KR20220153582A - 마크로시클릭 ulk1/2 억제제 - Google Patents

마크로시클릭 ulk1/2 억제제 Download PDF

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Publication number
KR20220153582A
KR20220153582A KR1020227028938A KR20227028938A KR20220153582A KR 20220153582 A KR20220153582 A KR 20220153582A KR 1020227028938 A KR1020227028938 A KR 1020227028938A KR 20227028938 A KR20227028938 A KR 20227028938A KR 20220153582 A KR20220153582 A KR 20220153582A
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KR
South Korea
Prior art keywords
alkyl
cycloalkyl
heterocycloalkyl
independently
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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KR1020227028938A
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English (en)
Korean (ko)
Inventor
니콜라스 디 피 코스포드
니콜 에이 바카스
루벤 제이 쇼
앨리슨 에스 림퍼트
소냐 엔 브런
Original Assignee
솔크 인스티튜트 포 바이올로지칼 스터디즈
샌포드 번햄 프레비즈 메디컬 디스커버리 인스티튜트
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Application filed by 솔크 인스티튜트 포 바이올로지칼 스터디즈, 샌포드 번햄 프레비즈 메디컬 디스커버리 인스티튜트 filed Critical 솔크 인스티튜트 포 바이올로지칼 스터디즈
Publication of KR20220153582A publication Critical patent/KR20220153582A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020227028938A 2020-02-14 2021-02-12 마크로시클릭 ulk1/2 억제제 Pending KR20220153582A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062977039P 2020-02-14 2020-02-14
US62/977,039 2020-02-14
PCT/US2021/018038 WO2021163627A1 (en) 2020-02-14 2021-02-12 Macrocyclic ulk1/2 inhibitors

Publications (1)

Publication Number Publication Date
KR20220153582A true KR20220153582A (ko) 2022-11-18

Family

ID=77292762

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227028938A Pending KR20220153582A (ko) 2020-02-14 2021-02-12 마크로시클릭 ulk1/2 억제제

Country Status (8)

Country Link
US (1) US12594277B2 (https=)
EP (1) EP4103183A4 (https=)
JP (1) JP2023513793A (https=)
KR (1) KR20220153582A (https=)
CN (1) CN115515588A (https=)
AU (1) AU2021221162A1 (https=)
CA (1) CA3171185A1 (https=)
WO (1) WO2021163627A1 (https=)

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* Cited by examiner, † Cited by third party
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WO2022072668A1 (en) * 2020-09-30 2022-04-07 Salk Institute For Biological Studies Patient selection biomarkers for treatment with ulk inhibitors
TW202404979A (zh) * 2022-07-18 2024-02-01 大陸商江蘇恆瑞醫藥股份有限公司 抑制並誘導ｅｇｆｒ降解的大環類化合物、其製備方法及其在醫藥上的應用
WO2024017258A1 (zh) * 2022-07-19 2024-01-25 百极弘烨(南通)医药科技有限公司 Egfr小分子抑制剂、含其的药物组合物及其用途
WO2024233766A1 (en) * 2023-05-10 2024-11-14 Erasca, Inc. Macrocyclic ulk1/2 inhibitors and their use thereof

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Also Published As

Publication number Publication date
WO2021163627A1 (en) 2021-08-19
CA3171185A1 (en) 2021-08-19
AU2021221162A1 (en) 2022-09-22
US12594277B2 (en) 2026-04-07
JP2023513793A (ja) 2023-04-03
CN115515588A (zh) 2022-12-23
US20230099804A1 (en) 2023-03-30
EP4103183A1 (en) 2022-12-21
EP4103183A4 (en) 2024-02-28

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