JP2024521895A5 - - Google Patents
Info
- Publication number
- JP2024521895A5 JP2024521895A5 JP2023574337A JP2023574337A JP2024521895A5 JP 2024521895 A5 JP2024521895 A5 JP 2024521895A5 JP 2023574337 A JP2023574337 A JP 2023574337A JP 2023574337 A JP2023574337 A JP 2023574337A JP 2024521895 A5 JP2024521895 A5 JP 2024521895A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- nhr
- formula
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/PL2021/000030 WO2022255888A1 (en) | 2021-06-01 | 2021-06-01 | Targeted protein degradation using bifunctional compounds that bind ubiquitin ligase and target mcl-1 protein |
| PLPCT/PL2021/000030 | 2021-06-01 | ||
| PCT/EP2022/064481 WO2022253713A1 (en) | 2021-06-01 | 2022-05-27 | Targeted protein degradation using bifunctional compounds that bind ubiquitin ligase and target mcl-1 protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024521895A JP2024521895A (ja) | 2024-06-04 |
| JP2024521895A5 true JP2024521895A5 (https=) | 2025-07-07 |
Family
ID=77168359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023574337A Pending JP2024521895A (ja) | 2021-06-01 | 2022-05-27 | ユビキチンリガーゼに結合しｍｃｌ－１タンパク質を標的とする二官能性化合物を用いた標的タンパク質分解 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240294499A1 (https=) |
| EP (1) | EP4347579A1 (https=) |
| JP (1) | JP2024521895A (https=) |
| KR (1) | KR20240029561A (https=) |
| CN (1) | CN117957218A (https=) |
| AU (1) | AU2022284249A1 (https=) |
| BR (1) | BR112023025067A2 (https=) |
| CA (1) | CA3218442A1 (https=) |
| IL (1) | IL308676A (https=) |
| MX (1) | MX2023014331A (https=) |
| WO (2) | WO2022255888A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022146151A1 (en) * | 2020-12-30 | 2022-07-07 | Captor Therapeutics S.A. | Novel compounds which bind to cereblon, and methods of use thereof |
| IL311606A (en) * | 2021-09-27 | 2024-05-01 | Univ Pennsylvania | Molluscum contagiosum infection inhibitors and methods of using them |
| WO2024015340A1 (en) * | 2022-07-12 | 2024-01-18 | Regents Of The University Of Michigan | Cereblon ligands and uses thereof |
| WO2024123195A1 (en) * | 2022-12-06 | 2024-06-13 | Captor Therapeutics S.A. | Targeted protein degradation using prodrugs of bifunctional compounds that bind ubiquitin ligase and target mcl-1 protein |
| KR20250130610A (ko) * | 2022-12-06 | 2025-09-02 | 캡터 테라퓨틱스 에스.에이. | 유비퀴틴 리가제 및 표적 mcl-1 단백질에 결합하는 이작용성 화합물을 사용하는 표적화된 단백질 분해 |
| WO2024167423A1 (en) | 2023-02-07 | 2024-08-15 | Captor Therapeutics S.A. | Gspt1 degrader compounds |
| WO2025136129A1 (en) * | 2023-12-22 | 2025-06-26 | Captor Therapeutics S.A. | Targeted protein degradation using bifunctional compounds that bind ubiquitin ligase and target protein kinase c |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306663B1 (en) | 1999-02-12 | 2001-10-23 | Proteinex, Inc. | Controlling protein levels in eucaryotic organisms |
| MY162157A (en) * | 2007-04-16 | 2017-05-31 | Abbott Lab | Substituted indole mcl-1 inhibitors |
| CA2922341C (en) * | 2013-08-28 | 2022-06-07 | Vanderbilt University | Substituted indole mcl-1 inhibitors |
| FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2016105518A1 (en) * | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| BR112018068906A2 (pt) * | 2016-03-16 | 2019-01-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | composição, método, método de redução de risco, prevenção ou tratamento de um indivíduo que tem uma doença ou distúrbio autoimune, método de indução de degradação de uma proteína-alvo numa célula, método para reduzir o risco, prevenir ou tratar um estado da doença ou afecção num paciente em que a atividade proteica desregulada é responsável pelo referido estado da doença ou afecção, método para reduzir o risco, prevenir ou tratar câncer num indivíduo e método de tratamento de uma doença ou distúrbio genético num indivíduo |
| CN109152933B (zh) * | 2016-04-21 | 2022-12-02 | 生物风险投资有限责任公司 | 诱导抗细胞凋亡bcl-2家族蛋白的降解的化合物及其用途 |
| CN110506039A (zh) * | 2016-10-11 | 2019-11-26 | 阿尔维纳斯股份有限公司 | 用于雄激素受体靶向降解的化合物和方法 |
| KR20250117470A (ko) * | 2016-12-23 | 2025-08-04 | 아비나스 오퍼레이션스, 인코포레이티드 | 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법 |
| IL312367A (en) * | 2017-01-31 | 2024-06-01 | Arvinas Operations Inc | Cereblon ligands and bifunctional compounds comprising the same |
| CN107382862A (zh) * | 2017-07-17 | 2017-11-24 | 大连理工大学 | 硫/氧代萘酰亚胺类化合物及其应用 |
| CN118108706A (zh) * | 2017-09-04 | 2024-05-31 | C4医药公司 | 戊二酰亚胺 |
| JP7852923B2 (ja) * | 2019-11-27 | 2026-04-28 | キャプター セラピューティクス エス．エー． | セレブロンに結合するピペリジン－２，６－ジオン誘導体、及びその使用方法 |
| WO2021105335A1 (en) * | 2019-11-27 | 2021-06-03 | Captor Therapeutics S.A. | Piperidine-2, 6-dione derivatives which bind to cereblon, and methods of use thereof |
-
2021
- 2021-06-01 WO PCT/PL2021/000030 patent/WO2022255888A1/en not_active Ceased
-
2022
- 2022-05-27 WO PCT/EP2022/064481 patent/WO2022253713A1/en not_active Ceased
- 2022-05-27 EP EP22731153.7A patent/EP4347579A1/en active Pending
- 2022-05-27 BR BR112023025067A patent/BR112023025067A2/pt unknown
- 2022-05-27 KR KR1020237045449A patent/KR20240029561A/ko active Pending
- 2022-05-27 JP JP2023574337A patent/JP2024521895A/ja active Pending
- 2022-05-27 US US18/565,630 patent/US20240294499A1/en active Pending
- 2022-05-27 CN CN202280053420.9A patent/CN117957218A/zh active Pending
- 2022-05-27 IL IL308676A patent/IL308676A/en unknown
- 2022-05-27 CA CA3218442A patent/CA3218442A1/en active Pending
- 2022-05-27 MX MX2023014331A patent/MX2023014331A/es unknown
- 2022-05-27 AU AU2022284249A patent/AU2022284249A1/en active Pending
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