JP2004500426A5 - - Google Patents

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Publication number
JP2004500426A5
JP2004500426A5 JP2001576014A JP2001576014A JP2004500426A5 JP 2004500426 A5 JP2004500426 A5 JP 2004500426A5 JP 2001576014 A JP2001576014 A JP 2001576014A JP 2001576014 A JP2001576014 A JP 2001576014A JP 2004500426 A5 JP2004500426 A5 JP 2004500426A5
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JP
Japan
Prior art keywords
compound
disease
pharmaceutical composition
pharmaceutically acceptable
parkinson
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2001576014A
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English (en)
Japanese (ja)
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JP4819280B2 (ja
JP2004500426A (ja
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Publication date
Priority claimed from SE0001438A external-priority patent/SE0001438D0/xx
Application filed filed Critical
Publication of JP2004500426A publication Critical patent/JP2004500426A/ja
Publication of JP2004500426A5 publication Critical patent/JP2004500426A5/ja
Application granted granted Critical
Publication of JP4819280B2 publication Critical patent/JP4819280B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2001576014A 2000-04-18 2001-04-17 カテコールアミンのプロドラッグとしてのフェニルエチルアミンおよび縮合環のヴァリアント（ｖａｒｉａｎｔ）、ならびにその使用 Expired - Fee Related JP4819280B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0001438-1 2000-04-18
SE0001438A SE0001438D0 (sv) 2000-04-18 2000-04-18 New chemical compounds and their use in therapy
PCT/SE2001/000840 WO2001078713A1 (en) 2000-04-18 2001-04-17 Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use

Publications (3)

Publication Number Publication Date
JP2004500426A JP2004500426A (ja) 2004-01-08
JP2004500426A5 true JP2004500426A5 (https=) 2008-06-19
JP4819280B2 JP4819280B2 (ja) 2011-11-24

Family

ID=20279367

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001576014A Expired - Fee Related JP4819280B2 (ja) 2000-04-18 2001-04-17 カテコールアミンのプロドラッグとしてのフェニルエチルアミンおよび縮合環のヴァリアント（ｖａｒｉａｎｔ）、ならびにその使用

Country Status (19)

Country Link
US (4) US6683087B2 (https=)
EP (1) EP1274411B1 (https=)
JP (1) JP4819280B2 (https=)
CN (2) CN100383126C (https=)
AT (1) ATE300290T1 (https=)
AU (2) AU4898201A (https=)
CA (1) CA2406044C (https=)
CZ (1) CZ20023455A3 (https=)
DE (1) DE60112269T2 (https=)
DK (1) DK1274411T3 (https=)
ES (1) ES2244604T3 (https=)
HU (1) HU229794B1 (https=)
NZ (1) NZ521860A (https=)
PL (1) PL204661B1 (https=)
PT (1) PT1274411E (https=)
SE (1) SE0001438D0 (https=)
SI (1) SI1274411T1 (https=)
WO (1) WO2001078713A1 (https=)
ZA (1) ZA200207919B (https=)

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* Cited by examiner, † Cited by third party
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WO2007013965A2 (en) * 2005-07-22 2007-02-01 Sloan-Kettering Institute For Cancer Research Synthesis of scabronines and analogues thereof
US7910623B2 (en) * 2005-07-22 2011-03-22 Sloan-Kettering Institute For Cancer Research Synthesis of scabronines and analogues thereof
AR058439A1 (es) 2005-07-26 2008-02-06 Portela & Ca Sa Derivados de nitrocatecol como inhibidores de comt. procesos de obtencion y composiciones farmaceuticas.
EP1845097A1 (en) * 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazole derivatives as COMT inhibitors
EP2481410B1 (en) 2007-01-31 2016-07-13 BIAL - Portela & Ca., S.A. Nitrocatechol derivates as COMT inhibitors administered with a specific dosage regime
US8129530B2 (en) 2007-08-31 2012-03-06 H. Lundbeck A/S Catecholamine derivatives and prodrugs thereof
KR20110002462A (ko) 2008-03-17 2011-01-07 바이알 - 포르텔라 앤드 씨에이 에스에이 5-[3-(2,5-디클로로-4,6-디메틸-1-옥시-피리딘-3-일)-[1,2,4]옥사디아졸-5-일]-3-나이트로벤젠-1,2-디올의 결정형
TW201036949A (en) * 2009-02-27 2010-10-16 Lundbeck & Co As H Treatment of dyskinesia related disorders
AU2010231961B2 (en) 2009-04-01 2015-05-21 Bial - Portela & Ca., S.A. Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof
US8492538B1 (en) * 2009-06-04 2013-07-23 Jose R. Matos Cyclodextrin derivative salts
US8558016B2 (en) * 2009-09-18 2013-10-15 Kabaushiki Kaisha Riverson Polyphenol derivative and method for producing the same
US20140045900A1 (en) 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
WO2013089573A1 (en) 2011-12-13 2013-06-20 BIAL - PORTELA & Cª., S.A. Chemical compound useful as intermediate for preparing a catechol-o-methyltransferase inhibitor
JP2018500300A (ja) 2014-11-28 2018-01-11 ノヴィファーマ，エス．アー． パーキンソン病を遅延させるための医薬
JP7320507B2 (ja) 2017-11-24 2023-08-03 ハー・ルンドベック・アクチエゼルスカベット パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
EP3972971A1 (en) 2019-05-21 2022-03-30 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's diseases
JP7562562B2 (ja) 2019-05-21 2024-10-07 ハー・ルンドベック・アクチエゼルスカベット パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ
WO2020234274A1 (en) 2019-05-21 2020-11-26 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's disease
CN113727712B (zh) 2019-05-21 2024-11-15 H.隆德贝克有限公司 用于治疗帕金森病的儿茶酚胺氨基甲酸酯前药
CN116568672B (zh) 2020-11-17 2026-03-24 H.隆德贝克有限公司 用于治疗帕金森病的新儿茶酚胺前药
JP2025514341A (ja) 2022-04-25 2025-05-02 インテグレーティブ リサーチ ラボラトリーズ スウェーデン アーベー 新規１，２，３，４，４ａ，５，６，７，８，９，１０，１０ａ－ドデカヒドロベンゾ［Ｇ］キノリン－６－オール化合物及びその使用
WO2023208867A1 (en) 2022-04-25 2023-11-02 Integrative Research Laboratories Sweden Ab NOVEL 1,2,3,4,4a,5,8,9,10,10a-DECAHYDROBENZO[G]QUINOLIN-6(7H)-ONE COMPOUNDS AND USES THEREOF
CN119053585A (zh) 2022-04-25 2024-11-29 综合研究实验室瑞典股份公司 新颖1,2,3,4,4a,5,6,7,8,9,10,10a-十二氢苯并[G]喹啉-6-醇酯化合物及其用途
WO2025078574A1 (en) 2023-10-12 2025-04-17 Integrative Research Laboratories Sweden Ab NOVEL ESTERS OF 1,2,3,4,4a,5,6,7,8,9,10,10a-DODECAHYDROBENZO[g]QUINOLIN-6-OL COMPOUNDS AND USES THEREOF
WO2025078571A1 (en) 2023-10-12 2025-04-17 Integrative Research Laboratories Sweden Ab NOVEL CARBONATES AND CARBAMATES OF 1,2,3,4,4a,5,6,7,8,9,10,10a- DODECAHYDROBENZO[g]QUINOLIN-6-OL COMPOUNDS AND USES THEREOF

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US3991207A (en) * 1971-03-18 1976-11-09 Pfizer Inc. Combination therapy for Parkinson's disease
GB1593888A (en) * 1977-12-22 1981-07-22 Wyeth John & Brother Ltd Hexahydroazepine piperidine and pyrrolidine derivatives
ZA805648B (en) * 1979-09-14 1982-04-28 Sandoz Ltd Tetraline derivatives, their production and pharmaceutical compositions containing them
DE3062971D1 (en) 1979-09-14 1983-06-09 Sandoz Ag Derivatives of tetraline, their preparation and medicaments containing these compounds
DE3280252D1 (de) * 1981-10-16 1990-10-31 Sandoz Ag 1,2,3,4,4a,5,10,10a-octahydrobenzo(g)chinolin-derivate mit pharmazeutischer wirkung.
WO1991000727A1 (en) 1989-07-05 1991-01-24 Whitby Research, Inc. Substituted 2-aminotetralins
DE69231854T2 (de) * 1991-04-17 2001-10-04 Pharmacia & Upjohn Co., Kalamazoo Substituierte (s)-3-phenylpiperidin derivate, deren herstellung und deren verwendung als dopamin autorezeptor antagonisten
DE4114325A1 (de) 1991-05-02 1992-11-05 Sandoz Ag Octahydrobenzo(g)chinolin, seine herstellung und verwendung
GB2260980A (en) * 1991-10-31 1993-05-05 Shell Int Research Preparation of unsaturated cyclic ketones
GB9326010D0 (en) * 1993-12-21 1994-02-23 Sandoz Ltd Improvements in or relating to organic compounds
DE69835004T2 (de) * 1997-08-07 2007-03-01 Fujimoto Brothers Co., Ltd., Matubara Neue ethylaminderivate
AU4413999A (en) * 1998-07-28 2000-02-21 Warner-Lambert Company Hexahydro-naphthalenone oximes and hydrazones
SV2001000202A (es) * 1999-10-20 2001-10-16 Warner Lambert Co Uso de (-)-5-ceto-2-n,n-d1-n-propilamino-tetrahidrotetralina para el tratamiento del mal de parkinson

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