JP2015520770A5 - - Google Patents
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- Publication number
- JP2015520770A5 JP2015520770A5 JP2015514538A JP2015514538A JP2015520770A5 JP 2015520770 A5 JP2015520770 A5 JP 2015520770A5 JP 2015514538 A JP2015514538 A JP 2015514538A JP 2015514538 A JP2015514538 A JP 2015514538A JP 2015520770 A5 JP2015520770 A5 JP 2015520770A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl group
- branched alkyl
- linear
- general formula
- ring structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C1C(C(CC(*)(*)C2)=*)=C2NC(*)=C1C(N*)=N Chemical compound *C1C(C(CC(*)(*)C2)=*)=C2NC(*)=C1C(N*)=N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12170403 | 2012-06-01 | ||
| EP12170403.5 | 2012-06-01 | ||
| PCT/EP2013/061363 WO2013178821A1 (en) | 2012-06-01 | 2013-06-03 | Inhibitors of the notch signalling pathway and secretion for use in medicine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520770A JP2015520770A (ja) | 2015-07-23 |
| JP2015520770A5 true JP2015520770A5 (https=) | 2015-12-17 |
| JP6138928B2 JP6138928B2 (ja) | 2017-05-31 |
Family
ID=48577739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514538A Expired - Fee Related JP6138928B2 (ja) | 2012-06-01 | 2013-06-03 | 医薬に使用されるｎｏｔｃｈシグナル伝達経路及び分泌の阻害物質 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9828344B2 (https=) |
| EP (1) | EP2854809B1 (https=) |
| JP (1) | JP6138928B2 (https=) |
| HK (1) | HK1204928A1 (https=) |
| WO (1) | WO2013178821A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3139942B1 (en) | 2014-05-05 | 2019-12-18 | Bioventures, Llc | COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS |
| WO2016014625A1 (en) | 2014-07-22 | 2016-01-28 | Board Of Trustees Of The University Of Arkansas | Compositions and methods for selectively depleting senescent cells |
| ES3057783T3 (en) | 2016-03-15 | 2026-03-04 | Oryzon Genomics Sa | Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases |
| CN109152933B (zh) | 2016-04-21 | 2022-12-02 | 生物风险投资有限责任公司 | 诱导抗细胞凋亡bcl-2家族蛋白的降解的化合物及其用途 |
| IT201600132360A1 (it) | 2016-12-29 | 2018-06-29 | Univ Degli Studi Roma La Sapienza | Inibitori di notch per uso nel trattamento della leucemia linfoblastica acuta a cellule t |
| ES3041854T3 (en) | 2018-01-22 | 2025-11-17 | Bioventures Llc | Bcl-2 proteins degraders for cancer treatment |
| US12084423B2 (en) | 2018-05-18 | 2024-09-10 | Bioventures, Llc | Piperlongumine analogues and uses thereof |
| CA3114113A1 (en) | 2018-10-02 | 2020-04-09 | Frequency Therapeutics, Inc. | Pharmaceutical compositions and methods related to otic therapeutic agents |
| US20220175776A1 (en) | 2019-04-08 | 2022-06-09 | Frequency Therapeutics, Inc. | Combination of chir99021 and valproic acid for treating hearing loss |
| US20210311023A1 (en) * | 2019-12-09 | 2021-10-07 | Wisconsin Alumni Research Foundation | Chemical cocktail for inducing senescence in human neurons to promote disease modeling and drug discovery |
| JP2023526521A (ja) * | 2020-05-21 | 2023-06-21 | ステムシナジー セラピューティクス， インク． | Ｎｏｔｃｈ阻害剤及びそれらの使用 |
| WO2022158610A1 (en) * | 2021-01-20 | 2022-07-28 | Prism BioLab Co., Ltd. | Novel bicyclic compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2003148A1 (de) * | 1970-01-24 | 1971-07-29 | Bayer Ag | Neue 1,4-Dihydropyridinderivate |
| DE2003146A1 (de) * | 1970-01-24 | 1971-07-29 | Bayer Ag | Neue 1,4-Dihydropyridinderivate |
| US7244757B2 (en) * | 2004-04-01 | 2007-07-17 | Pfizer Inc | Pyrazole-amine compounds for the treatment of neurodegenerative disorders |
| EP1858325A4 (en) | 2005-01-07 | 2010-06-30 | Roskamp Res Llc | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS FOR IDENTIFYING THESE COMPOUNDS |
| EP2120557A4 (en) | 2006-12-08 | 2010-02-10 | Roskamp Res Llc | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION |
| WO2008103470A2 (en) | 2007-02-21 | 2008-08-28 | Trustees Of Columbia University In The City Of New York | Oncogenic-ras-signal dependent lethal compounds |
| WO2009006580A1 (en) * | 2007-07-05 | 2009-01-08 | Cv Therapeutics, Inc. | Optionally condensed dihydropyridine, dihydropyrimidine and dihydropyrane derivatives acting as late sodium channel blockers |
| WO2009102864A1 (en) | 2008-02-12 | 2009-08-20 | Stanford University | Hedgehog pathway antagonists and methods of use |
| CA2770302A1 (en) * | 2008-09-17 | 2010-03-25 | Burnham Institute For Medical Research | Small molecule compounds for stem cell differentiation |
| US20110281356A1 (en) * | 2008-09-17 | 2011-11-17 | Human Biomolecular Research Institute | Compounds for stem cell differentiation |
| AP2012006277A0 (en) | 2009-10-23 | 2012-06-30 | Health Research Inc | Method for treating androgen receptor positive cancers. |
| SG190204A1 (en) * | 2010-11-11 | 2013-06-28 | Redx Pharma Ltd | Drug derivatives |
-
2013
- 2013-06-03 US US14/404,330 patent/US9828344B2/en not_active Expired - Fee Related
- 2013-06-03 WO PCT/EP2013/061363 patent/WO2013178821A1/en not_active Ceased
- 2013-06-03 JP JP2015514538A patent/JP6138928B2/ja not_active Expired - Fee Related
- 2013-06-03 HK HK15105506.9A patent/HK1204928A1/xx unknown
- 2013-06-03 EP EP13727588.9A patent/EP2854809B1/en not_active Not-in-force
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