|
US4675189A
(en)
|
1980-11-18 |
1987-06-23 |
Syntex (U.S.A.) Inc. |
Microencapsulation of water soluble active polypeptides
|
|
JPS60100516A
(ja)
|
1983-11-04 |
1985-06-04 |
Takeda Chem Ind Ltd |
徐放型マイクロカプセルの製造法
|
|
CA1256638A
(en)
|
1984-07-06 |
1989-06-27 |
Motoaki Tanaka |
Polymer and its production
|
|
JP2551756B2
(ja)
|
1985-05-07 |
1996-11-06 |
武田薬品工業株式会社 |
ポリオキシカルボン酸エステルおよびその製造法
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
US20050004186A1
(en)
|
2002-12-20 |
2005-01-06 |
Pfizer Inc |
MEK inhibiting compounds
|
|
ES2325440T3
(es)
|
2003-02-20 |
2009-09-04 |
Smithkline Beecham Corporation |
Compuestos de pirimidina.
|
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
|
US7504396B2
(en)
|
2003-06-24 |
2009-03-17 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
WO2005049021A1
(en)
|
2003-11-03 |
2005-06-02 |
Oy Helsinki Transplantation R & D Ltd |
Materials and methods for inhibiting neointimal hyperplasia
|
|
JP2007537238A
(ja)
|
2004-05-14 |
2007-12-20 |
ファイザー・プロダクツ・インク |
異常細胞増殖の治療のためのピリミジン誘導体
|
|
EP1794135A1
(en)
|
2004-09-27 |
2007-06-13 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
MY169441A
(en)
*
|
2004-12-08 |
2019-04-11 |
Janssen Pharmaceutica Nv |
2,4, (4,6) pyrimidine derivatives
|
|
WO2006124874A2
(en)
|
2005-05-12 |
2006-11-23 |
Kalypsys, Inc. |
Inhibitors of b-raf kinase
|
|
WO2006129100A1
(en)
|
2005-06-03 |
2006-12-07 |
Glaxo Group Limited |
Novel compounds
|
|
WO2007028445A1
(en)
|
2005-07-15 |
2007-03-15 |
Glaxo Group Limited |
6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives
|
|
JP5161233B2
(ja)
|
2006-10-19 |
2013-03-13 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
自己免疫疾患の処置のためのjakキナーゼの阻害剤としての2,4−ピリミジンアミン誘導体
|
|
DE102007010801A1
(de)
|
2007-03-02 |
2008-09-04 |
Bayer Cropscience Ag |
Diaminopyrimidine als Fungizide
|
|
JP2010523639A
(ja)
|
2007-04-12 |
2010-07-15 |
エフ.ホフマン−ラ ロシュ アーゲー |
医薬化合物
|
|
WO2008140421A2
(en)
*
|
2007-05-15 |
2008-11-20 |
S*Bio Pte Ltd |
Heterocycloalkyl substituted pyrimidine derivatives
|
|
US8461147B2
(en)
|
2007-12-03 |
2013-06-11 |
Boehringer Ingelheim International Gmbh |
Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation
|
|
WO2009083185A2
(en)
|
2007-12-28 |
2009-07-09 |
Fovea Pharmaceuticals Sa |
Compositions and methods for prophylaxis and treatment of cellular degenerative ophthalmic disorders
|
|
HRP20161310T1
(hr)
|
2008-04-16 |
2016-12-02 |
Portola Pharmaceuticals, Inc. |
2,6-diamino-pirimidin-5-il-karboksamidi kao inhibitori syk ili jak kinaza
|
|
EP2274288A2
(en)
*
|
2008-04-24 |
2011-01-19 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
|
AU2009262198B2
(en)
|
2008-06-25 |
2012-09-27 |
Irm Llc |
Pyrimidine derivatives as kinase inhibitors
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
EP2942392B1
(en)
*
|
2008-06-30 |
2018-10-03 |
Janssen Biotech, Inc. |
Differentiation of pluripotent stem cells
|
|
US20120114637A1
(en)
|
2009-05-04 |
2012-05-10 |
Santen Pharmaceutical Co., Ltd. |
Mtor pathway inhibitors for treating ocular disorders
|
|
CA2763720A1
(en)
|
2009-06-18 |
2010-12-23 |
Cellzome Limited |
Sulfonamides and sulfamides as zap-70 inhibitors
|
|
US20130040310A1
(en)
*
|
2009-12-15 |
2013-02-14 |
Salk Institute For Biological Studies |
Ulk1 compositions, inhibitors, screening and methods of use
|
|
CN102792160B
(zh)
|
2010-01-08 |
2015-08-19 |
新加坡科技研究局 |
用于治疗癌症的方法和组合物
|
|
WO2011133668A2
(en)
|
2010-04-20 |
2011-10-27 |
President And Fellows Of Harvard College |
Methods and compositions for the treatment of cancer
|
|
TW201217527A
(en)
|
2010-07-09 |
2012-05-01 |
Biogen Idec Hemophilia Inc |
Processable single chain molecules and polypeptides made using same
|
|
WO2012040602A2
(en)
|
2010-09-23 |
2012-03-29 |
President And Fellows Of Harvard College |
Targeting mtor substrates in treating proliferative diseases
|
|
WO2012045195A1
(en)
|
2010-10-09 |
2012-04-12 |
Abbott Laboratories |
Pyrrolopyrimidines as fak and alk inhibiters for treatment of cancers and other diseases
|
|
US8691777B2
(en)
|
2011-01-27 |
2014-04-08 |
Emory University |
Combination therapy
|
|
CA2864394C
(en)
|
2011-03-02 |
2021-10-19 |
Jack Roth |
A method of predicting a response to a tusc2 therapy
|
|
CN103458970A
(zh)
|
2011-03-07 |
2013-12-18 |
泰莱托恩基金会 |
Tfeb磷酸化抑制剂及其应用
|
|
US20140343128A1
(en)
|
2011-11-15 |
2014-11-20 |
Novartis Ag |
Combination of a phosphoinositide 3-kinase inhibitor and a modulator of the Janus Kinase 2 - Signal Transducer and Activator of Transcription 5 pathway
|
|
US9073944B2
(en)
|
2012-02-21 |
2015-07-07 |
Merck Patent Gmbh |
Cyclic diaminopyrimidine derivatives
|
|
WO2013173506A2
(en)
|
2012-05-16 |
2013-11-21 |
Rigel Pharmaceuticals, Inc. |
Method of treating muscular degradation
|
|
US20150250808A1
(en)
|
2012-10-15 |
2015-09-10 |
Vojo P. Deretic |
Treatment of autophagy-based disorders and related pharmaceutical compositions, diagnostic and screening assays and kits
|
|
AU2013337717B2
(en)
|
2012-11-01 |
2018-10-25 |
Infinity Pharmaceuticals, Inc. |
Treatment of cancers using PI3 kinase isoform modulators
|
|
WO2014098932A1
(en)
|
2012-12-17 |
2014-06-26 |
The Brigham And Women's Hosptial, Inc. |
Treatment of mtor hyperactive related diseases and disorders
|
|
CN103059030B
(zh)
|
2012-12-28 |
2015-04-29 |
北京师范大学 |
一种具有粘着斑激酶抑制作用的嘧啶类化合物及其制备方法和应用
|
|
JP2016506930A
(ja)
|
2013-01-25 |
2016-03-07 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
炎症性腸疾患を処置するための化合物および方法
|
|
EP3473299A1
(en)
|
2013-06-05 |
2019-04-24 |
Salk Institute for Biological Studies |
Vitamin d receptor agonists to treat diseases involving cxcl12 activity
|
|
US10300058B2
(en)
|
2014-04-18 |
2019-05-28 |
Xuanzhu Pharma Co., Ltd. |
Tyrosine kinase inhibitor and uses thereof
|
|
EP3159338A4
(en)
|
2014-06-17 |
2018-01-24 |
Korea Research Institute of Chemical Technology |
Pyrimidine-2,4-diamine derivative and anticancer pharmaceutical composition comprising same as effective ingredient
|
|
US10266549B2
(en)
|
2014-08-25 |
2019-04-23 |
Salk Institute For Biological Studies |
ULK1 inhibitors and methods using same
|
|
RS62017B1
(sr)
|
2014-09-17 |
2021-07-30 |
Celgene Car Llc |
Mk2 inhibitori i njihova upotreba
|
|
KR102608590B1
(ko)
|
2014-09-24 |
2023-12-01 |
솔크 인스티튜트 포 바이올로지칼 스터디즈 |
종양 살상 바이러스 및 이의 사용방법
|
|
CN105524045B
(zh)
|
2014-10-22 |
2020-04-10 |
山东轩竹医药科技有限公司 |
四环类间变性淋巴瘤激酶抑制剂
|
|
US20160159774A1
(en)
|
2014-12-05 |
2016-06-09 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
CN106188029B
(zh)
|
2015-05-05 |
2018-09-18 |
山东轩竹医药科技有限公司 |
二并环类间变性淋巴瘤激酶抑制剂
|
|
GB2555270A
(en)
*
|
2015-05-29 |
2018-04-25 |
Presage Biosciences Inc |
Autophagy-inhibiting compounds and uses thereof
|
|
WO2017024019A1
(en)
|
2015-08-04 |
2017-02-09 |
Celgene Corporation |
Methods for treating chronic lymphocytic leukemia and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies
|
|
CN105801603B
(zh)
*
|
2016-04-13 |
2018-10-02 |
成都倍特药业有限公司 |
一种具有大环结构的alk抑制剂及其制备方法
|
|
AU2017346845B2
(en)
|
2016-10-18 |
2021-12-02 |
Dana-Farber Cancer Institute, Inc. |
Pyrimido-diazepinone kinase scaffold compounds and methods of treating DCLK1/2-mediated disorders
|
|
WO2018102366A1
(en)
|
2016-11-30 |
2018-06-07 |
Ariad Pharmaceuticals, Inc. |
Anilinopyrimidines as haematopoietic progenitor kinase 1 (hpk1) inhibitors
|
|
JP6684700B2
(ja)
|
2016-12-26 |
2020-04-22 |
アイシン精機株式会社 |
乗員検知装置
|
|
CN110831937A
(zh)
|
2017-05-02 |
2020-02-21 |
韩国化学研究院 |
嘧啶衍生物化合物、其光学异构体或其药学上可接受的盐及包含其为有效成分的Tyro3相关疾病的预防或治疗用组合物
|
|
PE20220597A1
(es)
|
2019-05-10 |
2022-04-22 |
Deciphera Pharmaceuticals Llc |
Inhibidores de la autofagia de fenilaminopirimidina amida y metodos de uso de estos
|
|
US11518758B2
(en)
|
2019-05-10 |
2022-12-06 |
Deciphera Pharmaceuticals, Llc |
Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof
|
|
PE20221083A1
(es)
|
2019-06-17 |
2022-07-05 |
Deciphera Pharmaceuticals Llc |
Inhibidores de la autofagia de la amida aminopirimidina y sus metodos de uso
|
|
KR20220154094A
(ko)
|
2020-02-14 |
2022-11-21 |
솔크 인스티튜트 포 바이올로지칼 스터디즈 |
Ulk1/2 억제제를 이용한 단일 및 병용 요법
|
|
KR20220153581A
(ko)
|
2020-02-14 |
2022-11-18 |
솔크 인스티튜트 포 바이올로지칼 스터디즈 |
Ulk1/2 의 억제제 및 이의 사용 방법
|
|
US20230159556A1
(en)
*
|
2020-04-20 |
2023-05-25 |
Tenova Pharmaceuticals Inc. |
Novel protein kinase inhibitors
|
|
WO2022072668A1
(en)
|
2020-09-30 |
2022-04-07 |
Salk Institute For Biological Studies |
Patient selection biomarkers for treatment with ulk inhibitors
|