JP2022505987A5 - - Google Patents
Info
- Publication number
- JP2022505987A5 JP2022505987A5 JP2021523157A JP2021523157A JP2022505987A5 JP 2022505987 A5 JP2022505987 A5 JP 2022505987A5 JP 2021523157 A JP2021523157 A JP 2021523157A JP 2021523157 A JP2021523157 A JP 2021523157A JP 2022505987 A5 JP2022505987 A5 JP 2022505987A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- haloalkyl
- heterocycloalkyl
- cycloalkyl
- ome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025017826A JP2025090577A (ja) | 2018-10-22 | 2025-02-05 | Ｔｙｋ２阻害剤およびその使用 |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862749003P | 2018-10-22 | 2018-10-22 | |
| US62/749,003 | 2018-10-22 | ||
| US201862756942P | 2018-11-07 | 2018-11-07 | |
| US62/756,942 | 2018-11-07 | ||
| US201962839459P | 2019-04-26 | 2019-04-26 | |
| US62/839,459 | 2019-04-26 | ||
| US201962875449P | 2019-07-17 | 2019-07-17 | |
| US62/875,449 | 2019-07-17 | ||
| US201962893721P | 2019-08-29 | 2019-08-29 | |
| US62/893,721 | 2019-08-29 | ||
| US201962907354P | 2019-09-27 | 2019-09-27 | |
| US62/907,354 | 2019-09-27 | ||
| PCT/US2019/057485 WO2020086616A1 (en) | 2018-10-22 | 2019-10-22 | Tyk2 inhibitors and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025017826A Division JP2025090577A (ja) | 2018-10-22 | 2025-02-05 | Ｔｙｋ２阻害剤およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022505987A JP2022505987A (ja) | 2022-01-14 |
| JP2022505987A5 true JP2022505987A5 (https=) | 2022-10-28 |
| JP7631193B2 JP7631193B2 (ja) | 2025-02-18 |
Family
ID=70330735
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021523157A Active JP7631193B2 (ja) | 2018-10-22 | 2019-10-22 | Ｔｙｋ２阻害剤およびその使用 |
| JP2025017826A Pending JP2025090577A (ja) | 2018-10-22 | 2025-02-05 | Ｔｙｋ２阻害剤およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025017826A Pending JP2025090577A (ja) | 2018-10-22 | 2025-02-05 | Ｔｙｋ２阻害剤およびその使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US11053219B2 (https=) |
| EP (3) | EP4480953B1 (https=) |
| JP (2) | JP7631193B2 (https=) |
| KR (1) | KR102850357B1 (https=) |
| CN (1) | CN113490664B (https=) |
| AU (1) | AU2019364336B2 (https=) |
| BR (1) | BR112021007679A2 (https=) |
| CA (1) | CA3117200A1 (https=) |
| CL (1) | CL2021000989A1 (https=) |
| DK (3) | DK3870579T3 (https=) |
| ES (1) | ES3011855T3 (https=) |
| FI (3) | FI4480953T3 (https=) |
| HR (1) | HRP20250048T1 (https=) |
| HU (1) | HUE070644T2 (https=) |
| IL (1) | IL282487B1 (https=) |
| LT (1) | LT3870579T (https=) |
| MX (1) | MX2021004538A (https=) |
| PL (1) | PL3870579T3 (https=) |
| PT (1) | PT3870579T (https=) |
| RS (1) | RS66346B1 (https=) |
| SA (1) | SA521421806B1 (https=) |
| SG (1) | SG11202104017VA (https=) |
| SI (1) | SI3870579T1 (https=) |
| SM (1) | SMT202500070T1 (https=) |
| UA (1) | UA130518C2 (https=) |
| WO (1) | WO2020086616A1 (https=) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7113023B2 (ja) * | 2017-03-30 | 2022-08-04 | ブリストル－マイヤーズ スクイブ カンパニー | ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法 |
| JP7631193B2 (ja) | 2018-10-22 | 2025-02-18 | アルミス インコーポレイテッド | Ｔｙｋ２阻害剤およびその使用 |
| BR112021013807A2 (pt) | 2019-01-18 | 2021-11-30 | Astrazeneca Ab | Inibidores de pcsk9 e seus métodos de uso |
| MX2021008661A (es) | 2019-01-18 | 2021-08-19 | Astrazeneca Ab | Inhibidores de la pcsk9 y metodos de uso de los mismos. |
| CN111484480B (zh) * | 2019-01-29 | 2023-08-11 | 上海翰森生物医药科技有限公司 | 一种多环类衍生物抑制剂、其制备方法和应用 |
| SG11202108162SA (en) * | 2019-01-30 | 2021-08-30 | Bristol Myers Squibb Co | Amide-disubstituted pyridine or pyridazine compounds |
| US12473290B2 (en) * | 2019-03-05 | 2025-11-18 | Bristol Myers-Squibb Company | Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses |
| PH12021553233A1 (en) | 2019-07-16 | 2022-09-19 | Univ Michigan Regents | Imidazopyrimidines as eed inhibitors and the use thereof |
| WO2021011513A1 (en) * | 2019-07-16 | 2021-01-21 | Bristol-Myers Squibb Company | Prodrugs in the modulation of interleukin |
| WO2021060567A1 (en) | 2019-09-27 | 2021-04-01 | Takeda Pharmaceutical Company Limited | 2-isoindol-1,3,4-oxadiazole derivatives useful as hdac6 inhibitors |
| WO2021170046A1 (en) | 2020-02-26 | 2021-09-02 | Beigene, Ltd. | Tyk-2 inhibitor |
| SMT202400185T1 (it) * | 2020-03-11 | 2024-07-09 | Beijing Innocare Pharma Tech Co Ltd | Composti eterociclici per inibire attività di tyk2 |
| WO2021202652A1 (en) * | 2020-04-01 | 2021-10-07 | Eternity Bioscience Inc. | Tyrosine kinase 2 inhibitors, preparation methods and medicinal uses thereof |
| AU2021254764A1 (en) * | 2020-04-14 | 2022-11-03 | Gossamer Bio Services, Inc. | Substituted pyridines for the treatment of inflammatory diseases |
| CN113563309B (zh) * | 2020-04-28 | 2024-12-13 | 浙江海正药业股份有限公司 | 吡啶类衍生物及其制备方法和用途 |
| CN113735836B (zh) * | 2020-05-28 | 2023-05-30 | 江苏先声药业有限公司 | 哒嗪类化合物及其应用 |
| CN113735837B (zh) * | 2020-05-28 | 2023-09-01 | 江苏先声药业有限公司 | 哒嗪类化合物及其用途 |
| CN113773262B (zh) * | 2020-06-09 | 2024-08-09 | 江苏先声药业有限公司 | 哒嗪类化合物 |
| KR20230042278A (ko) * | 2020-06-22 | 2023-03-28 | 베이진 엘티디 | Tyk-2 저해제 |
| CN114057651B (zh) * | 2020-07-31 | 2025-05-27 | 正大天晴药业集团股份有限公司 | 含酰胺基的tyk2抑制剂化合物 |
| WO2022032484A1 (zh) * | 2020-08-11 | 2022-02-17 | 北京诺诚健华医药科技有限公司 | 哒嗪-3-甲酰胺类化合物、其制备方法及其在医药学上的应用 |
| US20230339977A1 (en) * | 2020-08-13 | 2023-10-26 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compound, and composition and application thereof |
| CN114075220A (zh) * | 2020-08-13 | 2022-02-22 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| TW202227430A (zh) * | 2020-11-17 | 2022-07-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 含氮雜環類衍生物、其製備方法及其在醫藥上的應用 |
| WO2022117016A1 (zh) * | 2020-12-02 | 2022-06-09 | 深圳微芯生物科技股份有限公司 | 羟肟酸酯化合物、其制备方法及其应用 |
| CN116547276A (zh) * | 2020-12-08 | 2023-08-04 | 正大天晴药业集团股份有限公司 | 含酰胺基和杂环烷基的tyk2抑制剂化合物 |
| US12492184B2 (en) | 2020-12-22 | 2025-12-09 | InventisBio Co., Ltd. | Heteroaryl compounds, preparation methods and uses thereof |
| EP4294806A1 (en) | 2021-02-19 | 2023-12-27 | Sudo Biosciences Limited | Tyk2 inhibitors and uses thereof |
| CA3208361A1 (en) | 2021-02-19 | 2022-08-25 | Anjali Pandey | Tyk2 inhibitors and uses thereof |
| AU2022222470A1 (en) | 2021-02-19 | 2023-09-21 | Sudo Biosciences Limited | Tyk2 inhibitors and uses thereof |
| WO2022179578A1 (zh) * | 2021-02-24 | 2022-09-01 | 南京明德新药研发有限公司 | 含有亚磺酰基吡啶结构的化合物以及应用 |
| CN112920103A (zh) * | 2021-03-02 | 2021-06-08 | 康化（上海）新药研发有限公司 | 一种温和制备2-氮杂螺[3.3]庚烷盐酸盐的方法 |
| CA3213816A1 (en) * | 2021-03-16 | 2022-09-22 | Anrui Biomedical Technology (Guangzhou) Co., Ltd. | Amino heteroaryl compounds and compositions |
| CN115197196B (zh) * | 2021-04-06 | 2024-06-18 | 扬子江药业集团有限公司 | Tyk2抑制剂及其用途 |
| TWI804266B (zh) * | 2021-04-07 | 2023-06-01 | 大陸商上海齊魯製藥研究中心有限公司 | Tyk2抑制劑及其用途 |
| JP7740849B2 (ja) * | 2021-05-04 | 2025-09-17 | シャンハイ ゼイ バイオテクノロジー カンパニー リミテッド | 含窒素複素環ピリジン化合物 |
| US11884650B2 (en) * | 2021-05-14 | 2024-01-30 | Bristol-Myers Squibb Company | Substituted heterocyclic compounds |
| KR20240008337A (ko) * | 2021-05-14 | 2024-01-18 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 헤테로시클릭 화합물 |
| WO2022253335A1 (zh) * | 2021-06-02 | 2022-12-08 | 南京明德新药研发有限公司 | 含磺酰基的芳基类化合物及其应用 |
| WO2022253333A1 (zh) * | 2021-06-02 | 2022-12-08 | 南京明德新药研发有限公司 | 酰胺类化合物及其应用 |
| CN115466289A (zh) * | 2021-06-11 | 2022-12-13 | 爱科诺生物医药(香港)有限公司 | 具有tyk2抑制活性的化合物，包含其的药物组合物，及其应用 |
| CA3223641A1 (en) * | 2021-06-22 | 2022-12-29 | Wenyuan Qian | Sulfoximine compound and use thereof |
| JP2024535865A (ja) * | 2021-07-15 | 2024-10-02 | メッドシャイン ディスカバリー インコーポレイテッド | 硫黄／リン含有アリール系化合物及びその使用 |
| CN118159338A (zh) * | 2021-08-10 | 2024-06-07 | 奇特实验室有限责任公司 | 用于毛发治疗的组合物、制剂和方法 |
| CN115724830A (zh) * | 2021-08-31 | 2023-03-03 | 浙江文达医药科技有限公司 | 作为tyk2/jak1假激酶结构域(jh2)抑制剂的化合物及合成和使用方法 |
| EP4410806A1 (en) * | 2021-09-30 | 2024-08-07 | ASKA Pharmaceutical Co., Ltd. | Degradation inducer |
| WO2023064223A1 (en) * | 2021-10-11 | 2023-04-20 | Gossamer Bio Services, Inc. | Tri-substituted pyridines |
| EP4423086A1 (en) | 2021-10-25 | 2024-09-04 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
| AU2022412835A1 (en) | 2021-12-16 | 2024-06-20 | Lynk Pharmaceuticals Co. Ltd. | Tyk2 inhibitors and compositions and methods thereof |
| TW202340203A (zh) * | 2021-12-23 | 2023-10-16 | 英屬開曼群島商百濟神州有限公司 | Ｔｙｋ２抑制劑的固體形式、製備方法及其用途 |
| US20250051360A1 (en) * | 2021-12-23 | 2025-02-13 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compound, and composition and use thereof |
| CN116693449A (zh) | 2022-03-04 | 2023-09-05 | 上海致根医药科技有限公司 | 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用 |
| US20250205211A1 (en) | 2022-03-29 | 2025-06-26 | Alumis Inc. | Tyk2 inhibitors and uses thereof |
| TW202409007A (zh) * | 2022-05-13 | 2024-03-01 | 美商雅盧米斯公司 | Ｔｙｋ２抑制劑之晶型及其用途 |
| AU2023283530A1 (en) * | 2022-06-07 | 2024-08-15 | Guangzhou Fermion Technology Co., Ltd. | Pyridazin-3-carboxamide compound as tyk2 inhibitor |
| EP4538269A1 (en) * | 2022-06-07 | 2025-04-16 | Guangzhou Fermion Technology Co., Ltd. | Substituted pyridazine-3-carboxamide compound serving as tyk2 inhibitor |
| EP4539840A4 (en) * | 2022-06-17 | 2026-04-15 | Sundance Biosciences Inc | Kinase Modulators and Their Methods of Use |
| CN117263913A (zh) * | 2022-06-20 | 2023-12-22 | 益方生物科技(上海)股份有限公司 | 杂芳基化合物、固体形式、制备方法及其用途 |
| CN120661462A (zh) * | 2022-06-20 | 2025-09-19 | 益方生物科技(上海)股份有限公司 | 药物组合物及其用途 |
| KR20250065683A (ko) * | 2022-09-12 | 2025-05-13 | 알루미스 인크. | Tyk2 억제제의 결정질 형태 및 그의 용도 |
| TW202428571A (zh) * | 2022-10-10 | 2024-07-16 | 美商雅盧米斯公司 | Tyk2抑制劑之晶型及其用途 |
| US12251459B2 (en) | 2022-10-12 | 2025-03-18 | Oddity Labs, Llc | Compositions, formulations, and methods for hair treatment |
| CN120152968A (zh) * | 2022-11-08 | 2025-06-13 | 百时美施贵宝公司 | 取代的杂环化合物 |
| WO2024123668A1 (en) * | 2022-12-05 | 2024-06-13 | Oddity Labs, Llc | Compositions, formulations, and methods for hair treatment |
| AR131375A1 (es) | 2022-12-16 | 2025-03-12 | Alembic Pharmaceuticals Ltd | Ligandos de pseudoquinasa tyk2 y sus usos |
| CN116284040B (zh) * | 2023-01-05 | 2024-05-28 | 华润医药研究院（深圳）有限公司 | 含氮杂环类化合物及其医药用途 |
| WO2024173764A1 (en) | 2023-02-16 | 2024-08-22 | Alumis Inc. | Methods of treating hidradenitis suppurativa |
| WO2024257023A1 (en) * | 2023-06-14 | 2024-12-19 | Alembic Pharmaceuticals Limited | Tyk2 pseudokinase ligands and uses thereof |
| WO2025064773A1 (en) | 2023-09-20 | 2025-03-27 | Alumis Inc. | Immediate-release formulations of a tyk2 inhibitor |
| WO2025186427A1 (en) | 2024-03-08 | 2025-09-12 | Curia Spain, S.A.U. | Process for the preparation of deucravacitinib and intermediates thereof and method for purifying deucravacitinib |
| WO2025194074A1 (en) * | 2024-03-15 | 2025-09-18 | Neuron23, Inc. | Kinase modulators and methods of use thereof |
| WO2025240835A2 (en) * | 2024-05-17 | 2025-11-20 | Prelude Therapeutics Incorporated | Jak2 inhibitors and their use as pharmaceuticals |
| WO2026019902A1 (en) * | 2024-07-16 | 2026-01-22 | Alumis Inc. | Crystalline forms of a tyk2 inhibitor and uses thereof |
| WO2026019900A1 (en) * | 2024-07-16 | 2026-01-22 | Alumis Inc. | Crystalline forms of a tyk2 inhibitor and uses thereof |
| WO2026026866A1 (zh) * | 2024-08-02 | 2026-02-05 | 北京普祺医药科技股份有限公司 | 作为tyk2抑制剂的大环化合物及其药物组合物 |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1351691A4 (en) | 2000-12-12 | 2005-06-22 | Cytovia Inc | SUBSTITUTED 2-ARYL-4-ARYLAMINOPYRIMIDINES AND ANALOGUES AS ACTIVATORS OF CASPASES AND APOPTOSIS INDUCERS, AND USE THEREOF |
| AU2003262642B2 (en) | 2002-08-14 | 2010-06-17 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors and uses thereof |
| WO2006105222A2 (en) | 2005-03-25 | 2006-10-05 | Scios Inc. | Carboxamide inhibitors of tgfb |
| US7517882B2 (en) | 2006-09-18 | 2009-04-14 | Polaris Group | Protein kinase inhibitors |
| SG165655A1 (en) | 2008-04-16 | 2010-11-29 | Portola Pharm Inc | 2, 6-diamino- pyrimidin- 5-yl-carboxamides as syk or JAK kinases inhibitors |
| EP2361902A4 (en) | 2008-11-21 | 2012-04-25 | Astellas Pharma Inc | 4,6-DIAMINONICOTINSÄUREAMIDVERBINDUNG |
| LT3009428T (lt) * | 2009-05-08 | 2018-04-10 | Astellas Pharma Inc. | Diamino heterociklinis karboksamido junginys |
| ME03376B (me) | 2010-05-20 | 2020-01-20 | Array Biopharma Inc | Makrociklička jedinjenja kао inhibiтori trk kinaze |
| CA2816219C (en) | 2010-11-01 | 2019-10-29 | Portola Pharmaceuticals, Inc. | Nicotinamides as syk modulators |
| EP2975027A1 (en) * | 2010-11-01 | 2016-01-20 | Portola Pharmaceuticals, Inc. | Nicotinamides as jak kinase modulators |
| CN102250065B (zh) | 2011-05-20 | 2015-05-13 | 浙江海正药业股份有限公司 | 取代的三嗪苯脲衍生物及其用途 |
| WO2013001310A1 (en) | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
| HUE029728T2 (en) | 2011-09-30 | 2017-03-28 | Ipsen Pharma Sas | Macrocyclic LRRK2 kinase inhibitors |
| CN104159891B (zh) | 2012-01-10 | 2016-09-07 | 霍夫曼-拉罗奇有限公司 | 哒嗪酰胺化合物和它们作为syk 抑制剂的用途 |
| LT3495358T (lt) | 2012-11-08 | 2022-05-25 | Bristol-Myers Squibb Company | Amidais pakeisti heterocikliniai junginiai, naudingi kaip il-12, il-23 ir (arba) ifn alfa atsako moduliatoriai |
| US9701689B2 (en) | 2012-11-30 | 2017-07-11 | Kyowa Hakko Kirin Co., Ltd. | Substituted pyridines and pyridazines as CCR10 receptor inhibitors |
| EA201591773A1 (ru) | 2013-03-15 | 2016-01-29 | Онкодизайн С.А. | Макроциклические ингибиторы rip2-киназы |
| PL3040329T3 (pl) * | 2013-08-29 | 2019-04-30 | Kyoto Pharma Ind | Związek aromatyczny i jego zastosowanie w leczeniu chorób związanych z metabolizmem kości |
| TWI582077B (zh) | 2013-11-07 | 2017-05-11 | 必治妥美雅史谷比公司 | 作爲ＩＬ－１２、ＩＬ－２３及／或ＩＦＮα反應調節劑之經烷基－醯胺取代之吡啶化合物 |
| US9382246B2 (en) * | 2013-12-05 | 2016-07-05 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
| ES2933350T3 (es) | 2014-01-24 | 2023-02-06 | Turning Point Therapeutics Inc | Macrociclos de diarilo como moduladores de proteína quinasas |
| US9834548B2 (en) * | 2014-02-14 | 2017-12-05 | Portola Pharmaceuticals, Inc. | Pyridazine compounds as JAK inhibitors |
| CN105111151B (zh) | 2015-04-17 | 2018-09-28 | 成都理工大学 | 作为PPAR-γ调节剂的氨基嘧啶衍生物 |
| MX2017015574A (es) | 2015-06-02 | 2018-08-09 | Pharmacyclics Llc | Inhibidores de tirosina quinasa de bruton. |
| AU2016287568B2 (en) | 2015-07-02 | 2020-08-20 | Turning Point Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
| RU2765181C2 (ru) | 2015-07-06 | 2022-01-26 | Тёрнинг Поинт Терапьютикс, Инк. | Полиморфная форма диарильного макроцикла |
| PT3733187T (pt) | 2015-07-21 | 2024-11-08 | Turning Point Therapeutics Inc | Macrociclo de diarilo quiral e utilização do mesmo no tratamento do cancro |
| EP3368039A1 (en) | 2015-10-26 | 2018-09-05 | The Regents of The University of Colorado, A Body Corporate | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| US10479793B2 (en) | 2015-11-18 | 2019-11-19 | Bristol-Myers Squibb Company | Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses |
| KR102720461B1 (ko) | 2016-01-22 | 2024-10-21 | 잔센파마슈티카엔.브이. | Nik 억제제로서의 신규 6원 헤테로방향족 치환된 시아노인돌린 유도체 |
| US10689400B2 (en) | 2016-07-28 | 2020-06-23 | Turning Point Therapeutics, Inc. | Macrocycle kinase inhibitors |
| ES2902995T3 (es) | 2016-10-07 | 2022-03-30 | Bristol Myers Squibb Co | Compuestos de imidazopiridazina útiles como moduladores de respuestas a IL-12, IL-23 y/o IFN alfa |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JP2020533269A (ja) | 2016-12-14 | 2020-11-19 | デベロップメント センター フォー バイオテクノロジー | 抗体−薬物複合体およびその使用 |
| TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| CN106866660B (zh) | 2017-02-15 | 2019-05-17 | 上海天马有机发光显示技术有限公司 | 电子传输材料、包含其的oled显示面板和电子设备 |
| TW202515876A (zh) | 2017-03-08 | 2025-04-16 | 日商武田藥品工業股份有限公司 | Tyk2抑制劑及其用途 |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| AU2018249154A1 (en) * | 2017-04-03 | 2019-11-21 | Kyoto Pharmaceutical Industries, Ltd. | Novel cyclin-dependent kinase 8 and/or 19 inhibitor |
| WO2018234345A1 (en) | 2017-06-21 | 2018-12-27 | F. Hoffmann-La Roche Ag | PYRAZOLO [1,5A] PYRIMIDINE DERIVATIVES AS MODULATORS OF IRAK4 |
| CN111182903A (zh) | 2017-07-28 | 2020-05-19 | 特普医药公司 | 巨环化合物及其用途 |
| US10180422B1 (en) | 2017-08-22 | 2019-01-15 | Scripps Health | Methods of treating a neuroendocrine tumor |
| CA3071032A1 (en) | 2017-08-23 | 2019-02-28 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof |
| EP3679932A1 (en) | 2017-09-06 | 2020-07-15 | ONO Pharmaceutical Co., Ltd. | METHOD FOR TREATING CANCER BY COMBINATION OF Trk INHIBITOR AND KINASE INHIBITOR |
| WO2019084285A1 (en) | 2017-10-26 | 2019-05-02 | Qian Zhao | FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR |
| US11065243B2 (en) | 2017-10-27 | 2021-07-20 | Sonic Master Limited | Inhibitors of DUX4 induction for regulation of muscle function |
| AU2018364938B2 (en) | 2017-11-10 | 2021-11-11 | Angex Pharmaceutical, Inc. | Macrocyclic compounds as TRK kinase inhibitors and uses thereof |
| LT3728271T (lt) | 2017-12-19 | 2022-12-12 | Turning Point Therapeutics, Inc. | Makrocikliniai junginiai, skirti ligų gydymui |
| US11345703B2 (en) | 2018-01-23 | 2022-05-31 | Shenzhen Targetrx, Inc. | Substituted pyrazolo[1,5-a]pyrimidine macrocyclic compound |
| WO2019165967A1 (zh) | 2018-02-28 | 2019-09-06 | 南京明德新药研发有限公司 | 吡唑并嘧啶衍生物及其用途 |
| WO2019191659A1 (en) | 2018-03-29 | 2019-10-03 | Loxo Oncology, Inc. | Treatment of trk-associated cancers |
| CN109053682B (zh) | 2018-07-27 | 2020-10-27 | 东南大学 | 一种tdo小分子抑制剂衍生物及其抗肿瘤偶联物和制备方法 |
| JP7631193B2 (ja) | 2018-10-22 | 2025-02-18 | アルミス インコーポレイテッド | Ｔｙｋ２阻害剤およびその使用 |
| CN113348021B (zh) | 2019-01-23 | 2025-07-11 | 武田药品工业株式会社 | Tyk2抑制剂和其用途 |
| CN115448910B (zh) | 2019-01-28 | 2024-04-19 | 江苏豪森药业集团有限公司 | 一种哒嗪类衍生物抑制剂、其制备方法和应用 |
| JP2022519696A (ja) | 2019-02-07 | 2022-03-24 | ベンティックス バイオサイエンシーズ，インク． | Ｔｙｋ２偽キナーゼリガンド |
| CA3132632A1 (en) | 2019-03-11 | 2020-09-17 | Esker Therapeutics, Inc. | Tyk2 inhibitors and uses thereof |
| CA3134814A1 (en) | 2019-03-26 | 2020-10-01 | Ventyx Biosciences, Inc. | Tyk2 pseudokinase ligands |
| JP7635228B2 (ja) | 2019-11-08 | 2025-02-25 | ベンティックス バイオサイエンシーズ，インク． | Ｔｙｋ２偽キナーゼリガンド |
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