PE20060481A1 - N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas - Google Patents
N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasasInfo
- Publication number
- PE20060481A1 PE20060481A1 PE2005000751A PE2005000751A PE20060481A1 PE 20060481 A1 PE20060481 A1 PE 20060481A1 PE 2005000751 A PE2005000751 A PE 2005000751A PE 2005000751 A PE2005000751 A PE 2005000751A PE 20060481 A1 PE20060481 A1 PE 20060481A1
- Authority
- PE
- Peru
- Prior art keywords
- alkylen
- inhibitors
- substitute
- aryl
- gamma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE REFIERE A COMPUESTOS DE N-ARILSUFONILAMINAS HETEROCICLICAS DE FORMULA (I), EN DONDE L ES -O-, -N(R6)-, -S-, ENTRE OTROS; R1 ES ARILO O HETEROARILO SUSTITUIDO CON R7; R2 ES -(C0-C6)ALQUILEN-(C3-C6)CICLOALQUILEN-(C0-C6)ALQUILEN-X-C(O)-Y, -(C0-C6)ALQUILEN-(C3-C6)CICLOALQUILEN-(C0-C6)ALQUILEN-C(O)-Y, -(C3-C6)CICLOALQUILEN-(C1-C6)ALQUILEN-C(O)-Y, ENTRE OTROS, SUSTITUIDO EL ALQUILENO CON UNO O MAS HIDROXI; R3 ES ARILO, ALQUILO, CICLOALQUILO,HETEROARILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON R7; X ES -O-, -N(R6)-, ENTRE OTROS; Y ES -NR8R9, -N(R6)-(CH2)b-NR8R9-, ARILO, ENTRE OTROS; m Yn SON INDEPENDIENTEMENTE DE 0 A 2, SIEMPRE QUE m + n SEA 1 0 2. SON PREFERIDOS: ESTER 4-(4-CLORO-BENCENSULFONIL)-5-(3,5-DIFLUORO-FENIL)-MORFOLIN-3-IL-METILICO DEL ACIDO 4-(2-HIDROXI-ETIL)-PIPERAZIN-1-CARBOXILICO, ALFA-[1-[4-[(4-CLOROFENIL)SULFONIL]-5(r)-CICLOPROPIL-3(S)-MORFOLINIL]CICLOPROPIL]-BETA-OXO-3,8-DIAZABICICLO[3.2.1]OCTAN-3-ETANOL, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE LA GAMMA SECRETASA POR LO QUE SON UTILES EN EL TRATAMIENTO DEL ALZHEIMER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58401004P | 2004-06-30 | 2004-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060481A1 true PE20060481A1 (es) | 2006-06-19 |
Family
ID=35783342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000751A PE20060481A1 (es) | 2004-06-30 | 2005-06-28 | N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas |
Country Status (14)
Country | Link |
---|---|
US (3) | US7763613B2 (es) |
EP (1) | EP1789404B1 (es) |
JP (1) | JP2008505100A (es) |
CN (2) | CN101602741A (es) |
AR (1) | AR050994A1 (es) |
AT (1) | ATE461926T1 (es) |
CA (1) | CA2570183A1 (es) |
DE (1) | DE602005020156D1 (es) |
ES (1) | ES2341560T3 (es) |
HK (1) | HK1099300A1 (es) |
MX (1) | MX2007000040A (es) |
PE (1) | PE20060481A1 (es) |
TW (1) | TWI297270B (es) |
WO (1) | WO2006004880A2 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20071321A1 (es) | 2006-01-20 | 2007-12-29 | Schering Corp | Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores de gamma secretasa relacionados |
PE20071232A1 (es) * | 2006-02-07 | 2008-02-18 | Wyeth Corp | Derivados de piperidina o piperazina como inhibidores de 11-beta hsd1 |
AU2007245435A1 (en) | 2006-04-26 | 2007-11-08 | Merck & Co., Inc. | Piperidines and related compounds for treatment of Alzheimer's disease |
ATE509956T1 (de) * | 2006-06-08 | 2011-06-15 | Helmholtz Zentrum Muenchen | Spezifische proteaseinhibitoren und ihre verwendung in der krebstherapie |
JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての3−ヒドロキシ−1,5−ジヒドロ−ピロール−2−オン誘導体 |
ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
NZ579310A (en) | 2007-03-01 | 2012-03-30 | Probiodrug Ag | Use of glutaminyl cyclase inhibitors for the treatment of mild cognitive impairment and diagnostic purposes thereof |
DK2142514T3 (da) | 2007-04-18 | 2015-03-23 | Probiodrug Ag | Thioureaderivater som glutaminylcyclase-inhibitorer |
MX2010004309A (es) * | 2007-10-19 | 2010-05-03 | Janssen Pharmaceutica Nv | Moduladores de piperidinil y piperazinil de gamma-secretasa. |
US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
US20110190269A1 (en) * | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
EP2542549B1 (en) | 2010-03-03 | 2016-05-11 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
BR112012022478B1 (pt) | 2010-03-10 | 2021-09-21 | Probiodrug Ag | Inibidores heterocíclicos de glutaminil ciclase (qc, ec 2.3.2.5), seu processo de preparação, e composição farmacêutica |
US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
CN109705052B (zh) * | 2019-01-25 | 2020-12-08 | 苏州大学 | 一种制备1,4-二氢噁嗪的方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04247081A (ja) | 1991-02-01 | 1992-09-03 | Takeda Chem Ind Ltd | 5員複素環酸アミド類 |
US5646167A (en) * | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
JP3834663B2 (ja) * | 1996-02-02 | 2006-10-18 | 株式会社デ・ウエスタン・セラピテクス研究所 | イソキノリン誘導体及び医薬 |
EP1102756A1 (en) * | 1998-06-03 | 2001-05-30 | GPI NIL Holdings, Inc. | Aza-heterocyclic compounds used to treat neurological disorders and hair loss |
AU773273B2 (en) | 1999-02-26 | 2004-05-20 | Bristol-Myers Squibb Company | Novel sulfonamide compounds and uses thereof |
FR2802206B1 (fr) * | 1999-12-14 | 2005-04-22 | Sod Conseils Rech Applic | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
SE9904738D0 (sv) * | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
JP2001261657A (ja) * | 2000-03-17 | 2001-09-26 | Yamanouchi Pharmaceut Co Ltd | シアノフェニル誘導体 |
AU2001254546A1 (en) | 2000-04-20 | 2001-11-07 | Nps Allelix Corp. | Aminopiperidines |
US6589978B2 (en) | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
AU2001291830A1 (en) | 2000-09-25 | 2002-04-02 | Actelion Pharmaceuticals Ltd. | Substituted amino-aza-cycloalkanes useful against malaria |
WO2003014075A2 (en) * | 2001-08-03 | 2003-02-20 | Schering Corporation | Novel gamma secretase inhibitors |
MXPA04001016A (es) * | 2001-08-03 | 2004-05-27 | Schering Corp | Derivados de sulfonamida como inhibidores de la gamma secretasa. |
US7256186B2 (en) * | 2002-02-06 | 2007-08-14 | Schering Corporation | Gamma secretase inhibitors |
US20040171614A1 (en) | 2002-02-06 | 2004-09-02 | Schering-Plough Corporation | Novel gamma secretase inhibitors |
TW200302717A (en) * | 2002-02-06 | 2003-08-16 | Schering Corp | Novel gamma secretase inhibitors |
ES2308206T3 (es) | 2003-05-13 | 2008-12-01 | Schering Corporation | N-arilsulfonilpiperidinas con fuentes como inhibidores de gamma-secretasa. |
JP4247081B2 (ja) | 2003-09-24 | 2009-04-02 | 三菱電機株式会社 | レーザアニール装置のレーザビーム強度モニタ方法とレーザアニール装置 |
CA2563033A1 (en) * | 2004-04-05 | 2005-10-20 | Schering Corporation | Novel gamma secretase inhibitors |
WO2005113542A2 (en) * | 2004-05-20 | 2005-12-01 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
PE20071321A1 (es) * | 2006-01-20 | 2007-12-29 | Schering Corp | Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores de gamma secretasa relacionados |
-
2005
- 2005-06-28 CN CNA200910152119XA patent/CN101602741A/zh active Pending
- 2005-06-28 MX MX2007000040A patent/MX2007000040A/es active IP Right Grant
- 2005-06-28 DE DE602005020156T patent/DE602005020156D1/de active Active
- 2005-06-28 CA CA002570183A patent/CA2570183A1/en not_active Abandoned
- 2005-06-28 EP EP05790194A patent/EP1789404B1/en active Active
- 2005-06-28 AT AT05790194T patent/ATE461926T1/de not_active IP Right Cessation
- 2005-06-28 WO PCT/US2005/023187 patent/WO2006004880A2/en active Application Filing
- 2005-06-28 PE PE2005000751A patent/PE20060481A1/es not_active Application Discontinuation
- 2005-06-28 ES ES05790194T patent/ES2341560T3/es active Active
- 2005-06-28 US US11/168,797 patent/US7763613B2/en not_active Expired - Fee Related
- 2005-06-28 AR ARP050102662A patent/AR050994A1/es not_active Application Discontinuation
- 2005-06-28 CN CNA2005800284229A patent/CN101048393A/zh active Pending
- 2005-06-28 JP JP2007519415A patent/JP2008505100A/ja active Pending
- 2005-06-29 TW TW094121770A patent/TWI297270B/zh not_active IP Right Cessation
-
2007
- 2007-06-15 HK HK07106506.7A patent/HK1099300A1/xx unknown
-
2009
- 2009-12-08 US US12/633,311 patent/US7998958B2/en not_active Expired - Fee Related
- 2009-12-08 US US12/633,286 patent/US20100087425A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US7763613B2 (en) | 2010-07-27 |
HK1099300A1 (en) | 2007-08-10 |
DE602005020156D1 (de) | 2010-05-06 |
US7998958B2 (en) | 2011-08-16 |
WO2006004880A3 (en) | 2007-03-08 |
JP2008505100A (ja) | 2008-02-21 |
CN101602741A (zh) | 2009-12-16 |
WO2006004880A2 (en) | 2006-01-12 |
MX2007000040A (es) | 2007-03-07 |
AR050994A1 (es) | 2006-12-13 |
EP1789404A2 (en) | 2007-05-30 |
US20060040936A1 (en) | 2006-02-23 |
ATE461926T1 (de) | 2010-04-15 |
CN101048393A (zh) | 2007-10-03 |
US20100093695A1 (en) | 2010-04-15 |
TWI297270B (en) | 2008-06-01 |
CA2570183A1 (en) | 2006-01-12 |
ES2341560T3 (es) | 2010-06-22 |
US20100087425A1 (en) | 2010-04-08 |
TW200612928A (en) | 2006-05-01 |
EP1789404B1 (en) | 2010-03-24 |
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Legal Events
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FG | Grant, registration | ||
FD | Application declared void or lapsed |