JP2024520481A5 - - Google Patents
Info
- Publication number
- JP2024520481A5 JP2024520481A5 JP2023573047A JP2023573047A JP2024520481A5 JP 2024520481 A5 JP2024520481 A5 JP 2024520481A5 JP 2023573047 A JP2023573047 A JP 2023573047A JP 2023573047 A JP2023573047 A JP 2023573047A JP 2024520481 A5 JP2024520481 A5 JP 2024520481A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- cycloalkyl
- haloalkyl
- tautomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163193990P | 2021-05-27 | 2021-05-27 | |
| US63/193,990 | 2021-05-27 | ||
| PCT/US2022/031141 WO2022251502A1 (en) | 2021-05-27 | 2022-05-26 | Checkpoint kinase 1 (chk1) inhibitors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024520481A JP2024520481A (ja) | 2024-05-24 |
| JP2024520481A5 true JP2024520481A5 (https=) | 2025-06-02 |
Family
ID=84229213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023573047A Pending JP2024520481A (ja) | 2021-05-27 | 2022-05-26 | チェックポイントキナーゼ１（ｃｈｋ１）阻害剤およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11707462B2 (https=) |
| EP (1) | EP4347582A4 (https=) |
| JP (1) | JP2024520481A (https=) |
| KR (1) | KR20240021188A (https=) |
| CN (1) | CN117715905A (https=) |
| AU (1) | AU2022282384A1 (https=) |
| BR (1) | BR112023024571A2 (https=) |
| CA (1) | CA3219348A1 (https=) |
| IL (1) | IL308759A (https=) |
| MX (1) | MX2023014028A (https=) |
| TW (1) | TW202313588A (https=) |
| WO (1) | WO2022251502A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3187760A1 (en) | 2020-08-12 | 2022-02-17 | Boundless Bio, Inc. | Replication stress pathway agent compositions and methods for treating cancer |
| TW202237586A (zh) | 2020-11-30 | 2022-10-01 | 日商住友製藥股份有限公司 | 5-雜芳基-1h-吡唑-3-胺衍生物 |
| BR112023024571A2 (pt) | 2021-05-27 | 2024-02-06 | Boundless Bio Inc | Inibidores de quinase do ponto de verificação 1 (chk1) e usos dos mesmos |
| AU2022421580A1 (en) * | 2021-12-24 | 2024-07-18 | Sumitomo Pharma Co., Ltd. | 1h-pyrazole-3-amine derivative having bicyclic backbone |
| CN119546588A (zh) * | 2022-05-24 | 2025-02-28 | 无界生物公司 | 吡啶检查点激酶1（chk1）抑制剂及其用途 |
| WO2023226658A1 (en) * | 2022-05-25 | 2023-11-30 | Sperogenix Therapeutics Limited | Nitrogen-containing five-membered heterocyclic derivatives as checkpoint kinase 1 inhibitor and uses thereof |
| TW202440549A (zh) * | 2022-11-29 | 2024-10-16 | 美商無界生物公司 | 檢查點激酶１（ｃｈｋ１）抑制劑及其用途 |
| JP2025540059A (ja) * | 2022-11-29 | 2025-12-11 | バウンドレス バイオ，インク． | チェックポイントキナーゼ１（ｃｈｋ１）阻害剤の組合せおよびその使用 |
| WO2024196923A1 (en) * | 2023-03-20 | 2024-09-26 | Boundless Bio, Inc. | Uses of a checkpoint kinase 1 (chk1) inhibitor |
| WO2024211271A1 (en) * | 2023-04-03 | 2024-10-10 | Boundless Bio, Inc. | Checkpoint kinase 1 (chk1) inhibitor pharmaceutical composition |
| WO2024211270A1 (en) * | 2023-04-03 | 2024-10-10 | Boundless Bio, Inc. | Checkpoint kinase 1 (chk1) inhibitor crystalline form and uses thereof |
| WO2025030049A1 (en) * | 2023-08-02 | 2025-02-06 | Health Research, Inc. | Sequential treatment method for p53-deficient cancer |
| WO2025217307A1 (en) | 2024-04-09 | 2025-10-16 | Revolution Medicines, Inc. | Methods for predicting response to a ras(on) inhibitor and combination therapies |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02010222A (es) * | 2000-04-18 | 2003-05-23 | Agouron Pharma | Pirazoles para inhibir proteina cinasa. |
| NZ523656A (en) * | 2000-08-31 | 2004-11-26 | Pfizer Prod Inc | Pyrazole derivatives and their use as protein kinase inhibitors |
| US20050209297A1 (en) * | 2000-08-31 | 2005-09-22 | Pfizer Inc | Pyrazole derivatives |
| PA8850801A1 (es) * | 2008-12-17 | 2010-07-27 | Lilly Co Eli | Compuestos útiles para inhibir chk1 |
| GB201402277D0 (en) * | 2014-02-10 | 2014-03-26 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| CN108601781B (zh) * | 2016-02-04 | 2019-11-22 | 广州必贝特医药技术有限公司 | 作为检测点激酶1(chk1)抑制剂的3,5-二取代吡唑及其制备及应用 |
| US12428395B2 (en) * | 2019-08-01 | 2025-09-30 | Sperogenix Therapeutics Limited | Heterocyclic compounds as kinase inhibitor and uses thereof |
| CN112457306A (zh) * | 2019-09-06 | 2021-03-09 | 上海瑛派药业有限公司 | 3,5-二取代吡唑化合物作为激酶抑制剂及其应用 |
| CN111253370B (zh) | 2020-03-24 | 2021-08-03 | 浙江大学 | N-多取代吡啶-2-氨基嘧啶类衍生物及用途 |
| DK4168401T3 (da) * | 2020-06-19 | 2026-04-13 | Anaxis Pharma Pty Ltd | Sulfonamidforbindelser |
| CA3187760A1 (en) | 2020-08-12 | 2022-02-17 | Boundless Bio, Inc. | Replication stress pathway agent compositions and methods for treating cancer |
| KR20230092972A (ko) | 2020-10-23 | 2023-06-26 | 셀진 코포레이션 | 연충 감염 및 질병의 치료를 위한 헤테로환식 화합물 및 이들의 용도 |
| TW202237586A (zh) * | 2020-11-30 | 2022-10-01 | 日商住友製藥股份有限公司 | 5-雜芳基-1h-吡唑-3-胺衍生物 |
| US11564920B2 (en) | 2020-11-30 | 2023-01-31 | Sumitomo Pharma Co., Ltd. | 5-heteroaryl-1H-pyrazol-3-amine derivative |
| BR112023024571A2 (pt) | 2021-05-27 | 2024-02-06 | Boundless Bio Inc | Inibidores de quinase do ponto de verificação 1 (chk1) e usos dos mesmos |
| AU2022421580A1 (en) | 2021-12-24 | 2024-07-18 | Sumitomo Pharma Co., Ltd. | 1h-pyrazole-3-amine derivative having bicyclic backbone |
| CN119546588A (zh) | 2022-05-24 | 2025-02-28 | 无界生物公司 | 吡啶检查点激酶1（chk1）抑制剂及其用途 |
| WO2023226658A1 (en) | 2022-05-25 | 2023-11-30 | Sperogenix Therapeutics Limited | Nitrogen-containing five-membered heterocyclic derivatives as checkpoint kinase 1 inhibitor and uses thereof |
| WO2023229032A1 (ja) | 2022-05-27 | 2023-11-30 | 住友ファーマ株式会社 | 免疫チェックポイント阻害剤に対して治療抵抗性を示すがんの治療薬 |
| JP2025540059A (ja) | 2022-11-29 | 2025-12-11 | バウンドレス バイオ，インク． | チェックポイントキナーゼ１（ｃｈｋ１）阻害剤の組合せおよびその使用 |
| TW202440549A (zh) | 2022-11-29 | 2024-10-16 | 美商無界生物公司 | 檢查點激酶１（ｃｈｋ１）抑制劑及其用途 |
| WO2024196923A1 (en) | 2023-03-20 | 2024-09-26 | Boundless Bio, Inc. | Uses of a checkpoint kinase 1 (chk1) inhibitor |
| WO2024211271A1 (en) | 2023-04-03 | 2024-10-10 | Boundless Bio, Inc. | Checkpoint kinase 1 (chk1) inhibitor pharmaceutical composition |
| WO2024211270A1 (en) | 2023-04-03 | 2024-10-10 | Boundless Bio, Inc. | Checkpoint kinase 1 (chk1) inhibitor crystalline form and uses thereof |
-
2022
- 2022-05-26 BR BR112023024571A patent/BR112023024571A2/pt unknown
- 2022-05-26 JP JP2023573047A patent/JP2024520481A/ja active Pending
- 2022-05-26 EP EP22812165.3A patent/EP4347582A4/en active Pending
- 2022-05-26 WO PCT/US2022/031141 patent/WO2022251502A1/en not_active Ceased
- 2022-05-26 CN CN202280052765.2A patent/CN117715905A/zh active Pending
- 2022-05-26 MX MX2023014028A patent/MX2023014028A/es unknown
- 2022-05-26 TW TW111119737A patent/TW202313588A/zh unknown
- 2022-05-26 CA CA3219348A patent/CA3219348A1/en active Pending
- 2022-05-26 KR KR1020237044236A patent/KR20240021188A/ko active Pending
- 2022-05-26 AU AU2022282384A patent/AU2022282384A1/en active Pending
- 2022-05-26 IL IL308759A patent/IL308759A/en unknown
- 2022-08-29 US US17/897,667 patent/US11707462B2/en active Active
-
2023
- 2023-06-01 US US18/327,775 patent/US12527790B2/en active Active