JP2020523351A5 - - Google Patents

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Publication number
JP2020523351A5
JP2020523351A5 JP2019568599A JP2019568599A JP2020523351A5 JP 2020523351 A5 JP2020523351 A5 JP 2020523351A5 JP 2019568599 A JP2019568599 A JP 2019568599A JP 2019568599 A JP2019568599 A JP 2019568599A JP 2020523351 A5 JP2020523351 A5 JP 2020523351A5
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JP
Japan
Prior art keywords
alkyl
formula
heterocycloalkyl
cycloalkyl
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019568599A
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English (en)
Japanese (ja)
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JP2020523351A (ja
JP7257338B2 (ja
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Publication date
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Priority claimed from PCT/US2018/037503 external-priority patent/WO2018232094A1/en
Publication of JP2020523351A publication Critical patent/JP2020523351A/ja
Publication of JP2020523351A5 publication Critical patent/JP2020523351A5/ja
Priority to JP2023060086A priority Critical patent/JP7636460B2/ja
Application granted granted Critical
Publication of JP7257338B2 publication Critical patent/JP7257338B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2019568599A 2017-06-15 2018-06-14 Ａｌｋ２キナーゼのイミダゾール含有阻害剤 Active JP7257338B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023060086A JP7636460B2 (ja) 2017-06-15 2023-04-03 Ａｌｋ２キナーゼのイミダゾール含有阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762520150P 2017-06-15 2017-06-15
US62/520,150 2017-06-15
PCT/US2018/037503 WO2018232094A1 (en) 2017-06-15 2018-06-14 Imidazole-containing inhibitors of alk2 kinase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023060086A Division JP7636460B2 (ja) 2017-06-15 2023-04-03 Ａｌｋ２キナーゼのイミダゾール含有阻害剤

Publications (3)

Publication Number Publication Date
JP2020523351A JP2020523351A (ja) 2020-08-06
JP2020523351A5 true JP2020523351A5 (https=) 2021-07-26
JP7257338B2 JP7257338B2 (ja) 2023-04-13

Family

ID=64659499

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019568599A Active JP7257338B2 (ja) 2017-06-15 2018-06-14 Ａｌｋ２キナーゼのイミダゾール含有阻害剤
JP2023060086A Active JP7636460B2 (ja) 2017-06-15 2023-04-03 Ａｌｋ２キナーゼのイミダゾール含有阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023060086A Active JP7636460B2 (ja) 2017-06-15 2023-04-03 Ａｌｋ２キナーゼのイミダゾール含有阻害剤

Country Status (21)

Country Link
US (3) US11661426B2 (https=)
EP (1) EP3638229A4 (https=)
JP (2) JP7257338B2 (https=)
KR (2) KR20240063970A (https=)
CN (2) CN119060060A (https=)
AR (1) AR112027A1 (https=)
AU (2) AU2018283053C1 (https=)
BR (1) BR112019026517A2 (https=)
CA (1) CA3066164A1 (https=)
CL (1) CL2019003669A1 (https=)
CO (1) CO2020000194A2 (https=)
EA (1) EA202090052A1 (https=)
IL (2) IL271109B2 (https=)
MA (1) MA49401A (https=)
MX (2) MX2019015226A (https=)
MY (1) MY204609A (https=)
NZ (1) NZ800669A (https=)
PH (1) PH12019502781A1 (https=)
SG (1) SG10202112496SA (https=)
TW (1) TWI833696B (https=)
WO (1) WO2018232094A1 (https=)

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EP3870181B1 (en) 2018-10-26 2024-08-14 Keros Therapeutics, Inc. Crystal forms of an alk2 inhibitor
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WO2020235902A1 (ko) * 2019-05-17 2020-11-26 주식회사 보로노이 헤테로고리 융합 피리미딘 유도체 및 이의 용도
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TWI870440B (zh) * 2019-08-13 2025-01-21 美商纜圖藥品公司 活化素受體樣激酶抑制劑之鹽及晶體形式
TWI885039B (zh) 2020-01-13 2025-06-01 美商邊際分析公司 經取代吡唑并嘧啶及其用途
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US12508262B2 (en) 2020-04-30 2025-12-30 Keros Therapeutics, Inc. Methods of using ALK2 inhibitors
WO2022098812A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating iron overload
WO2022140250A1 (en) * 2020-12-21 2022-06-30 Biocryst Pharmaceuticals, Inc. Dosing regimens for oral alk2 kinase inhibitors
CA3219966A1 (en) * 2021-05-25 2022-12-01 Biocryst Pharmaceuticals, Inc. Imidazole-containing inhibitors of alk2 kinase
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors
IL315733A (en) 2022-04-08 2024-11-01 SHY Therapeutics LLC Compounds that Interact with RAS Superfamily Proteins for the Treatment of Cancer, Inflammatory, Basoplastic, and Fibrotic Diseases
WO2023198114A1 (zh) * 2022-04-13 2023-10-19 杭州邦顺制药有限公司 Alk2激酶抑制剂
WO2025240752A1 (en) * 2024-05-15 2025-11-20 University Of Miami Mmp-13 antagonists

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