552854A patent/JP2006514626A/ja not_active Withdrawn
- 2003-11-13 DE DE60322267T patent/DE60322267D1/de not_active Expired - Fee Related
- 2003-11-13 AU AU2003282233A patent/AU2003282233A1/en not_active Abandoned
- 2003-11-13 EP EP03773851A patent/EP1583532B1/en not_active Expired - Lifetime
- 2003-11-13 WO PCT/GB2003/004915 patent/WO2004045614A1/en not_active Ceased
- 2003-11-13 ES ES03773851T patent/ES2307992T3/es not_active Expired - Lifetime
- 2003-11-13 US US10/534,651 patent/US7230108B2/en not_active Expired - Fee Related
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