MX2021004538A - Inhibidores de tyk2 y sus usos. - Google Patents
Inhibidores de tyk2 y sus usos.Info
- Publication number
- MX2021004538A MX2021004538A MX2021004538A MX2021004538A MX2021004538A MX 2021004538 A MX2021004538 A MX 2021004538A MX 2021004538 A MX2021004538 A MX 2021004538A MX 2021004538 A MX2021004538 A MX 2021004538A MX 2021004538 A MX2021004538 A MX 2021004538A
- Authority
- MX
- Mexico
- Prior art keywords
- disorder
- tyk2
- tyk2 inhibitors
- mediated
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Abstract
En la presente descripción se describen compuestos que son útiles para tratar un trastorno mediado por TYK2. En algunas modalidades, el trastorno mediado por TYK2 es un trastorno autoinmunitario, un trastorno inflamatorio, un trastorno proliferativo, un trastorno endocrino, un trastorno neurológico o un trastorno asociado con el trasplante.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862749003P | 2018-10-22 | 2018-10-22 | |
US201862756942P | 2018-11-07 | 2018-11-07 | |
US201962839459P | 2019-04-26 | 2019-04-26 | |
US201962875449P | 2019-07-17 | 2019-07-17 | |
US201962893721P | 2019-08-29 | 2019-08-29 | |
US201962907354P | 2019-09-27 | 2019-09-27 | |
PCT/US2019/057485 WO2020086616A1 (en) | 2018-10-22 | 2019-10-22 | Tyk2 inhibitors and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021004538A true MX2021004538A (es) | 2021-09-10 |
Family
ID=70330735
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021004538A MX2021004538A (es) | 2018-10-22 | 2019-10-22 | Inhibidores de tyk2 y sus usos. |
Country Status (13)
Country | Link |
---|---|
US (4) | US11053219B2 (es) |
EP (1) | EP3870579A4 (es) |
JP (1) | JP2022505987A (es) |
KR (1) | KR20210095634A (es) |
CN (1) | CN113490664A (es) |
AU (1) | AU2019364336B2 (es) |
BR (1) | BR112021007679A2 (es) |
CA (1) | CA3117200A1 (es) |
CL (1) | CL2021000989A1 (es) |
IL (1) | IL282487A (es) |
MX (1) | MX2021004538A (es) |
SG (1) | SG11202104017VA (es) |
WO (1) | WO2020086616A1 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2022505987A (ja) | 2018-10-22 | 2022-01-14 | エスカー セラピューティクス,インコーポレイテッド | Tyk2阻害剤およびその使用 |
CN111484480B (zh) * | 2019-01-29 | 2023-08-11 | 上海翰森生物医药科技有限公司 | 一种多环类衍生物抑制剂、其制备方法和应用 |
AU2020216914A1 (en) * | 2019-01-30 | 2021-09-16 | Bristol-Myers Squibb Company | Amide-disubstituted pyridine or pyridazine compounds |
US20230167082A1 (en) * | 2019-07-16 | 2023-06-01 | Bristol-Myers Squibb Company | Prodrugs in the modulation of interleukin |
AU2021234496A1 (en) * | 2020-03-11 | 2022-10-20 | Beijing Innocare Pharma Tech Co., Ltd. | Heterocyclic compounds for inhibiting TYK2 activities |
WO2021202652A1 (en) * | 2020-04-01 | 2021-10-07 | Eternity Bioscience Inc. | Tyrosine kinase 2 inhibitors, preparation methods and medicinal uses thereof |
CA3174845A1 (en) * | 2020-04-14 | 2021-10-21 | Craig Alan Coburn | Substituted pyridines for the treatment of inflammatory diseases |
CN113563309A (zh) * | 2020-04-28 | 2021-10-29 | 浙江海正药业股份有限公司 | 吡啶类衍生物及其制备方法和用途 |
CN113735836B (zh) * | 2020-05-28 | 2023-05-30 | 江苏先声药业有限公司 | 哒嗪类化合物及其应用 |
CN113735837B (zh) * | 2020-05-28 | 2023-09-01 | 江苏先声药业有限公司 | 哒嗪类化合物及其用途 |
CN113773262A (zh) * | 2020-06-09 | 2021-12-10 | 江苏先声药业有限公司 | 哒嗪类化合物 |
IL299294A (en) * | 2020-06-22 | 2023-02-01 | Beigene Ltd | tyk-2 inhibitor |
WO2022032484A1 (zh) * | 2020-08-11 | 2022-02-17 | 北京诺诚健华医药科技有限公司 | 哒嗪-3-甲酰胺类化合物、其制备方法及其在医药学上的应用 |
US20230339977A1 (en) * | 2020-08-13 | 2023-10-26 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compound, and composition and application thereof |
TW202227430A (zh) * | 2020-11-17 | 2022-07-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 含氮雜環類衍生物、其製備方法及其在醫藥上的應用 |
JP2024504239A (ja) * | 2020-12-02 | 2024-01-31 | シェンチェン チップスクリーン バイオサイエンシズ カンパニー、リミテッド | ヒドロキサマート化合物、その調製方法及びその用途 |
WO2022121868A1 (zh) * | 2020-12-08 | 2022-06-16 | 正大天晴药业集团股份有限公司 | 含酰胺基和杂环烷基的tyk2抑制剂化合物 |
EP4267565A1 (en) * | 2020-12-22 | 2023-11-01 | InventisBio Co., Ltd. | Heteroaryl compounds, preparation methods and uses thereof |
BR112023016590A2 (pt) | 2021-02-19 | 2023-11-14 | Sudo Biosciences Ltd | Inibidores de tyk2 e seus usos |
WO2022179578A1 (zh) * | 2021-02-24 | 2022-09-01 | 南京明德新药研发有限公司 | 含有亚磺酰基吡啶结构的化合物以及应用 |
CN112920103A (zh) * | 2021-03-02 | 2021-06-08 | 康化(上海)新药研发有限公司 | 一种温和制备2-氮杂螺[3.3]庚烷盐酸盐的方法 |
CN117083268A (zh) * | 2021-03-16 | 2023-11-17 | 安锐生物医药科技(广州)有限公司 | 氨基杂芳基化合物和组合物 |
CN115197196A (zh) * | 2021-04-06 | 2022-10-18 | 扬子江药业集团有限公司 | Tyk2抑制剂及其用途 |
WO2022213980A1 (zh) * | 2021-04-07 | 2022-10-13 | 上海齐鲁制药研究中心有限公司 | Tyk2抑制剂及其用途 |
KR20240016974A (ko) * | 2021-05-04 | 2024-02-06 | 상하이 즈헤예 바이오테크놀로지 씨오. 엘티디. | 질소-함유 헤테로시클릭 피리딘 화합물 |
US11884650B2 (en) * | 2021-05-14 | 2024-01-30 | Bristol-Myers Squibb Company | Substituted heterocyclic compounds |
WO2022253335A1 (zh) * | 2021-06-02 | 2022-12-08 | 南京明德新药研发有限公司 | 含磺酰基的芳基类化合物及其应用 |
WO2022253333A1 (zh) * | 2021-06-02 | 2022-12-08 | 南京明德新药研发有限公司 | 酰胺类化合物及其应用 |
CA3223641A1 (en) * | 2021-06-22 | 2022-12-29 | Wenyuan Qian | Sulfoximine compound and use thereof |
WO2023284869A1 (zh) * | 2021-07-15 | 2023-01-19 | 南京明德新药研发有限公司 | 含硫/磷的芳基类化合物及其应用 |
CA3228394A1 (en) * | 2021-08-10 | 2023-02-16 | Avinash BOPPANA | Compositions, formulations, and methods for hair treatment |
CN115724830A (zh) * | 2021-08-31 | 2023-03-03 | 浙江文达医药科技有限公司 | 作为tyk2/jak1假激酶结构域(jh2)抑制剂的化合物及合成和使用方法 |
WO2023054549A1 (ja) * | 2021-09-30 | 2023-04-06 | あすか製薬株式会社 | 分解誘導剤 |
WO2023064223A1 (en) * | 2021-10-11 | 2023-04-20 | Gossamer Bio Services, Inc. | Tri-substituted pyridines |
WO2023076161A1 (en) | 2021-10-25 | 2023-05-04 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
WO2023109954A1 (en) * | 2021-12-16 | 2023-06-22 | Lynk Pharmaceuticals Co. Ltd. | Tyk2 inhibitors and compositions and methods thereof |
WO2023116748A1 (zh) * | 2021-12-23 | 2023-06-29 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
TW202340203A (zh) * | 2021-12-23 | 2023-10-16 | 英屬開曼群島商百濟神州有限公司 | Tyk2抑制劑的固體形式、製備方法及其用途 |
CN116693449A (zh) * | 2022-03-04 | 2023-09-05 | 上海致根医药科技有限公司 | 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用 |
TW202342000A (zh) | 2022-03-29 | 2023-11-01 | 美商雅盧米斯公司 | Tyk2抑制劑及其用途 |
WO2023220338A1 (en) * | 2022-05-13 | 2023-11-16 | Alumis Inc. | Crystalline forms of a tyk2 inhibitor and uses thereof |
WO2023236945A1 (zh) * | 2022-06-07 | 2023-12-14 | 广州费米子科技有限责任公司 | 哒嗪-3-甲酰胺化合物作为tyk2抑制剂 |
WO2024059529A1 (en) * | 2022-09-12 | 2024-03-21 | Alumis Inc. | Crystalline forms of a tyk2 inhibitor and uses thereof |
CN116284040A (zh) * | 2023-01-05 | 2023-06-23 | 华润医药研究院(深圳)有限公司 | 含氮杂环类化合物及其医药用途 |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1351691A4 (en) | 2000-12-12 | 2005-06-22 | Cytovia Inc | SUBSTITUTED 2-ARYL-4-ARYLAMINOPYRIMIDINES AND ANALOGUES AS ACTIVATORS OF CASPASES AND APOPTOSIS INDUCERS, AND USE THEREOF |
BR0313397A (pt) | 2002-08-14 | 2005-06-28 | Vertex Pharmaceuticals Incorpo | Inibidores de proteina cinase e usos destes |
US20060281763A1 (en) * | 2005-03-25 | 2006-12-14 | Axon Jonathan R | Carboxamide inhibitors of TGFbeta |
KR20100132550A (ko) * | 2008-04-16 | 2010-12-17 | 포톨라 파마슈티컬스, 인코포레이티드 | syk 또는 JAK 키나제 억제제로서의 2,6-디아미노-피리미딘-5-일-카르복스아미드 |
EP2361902A4 (en) | 2008-11-21 | 2012-04-25 | Astellas Pharma Inc | 4,6-DIAMINONICOTINSÄUREAMIDVERBINDUNG |
CA2760061C (en) * | 2009-05-08 | 2017-02-28 | Astellas Pharma Inc. | Diamino heterocyclic carboxamide compound |
BR122019024201B1 (pt) | 2010-05-20 | 2021-08-03 | Array Biopharma Inc | Composto macrocíclico como inibidores de trk quinase, seu uso, e composição farmacêutica |
CN103282352B (zh) * | 2010-11-01 | 2016-08-10 | 波托拉医药品公司 | 作为syk调节剂的苯甲酰胺类和烟酰胺类 |
US9102625B2 (en) * | 2010-11-01 | 2015-08-11 | Portola Pharmaceuticals, Inc. | Nicotinamides as JAK kinase modulators |
CN102250065B (zh) | 2011-05-20 | 2015-05-13 | 浙江海正药业股份有限公司 | 取代的三嗪苯脲衍生物及其用途 |
WO2013001310A1 (en) | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
US9096609B2 (en) | 2011-09-30 | 2015-08-04 | Ipsen Pharma S.A.S. | Macrocyclic LRRK2 kinase inhibitors |
KR20140108594A (ko) * | 2012-01-10 | 2014-09-11 | 에프. 호프만-라 로슈 아게 | 피리다진 아미드 화합물 및 syk 저해제로서의 이의 용도 |
MY194668A (en) * | 2012-11-08 | 2022-12-12 | Bristol Myers Squibb Co | Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn() responses |
SG11201504231PA (en) | 2012-11-30 | 2015-07-30 | Kyowa Hakko Kirin Co Ltd | Nitrogen-containing heterocyclic compound |
WO2014140299A1 (en) | 2013-03-15 | 2014-09-18 | Oncodesign S.A | Macrocyclic rip2 kinase inhibitors |
JP6484555B2 (ja) * | 2013-08-29 | 2019-03-13 | 京都薬品工業株式会社 | 新規芳香族化合物およびその用途 |
TWI582077B (zh) * | 2013-11-07 | 2017-05-11 | 必治妥美雅史谷比公司 | 作爲IL-12、IL-23及/或IFNα反應調節劑之經烷基-醯胺取代之吡啶化合物 |
KR20160093675A (ko) * | 2013-12-05 | 2016-08-08 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 키나제의 억제제 |
MY193524A (en) | 2014-01-24 | 2022-10-18 | Turning Point Therapeutics Inc | Diaryl macrocycles as modulators of protein kinases |
WO2015123453A1 (en) * | 2014-02-14 | 2015-08-20 | Portola Pharmaceuticals, Inc. | Pyridazine compounds as jak inhibitors |
CN105111151B (zh) | 2015-04-17 | 2018-09-28 | 成都理工大学 | 作为PPAR-γ调节剂的氨基嘧啶衍生物 |
JP2018522823A (ja) * | 2015-06-02 | 2018-08-16 | ファーマサイクリックス エルエルシー | ブルトン型チロシンキナーゼの阻害剤 |
CA2989327A1 (en) | 2015-07-02 | 2017-01-05 | Tp Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
MX2017017081A (es) | 2015-07-06 | 2018-08-16 | Tp Therapeutics Inc | Polimorfo de macrociclo de diarilo. |
CA2992324A1 (en) | 2015-07-21 | 2017-01-26 | Tp Therapeutics, Inc. | Chiral diaryl macrocycles and uses thereof |
CA3003153A1 (en) | 2015-10-26 | 2017-05-04 | Loxo Oncology, Inc. | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
CN108473500B (zh) | 2015-11-18 | 2021-06-08 | 百时美施贵宝公司 | 用作IL-12、IL-23和/或IFNα响应的调节剂的咪唑并哒嗪化合物 |
ES2776658T3 (es) | 2016-01-22 | 2020-07-31 | Janssen Pharmaceutica Nv | Nuevos derivados de cianoindolina con sustituyente heteroaromático de 6 miembros como inhibidores de NIK |
US10689400B2 (en) | 2016-07-28 | 2020-06-23 | Turning Point Therapeutics, Inc. | Macrocycle kinase inhibitors |
US10836770B2 (en) | 2016-10-07 | 2020-11-17 | Bristol-Myers Squibb Company | Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or INF alpha responses |
JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
JP2020533269A (ja) | 2016-12-14 | 2020-11-19 | デベロップメント センター フォー バイオテクノロジー | 抗体−薬物複合体およびその使用 |
TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
CN106866660B (zh) | 2017-02-15 | 2019-05-17 | 上海天马有机发光显示技术有限公司 | 电子传输材料、包含其的oled显示面板和电子设备 |
EP4338802A2 (en) * | 2017-03-08 | 2024-03-20 | Takeda Pharmaceutical Company Limited | Tyk2 inhibitors, uses, and methods for production thereof |
JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
JP7152784B2 (ja) | 2017-04-03 | 2022-10-13 | 京都薬品工業株式会社 | 新規サイクリン依存性キナーゼ8及び/又は19阻害剤 |
WO2018234345A1 (en) | 2017-06-21 | 2018-12-27 | F. Hoffmann-La Roche Ag | PYRAZOLO [1,5A] PYRIMIDINE DERIVATIVES AS MODULATORS OF IRAK4 |
US11286264B2 (en) | 2017-07-28 | 2022-03-29 | Turning Point Therapeutics, Inc. | Macrocyclic compounds and uses thereof |
US10180422B1 (en) | 2017-08-22 | 2019-01-15 | Scripps Health | Methods of treating a neuroendocrine tumor |
AU2018320021C1 (en) | 2017-08-23 | 2023-02-23 | Centaurus Biopharma Co., Ltd. | Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof |
EP3679932A1 (en) | 2017-09-06 | 2020-07-15 | ONO Pharmaceutical Co., Ltd. | METHOD FOR TREATING CANCER BY COMBINATION OF Trk INHIBITOR AND KINASE INHIBITOR |
CA3080157A1 (en) | 2017-10-26 | 2019-05-02 | Array Biopharma Inc. | Formulations of a macrocyclic trk kinase inhibitor |
US11065243B2 (en) | 2017-10-27 | 2021-07-20 | Sonic Master Limited | Inhibitors of DUX4 induction for regulation of muscle function |
EP3706749B1 (en) | 2017-11-10 | 2024-03-13 | Angex Pharmaceutical, Inc. | Macrocyclic compounds as trk kinase inhibitors and uses thereof |
DK3728271T3 (da) | 2017-12-19 | 2022-12-19 | Turning Point Therapeutics Inc | Makrocykliske forbindelser til behandling af sygdomme |
CN111848622A (zh) | 2018-01-23 | 2020-10-30 | 深圳市塔吉瑞生物医药有限公司 | 取代的吡唑并[1,5-a]嘧啶类的大环化合物 |
EP3760632B1 (en) | 2018-02-28 | 2023-07-19 | Simcere Pharmaceutical Co. Ltd. | Pyrazolopyrimidine derivative and use thereof |
WO2019191659A1 (en) | 2018-03-29 | 2019-10-03 | Loxo Oncology, Inc. | Treatment of trk-associated cancers |
JP2022505987A (ja) | 2018-10-22 | 2022-01-14 | エスカー セラピューティクス,インコーポレイテッド | Tyk2阻害剤およびその使用 |
CA3126034A1 (en) | 2019-01-23 | 2020-07-30 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
KR20210119426A (ko) | 2019-01-28 | 2021-10-05 | 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 | 피리다진 유도체 억제제, 및 그의 제조 방법 및 용도 |
KR20210124409A (ko) | 2019-02-07 | 2021-10-14 | 벤틱스 바이오사이언스, 인크. | Tyk2 슈도키나제 리간드 |
CA3132632A1 (en) | 2019-03-11 | 2020-09-17 | Esker Therapeutics, Inc. | Tyk2 inhibitors and uses thereof |
JP2022529311A (ja) | 2019-03-26 | 2022-06-21 | ベンティックス バイオサイエンシーズ,インク. | Tyk2偽キナーゼリガンド |
-
2019
- 2019-10-22 JP JP2021523157A patent/JP2022505987A/ja active Pending
- 2019-10-22 BR BR112021007679-4A patent/BR112021007679A2/pt unknown
- 2019-10-22 WO PCT/US2019/057485 patent/WO2020086616A1/en active Application Filing
- 2019-10-22 CN CN201980084885.9A patent/CN113490664A/zh active Pending
- 2019-10-22 CA CA3117200A patent/CA3117200A1/en active Pending
- 2019-10-22 SG SG11202104017VA patent/SG11202104017VA/en unknown
- 2019-10-22 AU AU2019364336A patent/AU2019364336B2/en active Active
- 2019-10-22 EP EP19877015.8A patent/EP3870579A4/en active Pending
- 2019-10-22 MX MX2021004538A patent/MX2021004538A/es unknown
- 2019-10-22 KR KR1020217015306A patent/KR20210095634A/ko active Search and Examination
-
2020
- 2020-07-24 US US16/938,183 patent/US11053219B2/en active Active
-
2021
- 2021-04-20 CL CL2021000989A patent/CL2021000989A1/es unknown
- 2021-04-20 IL IL282487A patent/IL282487A/en unknown
-
2022
- 2022-04-05 US US17/713,646 patent/US20220235035A1/en active Pending
- 2022-08-19 US US17/891,817 patent/US11731956B2/en active Active
-
2023
- 2023-06-15 US US18/335,262 patent/US20230391751A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112021007679A2 (pt) | 2021-07-27 |
US20230391751A1 (en) | 2023-12-07 |
CN113490664A (zh) | 2021-10-08 |
AU2019364336B2 (en) | 2023-11-16 |
US11731956B2 (en) | 2023-08-22 |
EP3870579A1 (en) | 2021-09-01 |
AU2019364336A1 (en) | 2021-05-27 |
WO2020086616A1 (en) | 2020-04-30 |
CL2021000989A1 (es) | 2021-10-29 |
IL282487A (en) | 2021-06-30 |
SG11202104017VA (en) | 2021-05-28 |
US11053219B2 (en) | 2021-07-06 |
KR20210095634A (ko) | 2021-08-02 |
EP3870579A4 (en) | 2022-10-19 |
US20230021554A1 (en) | 2023-01-26 |
JP2022505987A (ja) | 2022-01-14 |
US20220235035A1 (en) | 2022-07-28 |
CA3117200A1 (en) | 2020-04-30 |
US20200354338A1 (en) | 2020-11-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2021004538A (es) | Inhibidores de tyk2 y sus usos. | |
MX2021000077A (es) | Composiciones que comprenden cepas bacterianas. | |
MX2021011493A (es) | Métodos y dispositivos de terapia digital personalizados. | |
PL3662634T3 (pl) | Systemy i sposoby zarządzania cyfrowymi tożsamościami w związku z urządzeniami mobilnymi | |
MX2020010379A (es) | Sistemas y metodos de procesamiento. | |
PH12021550152A1 (en) | Anti-cd112r compositions and methods | |
MX2020003579A (es) | Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos. | |
MX2018015761A (es) | Composiciones que comprenden cepas bacterianas. | |
MX2020004708A (es) | Sistema y metodos de transporte. | |
CL2018002698A1 (es) | Tratamiento de enfermedades inflamatorias con inhibidores de actividad c5a | |
MX2020010439A (es) | Neurotoxinas para usarse en la inhibicion de cgrp. | |
UY37834A (es) | Tratamiento de mh con compuestos de pirimidinadiona | |
MX2019005696A (es) | Polipeptidos de reclutamiento de celulas t capaces de unir cd123 y tcr alfa/beta. | |
MX2020003515A (es) | Laminados elasticos con elasticos curvos y metodos para la fabricacion. | |
MX2020004079A (es) | Paso de sincronizacion y canal. | |
MX2020002613A (es) | Accionador lineal de alta reduccion impulsado por correas. | |
CA185542S (en) | Table | |
MX2021002616A (es) | Anticuerpos agonistas anti receptor desencadenante expresado en celulas mieloides 2 (trem-2). | |
PH12021550289A1 (en) | Ox40-binding polypeptides and uses thereof | |
MX2020009465A (es) | Anticuerpos anti-klk5 y metodos de uso. | |
CL2017002765A1 (es) | El uso de estimuladores sgc, activadores gc, solos y combinaciones con inhibidores pde5 para el tratamiento de úlceras digitales (du) concomitante con esclerosis sistémica (ssc). | |
MX2020004241A (es) | Conector y montaje de conector. | |
PH12018502233A1 (en) | ErbB INHIBITORS AND USES THEREOF | |
MX2020003633A (es) | Metodo de tratamiento de una lamina de metal y la lamina de metal tratada con este metodo. | |
AU201715551S (en) | Mobile Phone |