JP2004517128A5 - - Google Patents
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- Publication number
- JP2004517128A5 JP2004517128A5 JP2002555749A JP2002555749A JP2004517128A5 JP 2004517128 A5 JP2004517128 A5 JP 2004517128A5 JP 2002555749 A JP2002555749 A JP 2002555749A JP 2002555749 A JP2002555749 A JP 2002555749A JP 2004517128 A5 JP2004517128 A5 JP 2004517128A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- nha
- cycloalkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000547 substituted alkyl group Chemical group 0.000 description 18
- 150000001875 compounds Chemical class 0.000 description 17
- 125000000623 heterocyclic group Chemical group 0.000 description 16
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 14
- 125000000217 alkyl group Chemical group 0.000 description 12
- 125000003118 aryl group Chemical group 0.000 description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 11
- 125000004093 cyano group Chemical group *C#N 0.000 description 10
- 229910052736 halogen Inorganic materials 0.000 description 10
- 150000002367 halogens Chemical class 0.000 description 10
- -1 -C (= O) NH 2 Chemical group 0.000 description 8
- 125000005017 substituted alkenyl group Chemical group 0.000 description 8
- 125000004426 substituted alkynyl group Chemical group 0.000 description 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 6
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 125000001424 substituent group Chemical group 0.000 description 6
- 229910052717 sulfur Inorganic materials 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 4
- 125000000753 cycloalkyl group Chemical group 0.000 description 4
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 4
- 125000002950 monocyclic group Chemical group 0.000 description 4
- 125000003107 substituted aryl group Chemical group 0.000 description 4
- 125000002373 5 membered heterocyclic group Chemical group 0.000 description 3
- 125000006413 ring segment Chemical group 0.000 description 3
- 0 CCIC*(C)CCN(*)*(C)C Chemical compound CCIC*(C)CCN(*)*(C)C 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 125000002619 bicyclic group Chemical group 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 2
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 2
- GHURHFMYQRJGDU-RXMQYKEDSA-N C(C1)[C@H]2C3=C1C=C23 Chemical compound C(C1)[C@H]2C3=C1C=C23 GHURHFMYQRJGDU-RXMQYKEDSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007942 carboxylates Chemical group 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26210701P | 2001-01-16 | 2001-01-16 | |
| SE0103650A SE0103650D0 (sv) | 2001-11-01 | 2001-11-01 | Therapeutic heterocyclic compounds |
| PCT/SE2002/000068 WO2002055012A2 (en) | 2001-01-16 | 2002-01-15 | Therapeutic heterocyclic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004517128A JP2004517128A (ja) | 2004-06-10 |
| JP2004517128A5 true JP2004517128A5 (https=) | 2009-03-05 |
| JP4280067B2 JP4280067B2 (ja) | 2009-06-17 |
Family
ID=26655583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002555749A Expired - Fee Related JP4280067B2 (ja) | 2001-01-16 | 2002-01-15 | 治療用ヘテロ環式化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US6812225B2 (https=) |
| EP (1) | EP1353913A2 (https=) |
| JP (1) | JP4280067B2 (https=) |
| KR (2) | KR100864356B1 (https=) |
| CN (1) | CN100509794C (https=) |
| AR (2) | AR035733A1 (https=) |
| AU (1) | AU2002217742B2 (https=) |
| BR (1) | BR0206512A (https=) |
| CA (1) | CA2434152A1 (https=) |
| IL (1) | IL156595A0 (https=) |
| MX (1) | MXPA03006250A (https=) |
| NO (1) | NO20033203L (https=) |
| NZ (2) | NZ535574A (https=) |
| SA (1) | SA02220710B1 (https=) |
| WO (1) | WO2002055012A2 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000001793A (ko) * | 1998-06-13 | 2000-01-15 | 이경하 | 신규한 벤조피란 또는 티오벤조피란 유도체 |
| SE0103646D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic chroman compounds |
| NZ535574A (en) | 2001-01-16 | 2006-07-28 | Astrazeneca Ab | Therapeutic heterocyclic compounds |
| SE0103649D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinoline compounds |
| SE0103648D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinolone compounds |
| US6963002B2 (en) * | 2003-07-04 | 2005-11-08 | Glenmark Pharmaceuticals Limited | Process for the preparation of 4,4-dimethyl-6-ethynylthiochroman |
| GB0322510D0 (en) * | 2003-09-25 | 2003-10-29 | Glaxo Group Ltd | Novel compounds |
| AU2005286648A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| CA2580762A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| AR051091A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| EP2289510A1 (en) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| CA2580857A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| EP1807085B1 (en) | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| EP1856126A2 (en) | 2005-02-17 | 2007-11-21 | Wyeth a Corporation of the State of Delaware | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
| US7538113B2 (en) | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
| US7582636B2 (en) | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
| AU2006343359A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| AU2006286654A1 (en) | 2005-07-27 | 2007-03-08 | F. Hoffmann-La Roche Ag | 4-aryloxy quinoline derivatives as 5-HT6 modulators |
| WO2007053093A1 (en) * | 2005-11-04 | 2007-05-10 | Astrazeneca Ab | Chroman compounds as 5 ht1b antagonists |
| UY29892A1 (es) * | 2005-11-04 | 2007-06-29 | Astrazeneca Ab | Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones |
| UY29896A1 (es) * | 2005-11-04 | 2007-06-29 | Astrazeneca Ab | Nuevos derivados de cromano, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones |
| AR059356A1 (es) * | 2006-02-14 | 2008-03-26 | Astrazeneca Ab | Nuevos radioligandos |
| WO2007097697A1 (en) * | 2006-02-23 | 2007-08-30 | Astrazeneca Ab | Therapeutic quinoline compounds that are 5ht1b modulators |
| WO2008142623A2 (en) * | 2007-05-17 | 2008-11-27 | Piramal Life Sciences Limited | Tumor necrosis factor - alpha inhibitors |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| ES2558152T3 (es) | 2007-06-08 | 2016-02-02 | Janssen Pharmaceutica, N.V. | Derivados de piperidina/piperazina |
| AU2008258560C1 (en) | 2007-06-08 | 2014-04-10 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| ES2536406T3 (es) | 2007-06-08 | 2015-05-25 | Janssen Pharmaceutica, N.V. | Derivados de piperidina/piperazina |
| CN106039505A (zh) * | 2008-06-04 | 2016-10-26 | 瑞思迈有限公司 | 患者接口系统 |
| ES2617619T3 (es) | 2008-06-05 | 2017-06-19 | Janssen Pharmaceutica, N.V. | Combinaciones de fármacos que comprenden un inhibidor de DGAT y un agonista de PPAR |
| US20140182600A1 (en) * | 2012-12-27 | 2014-07-03 | 3M Innovative Properties Company | Filtering face-piece respirator having welded indicia hidden in pleat |
| AU2017275657B2 (en) | 2016-06-02 | 2021-08-19 | Novartis Ag | Potassium channel modulators |
| PL3571193T3 (pl) | 2017-01-23 | 2022-04-25 | Cadent Therapeutics, Inc. | Modulatory kanału potasowego |
| JP7542538B2 (ja) | 2018-09-18 | 2024-08-30 | ニカング セラピューティクス， インコーポレイテッド | Ｓｒｃホモロジー－２ホスファターゼ阻害剤としての縮合三環式環誘導体 |
| EP3870291A1 (en) | 2018-10-22 | 2021-09-01 | Cadent Therapeutics, Inc. | Crystalline forms of potassium channel modulators |
| CA3164134A1 (en) | 2019-12-06 | 2021-06-10 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofurans as modulators of sodium channels |
| MX2023003273A (es) | 2020-09-21 | 2023-04-26 | Landos Biopharma Inc | Ligandos de nlrx1. |
| SI4347031T1 (sl) | 2021-06-04 | 2026-01-30 | Vertex Pharmaceuticals Incorporated | N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov |
| UY40234A (es) | 2022-04-22 | 2023-11-15 | Vertex Pharma | Compuestos heteroarilo para el tratamiento del dolor |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1428186A (en) * | 1972-06-21 | 1976-03-17 | Fujisawa Pharmaceutical Co | Chromone derivatives |
| US3862143A (en) | 1972-12-04 | 1975-01-21 | Warner Lambert Co | Substituted chromone-3-carbonitriles, carboxamides and carboxylic acids |
| US3937837A (en) | 1972-12-04 | 1976-02-10 | Warner-Lambert Company | Substituted chromone-3-carbonitriles, carboxamides and carboxylic acids useful for preventing asthmatic symptoms |
| DE2731566A1 (de) | 1977-07-13 | 1979-02-01 | Bayer Ag | Verfahren zur herstellung von neuen chromon-derivaten, sowie ihre verwendung als pflanzenschutzmittel |
| FR2453170A1 (fr) * | 1979-04-06 | 1980-10-31 | Clin Midy | Acides 5-(2-hydroxy-3-thiopropoxy)chromone-2-carboxyliques et leurs applications comme medicaments presentant notamment des proprietes antianaphylactiques et antiallergiques |
| EP0104018A3 (en) * | 1982-09-21 | 1985-06-26 | FISONS plc | Benzopyran, benzothiapyran and quinoline compounds and pharmaceutical compositions containing them |
| DE3413007A1 (de) * | 1984-04-06 | 1985-10-17 | Audi AG, 8070 Ingolstadt | Lenkeinrichtung fuer ein kraftfahrzeug |
| EP0172352B1 (en) | 1984-06-22 | 1990-08-29 | Beecham Group Plc | Active benzopyran compounds |
| GB8515389D0 (en) | 1985-06-18 | 1985-07-17 | Ici Plc | Heterocyclic compounds |
| IT1190405B (it) | 1985-10-22 | 1988-02-16 | Recordati Chem Pharm | Derivati del flavone |
| US5112856A (en) * | 1986-08-15 | 1992-05-12 | Hoffmann-La Roche Inc. | Therapeutic treatment of intestinal inflammation by administration of 3,4-dihydro-2H-1-benzopyran derivatives |
| US5387587A (en) | 1986-12-23 | 1995-02-07 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chroman derivatives |
| US5171865A (en) | 1988-02-29 | 1992-12-15 | Sanwa Kagaku Kenkyusho Co., Ltd. | Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof |
| DE69005625T2 (de) | 1989-04-27 | 1994-05-11 | Upjohn Co | Substituierte 3-amino-chromane. |
| US5420151A (en) | 1989-12-22 | 1995-05-30 | Aktiebolaget Astra | Chroman derivatives |
| SE8904361D0 (sv) | 1989-12-22 | 1989-12-22 | Astra Ab | New chroman and thiochroman derivatives |
| DE4140542A1 (de) | 1991-12-09 | 1993-06-17 | Bayer Ag | Piperdylmethyl substituierte chormanderivate |
| IT1254469B (it) * | 1992-02-25 | 1995-09-25 | Recordati Chem Pharm | Derivati benzopiranici e benzotiopiranici |
| US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
| AU6936194A (en) * | 1993-06-10 | 1995-01-03 | Yamanouchi Pharmaceutical Co., Ltd. | Novel 8-(2-aminoalkoxy)fluorochroman derivative |
| WO1997007120A1 (en) | 1995-08-11 | 1997-02-27 | Smithkline Beecham Plc | Biphenyl(thio)amide and biphenylethan(thi)one derivatives, their preparation and their use as 5-ht1d receptor antagonists |
| SE9601110D0 (sv) | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| WO1998027080A1 (en) | 1996-12-19 | 1998-06-25 | Agrevo Uk Limited | Chromones useful as fungicides |
| CA2274055A1 (en) | 1996-12-19 | 1998-06-25 | Smithkline Beecham P.L.C. | N-piperazin-1-ylphenyl-benzamide derivatives |
| FR2760014B1 (fr) * | 1997-02-27 | 1999-04-09 | Adir | Nouveaux composes de 2-amino indane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2199645C (en) * | 1997-03-11 | 1999-06-29 | Apotex Inc. | Methods for the manufacture of quinolone carboxylic acids derivatives and intermediates thereof |
| FR2761358B1 (fr) * | 1997-03-27 | 1999-05-07 | Adir | Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP0874043A1 (de) * | 1997-04-10 | 1998-10-28 | Preussag AG | Verfahren zur Herstellung von Biomasse mittels Photosynthese |
| US6034256A (en) * | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
| CZ295937B6 (cs) * | 1997-07-25 | 2005-12-14 | H. Lundbeck A/S | Indolové nebo 2,3-dihydroindolové deriváty |
| SE9703377D0 (sv) | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| SE9703379D0 (sv) | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| SE9703378D0 (sv) | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| WO1999051401A1 (en) * | 1998-04-06 | 1999-10-14 | Acs Industries Inc. | Antimicrobial scrub pad |
| FR2782515B1 (fr) * | 1998-08-21 | 2000-09-22 | Adir | NOUVEAUX DERIVES DE L'INDANE-1-Ol, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT |
| GB9818914D0 (en) | 1998-08-28 | 1998-10-21 | Smithkline Beecham Plc | Use |
| CA2355342A1 (en) * | 1999-01-07 | 2000-07-13 | American Home Products Corporation | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression |
| US6552054B1 (en) * | 1999-09-01 | 2003-04-22 | Takeda Chemical Industries, Ltd. | Chromone derivatives, process for the preparation of the same and uses thereof |
| JP2001261657A (ja) | 2000-03-17 | 2001-09-26 | Yamanouchi Pharmaceut Co Ltd | シアノフェニル誘導体 |
| CN1592745A (zh) | 2001-01-16 | 2005-03-09 | 阿斯特拉曾尼卡有限公司 | 治疗用苯并－γ－吡喃酮化合物 |
| NZ535574A (en) | 2001-01-16 | 2006-07-28 | Astrazeneca Ab | Therapeutic heterocyclic compounds |
| SE0103649D0 (sv) | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinoline compounds |
-
2002
- 2002-01-15 NZ NZ535574A patent/NZ535574A/en unknown
- 2002-01-15 EP EP02729622A patent/EP1353913A2/en not_active Withdrawn
- 2002-01-15 CA CA002434152A patent/CA2434152A1/en not_active Abandoned
- 2002-01-15 KR KR1020037009432A patent/KR100864356B1/ko not_active Expired - Fee Related
- 2002-01-15 BR BR0206512-6A patent/BR0206512A/pt not_active IP Right Cessation
- 2002-01-15 NZ NZ526697A patent/NZ526697A/en unknown
- 2002-01-15 JP JP2002555749A patent/JP4280067B2/ja not_active Expired - Fee Related
- 2002-01-15 IL IL15659502A patent/IL156595A0/xx unknown
- 2002-01-15 CN CNB028063929A patent/CN100509794C/zh not_active Expired - Fee Related
- 2002-01-15 AU AU2002217742A patent/AU2002217742B2/en not_active Ceased
- 2002-01-15 MX MXPA03006250A patent/MXPA03006250A/es active IP Right Grant
- 2002-01-15 WO PCT/SE2002/000068 patent/WO2002055012A2/en not_active Ceased
- 2002-01-15 KR KR1020087020183A patent/KR20080079341A/ko not_active Ceased
- 2002-01-16 AR ARP020100144A patent/AR035733A1/es unknown
- 2002-01-16 US US10/051,776 patent/US6812225B2/en not_active Expired - Fee Related
- 2002-03-11 SA SA02220710A patent/SA02220710B1/ar unknown
-
2003
- 2003-07-15 NO NO20033203A patent/NO20033203L/no not_active Application Discontinuation
-
2004
- 2004-07-12 US US10/889,350 patent/US7045514B2/en not_active Expired - Fee Related
-
2005
- 2005-04-18 US US11/108,587 patent/US7285662B2/en not_active Expired - Fee Related
-
2007
- 2007-09-28 US US11/864,102 patent/US20080076759A1/en not_active Abandoned
-
2008
- 2008-09-11 AR ARP080103946A patent/AR068413A2/es unknown
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