|
US4675189A
(en)
|
1980-11-18 |
1987-06-23 |
Syntex (U.S.A.) Inc. |
Microencapsulation of water soluble active polypeptides
|
|
JPS60100516A
(ja)
|
1983-11-04 |
1985-06-04 |
Takeda Chem Ind Ltd |
徐放型マイクロカプセルの製造法
|
|
CA1256638A
(en)
|
1984-07-06 |
1989-06-27 |
Motoaki Tanaka |
Polymer and its production
|
|
JP2551756B2
(ja)
|
1985-05-07 |
1996-11-06 |
武田薬品工業株式会社 |
ポリオキシカルボン酸エステルおよびその製造法
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
US20050004186A1
(en)
|
2002-12-20 |
2005-01-06 |
Pfizer Inc |
MEK inhibiting compounds
|
|
ES2325440T3
(es)
|
2003-02-20 |
2009-09-04 |
Smithkline Beecham Corporation |
Compuestos de pirimidina.
|
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
|
US7504396B2
(en)
|
2003-06-24 |
2009-03-17 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
WO2005049021A1
(en)
|
2003-11-03 |
2005-06-02 |
Oy Helsinki Transplantation R & D Ltd |
Materials and methods for inhibiting neointimal hyperplasia
|
|
MXPA06013165A
(es)
|
2004-05-14 |
2007-02-13 |
Pfizer Prod Inc |
Derivados de pirimidina para el tratamiento de crecimiento de celulas anormal.
|
|
WO2006037117A1
(en)
|
2004-09-27 |
2006-04-06 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
MY169441A
(en)
*
|
2004-12-08 |
2019-04-11 |
Janssen Pharmaceutica Nv |
2,4, (4,6) pyrimidine derivatives
|
|
WO2006124874A2
(en)
|
2005-05-12 |
2006-11-23 |
Kalypsys, Inc. |
Inhibitors of b-raf kinase
|
|
WO2006129100A1
(en)
|
2005-06-03 |
2006-12-07 |
Glaxo Group Limited |
Novel compounds
|
|
WO2007028445A1
(en)
|
2005-07-15 |
2007-03-15 |
Glaxo Group Limited |
6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives
|
|
EP2089369B1
(en)
|
2006-10-19 |
2011-02-02 |
Rigel Pharmaceuticals, Inc. |
2,4 -pyrimidinediamine derivatives as inhibitors of jak kinases for the treatment of autoimmune diseases
|
|
DE102007010801A1
(de)
|
2007-03-02 |
2008-09-04 |
Bayer Cropscience Ag |
Diaminopyrimidine als Fungizide
|
|
BRPI0810641A2
(pt)
|
2007-04-12 |
2019-09-24 |
Hoffmann La Roche |
"compostos farmacêuticos".
|
|
WO2008140421A2
(en)
*
|
2007-05-15 |
2008-11-20 |
S*Bio Pte Ltd |
Heterocycloalkyl substituted pyrimidine derivatives
|
|
JP2011505407A
(ja)
|
2007-12-03 |
2011-02-24 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
過剰な又は異常な細胞増殖を特徴とする疾患を治療するためのジアミノピリジン
|
|
WO2009083185A2
(en)
|
2007-12-28 |
2009-07-09 |
Fovea Pharmaceuticals Sa |
Compositions and methods for prophylaxis and treatment of cellular degenerative ophthalmic disorders
|
|
EA024109B1
(ru)
|
2008-04-16 |
2016-08-31 |
Портола Фармасьютиклз, Инк. |
Ингибиторы протеинкиназ
|
|
WO2009132202A2
(en)
|
2008-04-24 |
2009-10-29 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
|
EA201100078A1
(ru)
|
2008-06-25 |
2011-08-30 |
Айрм Ллк |
Производные пиримидина в качестве ингибиторов киназы
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
PL2310492T3
(pl)
*
|
2008-06-30 |
2015-12-31 |
Janssen Biotech Inc |
Różnocowanie pluripotencjalnych komórek macierzystych
|
|
US20120114637A1
(en)
|
2009-05-04 |
2012-05-10 |
Santen Pharmaceutical Co., Ltd. |
Mtor pathway inhibitors for treating ocular disorders
|
|
US20120165332A1
(en)
|
2009-06-18 |
2012-06-28 |
Cellzome Limited |
Sulfonamides and sulfamides as zap-70 inhibitors
|
|
US20130040310A1
(en)
|
2009-12-15 |
2013-02-14 |
Salk Institute For Biological Studies |
Ulk1 compositions, inhibitors, screening and methods of use
|
|
WO2011084108A1
(en)
|
2010-01-08 |
2011-07-14 |
Agency For Science, Technology And Research |
Methods and compositions for treating cancer
|
|
WO2011133668A2
(en)
|
2010-04-20 |
2011-10-27 |
President And Fellows Of Harvard College |
Methods and compositions for the treatment of cancer
|
|
SG10201505217WA
(en)
|
2010-07-09 |
2015-08-28 |
Biogen Hemophilia Inc |
Chimeric clotting factors
|
|
WO2012040602A2
(en)
|
2010-09-23 |
2012-03-29 |
President And Fellows Of Harvard College |
Targeting mtor substrates in treating proliferative diseases
|
|
WO2012045195A1
(en)
|
2010-10-09 |
2012-04-12 |
Abbott Laboratories |
Pyrrolopyrimidines as fak and alk inhibiters for treatment of cancers and other diseases
|
|
US8691777B2
(en)
|
2011-01-27 |
2014-04-08 |
Emory University |
Combination therapy
|
|
US20120244209A1
(en)
|
2011-03-02 |
2012-09-27 |
Roth Jack A |
Tusc2 therapies
|
|
JP2014511391A
(ja)
|
2011-03-07 |
2014-05-15 |
フォンダッツィオーネ・テレソン |
Tfebリン酸化阻害剤およびその使用
|
|
EP2780017A1
(en)
|
2011-11-15 |
2014-09-24 |
Novartis AG |
Combination of a phosphoinositide 3-kinase inhibitor and a modulator of the janus kinase 2-signal transducer and activator of transcription 5 pathway
|
|
ES2552518T3
(es)
|
2012-02-21 |
2015-11-30 |
Merck Patent Gmbh |
Derivados cíclicos de diaminopiridina como inhibidores de Syk
|
|
US20130310340A1
(en)
|
2012-05-16 |
2013-11-21 |
Rigel Pharmaceuticals, Inc. |
Method of treating muscular degradation
|
|
US20150250808A1
(en)
|
2012-10-15 |
2015-09-10 |
Vojo P. Deretic |
Treatment of autophagy-based disorders and related pharmaceutical compositions, diagnostic and screening assays and kits
|
|
EP2914296B2
(en)
|
2012-11-01 |
2021-09-29 |
Infinity Pharmaceuticals, Inc. |
Treatment of cancers using pi3 kinase isoform modulators
|
|
WO2014098932A1
(en)
|
2012-12-17 |
2014-06-26 |
The Brigham And Women's Hosptial, Inc. |
Treatment of mtor hyperactive related diseases and disorders
|
|
CN103059030B
(zh)
|
2012-12-28 |
2015-04-29 |
北京师范大学 |
一种具有粘着斑激酶抑制作用的嘧啶类化合物及其制备方法和应用
|
|
CA2899281C
(en)
|
2013-01-25 |
2022-05-31 |
Rigel Pharmaceuticals, Inc. |
Pyrimidinediamine compounds for use in treating or preventing autoimmune alopecia
|
|
WO2014197680A1
(en)
|
2013-06-05 |
2014-12-11 |
Salk Institute For Biological Studies |
Vitamin d receptor agonists to treat diseases involving cxcl12 activity
|
|
US10300058B2
(en)
|
2014-04-18 |
2019-05-28 |
Xuanzhu Pharma Co., Ltd. |
Tyrosine kinase inhibitor and uses thereof
|
|
CA2952787A1
(en)
|
2014-06-17 |
2015-12-23 |
Korea Research Institute Of Chemical Technology |
Pyrimidine-2,4-diamine derivative and anticancer pharmaceutical composition comprising same as effective ingredient
|
|
DK3185868T3
(da)
*
|
2014-08-25 |
2022-05-23 |
Salk Inst For Biological Studi |
Hidtil ukendte ULK1-inhibitorer og fremgangsmåder til anvendelse af samme
|
|
RS62017B1
(sr)
|
2014-09-17 |
2021-07-30 |
Celgene Car Llc |
Mk2 inhibitori i njihova upotreba
|
|
KR20250081944A
(ko)
|
2014-09-24 |
2025-06-05 |
솔크 인스티튜트 포 바이올로지칼 스터디즈 |
종양 살상 바이러스 및 이의 사용방법
|
|
CN105524045B
(zh)
|
2014-10-22 |
2020-04-10 |
山东轩竹医药科技有限公司 |
四环类间变性淋巴瘤激酶抑制剂
|
|
WO2016090079A1
(en)
|
2014-12-05 |
2016-06-09 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
CN106188029B
(zh)
|
2015-05-05 |
2018-09-18 |
山东轩竹医药科技有限公司 |
二并环类间变性淋巴瘤激酶抑制剂
|
|
WO2016196393A2
(en)
*
|
2015-05-29 |
2016-12-08 |
Presage Biosciences, Inc. |
Autophagy-inhibiting compounds and uses thereof
|
|
WO2017024019A1
(en)
|
2015-08-04 |
2017-02-09 |
Celgene Corporation |
Methods for treating chronic lymphocytic leukemia and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies
|
|
CN105801603B
(zh)
|
2016-04-13 |
2018-10-02 |
成都倍特药业有限公司 |
一种具有大环结构的alk抑制剂及其制备方法
|
|
EP3528814B1
(en)
|
2016-10-18 |
2024-08-14 |
Dana-Farber Cancer Institute, Inc. |
Pyrimido-diazepinone kinase scaffold compounds and methods of treating dclk1/2-mediated disorders
|
|
US11180482B2
(en)
|
2016-11-30 |
2021-11-23 |
Ariad Pharmaceuticals, Inc. |
Anilinopyrimidines as haematopoietic progenitor kinase 1 (HPK1) inhibitors
|
|
JP6684700B2
(ja)
|
2016-12-26 |
2020-04-22 |
アイシン精機株式会社 |
乗員検知装置
|
|
EP3620457A4
(en)
|
2017-05-02 |
2021-01-06 |
Korea Research Institute of Chemical Technology |
PYRIMIDE-DERIVATIVE COMPOUND, OPTICAL ISOMER THEREOF, OR PHARMACEUTICAL SALT THEREOF AND COMPOSITION FOR THE PREVENTION OR TREATMENT OF TYRO-3 RELATED DISEASES THEREOF AS ACTIVE SUBSTANCE
|
|
EP3966207B1
(en)
|
2019-05-10 |
2023-11-01 |
Deciphera Pharmaceuticals, LLC |
Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof
|
|
MX2021013662A
(es)
|
2019-05-10 |
2022-03-11 |
Deciphera Pharmaceuticals Llc |
Inhibidores de la autofagia de heteroarilaminopirimidina amida y metodos de uso de estos.
|
|
IL325201A
(en)
|
2019-06-17 |
2026-02-01 |
Deciphera Pharmaceuticals Llc |
Aminopyrimidine amide autophagy inhibitors and methods of using them
|
|
CN115515589A
(zh)
|
2020-02-14 |
2022-12-23 |
萨克生物研究学院 |
Ulk1/2抑制剂及其使用方法
|
|
JP2023513797A
(ja)
|
2020-02-14 |
2023-04-03 |
ソーク インスティテュート フォー バイオロジカル スタディーズ |
Ulk1/2阻害剤による単剤療法および併用療法
|
|
WO2021216440A1
(en)
|
2020-04-20 |
2021-10-28 |
Tenova Pharmaceuticals Inc. |
Novel protein kinase inhibitors
|
|
WO2022072668A1
(en)
|
2020-09-30 |
2022-04-07 |
Salk Institute For Biological Studies |
Patient selection biomarkers for treatment with ulk inhibitors
|