JP2024514223A5 - - Google Patents
Info
- Publication number
- JP2024514223A5 JP2024514223A5 JP2023563990A JP2023563990A JP2024514223A5 JP 2024514223 A5 JP2024514223 A5 JP 2024514223A5 JP 2023563990 A JP2023563990 A JP 2023563990A JP 2023563990 A JP2023563990 A JP 2023563990A JP 2024514223 A5 JP2024514223 A5 JP 2024514223A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- stereoisomer
- solvate
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163176610P | 2021-04-19 | 2021-04-19 | |
| US63/176,610 | 2021-04-19 | ||
| US202163183563P | 2021-05-03 | 2021-05-03 | |
| US63/183,563 | 2021-05-03 | ||
| US202163254832P | 2021-10-12 | 2021-10-12 | |
| US63/254,832 | 2021-10-12 | ||
| PCT/US2022/025357 WO2022225934A1 (en) | 2021-04-19 | 2022-04-19 | Parp1 inhibitors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024514223A JP2024514223A (ja) | 2024-03-28 |
| JP2024514223A5 true JP2024514223A5 (https=) | 2025-04-28 |
Family
ID=83723349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023563990A Pending JP2024514223A (ja) | 2021-04-19 | 2022-04-19 | Ｐａｒｐ１阻害薬及びその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11591331B2 (https=) |
| EP (1) | EP4326720A4 (https=) |
| JP (1) | JP2024514223A (https=) |
| KR (1) | KR20230172550A (https=) |
| AU (1) | AU2022260495A1 (https=) |
| CA (1) | CA3216373A1 (https=) |
| TW (1) | TW202309025A (https=) |
| WO (1) | WO2022225934A1 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11591331B2 (en) | 2021-04-19 | 2023-02-28 | Xinthera, Inc. | PARP1 inhibitors and uses thereof |
| EP4328224A4 (en) * | 2021-04-22 | 2025-06-18 | Wigen Biomedicine Technology (Shanghai) Co., Ltd. | PARP INHIBITOR WITH PIPERAZINE STRUCTURE, MANUFACTURING METHOD THEREOF AND PHARMACEUTICAL USE THEREOF |
| AU2022261029A1 (en) * | 2021-04-23 | 2023-10-19 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Heterocyclic derivative inhibitor and preparation method therefor and application thereof |
| BR112023022496A2 (pt) * | 2021-05-24 | 2024-01-16 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Composto heterocíclico contendo nitrogênio, método de preparação do mesmo, e aplicação do mesmo em medicamentos |
| AU2022334408A1 (en) * | 2021-08-27 | 2024-02-15 | Impact Therapeutics (Shanghai), Inc. | Substituted tricyclic compounds as parp inhibitors and use thereof |
| WO2023046034A1 (zh) * | 2021-09-22 | 2023-03-30 | 明慧医药（杭州）有限公司 | 一种含氮杂环化合物、其制备方法、其中间体及其应用 |
| WO2023046158A1 (zh) * | 2021-09-26 | 2023-03-30 | 张文燕 | 氮杂喹啉酮类化合物及其医药用途 |
| EP4410792A4 (en) * | 2021-09-30 | 2025-12-03 | Xizang Haisco Pharmaceutical Co Ltd | NITROGEN-CONTAINS HETEROCYCLIC DERIVATIVE FOR USE AS A PARP INHIBITOR AND ITS USE |
| KR102867210B1 (ko) * | 2021-10-01 | 2025-10-14 | 신테라, 인크. | 아제티딘 및 피롤리딘 parp1 저해제, 및 이의 용도 |
| US20250289800A1 (en) * | 2021-11-19 | 2025-09-18 | Kangbaida (Sichuan) Biotechnology Co., Ltd. | Selective Parp1 Inhibitor And Application Thereof |
| KR20240144125A (ko) * | 2021-12-17 | 2024-10-02 | 키테라 (쑤저우) 바이오-파마슈티컬스 컴퍼니 리미티드 | Parp 억제제, 이를 포함하는 약제학적 조성물, 및 이의 용도 |
| WO2023133413A1 (en) * | 2022-01-07 | 2023-07-13 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| KR20240134366A (ko) * | 2022-01-13 | 2024-09-09 | 에이스랜드 테라퓨틱스 (홍콩) 리미티드 | 피페라진 고리 함유 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 용도 |
| CN118434725B (zh) * | 2022-01-20 | 2026-01-02 | 微境生物医药科技(上海)有限公司 | 吡啶酰胺类parp抑制剂、及其制备方法和医药用途 |
| CN120081844A (zh) | 2022-01-21 | 2025-06-03 | 新特拉有限公司 | Parp1抑制剂及其用途 |
| JP7794989B2 (ja) * | 2022-01-27 | 2026-01-06 | シンセラ， インコーポレイテッド | Ｐａｒｐ１阻害薬及びその使用 |
| WO2023146960A1 (en) * | 2022-01-28 | 2023-08-03 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| CN119013279A (zh) * | 2022-03-11 | 2024-11-22 | 上海瑛派药业有限公司 | 作为parp抑制剂的取代的三环类化合物及其应用 |
| AU2023235233A1 (en) | 2022-03-14 | 2024-09-12 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| AU2023259236B2 (en) * | 2022-04-28 | 2025-01-09 | Xinthera, Inc. | Tricyclic parp1 inhibitors and uses thereof |
| CN119487027A (zh) * | 2022-04-28 | 2025-02-18 | 宁波新湾科技发展有限公司 | 作为parp1抑制剂的化合物 |
| US20250346573A1 (en) * | 2022-06-02 | 2025-11-13 | Chengdu Easton Biopharmaceuticals Co., Ltd. | Azaquinolinone derivative, preparation method therefor and use thereof |
| CN115919859B (zh) * | 2022-07-14 | 2024-01-05 | 四川海思科制药有限公司 | 一种杂芳基衍生物的药物组合物及其在医药上的应用 |
| CN115232129B (zh) * | 2022-08-18 | 2023-12-01 | 上海闻耐医药科技有限公司 | 一种parp1选择性抑制剂及其制备方法和用途 |
| CN119677736A (zh) * | 2022-08-24 | 2025-03-21 | 四川海思科制药有限公司 | 一种杂芳基衍生物parp抑制剂药学上可接受的盐及其用途 |
| WO2024041608A1 (zh) * | 2022-08-24 | 2024-02-29 | 四川海思科制药有限公司 | 一种杂芳基衍生物parp抑制剂的晶体形式及其用途 |
| WO2024067694A1 (zh) * | 2022-09-30 | 2024-04-04 | 中国医药研究开发中心有限公司 | 含氮杂环类化合物及其医药用途 |
| US20240174669A1 (en) | 2022-10-06 | 2024-05-30 | Xinthera, Inc. | Crystalline forms of a parp1 inhibitor |
| WO2024083218A1 (zh) * | 2022-10-20 | 2024-04-25 | 成都赜灵生物医药科技有限公司 | 取代四氢吡啶类化合物及其用途 |
| WO2024083201A1 (zh) * | 2022-10-20 | 2024-04-25 | 成都赜灵生物医药科技有限公司 | 并杂环类化合物及其用途 |
| WO2024083211A1 (zh) * | 2022-10-20 | 2024-04-25 | 成都赜灵生物医药科技有限公司 | 并杂环类氘代化合物及其用途 |
| WO2024099416A1 (zh) * | 2022-11-10 | 2024-05-16 | 上海海和药物研究开发股份有限公司 | 一种稠合三环类parp1抑制剂、其制备方法及用途 |
| KR20250103668A (ko) * | 2022-11-10 | 2025-07-07 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 축합 이환 화합물 |
| AU2023412594A1 (en) * | 2022-12-23 | 2025-07-10 | Zhejiang Yangli Pharmaceutical Technology Co., Ltd. | Parp1 inhibitors |
| WO2024158878A1 (en) * | 2023-01-25 | 2024-08-02 | Enliven Inc. | Fused tetracyclic selective parp1 inhibitors |
| WO2024178125A1 (en) * | 2023-02-21 | 2024-08-29 | 1Cbio, Inc. | Heterocyclic compounds and methods of use thereof |
| TW202502341A (zh) * | 2023-03-13 | 2025-01-16 | 大陸商江蘇豪森藥業集團有限公司 | 哌啶烯類化合物在製備治療癌症的藥物中的應用 |
| WO2024206172A1 (en) * | 2023-03-24 | 2024-10-03 | Xinthera, Inc. | Crystalline forms of an azetidine parp1 inhibitor |
| TW202506680A (zh) * | 2023-04-28 | 2025-02-16 | 美商思諾維新醫藥公司 | 作為ｐａｒｐ１抑制劑之雜環化合物 |
| CN120917007A (zh) * | 2023-05-19 | 2025-11-07 | 上海海和药物研究开发股份有限公司 | 一种芳基脲类parp1抑制剂、其制备方法及用途 |
| WO2024255697A1 (zh) * | 2023-06-13 | 2024-12-19 | 中国医药研究开发中心有限公司 | 含氮杂环类化合物及其医药用途 |
| CN121464135A (zh) * | 2023-07-07 | 2026-02-03 | 优领医药科技(香港)有限公司 | 含哌嗪并环类衍生物的晶型、其盐型、其制备方法及应用 |
| CN119462669A (zh) * | 2023-08-11 | 2025-02-18 | 上海海和药物研究开发股份有限公司 | 稠合三环类化合物、其药物组合物和用途 |
| WO2025092973A1 (zh) * | 2023-11-03 | 2025-05-08 | 成都赜灵生物医药科技有限公司 | Parp1靶向化合物及其用途 |
| WO2025168048A1 (zh) * | 2024-02-08 | 2025-08-14 | 上海璎黎药业有限公司 | 一种三键结构化合物、其药物组合物及其应用 |
| WO2025261449A1 (zh) * | 2024-06-19 | 2025-12-26 | 浙江扬厉医药技术有限公司 | 一种parp1抑制剂吡啶酰胺类化合物、中间体及其制备方法 |
| WO2025261448A1 (zh) * | 2024-06-19 | 2025-12-26 | 浙江扬厉医药技术有限公司 | 一类吡啶酰胺化合物的盐型、晶型及其制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPS137402A0 (en) | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
| US8404713B2 (en) | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
| CN102341394B (zh) * | 2009-01-23 | 2015-04-15 | 武田药品工业株式会社 | 聚(adp-核糖)聚合酶(parp)抑制剂 |
| EP2459561A1 (en) | 2009-07-30 | 2012-06-06 | Takeda Pharmaceutical Company Limited | Poly (adp-ribose) polymerase (parp) inhibitors |
| PL2912032T3 (pl) | 2012-10-26 | 2020-11-16 | Nerviano Medical Sciences S.R.L. | Pochodne 4-karboksyamido-izoindolinonu jako selektywne inhibitory parp-1 |
| MX375707B (es) | 2015-06-09 | 2025-03-06 | Onconic Therapeutics Inc | Compuesto derivativo triciclico, metodo para prepararlo y composicion farmaceutica que comprende el mismo. |
| SI3999506T1 (sl) | 2019-07-19 | 2025-06-30 | Astrazeneca Ab | Zaviralci PARP1 |
| US11795158B2 (en) | 2020-06-25 | 2023-10-24 | Astrazeneca Ab | Chemical compounds |
| JP2023545096A (ja) * | 2020-10-09 | 2023-10-26 | アストラゼネカ ユーケー リミテッド | 抗体－薬物コンジュゲート及びｐａｒｐ１選択的阻害薬の組み合わせ |
| US11591331B2 (en) * | 2021-04-19 | 2023-02-28 | Xinthera, Inc. | PARP1 inhibitors and uses thereof |
| EP4328224A4 (en) * | 2021-04-22 | 2025-06-18 | Wigen Biomedicine Technology (Shanghai) Co., Ltd. | PARP INHIBITOR WITH PIPERAZINE STRUCTURE, MANUFACTURING METHOD THEREOF AND PHARMACEUTICAL USE THEREOF |
| CN115702156A (zh) * | 2021-04-23 | 2023-02-14 | 南京明德新药研发有限公司 | 吡啶酰胺类化合物 |
| AU2022261029A1 (en) * | 2021-04-23 | 2023-10-19 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Heterocyclic derivative inhibitor and preparation method therefor and application thereof |
| WO2022222966A1 (zh) | 2021-04-23 | 2022-10-27 | 成都百裕制药股份有限公司 | 一种选择性parp1抑制剂及其应用 |
| WO2022222965A1 (zh) | 2021-04-23 | 2022-10-27 | 成都百裕制药股份有限公司 | 吡啶衍生物及其在医药上的应用 |
| WO2022228387A1 (en) * | 2021-04-26 | 2022-11-03 | Fochon Biosciences, Ltd. | Compounds as parp inhibitors |
| WO2023046034A1 (zh) * | 2021-09-22 | 2023-03-30 | 明慧医药（杭州）有限公司 | 一种含氮杂环化合物、其制备方法、其中间体及其应用 |
| EP4410791A4 (en) * | 2021-09-30 | 2025-10-22 | Xizang Haisco Pharmaceutical Co Ltd | BICYCLIC DERIVATIVE PARP INHIBITOR AND ITS USE |
| KR20240144125A (ko) * | 2021-12-17 | 2024-10-02 | 키테라 (쑤저우) 바이오-파마슈티컬스 컴퍼니 리미티드 | Parp 억제제, 이를 포함하는 약제학적 조성물, 및 이의 용도 |
| KR20240134366A (ko) * | 2022-01-13 | 2024-09-09 | 에이스랜드 테라퓨틱스 (홍콩) 리미티드 | 피페라진 고리 함유 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 용도 |
| CN118434725B (zh) * | 2022-01-20 | 2026-01-02 | 微境生物医药科技(上海)有限公司 | 吡啶酰胺类parp抑制剂、及其制备方法和医药用途 |
| CN115232129B (zh) | 2022-08-18 | 2023-12-01 | 上海闻耐医药科技有限公司 | 一种parp1选择性抑制剂及其制备方法和用途 |
-
2022
- 2022-04-19 US US17/723,929 patent/US11591331B2/en active Active
- 2022-04-19 EP EP22792317.4A patent/EP4326720A4/en active Pending
- 2022-04-19 AU AU2022260495A patent/AU2022260495A1/en active Pending
- 2022-04-19 KR KR1020237039422A patent/KR20230172550A/ko active Pending
- 2022-04-19 TW TW111114905A patent/TW202309025A/zh unknown
- 2022-04-19 JP JP2023563990A patent/JP2024514223A/ja active Pending
- 2022-04-19 CA CA3216373A patent/CA3216373A1/en active Pending
- 2022-04-19 WO PCT/US2022/025357 patent/WO2022225934A1/en not_active Ceased
- 2022-09-19 US US17/933,326 patent/US20230128041A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024514223A5 (https=) | ||
| JP2024520481A5 (https=) | ||
| JP2023535453A5 (https=) | ||
| RU2014115847A (ru) | Пирролопиримидиновые соединения для лечения злокачественной опухоли | |
| JP2016503799A5 (https=) | ||
| RU2017112048A (ru) | Синергистические комбинации ауристана | |
| JP2023513793A5 (https=) | ||
| RU2013156074A (ru) | Диазакарбазолы и способы применения | |
| JP2018533593A5 (https=) | ||
| JP2005523922A5 (https=) | ||
| NZ710745A (en) | Pyrrolobenzodiazepines and conjugates thereof | |
| JP2014528467A5 (https=) | ||
| JP2022512736A5 (https=) | ||
| JP2009536221A5 (https=) | ||
| JP2023549494A5 (https=) | ||
| JP2023537271A5 (https=) | ||
| JP2024534420A5 (https=) | ||
| JP2015517574A5 (https=) | ||
| JP2024541910A5 (https=) | ||
| JP2022071077A5 (https=) | ||
| JP2019535723A5 (https=) | ||
| JP2025503970A5 (https=) | ||
| JP2020535124A5 (https=) | ||
| RU2020109775A (ru) | Комплексная терапия | |
| JP2022541545A5 (https=) |