JP2024520481A - チェックポイントキナーゼ１（ｃｈｋ１）阻害剤およびその使用 - Google Patents
チェックポイントキナーゼ１（ｃｈｋ１）阻害剤およびその使用 Download PDFInfo
- Publication number
- JP2024520481A JP2024520481A JP2023573047A JP2023573047A JP2024520481A JP 2024520481 A JP2024520481 A JP 2024520481A JP 2023573047 A JP2023573047 A JP 2023573047A JP 2023573047 A JP2023573047 A JP 2023573047A JP 2024520481 A JP2024520481 A JP 2024520481A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharma
- tautomer
- stereoisomer
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163193990P | 2021-05-27 | 2021-05-27 | |
| US63/193,990 | 2021-05-27 | ||
| PCT/US2022/031141 WO2022251502A1 (en) | 2021-05-27 | 2022-05-26 | Checkpoint kinase 1 (chk1) inhibitors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024520481A true JP2024520481A (ja) | 2024-05-24 |
| JP2024520481A5 JP2024520481A5 (https=) | 2025-06-02 |
Family
ID=84229213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023573047A Pending JP2024520481A (ja) | 2021-05-27 | 2022-05-26 | チェックポイントキナーゼ１（ｃｈｋ１）阻害剤およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11707462B2 (https=) |
| EP (1) | EP4347582A4 (https=) |
| JP (1) | JP2024520481A (https=) |
| KR (1) | KR20240021188A (https=) |
| CN (1) | CN117715905A (https=) |
| AU (1) | AU2022282384A1 (https=) |
| BR (1) | BR112023024571A2 (https=) |
| CA (1) | CA3219348A1 (https=) |
| IL (1) | IL308759A (https=) |
| MX (1) | MX2023014028A (https=) |
| TW (1) | TW202313588A (https=) |
| WO (1) | WO2022251502A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3187760A1 (en) | 2020-08-12 | 2022-02-17 | Boundless Bio, Inc. | Replication stress pathway agent compositions and methods for treating cancer |
| TW202237586A (zh) | 2020-11-30 | 2022-10-01 | 日商住友製藥股份有限公司 | 5-雜芳基-1h-吡唑-3-胺衍生物 |
| BR112023024571A2 (pt) | 2021-05-27 | 2024-02-06 | Boundless Bio Inc | Inibidores de quinase do ponto de verificação 1 (chk1) e usos dos mesmos |
| AU2022421580A1 (en) * | 2021-12-24 | 2024-07-18 | Sumitomo Pharma Co., Ltd. | 1h-pyrazole-3-amine derivative having bicyclic backbone |
| CN119546588A (zh) * | 2022-05-24 | 2025-02-28 | 无界生物公司 | 吡啶检查点激酶1（chk1）抑制剂及其用途 |
| WO2023226658A1 (en) * | 2022-05-25 | 2023-11-30 | Sperogenix Therapeutics Limited | Nitrogen-containing five-membered heterocyclic derivatives as checkpoint kinase 1 inhibitor and uses thereof |
| TW202440549A (zh) * | 2022-11-29 | 2024-10-16 | 美商無界生物公司 | 檢查點激酶１（ｃｈｋ１）抑制劑及其用途 |
| JP2025540059A (ja) * | 2022-11-29 | 2025-12-11 | バウンドレス バイオ，インク． | チェックポイントキナーゼ１（ｃｈｋ１）阻害剤の組合せおよびその使用 |
| WO2024196923A1 (en) * | 2023-03-20 | 2024-09-26 | Boundless Bio, Inc. | Uses of a checkpoint kinase 1 (chk1) inhibitor |
| WO2024211271A1 (en) * | 2023-04-03 | 2024-10-10 | Boundless Bio, Inc. | Checkpoint kinase 1 (chk1) inhibitor pharmaceutical composition |
| WO2024211270A1 (en) * | 2023-04-03 | 2024-10-10 | Boundless Bio, Inc. | Checkpoint kinase 1 (chk1) inhibitor crystalline form and uses thereof |
| WO2025030049A1 (en) * | 2023-08-02 | 2025-02-06 | Health Research, Inc. | Sequential treatment method for p53-deficient cancer |
| WO2025217307A1 (en) | 2024-04-09 | 2025-10-16 | Revolution Medicines, Inc. | Methods for predicting response to a ras(on) inhibitor and combination therapies |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004501083A (ja) * | 2000-04-18 | 2004-01-15 | アゴーロン・ファーマシューティカルズ・インコーポレイテッド | プロテインキナーゼを阻害するためのピラゾール |
| JP2004507526A (ja) * | 2000-08-31 | 2004-03-11 | ファイザー・プロダクツ・インク | ピラゾール誘導体及びそのプロテインキナーゼ阻害剤としての使用 |
| JP2017508787A (ja) * | 2014-02-10 | 2017-03-30 | カスカディアン セラピューティクス， インコーポレイテッド | 医薬化合物 |
| JP2019509990A (ja) * | 2016-02-04 | 2019-04-11 | ファーマエンジン インコーポレーテッドＰｈａｒｍａｅｎｇｉｎｅ， Ｉｎｃ． | チェックポイントキナーゼ１（ｃｈｋ１）阻害剤として有用な３，５−二置換ピラゾール、並びにその調製及び用途 |
| WO2021019514A1 (en) * | 2019-08-01 | 2021-02-04 | Integral Biosciences Pvt. Ltd. | Heterocyclic compounds as kinase inhibitor and uses thereof |
| WO2021043208A1 (en) * | 2019-09-06 | 2021-03-11 | Impact Therapeutics, Inc | 3, 5-disubstituted pyrazole compounds as kinase inhibitors and uses thereof |
| WO2021253095A1 (en) * | 2020-06-19 | 2021-12-23 | Anaxis Pharma Pty Ltd | Sulphonamide compounds |
| WO2022114189A1 (ja) * | 2020-11-30 | 2022-06-02 | 住友ファーマ株式会社 | ５－ヘテロアリール－１ｈ－ピラゾール－３－アミン誘導体 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050209297A1 (en) * | 2000-08-31 | 2005-09-22 | Pfizer Inc | Pyrazole derivatives |
| PA8850801A1 (es) * | 2008-12-17 | 2010-07-27 | Lilly Co Eli | Compuestos útiles para inhibir chk1 |
| CN111253370B (zh) | 2020-03-24 | 2021-08-03 | 浙江大学 | N-多取代吡啶-2-氨基嘧啶类衍生物及用途 |
| CA3187760A1 (en) | 2020-08-12 | 2022-02-17 | Boundless Bio, Inc. | Replication stress pathway agent compositions and methods for treating cancer |
| KR20230092972A (ko) | 2020-10-23 | 2023-06-26 | 셀진 코포레이션 | 연충 감염 및 질병의 치료를 위한 헤테로환식 화합물 및 이들의 용도 |
| US11564920B2 (en) | 2020-11-30 | 2023-01-31 | Sumitomo Pharma Co., Ltd. | 5-heteroaryl-1H-pyrazol-3-amine derivative |
| BR112023024571A2 (pt) | 2021-05-27 | 2024-02-06 | Boundless Bio Inc | Inibidores de quinase do ponto de verificação 1 (chk1) e usos dos mesmos |
| AU2022421580A1 (en) | 2021-12-24 | 2024-07-18 | Sumitomo Pharma Co., Ltd. | 1h-pyrazole-3-amine derivative having bicyclic backbone |
| CN119546588A (zh) | 2022-05-24 | 2025-02-28 | 无界生物公司 | 吡啶检查点激酶1（chk1）抑制剂及其用途 |
| WO2023226658A1 (en) | 2022-05-25 | 2023-11-30 | Sperogenix Therapeutics Limited | Nitrogen-containing five-membered heterocyclic derivatives as checkpoint kinase 1 inhibitor and uses thereof |
| WO2023229032A1 (ja) | 2022-05-27 | 2023-11-30 | 住友ファーマ株式会社 | 免疫チェックポイント阻害剤に対して治療抵抗性を示すがんの治療薬 |
| JP2025540059A (ja) | 2022-11-29 | 2025-12-11 | バウンドレス バイオ，インク． | チェックポイントキナーゼ１（ｃｈｋ１）阻害剤の組合せおよびその使用 |
| TW202440549A (zh) | 2022-11-29 | 2024-10-16 | 美商無界生物公司 | 檢查點激酶１（ｃｈｋ１）抑制劑及其用途 |
| WO2024196923A1 (en) | 2023-03-20 | 2024-09-26 | Boundless Bio, Inc. | Uses of a checkpoint kinase 1 (chk1) inhibitor |
| WO2024211271A1 (en) | 2023-04-03 | 2024-10-10 | Boundless Bio, Inc. | Checkpoint kinase 1 (chk1) inhibitor pharmaceutical composition |
| WO2024211270A1 (en) | 2023-04-03 | 2024-10-10 | Boundless Bio, Inc. | Checkpoint kinase 1 (chk1) inhibitor crystalline form and uses thereof |
-
2022
- 2022-05-26 BR BR112023024571A patent/BR112023024571A2/pt unknown
- 2022-05-26 JP JP2023573047A patent/JP2024520481A/ja active Pending
- 2022-05-26 EP EP22812165.3A patent/EP4347582A4/en active Pending
- 2022-05-26 WO PCT/US2022/031141 patent/WO2022251502A1/en not_active Ceased
- 2022-05-26 CN CN202280052765.2A patent/CN117715905A/zh active Pending
- 2022-05-26 MX MX2023014028A patent/MX2023014028A/es unknown
- 2022-05-26 TW TW111119737A patent/TW202313588A/zh unknown
- 2022-05-26 CA CA3219348A patent/CA3219348A1/en active Pending
- 2022-05-26 KR KR1020237044236A patent/KR20240021188A/ko active Pending
- 2022-05-26 AU AU2022282384A patent/AU2022282384A1/en active Pending
- 2022-05-26 IL IL308759A patent/IL308759A/en unknown
- 2022-08-29 US US17/897,667 patent/US11707462B2/en active Active
-
2023
- 2023-06-01 US US18/327,775 patent/US12527790B2/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004501083A (ja) * | 2000-04-18 | 2004-01-15 | アゴーロン・ファーマシューティカルズ・インコーポレイテッド | プロテインキナーゼを阻害するためのピラゾール |
| JP2004507526A (ja) * | 2000-08-31 | 2004-03-11 | ファイザー・プロダクツ・インク | ピラゾール誘導体及びそのプロテインキナーゼ阻害剤としての使用 |
| JP2017508787A (ja) * | 2014-02-10 | 2017-03-30 | カスカディアン セラピューティクス， インコーポレイテッド | 医薬化合物 |
| JP2019509990A (ja) * | 2016-02-04 | 2019-04-11 | ファーマエンジン インコーポレーテッドＰｈａｒｍａｅｎｇｉｎｅ， Ｉｎｃ． | チェックポイントキナーゼ１（ｃｈｋ１）阻害剤として有用な３，５−二置換ピラゾール、並びにその調製及び用途 |
| WO2021019514A1 (en) * | 2019-08-01 | 2021-02-04 | Integral Biosciences Pvt. Ltd. | Heterocyclic compounds as kinase inhibitor and uses thereof |
| WO2021043208A1 (en) * | 2019-09-06 | 2021-03-11 | Impact Therapeutics, Inc | 3, 5-disubstituted pyrazole compounds as kinase inhibitors and uses thereof |
| WO2021253095A1 (en) * | 2020-06-19 | 2021-12-23 | Anaxis Pharma Pty Ltd | Sulphonamide compounds |
| WO2022114189A1 (ja) * | 2020-11-30 | 2022-06-02 | 住友ファーマ株式会社 | ５－ヘテロアリール－１ｈ－ピラゾール－３－アミン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20230310423A1 (en) | 2023-10-05 |
| EP4347582A1 (en) | 2024-04-10 |
| KR20240021188A (ko) | 2024-02-16 |
| US11707462B2 (en) | 2023-07-25 |
| AU2022282384A1 (en) | 2023-12-14 |
| CN117715905A (zh) | 2024-03-15 |
| US12527790B2 (en) | 2026-01-20 |
| EP4347582A4 (en) | 2025-05-07 |
| TW202313588A (zh) | 2023-04-01 |
| IL308759A (en) | 2024-01-01 |
| WO2022251502A1 (en) | 2022-12-01 |
| CA3219348A1 (en) | 2022-12-01 |
| BR112023024571A2 (pt) | 2024-02-06 |
| MX2023014028A (es) | 2023-12-12 |
| US20230026313A1 (en) | 2023-01-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024520481A (ja) | チェックポイントキナーゼ１（ｃｈｋ１）阻害剤およびその使用 | |
| EP4532486A1 (en) | Pyridine checkpoint kinase 1 (chk1) inhibitors and uses thereof | |
| WO2024118564A1 (en) | Checkpoint kinase 1 (chk1) inhibitors and uses thereof | |
| JP7607841B1 (ja) | Ｐａｒｐ１阻害薬及びその使用 | |
| JP2024534420A (ja) | 環状スルホンアミドリボヌクレオチドレダクターゼ（ｒｎｒ）阻害剤およびその使用 | |
| EP4301735A1 (en) | Ribonucleotide reductase (rnr) inhibitors and uses thereof | |
| JP2024534421A (ja) | スルファミドリボヌクレオチドレダクターゼ（ｒｎｒ）阻害剤およびその使用 | |
| EP4626433A1 (en) | Checkpoint kinase 1 (chk1) inhibitors combinations and uses thereof | |
| EA051928B1 (ru) | Пиридиновые ингибиторы киназы 1 контрольной точки (chk1) и их применение | |
| BR112024014920B1 (pt) | Inibidores de parp1, composições que os compreendem, e usos dos mesmos | |
| JP2025531147A (ja) | 環状スルホンアミドリボヌクレオチドレダクターゼ（ｒｎｒ）阻害剤およびその使用 | |
| BR122025009667A2 (pt) | Inibidores de parp1, composições que os compreendem, e usos dos mesmos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20240328 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20250523 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20250523 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20260304 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20260312 |