JP2005511559A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005511559A5 JP2005511559A5 JP2003539677A JP2003539677A JP2005511559A5 JP 2005511559 A5 JP2005511559 A5 JP 2005511559A5 JP 2003539677 A JP2003539677 A JP 2003539677A JP 2003539677 A JP2003539677 A JP 2003539677A JP 2005511559 A5 JP2005511559 A5 JP 2005511559A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- pyridin
- compound
- amine
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 27
- 150000003839 salts Chemical class 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- -1 3,4-dihydro-naphthalen-2-yl Chemical group 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 230000004770 neurodegeneration Effects 0.000 claims 5
- 208000002193 Pain Diseases 0.000 claims 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 4
- 230000001684 chronic effect Effects 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- VXARDGMDMUMINC-UHFFFAOYSA-N 2-(2-phenylethenyl)pyridin-3-amine Chemical compound NC1=CC=CN=C1C=CC1=CC=CC=C1 VXARDGMDMUMINC-UHFFFAOYSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims 2
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 208000005298 acute pain Diseases 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- MKRTXPORKIRPDG-UHFFFAOYSA-N diphenylphosphoryl azide Chemical compound C=1C=CC=CC=1P(=O)(N=[N+]=[N-])C1=CC=CC=C1 MKRTXPORKIRPDG-UHFFFAOYSA-N 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- BALMNUYDNZTRGL-UHFFFAOYSA-N 2-(3,4-dihydronaphthalen-2-yl)-6-methylpyridin-4-amine Chemical compound CC1=CC(N)=CC(C=2CCC3=CC=CC=C3C=2)=N1 BALMNUYDNZTRGL-UHFFFAOYSA-N 0.000 claims 1
- KGFGDIMGKWUXPR-UHFFFAOYSA-N 2-(3,4-dihydronaphthalen-2-yl)pyridin-4-amine Chemical compound NC1=CC=NC(C=2CCC3=CC=CC=C3C=2)=C1 KGFGDIMGKWUXPR-UHFFFAOYSA-N 0.000 claims 1
- DLGPEZQGUDCXJM-UHFFFAOYSA-N 2-(5,7-dimethyl-3,4-dihydronaphthalen-2-yl)pyridin-4-amine Chemical compound C=1C2=CC(C)=CC(C)=C2CCC=1C1=CC(N)=CC=N1 DLGPEZQGUDCXJM-UHFFFAOYSA-N 0.000 claims 1
- VPEVEVRKQIKMEA-UHFFFAOYSA-N 2-(6,7-dihydro-1-benzothiophen-5-yl)pyridin-4-amine Chemical compound NC1=CC=NC(C=2CCC=3SC=CC=3C=2)=C1 VPEVEVRKQIKMEA-UHFFFAOYSA-N 0.000 claims 1
- MTXVPTXXMDUOII-UHFFFAOYSA-N 2-(7-chloro-3,4-dihydronaphthalen-2-yl)-6-ethylpyridin-4-amine Chemical compound CCC1=CC(N)=CC(C=2CCC3=CC=C(Cl)C=C3C=2)=N1 MTXVPTXXMDUOII-UHFFFAOYSA-N 0.000 claims 1
- ZHMNZUJREAWPIV-UHFFFAOYSA-N 2-(7-chloro-3,4-dihydronaphthalen-2-yl)-6-methylpyridin-4-amine Chemical compound CC1=CC(N)=CC(C=2CCC3=CC=C(Cl)C=C3C=2)=N1 ZHMNZUJREAWPIV-UHFFFAOYSA-N 0.000 claims 1
- KADSWFSQJACMOT-UHFFFAOYSA-N 2-(7-chloro-3,4-dihydronaphthalen-2-yl)pyridin-4-amine Chemical compound NC1=CC=NC(C=2CCC3=CC=C(Cl)C=C3C=2)=C1 KADSWFSQJACMOT-UHFFFAOYSA-N 0.000 claims 1
- HROXYBXSZXJQQN-VOTSOKGWSA-N 2-[(e)-2-phenylethenyl]pyridin-4-amine Chemical compound NC1=CC=NC(\C=C\C=2C=CC=CC=2)=C1 HROXYBXSZXJQQN-VOTSOKGWSA-N 0.000 claims 1
- GNTNYOIAUFZGPK-UHFFFAOYSA-N 2-methyl-6-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridin-4-amine Chemical compound C=1C2=CC=CC=C2C(C)CC=1C1=CC(N)=CC(C)=N1 GNTNYOIAUFZGPK-UHFFFAOYSA-N 0.000 claims 1
- WLDMSTVZYSHYAN-UHFFFAOYSA-N 4-(2-phenylethenyl)pyridin-2-amine Chemical compound C1=NC(N)=CC(C=CC=2C=CC=CC=2)=C1 WLDMSTVZYSHYAN-UHFFFAOYSA-N 0.000 claims 1
- JNKAKPOJAADXPI-BQYQJAHWSA-N 4-methyl-6-[(e)-2-phenylethenyl]pyridin-2-amine Chemical compound CC1=CC(N)=NC(\C=C\C=2C=CC=CC=2)=C1 JNKAKPOJAADXPI-BQYQJAHWSA-N 0.000 claims 1
- VZOYVGQAPOCCMI-UHFFFAOYSA-N 6-(2-phenylethenyl)pyridin-2-amine Chemical compound NC1=CC=CC(C=CC=2C=CC=CC=2)=N1 VZOYVGQAPOCCMI-UHFFFAOYSA-N 0.000 claims 1
- XHUQFKUYBTVYNB-BQYQJAHWSA-N 6-methyl-4-[(e)-2-phenylethenyl]pyridin-2-amine Chemical compound NC1=NC(C)=CC(\C=C\C=2C=CC=CC=2)=C1 XHUQFKUYBTVYNB-BQYQJAHWSA-N 0.000 claims 1
- POZGKKTZKLMMIG-UHFFFAOYSA-N [4-amino-6-(3,4-dihydronaphthalen-2-yl)pyridin-2-yl]methanol Chemical compound NC1=CC(CO)=NC(C=2CCC3=CC=CC=C3C=2)=C1 POZGKKTZKLMMIG-UHFFFAOYSA-N 0.000 claims 1
- IMJOZNZWAXXSQG-MDZDMXLPSA-N [6-[(e)-2-phenylethenyl]pyridin-2-yl]methanamine Chemical compound NCC1=CC=CC(\C=C\C=2C=CC=CC=2)=N1 IMJOZNZWAXXSQG-MDZDMXLPSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- LSCYTCMNCWMCQE-UHFFFAOYSA-N n-methylpyridin-4-amine Chemical compound CNC1=CC=NC=C1 LSCYTCMNCWMCQE-UHFFFAOYSA-N 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01125765 | 2001-10-29 | ||
| PCT/EP2002/011782 WO2003037333A1 (en) | 2001-10-29 | 2002-10-22 | Pyridine derivatives as nmda-receptor subtype blockers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005511559A JP2005511559A (ja) | 2005-04-28 |
| JP2005511559A5 true JP2005511559A5 (https=) | 2005-12-22 |
Family
ID=8179103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003539677A Pending JP2005511559A (ja) | 2001-10-29 | 2002-10-22 | Ｎｍｄａ受容体サブタイプブロッカーとしてのピリジン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US6951875B2 (https=) |
| EP (1) | EP1443926A1 (https=) |
| JP (1) | JP2005511559A (https=) |
| KR (1) | KR100591935B1 (https=) |
| CN (2) | CN1578662A (https=) |
| AR (1) | AR037249A1 (https=) |
| BR (1) | BR0213572A (https=) |
| CA (1) | CA2464888A1 (https=) |
| MX (1) | MXPA04003935A (https=) |
| PL (1) | PL370693A1 (https=) |
| RU (1) | RU2004116473A (https=) |
| WO (1) | WO2003037333A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030073712A1 (en) * | 2001-07-23 | 2003-04-17 | Bing Wang | Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods |
| EP1802587A4 (en) * | 2004-10-15 | 2010-02-17 | Astrazeneca Ab | SUBSTITUTED AMINO BINDINGS AND THEIR APPLICATIONS |
| WO2006041405A1 (en) * | 2004-10-15 | 2006-04-20 | Astrazeneca Ab | Substituted amino-pyrimidones and uses thereof |
| EP1831170A4 (en) * | 2004-12-14 | 2009-10-14 | Astrazeneca Ab | SUBSTITUTED AMINOPYRIDINES AND THEIR USE |
| CN101360720A (zh) * | 2005-11-15 | 2009-02-04 | 阿斯利康(瑞典)有限公司 | 新颖的2-氨基嘧啶酮衍生物及其用途 |
| WO2007058582A1 (en) * | 2005-11-15 | 2007-05-24 | Astrazeneca Ab | Novel 2-aminopyrimidinone or 2-aminopyridinone derivatives and their use |
| AR058381A1 (es) * | 2005-12-19 | 2008-01-30 | Astrazeneca Ab | Compuestos derivados de 2-aminopiridin-4-onas y una composicion farmaceutica |
| US20090099217A1 (en) * | 2006-04-05 | 2009-04-16 | Astex Therapeutics Ltd. | 2-Aminopyrimidin-4-Ones And Their Use For Treating Or Preventing Alpha Beta-Related Pathologies |
| US8340014B2 (en) | 2007-12-26 | 2012-12-25 | Lg Electronics Inc. | Method for transmitting and receiving signals using multi-band radio frequencies |
| MX344772B (es) * | 2011-01-28 | 2017-01-06 | Univ Kentucky Res Found | Analogos de estilbeno y metodos para tratar cancer. |
| US8993258B2 (en) * | 2012-06-12 | 2015-03-31 | The University Of Connecticut | Fluorinated voltage sensitive dyes, preparation thereof, and optical methods of use |
| EP3283487B1 (en) * | 2015-04-15 | 2019-10-16 | H. Hoffnabb-La Roche Ag | Pyridopyrimidinones and their use as nmda receptor modulators |
| US10300155B2 (en) | 2015-12-31 | 2019-05-28 | Washington University | Alpha-synuclein ligands |
| US10449186B2 (en) | 2017-06-21 | 2019-10-22 | University Of Kentucky Research Foundation | Phenylethynyl-substituted benzenes and heterocycles for the treatment of cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5648369A (en) | 1991-11-20 | 1997-07-15 | University Of Kentucky Research Foundation | Aminoalkylpyridine compounds which are useful as anitconvulsant drugs, excitatory amino acid inhibitors and NMDA sigma receptor antagonists |
| CA2187214C (en) * | 1994-04-06 | 2002-03-12 | Hiroyoshi Hidaka | Aminostilbazole derivative and medicine |
| PT885004E (pt) | 1996-03-08 | 2002-08-30 | Hoffmann La Roche | Utilizacao de derivados de 4-fenil-3,6-di-hidro-2h-piridilo como bloqueadores dos subtipos dos receptores nmda |
| US5869676A (en) | 1997-05-15 | 1999-02-09 | Vion Pharmaceuticals, Inc. | Process for the synthesis of ribonucleotide reductase inhibitors 3-AP and 3-AMP |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| TWI254043B (en) | 1999-06-08 | 2006-05-01 | Hoffmann La Roche | Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor |
| EP1070708B1 (en) | 1999-07-21 | 2004-01-14 | F. Hoffmann-La Roche Ag | Triazole derivatives |
| DK1088818T3 (da) | 1999-10-01 | 2005-03-14 | Hoffmann La Roche | Quinolin-4-yl-derivater |
-
2002
- 2002-10-21 US US10/277,002 patent/US6951875B2/en not_active Expired - Fee Related
- 2002-10-22 KR KR1020047006334A patent/KR100591935B1/ko not_active Expired - Fee Related
- 2002-10-22 CN CNA028214242A patent/CN1578662A/zh active Pending
- 2002-10-22 EP EP02782972A patent/EP1443926A1/en not_active Withdrawn
- 2002-10-22 PL PL02370693A patent/PL370693A1/xx not_active Application Discontinuation
- 2002-10-22 RU RU2004116473/04A patent/RU2004116473A/ru not_active Application Discontinuation
- 2002-10-22 JP JP2003539677A patent/JP2005511559A/ja active Pending
- 2002-10-22 WO PCT/EP2002/011782 patent/WO2003037333A1/en not_active Ceased
- 2002-10-22 BR BR0213572-8A patent/BR0213572A/pt not_active IP Right Cessation
- 2002-10-22 MX MXPA04003935A patent/MXPA04003935A/es unknown
- 2002-10-22 CN CNA2006100670615A patent/CN1837195A/zh active Pending
- 2002-10-22 CA CA002464888A patent/CA2464888A1/en not_active Abandoned
- 2002-10-25 AR ARP020104048A patent/AR037249A1/es not_active Application Discontinuation
-
2003
- 2003-09-26 US US10/672,950 patent/US7034044B2/en not_active Expired - Fee Related
-
2005
- 2005-10-21 US US11/255,526 patent/US20060058354A1/en not_active Abandoned