JP2009529540A5 - - Google Patents

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Publication number
JP2009529540A5
JP2009529540A5 JP2008558543A JP2008558543A JP2009529540A5 JP 2009529540 A5 JP2009529540 A5 JP 2009529540A5 JP 2008558543 A JP2008558543 A JP 2008558543A JP 2008558543 A JP2008558543 A JP 2008558543A JP 2009529540 A5 JP2009529540 A5 JP 2009529540A5
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JP
Japan
Prior art keywords
tetrazole
conr
alkyl
conh
och
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008558543A
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English (en)
Japanese (ja)
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JP2009529540A (ja
JP4851546B2 (ja
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Application filed filed Critical
Priority claimed from PCT/US2007/063631 external-priority patent/WO2007106721A2/en
Publication of JP2009529540A publication Critical patent/JP2009529540A/ja
Publication of JP2009529540A5 publication Critical patent/JP2009529540A5/ja
Application granted granted Critical
Publication of JP4851546B2 publication Critical patent/JP4851546B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2008558543A 2006-03-10 2007-03-09 肥満治療に有用なカンナビノイド受容体アンタゴニスト／インバースアゴニスト Expired - Fee Related JP4851546B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78148506P 2006-03-10 2006-03-10
US60/781,485 2006-03-10
PCT/US2007/063631 WO2007106721A2 (en) 2006-03-10 2007-03-09 Cannabinoid receptor antagonists/inverse agonists useful for treating obesity

Publications (3)

Publication Number Publication Date
JP2009529540A JP2009529540A (ja) 2009-08-20
JP2009529540A5 true JP2009529540A5 (https=) 2010-07-15
JP4851546B2 JP4851546B2 (ja) 2012-01-11

Family

ID=38510173

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008558543A Expired - Fee Related JP4851546B2 (ja) 2006-03-10 2007-03-09 肥満治療に有用なカンナビノイド受容体アンタゴニスト／インバースアゴニスト

Country Status (8)

Country Link
US (2) US7687481B2 (https=)
EP (1) EP1993560B1 (https=)
JP (1) JP4851546B2 (https=)
CN (1) CN101437398A (https=)
AT (1) ATE538650T1 (https=)
AU (1) AU2007226673A1 (https=)
CA (1) CA2647031A1 (https=)
WO (1) WO2007106721A2 (https=)

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RU2392943C2 (ru) * 2007-11-22 2010-06-27 Людмила Александровна Орлова Способ разгрузочно-диетической терапии
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WO2009117095A1 (en) * 2008-03-18 2009-09-24 Arena Pharmaceuticals, Inc. Modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto
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DE102009036604A1 (de) 2009-07-30 2011-02-03 Aicuris Gmbh & Co. Kg Substituierte Bis-Arylpyrazolamide mit terminaler primärer Amidfunktionalisierung und ihre Verwendung
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CN102603713B (zh) * 2011-01-25 2014-05-14 范如霖 手性cb1受体抑制剂、制备方法及其医学用途
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
CN102212058B (zh) * 2011-04-14 2014-04-02 范如霖 “单一的复合药”：手性含氮杂环酯、合成法及其在制备低毒性cb1受体抑制剂中的应用
CN102250006B (zh) * 2011-05-12 2014-03-05 范如霖 3-吡唑羧酸酰胺类化合物、其制备方法及其在制备作为cb1受体抑制剂药物中的应用
CN103554025B (zh) * 2011-05-12 2016-08-10 范如霖 3-砒唑羧酸酰胺类化合物、其制备方法及其在制备作为cb1受体抑制剂药物中的应用
WO2012174362A1 (en) * 2011-06-17 2012-12-20 Research Triangle Institute Pyrazole derivatives as cannabinoid receptor 1 antagonists
MY169319A (en) 2011-07-26 2019-03-21 Sanofi Sa 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
KR101586714B1 (ko) 2011-09-30 2016-01-19 내셔날 헬스 리서치 인스티튜트 피라졸 화합물
BR102012017421A2 (pt) 2012-07-13 2015-04-14 Proteimax Biotecnolgia Ltda Peptídeo, composicão farmacêutica, ligante de receptor cb, metodo para modular a funcao de receptor cb, uso, método para o tratamento de obesidade, e, método para promover a redução de peso estetica em um indivíduo
MX387055B (es) 2014-06-06 2025-03-19 Res Triangle Inst Agonistas del receptor de apelina (apj) y usos de los mismos.
WO2017100558A1 (en) 2015-12-09 2017-06-15 Research Triangle Institute Improved apelin receptor (apj) agonists and uses thereof
EP3279197A1 (en) 2016-08-03 2018-02-07 Friedrich-Alexander-Universität Erlangen-Nürnberg Diagnosis, treatment and prevention of neurotensin receptor-related conditions
MX394907B (es) 2016-10-12 2025-03-24 Res Triangle Inst Agonistas heterociclicos del receptor de apelina (apj) y usos de los mismos
WO2018068120A1 (pt) * 2016-10-13 2018-04-19 Proteimax Biotecnologia Ltda Uso de composto, intermediário de síntese, composição farmacêutica e método terapêutico neuromodulador
KR101974414B1 (ko) * 2017-09-12 2019-05-02 주식회사 티에스디라이프사이언스 1h-피라졸-3-아마이드계 화합물 유도체를 포함하는 섬유증 예방 또는 치료용 조성물
JP7307079B2 (ja) * 2018-01-30 2023-07-11 ピーアイ インダストリーズ リミテッド 新規アントラニルアミド、殺虫剤としてのその使用およびその製造方法
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
US20200035118A1 (en) 2018-07-27 2020-01-30 Joseph Pandolfino Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
IL317596A (en) * 2019-01-15 2025-02-01 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Peripheral CB1 receptor inhibitors
KR102707476B1 (ko) * 2021-01-28 2024-09-20 주식회사 파미노젠 피라졸-카르복스아미드 유도체 화합물 및 이의 용도
WO2024092205A1 (en) * 2022-10-27 2024-05-02 The Trustees Of Indiana University Inhibition of ship1 as a therapeutic strategy for the treatment of alzheimer's disease
WO2025175318A2 (en) * 2024-02-18 2025-08-21 Luminous Mind Inc. Pharmacotherapies for improving treatment adherence after discontinuation of incretin-based therapies
WO2025199092A1 (en) * 2024-03-20 2025-09-25 The Trustees Of Indiana University Ship1 modulators and methods of treatment and uses thereof

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FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2714057B1 (fr) * 1993-12-17 1996-03-08 Sanofi Elf Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
FR2741621B1 (fr) * 1995-11-23 1998-02-13 Sanofi Sa Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2742148B1 (fr) * 1995-12-08 1999-10-22 Sanofi Sa Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2789079B3 (fr) * 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
US6509367B1 (en) * 2001-09-22 2003-01-21 Virginia Commonwealth University Pyrazole cannabinoid agonist and antagonists
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JP2008525404A (ja) 2004-12-23 2008-07-17 アストラゼネカ アクチボラグ 治療剤
EP1928859A1 (en) 2005-06-17 2008-06-11 Carex SA Pyrazole derivates as cannabinoid receptor modulators
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BR112013030793A2 (pt) 2011-07-01 2016-12-06 Inst De Pesquisas Tecnológicas Do Estado De São Paulo processo de recuperação de liga lantanídeo-metal-metalóide em pó nanoparticulado com recuperação magnética e produto

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