|
US949A
(en)
|
|
1838-09-27 |
|
Improvement in roller cotton-gins for ginning long-staple and other kinds of cotton |
|
US5861A
(en)
|
|
1848-10-17 |
|
Locking umbrella and parasol |
|
US5863A
(en)
|
|
1848-10-17 |
|
Matthias p |
|
US510A
(en)
|
|
1837-12-07 |
|
soeel |
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
DE4239169A1
(de)
|
1992-11-21 |
1994-05-26 |
Merck Patent Gmbh |
Cyclobutan - Benzol - Derivate
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
DK0821671T3
(da)
|
1995-04-20 |
2001-04-23 |
Pfizer |
Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer
|
|
DE69624081T2
(de)
|
1995-12-20 |
2003-06-12 |
Agouron Pharmaceuticals, Inc. |
Matrix-metalloprotease Inhibitoren
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
EP0923585B1
(en)
|
1996-07-18 |
2002-05-08 |
Pfizer Inc. |
Phosphinate based inhibitors of matrix metalloproteases
|
|
US5782605A
(en)
|
1996-07-19 |
1998-07-21 |
Andritz Sprout-Bauer, Inc. |
Impeller for separating a conveyed stream of material
|
|
WO1998007697A1
(en)
|
1996-08-23 |
1998-02-26 |
Pfizer Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
US5914251A
(en)
|
1996-10-22 |
1999-06-22 |
Amgen Inc. |
Nucleic acid molecules encoding placental-derived growth factors
|
|
US5866562A
(en)
|
1996-10-25 |
1999-02-02 |
Bayer Aktiengesellschaft |
Ring-bridged bis-quinolines
|
|
WO1998030566A1
(en)
|
1997-01-06 |
1998-07-16 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
EP0977733B1
(en)
|
1997-02-03 |
2003-09-03 |
Pfizer Products Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
JP2000507975A
(ja)
|
1997-02-07 |
2000-06-27 |
ファイザー・インク |
N−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
|
|
EA002546B1
(ru)
|
1997-02-11 |
2002-06-27 |
Пфайзер Инк. |
Производные арилсульфонилгидроксамовой кислоты
|
|
JPH10330377A
(ja)
|
1997-06-02 |
1998-12-15 |
Kyowa Hakko Kogyo Co Ltd |
ピペリジン誘導体
|
|
AU730248B2
(en)
|
1997-08-08 |
2001-03-01 |
Pfizer Products Inc. |
Aryloxyarylsulfonylamino hydroxamic acid derivatives
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
JP3890193B2
(ja)
|
1997-12-22 |
2007-03-07 |
株式会社ルネサステクノロジ |
電力増幅システムおよび移動体通信端末装置
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
US6479487B1
(en)
|
1998-02-26 |
2002-11-12 |
Aventis Pharmaceuticals Inc. |
6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
|
|
JP4462654B2
(ja)
|
1998-03-26 |
2010-05-12 |
ソニー株式会社 |
映像素材選択装置及び映像素材選択方法
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
PA8474101A1
(es)
|
1998-06-19 |
2000-09-29 |
Pfizer Prod Inc |
Compuestos de pirrolo [2,3-d] pirimidina
|
|
DK1004578T3
(da)
|
1998-11-05 |
2004-06-28 |
Pfizer Prod Inc |
5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater
|
|
GB9912961D0
(en)
|
1999-06-03 |
1999-08-04 |
Pfizer Ltd |
Metalloprotease inhibitors
|
|
US6511993B1
(en)
|
1999-06-03 |
2003-01-28 |
Kevin Neil Dack |
Metalloprotease inhibitors
|
|
EP1081137A1
(en)
|
1999-08-12 |
2001-03-07 |
Pfizer Products Inc. |
Selective inhibitors of aggrecanase in osteoarthritis treatment
|
|
US20070208087A1
(en)
|
2001-11-02 |
2007-09-06 |
Sanders Virginia J |
Compounds, compositions and methods for the treatment of inflammatory diseases
|
|
US7074801B1
(en)
|
2001-04-26 |
2006-07-11 |
Eisai Co., Ltd. |
Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof
|
|
US6849638B2
(en)
|
2001-04-30 |
2005-02-01 |
Bayer Pharmaceuticals Corporation |
4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same, and their use in the treatment or prevention of pde7b-mediated diseases and conditions
|
|
AU2002336462A1
(en)
|
2001-09-06 |
2003-03-24 |
Millennium Pharmaceuticals, Inc. |
Piperazine and homopiperazine compounds
|
|
AU2003258662A1
(en)
|
2002-10-02 |
2004-04-23 |
Merck Patent Gmbh |
Use of 4-amino-quinazolines as anti cancer agents
|
|
AU2003255482A1
(en)
|
2002-10-02 |
2004-04-23 |
Merck Patent Gmbh |
Use of 4 amino-quinazolines as anti cancer agents
|
|
JP4677518B2
(ja)
|
2003-03-31 |
2011-04-27 |
エピックス デラウェア, インコーポレイテッド |
新規ピペリジニルアミノ−チエノ[2,3−d]ピリミジン化合物
|
|
US7612078B2
(en)
|
2003-03-31 |
2009-11-03 |
Epix Delaware, Inc. |
Piperidinylamino-thieno[2,3-D] pyrimidine compounds
|
|
US20050222175A1
(en)
|
2004-03-31 |
2005-10-06 |
Dhanoa Dale S |
New piperidinylamino-thieno[2,3-D] pyrimidine compounds
|
|
EP1663962A4
(en)
|
2003-08-22 |
2007-08-22 |
Dendreon Corp |
COMPOSITIONS AND METHODS FOR TREATING A DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION
|
|
US20050123906A1
(en)
|
2003-11-06 |
2005-06-09 |
Rana Tariq M. |
Protein modulation
|
|
CN101031551A
(zh)
|
2004-07-06 |
2007-09-05 |
安吉永生物制药公司 |
针对癌症治疗的肝细胞生长因子/c-met活性的喹唑啉调节剂
|
|
US7553964B2
(en)
|
2005-06-03 |
2009-06-30 |
Abbott Laboratories |
Cyclobutyl amine derivatives
|
|
US20060281769A1
(en)
|
2005-06-10 |
2006-12-14 |
Baumann Christian A |
Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators
|
|
US20060281771A1
(en)
|
2005-06-10 |
2006-12-14 |
Baumann Christian A |
Synergistic modulation of flt3 kinase using aminoquinoline and aminoquinazoline kinase modulators
|
|
AU2006286441A1
(en)
|
2005-09-02 |
2007-03-08 |
Janssen R&D Ireland |
Benzodiazepines as HCV inhibitors
|
|
JP5456315B2
(ja)
|
2005-09-19 |
2014-03-26 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
シクロブタンおよびスピロ[3.3]ヘプタン化合物類
|
|
FR2891829A1
(fr)
|
2005-10-12 |
2007-04-13 |
Sanofi Aventis Sa |
Derives de la 4-amino-quinazoline, leur preparation et leur application en therapeutique
|
|
EP1979348B1
(en)
|
2005-12-21 |
2012-01-18 |
Abbott Laboratories |
Anti-viral compounds
|
|
CA2651898A1
(en)
|
2006-04-07 |
2007-10-18 |
Develogen Aktiengesellschaft |
Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions
|
|
EP1903044A1
(en)
|
2006-09-14 |
2008-03-26 |
Novartis AG |
Adenosine Derivatives as A2A Receptor Agonists
|
|
US8242078B2
(en)
|
2006-10-19 |
2012-08-14 |
The University Of Chicago |
Therapeutics to inhibit MLL-menin interaction for treating leukemia
|
|
EP1947103A1
(en)
|
2007-01-22 |
2008-07-23 |
4Sc Ag |
Aryloxypropanolamines, methods of preparation thereof and use of aryloxypropanolamines as medicaments
|
|
WO2008099019A1
(en)
|
2007-02-16 |
2008-08-21 |
Tibotec Pharmaceuticals Ltd. |
6-hydroxy-dibenzodiazepinones useful as hepatitis c virus inhibitors
|
|
FR2913017A1
(fr)
|
2007-02-23 |
2008-08-29 |
Cerep Sa |
Derives de piperidine et piperazine comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire
|
|
ATE496022T1
(de)
|
2007-03-19 |
2011-02-15 |
Council Scient Ind Res |
Anthranilsäure-derivat als antikrebswirkstoff und verfahren zur herstellung davon
|
|
WO2008135232A1
(en)
|
2007-05-02 |
2008-11-13 |
Riccardo Cortese |
Use and compositions of purine derivatives for the treatment of proliferative disorders
|
|
EP2148944A1
(en)
|
2007-05-25 |
2010-02-03 |
Burnham Institute for Medical Research |
Inhibitors of thapsigargin-induced cell death
|
|
WO2009017838A2
(en)
|
2007-08-01 |
2009-02-05 |
Exelixis, Inc. |
Combinations of jak-2 inhibitors and other agents
|
|
WO2009064388A2
(en)
|
2007-11-09 |
2009-05-22 |
Liu Jun O |
Inhibitors of human methionine aminopeptidase 1 and methods of treating disorders
|
|
CA2709784A1
(en)
|
2007-12-21 |
2009-07-09 |
University Of Rochester |
Method for altering the lifespan of eukaryotic organisms
|
|
KR20110018380A
(ko)
|
2008-05-22 |
2011-02-23 |
알러간, 인코포레이티드 |
Cxcr4 수용체에서 활성을 갖는 이환식 화합물
|
|
DE102008027574A1
(de)
|
2008-06-10 |
2009-12-17 |
Merck Patent Gmbh |
Neue Pyrrolidinderivate als MetAP-2 Inhibitoren
|
|
BRPI0917936A2
(pt)
|
2008-08-25 |
2017-07-11 |
Irm Llc |
Moduladores de via hedgehog
|
|
AU2009291783A1
(en)
|
2008-09-10 |
2010-03-18 |
Alcon Research, Ltd |
Aminopyrimidine inhibitors of histamine receptors for the treatment of disease
|
|
US9346809B2
(en)
|
2009-07-08 |
2016-05-24 |
Leo Pharma A/S |
Heterocyclic compounds as JAK receptor and protein tyrosine kinase inhibitors
|
|
CN102574787B
(zh)
|
2009-07-30 |
2014-12-31 |
新加坡国立大学 |
具有潜在的抗癌活性的小分子异戊二烯基半胱氨酸羧基甲基转移酶抑制剂
|
|
EP2473054B1
(en)
|
2009-09-04 |
2017-06-14 |
The Regents of the University of Michigan |
Compositions and methods for treatment of leukemia
|
|
ES2528441T3
(es)
|
2010-02-22 |
2015-02-10 |
Merck Patent Gmbh |
Hetarilaminonaftiridinas
|
|
EP2606051B1
(en)
|
2010-08-20 |
2016-10-05 |
Hutchison Medipharma Limited |
Pyrrolopyrimidine compounds and uses thereof
|
|
US8580762B2
(en)
|
2010-12-03 |
2013-11-12 |
Epizyme, Inc. |
Substituted purine and 7-deazapurine compounds
|
|
US9394310B2
(en)
|
2010-12-03 |
2016-07-19 |
Epizyme, Inc. |
Carbocycle-substituted purine and 7-deazapurine compounds
|
|
EP2646454B1
(en)
|
2010-12-03 |
2015-07-08 |
Epizyme, Inc. |
7-deazapurine modulators of histone methyltransferase, and methods of use thereof
|
|
CA2819620A1
(en)
|
2010-12-03 |
2012-06-21 |
Epizyme, Inc. |
Modulators of histone methyltransferase, and methods of use thereof
|
|
WO2013019966A1
(en)
|
2011-08-04 |
2013-02-07 |
Allergan, Inc. |
Aromatic bycyclic derivatives as cxcr4 receptor modulators
|
|
GB201114212D0
(en)
|
2011-08-18 |
2011-10-05 |
Ucb Pharma Sa |
Therapeutic agents
|
|
AR090037A1
(es)
|
2011-11-15 |
2014-10-15 |
Xention Ltd |
Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
|
|
CN103833759A
(zh)
|
2012-11-23 |
2014-06-04 |
华东理工大学 |
作为blk、flt3抑制剂的蝶啶酮衍生物及其应用
|
|
US20150284422A1
(en)
|
2012-08-10 |
2015-10-08 |
Epizyme, Inc. |
Inhibitors of protein methyltransferase dot1l and methods of use thereof
|
|
US20140100184A1
(en)
|
2012-08-31 |
2014-04-10 |
Baylor College Of Medicine |
Selective inhibitors of histone methyltransferase dot1l
|
|
US9597348B2
(en)
|
2012-09-06 |
2017-03-21 |
Epizyme, Inc. |
Method of treating leukemia
|
|
GB201217704D0
(en)
|
2012-10-03 |
2012-11-14 |
Ucb Pharma Sa |
Therapeutic agents
|
|
JP2016510316A
(ja)
|
2012-12-21 |
2016-04-07 |
エピザイム,インコーポレイティド |
白血病の治療に使用するためのdot1l阻害剤
|
|
EP2968285A4
(en)
|
2013-03-13 |
2016-12-21 |
Flatley Discovery Lab |
COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
|
|
KR20150130389A
(ko)
|
2013-03-13 |
2015-11-23 |
더 리젠츠 오브 더 유니버시티 오브 미시간 |
티에노피리미딘 및 티에노피리딘 화합물을 포함하는 조성물 및 이의 사용 방법
|
|
US9212180B2
(en)
|
2013-06-12 |
2015-12-15 |
The Regents Of The University Of Michigan |
Menin-MLL inhibitors and methods of use thereof
|
|
CA2920252A1
(en)
|
2013-08-02 |
2015-02-05 |
Memorial Sloan-Kettering Cancer Center |
Methods for the detection and treatment of leukemias that are responsive to dot1l inhibition
|
|
CN106458990B
(zh)
|
2014-04-04 |
2019-06-07 |
希洛斯医药品股份有限公司 |
细胞周期蛋白依赖性激酶7(cdk7)的抑制剂
|
|
JP2017514505A
(ja)
|
2014-05-07 |
2017-06-08 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
急性骨髄性白血病の新規バイオマーカー
|
|
US20170119769A1
(en)
|
2014-06-10 |
2017-05-04 |
The Trustees Of The University Of Pennsylvania |
Scaffolds for inhibitors of menin-mll interactions
|
|
WO2016025635A2
(en)
*
|
2014-08-13 |
2016-02-18 |
Epizyme, Inc. |
Combination therapy for treating cancer
|
|
WO2016025649A1
(en)
|
2014-08-13 |
2016-02-18 |
Celgene Avilomics Research, Inc. |
Combinations of an erk inhibitor and a dot1l inhibitor and related methods
|
|
WO2016040330A1
(en)
*
|
2014-09-09 |
2016-03-17 |
The Regents Of The University Of Michigan |
Thienopyrimidine and thienopyridine compounds and methods of use thereof
|
|
WO2016081732A1
(en)
|
2014-11-19 |
2016-05-26 |
Memorial Sloan-Kettering Cancer Center |
Thienopyrimidines and uses thereof
|
|
WO2016197027A1
(en)
|
2015-06-04 |
2016-12-08 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with mll proteins
|
|
AR104020A1
(es)
|
2015-06-04 |
2017-06-21 |
Kura Oncology Inc |
Métodos y composiciones para inhibir la interacción de menina con proteínas mill
|
|
AU2016324920B2
(en)
|
2015-09-14 |
2022-03-03 |
Brunangelo Falini |
Dactinomycin compositions and methods for the treatment of acute myeloid leukemia
|
|
AU2016378579A1
(en)
|
2015-12-22 |
2018-06-14 |
Vitae Pharmaceuticals, Inc. |
Inhibitors of the menin-MLL interaction
|
|
EP4643952A3
(en)
|
2016-01-26 |
2026-01-14 |
Memorial Sloan Kettering Cancer Center |
Targeting chromatin regulators for inhibiting leukemogenic gene expression in npm1
|
|
CN109152784B
(zh)
*
|
2016-03-16 |
2021-12-28 |
库拉肿瘤学公司 |
经取代的menin-mll抑制剂及使用方法
|
|
CN109640987B
(zh)
|
2016-03-16 |
2022-12-02 |
库拉肿瘤学公司 |
Menin-mll的桥联双环抑制剂及使用方法
|
|
WO2017192543A1
(en)
|
2016-05-02 |
2017-11-09 |
Regents Of The University Of Michigan |
Piperidines as menin inhibitors
|
|
WO2017207387A1
(en)
|
2016-05-31 |
2017-12-07 |
Bayer Pharma Aktiengesellschaft |
Spiro condensed azetidine derivatives as inhibitors of the menin-mml1 interaction
|
|
EP3805215A1
(en)
|
2016-06-10 |
2021-04-14 |
Vitae Pharmaceuticals, LLC |
Inhibitors of the menin-mll interaction
|
|
TW201805000A
(zh)
|
2016-06-20 |
2018-02-16 |
庫拉腫瘤技術股份有限公司 |
利用erk抑制劑之鱗狀細胞癌之治療
|
|
CA2937896A1
(en)
|
2016-08-02 |
2018-02-02 |
Universite De Montreal |
Use of mubritinib for the treatment of poor prognosis acute myeloid leukemia
|
|
WO2018024602A1
(en)
|
2016-08-04 |
2018-02-08 |
Bayer Aktiengesellschaft |
2,7-diazaspiro[4.4]nonanes
|
|
CA3033239A1
(en)
|
2016-09-14 |
2018-03-22 |
Janssen Pharmaceutica Nv |
Spiro bicyclic inhibitors of menin-mll interaction
|
|
MA46228A
(fr)
|
2016-09-14 |
2019-07-24 |
Janssen Pharmaceutica Nv |
Inhibiteurs bicycliques fusionnés de l'interaction ménine-mll
|
|
US10899758B2
(en)
|
2016-09-16 |
2021-01-26 |
Vitae Pharmaceuticals, Llc |
Inhibitors of the menin-MLL interaction
|
|
BR112019008762A2
(pt)
|
2016-11-02 |
2019-07-16 |
Arog Pharmaceuticals, Inc. |
método para o tratamento de um distúrbio proliferativo mutado em flt3
|
|
WO2018106820A1
(en)
|
2016-12-07 |
2018-06-14 |
Kura Oncology, Inc. |
Methods of promoting beta cell proliferation
|
|
WO2018106818A1
(en)
|
2016-12-07 |
2018-06-14 |
Kura Oncology, Inc. |
Methods of promoting beta cell proliferation
|
|
US10703757B2
(en)
|
2016-12-23 |
2020-07-07 |
Plexxikon Inc. |
Compounds and methods for CDK8 modulation and indications therefor
|
|
CN110691779B
(zh)
|
2017-03-24 |
2023-10-10 |
库拉肿瘤学公司 |
治疗血液系统恶性肿瘤和尤因肉瘤的方法
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