JP2015500795A5 - - Google Patents
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- JP2015500795A5 JP2015500795A5 JP2014535990A JP2014535990A JP2015500795A5 JP 2015500795 A5 JP2015500795 A5 JP 2015500795A5 JP 2014535990 A JP2014535990 A JP 2014535990A JP 2014535990 A JP2014535990 A JP 2014535990A JP 2015500795 A5 JP2015500795 A5 JP 2015500795A5
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- JP
- Japan
- Prior art keywords
- optionally substituted
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- compound
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- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 54
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- -1 t-butyloxycarbonyl (Boc) protecting group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 108700011259 MicroRNAs Proteins 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 108091023663 let-7 stem-loop Proteins 0.000 claims 1
- 108091063478 let-7-1 stem-loop Proteins 0.000 claims 1
- 108091049777 let-7-2 stem-loop Proteins 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161548076P | 2011-10-17 | 2011-10-17 | |
| US61/548,076 | 2011-10-17 | ||
| PCT/US2012/060464 WO2013059215A1 (en) | 2011-10-17 | 2012-10-16 | Substituted biaryl alkyl amides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500795A JP2015500795A (ja) | 2015-01-08 |
| JP2015500795A5 true JP2015500795A5 (https=) | 2015-12-03 |
| JP6254088B2 JP6254088B2 (ja) | 2017-12-27 |
Family
ID=47148954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014535990A Expired - Fee Related JP6254088B2 (ja) | 2011-10-17 | 2012-10-16 | 置換ビアリールアルキルアミド |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8822527B2 (https=) |
| EP (1) | EP2768799B1 (https=) |
| JP (1) | JP6254088B2 (https=) |
| CN (1) | CN104011013B (https=) |
| AU (1) | AU2012326361B2 (https=) |
| CA (1) | CA2850987C (https=) |
| MX (2) | MX2014004503A (https=) |
| WO (1) | WO2013059215A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2850987C (en) | 2011-10-17 | 2019-10-15 | Biotheryx, Inc. | Substituted biaryl alkyl amides |
| CN107635959A (zh) * | 2015-06-10 | 2018-01-26 | 住友化学株式会社 | 氨基甲酸酯化合物的制造方法 |
| EP4491236A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| EP4717317A2 (en) | 2017-06-20 | 2026-04-01 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| WO2019027366A1 (en) * | 2017-08-01 | 2019-02-07 | Agency For Science, Technology And Research | PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY |
| CN111278816B (zh) | 2017-09-04 | 2024-03-15 | C4医药公司 | 二氢喹啉酮 |
| CN118206529A (zh) | 2017-09-04 | 2024-06-18 | C4医药公司 | 二氢苯并咪唑酮 |
| CN118108706A (zh) | 2017-09-04 | 2024-05-31 | C4医药公司 | 戊二酰亚胺 |
| CN107540574B (zh) * | 2017-09-19 | 2021-06-11 | 成都西岭源药业有限公司 | R-联苯丙氨醇的制备方法 |
| EP3710002A4 (en) | 2017-11-16 | 2021-07-07 | C4 Therapeutics, Inc. | DEGRADER AND DEGRONE FOR TARGETED PROTEIN DEGRADATION |
| JP2021519337A (ja) | 2018-03-26 | 2021-08-10 | シー４ セラピューティクス， インコーポレイテッド | Ｉｋａｒｏｓの分解のためのセレブロン結合剤 |
| CN119751456A (zh) | 2018-04-16 | 2025-04-04 | C4医药公司 | 螺环化合物 |
| CN109053495B (zh) * | 2018-07-23 | 2021-05-28 | 江苏宇田医药有限公司 | 一种lcz696中间体的合成方法 |
| CN120698983A (zh) | 2018-12-20 | 2025-09-26 | C4医药公司 | 靶向蛋白降解 |
| WO2020181232A1 (en) | 2019-03-06 | 2020-09-10 | C4 Therapeutics, Inc. | Heterocyclic compounds for medical treatment |
| JP7687721B2 (ja) * | 2020-12-25 | 2025-06-03 | エムティックスバイオ カンパニ－ リミテッド | 新規なアミノアルカン酸にビフェニル基を導入した誘導体化合物およびそれを含む抗炎症用組成物 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0502690B1 (en) | 1991-03-05 | 1999-12-01 | Ajinomoto Co., Inc. | Cyclopropane derivative |
| JPH10101656A (ja) | 1996-10-01 | 1998-04-21 | Sumitomo Chem Co Ltd | オキサゾール化合物の製造法 |
| JPH10101655A (ja) | 1996-10-01 | 1998-04-21 | Sumitomo Chem Co Ltd | オキサゾリン類、その製造法およびそれを用いるスレオ−３−芳香族セリン類の製造法 |
| BR9811779A (pt) | 1997-09-09 | 2000-09-12 | Procter & Gamble | Tetrahidro prostaglandina s substituìdas por c16-c20 aromáticos úteis como agonistas fp |
| PT1161424E (pt) | 1999-03-03 | 2004-08-31 | Wyeth Corp | Novos derivados de diazole como agentes serotonergicos |
| US6239134B1 (en) | 1999-03-03 | 2001-05-29 | American Home Products Corp. | Diazole derivatives as serotonergic agents |
| EP1438044A1 (en) | 2001-10-19 | 2004-07-21 | Transtech Pharma, Inc. | Bis-heteroaryl alkanes as therapeutic agents |
| ITRM20020016A1 (it) | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
| US7109243B2 (en) | 2003-03-24 | 2006-09-19 | Irm Llc | Inhibitors of cathepsin S |
| US7501538B2 (en) | 2003-08-08 | 2009-03-10 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
| WO2005014533A2 (en) | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| AU2004283147A1 (en) | 2003-10-28 | 2005-05-06 | Dr. Reddy's Laboratories Ltd. | Novel compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
| US7618981B2 (en) | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| US7795448B2 (en) * | 2004-05-06 | 2010-09-14 | Cytokinetics, Incorporated | Imidazoyl-benzamide anti-cancer agents |
| WO2006015279A1 (en) | 2004-07-28 | 2006-02-09 | Neurogen Corporation | Heterocyclic diamine compounds as ligands of the melanin concentrating hormone receptor useful for the treatment of obesity, diabetes, eating and sexual disorders |
| WO2006052962A2 (en) | 2004-11-10 | 2006-05-18 | Janssen Pharmaceutica, N.V. | Bicyclic triazole a4 integrin inhibitors |
| US20080175795A1 (en) | 2005-06-30 | 2008-07-24 | Bexel Pharmaceuticals, Inc. | Novel derivatives of amino acids for treatment of obesity and related disorders |
| US7399786B2 (en) | 2005-06-30 | 2008-07-15 | Bexel Pharmaceuticals, Inc. | Derivatives of amino acids for treatment of obesity and related disorders |
| WO2007047306A1 (en) | 2005-10-12 | 2007-04-26 | Elan Pharmaceuticals, Inc. | Methods of treating amyloidosis using aryl-cyclopropyl derivative aspartyl protease inhibitors |
| AU2006315817A1 (en) | 2005-11-16 | 2007-05-24 | Merck & Co., Inc. | Imidazolidinone compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease |
| EP1980622B1 (en) | 2006-01-17 | 2010-08-18 | Sumitomo Chemical Company, Limited | Method for production of an optically active biphenylalanine compound or salt or ester thereof |
| US8980833B2 (en) * | 2007-05-10 | 2015-03-17 | R&D-Biopharmaceuticals Gmbh | Tubulysine derivatives |
| PT2185561E (pt) | 2007-07-27 | 2011-09-07 | Sanofi Aventis | Derivados de 1,2,3,4-tetra-hidropirrolo(1,2-a)pirazina-6- carboxamidas e de 2,3,4,5-tetra-hidropirrolo(1,2-a)-diazepina-7- carboxamidas, sua preparação e sua aplicação em terapia |
| CA2702469A1 (en) | 2007-10-19 | 2009-04-23 | Boehringer Ingelheim International Gmbh | Ccr10 antagonists |
| US20100022767A1 (en) | 2008-07-25 | 2010-01-28 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Development of a synthesis of syringolin a and b and derivatives thereof |
| CA2731685A1 (en) * | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| JP5755217B2 (ja) | 2009-03-30 | 2015-07-29 | トランステック・ファーマ，エルエルシー | 置換アゾアントラセン誘導体、その医薬組成物とその使用の方法 |
| CN101555211B (zh) | 2009-05-13 | 2012-01-25 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的化学合成方法 |
| CN103896796B (zh) | 2009-05-28 | 2016-04-27 | 诺华股份有限公司 | 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物 |
| KR20120107461A (ko) | 2009-10-21 | 2012-10-02 | 미츠비시 다나베 파마 코포레이션 | 페닐알라닌 유도체의 제조방법 |
| US8575170B2 (en) * | 2010-02-26 | 2013-11-05 | The Regents Of The Unversity Of Colorado, A Body Corporate | Flurbiprofen analogs and methods of use in treating cancer |
| US8586536B2 (en) * | 2010-12-15 | 2013-11-19 | Theravance, Inc. | Neprilysin inhibitors |
| CA2850987C (en) | 2011-10-17 | 2019-10-15 | Biotheryx, Inc. | Substituted biaryl alkyl amides |
-
2012
- 2012-10-16 CA CA2850987A patent/CA2850987C/en active Active
- 2012-10-16 CN CN201280060656.1A patent/CN104011013B/zh not_active Expired - Fee Related
- 2012-10-16 WO PCT/US2012/060464 patent/WO2013059215A1/en not_active Ceased
- 2012-10-16 MX MX2014004503A patent/MX2014004503A/es active IP Right Grant
- 2012-10-16 AU AU2012326361A patent/AU2012326361B2/en not_active Ceased
- 2012-10-16 JP JP2014535990A patent/JP6254088B2/ja not_active Expired - Fee Related
- 2012-10-16 EP EP12784158.3A patent/EP2768799B1/en not_active Not-in-force
- 2012-10-16 US US13/653,115 patent/US8822527B2/en active Active
- 2012-10-16 MX MX2015015685A patent/MX360188B/es unknown
-
2014
- 2014-07-30 US US14/447,473 patent/US9546131B2/en active Active
-
2016
- 2016-12-16 US US15/381,535 patent/US10106491B2/en active Active