JP2023513793A - 大環状ｕｌｋ１／２阻害剤 - Google Patents

大環状ｕｌｋ１／２阻害剤 Download PDF

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Publication number
JP2023513793A
JP2023513793A JP2022549144A JP2022549144A JP2023513793A JP 2023513793 A JP2023513793 A JP 2023513793A JP 2022549144 A JP2022549144 A JP 2022549144A JP 2022549144 A JP2022549144 A JP 2022549144A JP 2023513793 A JP2023513793 A JP 2023513793A
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alkyl
independently
cycloalkyl
heterocycloalkyl
aryl
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JPWO2021163627A5 (https=
JP2023513793A5 (https=
Inventor
ニコラス ディー．ピー． コスフォード、
ニコル エー． バカス、
ルーベン ジェイ． ショー、
アリソン エス． リンパート、
ソーニャ エヌ． ブラン、
Original Assignee
ソーク インスティテュート フォー バイオロジカル スタディーズ
サンフォード バーナム プレビーズ メディカル ディスカバリー インスティテュート
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Publication of JP2023513793A publication Critical patent/JP2023513793A/ja
Publication of JPWO2021163627A5 publication Critical patent/JPWO2021163627A5/ja
Publication of JP2023513793A5 publication Critical patent/JP2023513793A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2022549144A 2020-02-14 2021-02-12 大環状ｕｌｋ１／２阻害剤 Pending JP2023513793A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062977039P 2020-02-14 2020-02-14
US62/977,039 2020-02-14
PCT/US2021/018038 WO2021163627A1 (en) 2020-02-14 2021-02-12 Macrocyclic ulk1/2 inhibitors

Publications (3)

Publication Number Publication Date
JP2023513793A true JP2023513793A (ja) 2023-04-03
JPWO2021163627A5 JPWO2021163627A5 (https=) 2024-02-20
JP2023513793A5 JP2023513793A5 (https=) 2024-02-20

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JP2022549144A Pending JP2023513793A (ja) 2020-02-14 2021-02-12 大環状ｕｌｋ１／２阻害剤

Country Status (8)

Country Link
US (1) US12594277B2 (https=)
EP (1) EP4103183A4 (https=)
JP (1) JP2023513793A (https=)
KR (1) KR20220153582A (https=)
CN (1) CN115515588A (https=)
AU (1) AU2021221162A1 (https=)
CA (1) CA3171185A1 (https=)
WO (1) WO2021163627A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
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WO2021216440A1 (en) * 2020-04-20 2021-10-28 Tenova Pharmaceuticals Inc. Novel protein kinase inhibitors
WO2022072668A1 (en) * 2020-09-30 2022-04-07 Salk Institute For Biological Studies Patient selection biomarkers for treatment with ulk inhibitors
TW202404979A (zh) * 2022-07-18 2024-02-01 大陸商江蘇恆瑞醫藥股份有限公司 抑制並誘導ｅｇｆｒ降解的大環類化合物、其製備方法及其在醫藥上的應用
WO2024017258A1 (zh) * 2022-07-19 2024-01-25 百极弘烨(南通)医药科技有限公司 Egfr小分子抑制剂、含其的药物组合物及其用途
WO2024233766A1 (en) * 2023-05-10 2024-11-14 Erasca, Inc. Macrocyclic ulk1/2 inhibitors and their use thereof

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Also Published As

Publication number Publication date
EP4103183A4 (en) 2024-02-28
WO2021163627A1 (en) 2021-08-19
US12594277B2 (en) 2026-04-07
CN115515588A (zh) 2022-12-23
KR20220153582A (ko) 2022-11-18
EP4103183A1 (en) 2022-12-21
US20230099804A1 (en) 2023-03-30
AU2021221162A1 (en) 2022-09-22
CA3171185A1 (en) 2021-08-19

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