PE20090183A1 - Derivados de 1-oxa-3,9-diaza-espiro-[5.5]undecan-2-ona como moduladores de ccr5 - Google Patents
Derivados de 1-oxa-3,9-diaza-espiro-[5.5]undecan-2-ona como moduladores de ccr5Info
- Publication number
- PE20090183A1 PE20090183A1 PE2008000546A PE2008000546A PE20090183A1 PE 20090183 A1 PE20090183 A1 PE 20090183A1 PE 2008000546 A PE2008000546 A PE 2008000546A PE 2008000546 A PE2008000546 A PE 2008000546A PE 20090183 A1 PE20090183 A1 PE 20090183A1
- Authority
- PE
- Peru
- Prior art keywords
- dimethyl
- diaza
- oxa
- undecan
- ona
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- AIDS & HIV (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE PIPERIDINA DE FORMULA (I), DONDE R1 ES CICLOALQUILO C3-C6, (CICLOALQUILO C3-C6)-ALQUILO C1-C3HALOALQUILO C1-C3, ENTRE OTROS; R2 ES ALQUILO C1-C6; R3 ES H O ALQUILO C1-C3; R4 ES 4,6-DIMETIL-PIRIMIDIN-5-ILO, 4,6-DIMETIL-2-TRIFLUORMETIL-PIRIMIDIN-5-ILO, 2,4-DIMETIL-PIRIDIN-3-ILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-BUTIL-9-[1-(4,6-DIMETIL-PIRIMIDINA-5-CARBONIL)-4-METIL-PIPERIDIN-4-IL]-3-((1S,3S)-3-METOXI-CICLOHEXILMETIL)-1-OXA-3,9-DIAZA-ESPIRO[5.5]UNDECAN-2-ONA, 5-{4-[(S)-5-BUTIL-3-(4-HIDROXI-CICLOHEXILMETIL)-2-OXO-1-OXA-3,9-DIAZA-ESPIRO[5.5]UNDEC-9-IL]-4-MEYIL-PIPERIDINA-1-CARBONIL}-4,6-DIMETIL-PIRIDINA-2-CARBONITRILO, (S)-5-BUTIL-9-[1-(4,6-DIMETIL-PIRIMIDINA-5-CARBONIL)-4-METIL-PIPERIDIN-4-IL]-3-(HEXAHIDRO-FURO[2,3-b]FURAN-3-ILMETIL)-1-OXA-3,9-DIAZA-ESPIRO[5.5]UNDECAN-2-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR DE QUIMIOQUINA CCR5 Y SON UTILES EN EL TRATAMIENTO DE INFECCIONES RETROVIRICAS DEL VIH-1, ARTRITIS REUMATOIDE, ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, ENTRE OTRAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92069407P | 2007-03-29 | 2007-03-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090183A1 true PE20090183A1 (es) | 2009-03-12 |
Family
ID=39535486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000546A PE20090183A1 (es) | 2007-03-29 | 2008-03-26 | Derivados de 1-oxa-3,9-diaza-espiro-[5.5]undecan-2-ona como moduladores de ccr5 |
Country Status (15)
Country | Link |
---|---|
US (1) | US7625891B2 (es) |
EP (1) | EP2142555A1 (es) |
JP (1) | JP2010522707A (es) |
KR (1) | KR20090127298A (es) |
CN (1) | CN101646679A (es) |
AR (1) | AR065854A1 (es) |
AU (1) | AU2008233930A1 (es) |
BR (1) | BRPI0809646A2 (es) |
CA (1) | CA2682639A1 (es) |
CL (1) | CL2008000863A1 (es) |
IL (1) | IL200661A0 (es) |
MX (1) | MX2009010503A (es) |
PE (1) | PE20090183A1 (es) |
TW (1) | TW200902020A (es) |
WO (1) | WO2008119663A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009017664A1 (en) * | 2007-07-26 | 2009-02-05 | Vitae Pharmaceuticals, Inc. | CYCLIC INHIBITORS OF 11β-HYDROXYSTERIOD DEHYDROGENASE 1 |
WO2009037168A1 (en) * | 2007-09-19 | 2009-03-26 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
AR069207A1 (es) * | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
EP2229368A1 (en) | 2007-12-11 | 2010-09-22 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
TW200934490A (en) * | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
US8592409B2 (en) | 2008-01-24 | 2013-11-26 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
EP2252598A2 (en) * | 2008-02-11 | 2010-11-24 | Vitae Pharmaceuticals, Inc. | 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
JP5730021B2 (ja) * | 2008-02-15 | 2015-06-03 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤としてのシクロアルキルラクタム誘導体 |
US20110105504A1 (en) * | 2008-03-18 | 2011-05-05 | Vitae Pharmaceuticals ,Inc. | Inhibitors Of 11beta-Hydroxysteroid Dehydrogenase Type 1 |
US8592410B2 (en) | 2008-05-01 | 2013-11-26 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1 |
US8138178B2 (en) * | 2008-05-01 | 2012-03-20 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
JP5696037B2 (ja) | 2008-05-01 | 2015-04-08 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状インヒビター |
CA2723032A1 (en) * | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
EP2324018B1 (en) * | 2008-07-25 | 2013-09-04 | Boehringer Ingelheim International GmbH | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
JP5777030B2 (ja) | 2008-07-25 | 2015-09-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤 |
BRPI0919024A2 (pt) | 2008-09-25 | 2019-09-24 | Boehringer Ingelheim Int | compostos que seletivamente modulam o receptor cb2 |
US8637505B2 (en) | 2009-02-04 | 2014-01-28 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
JP5656986B2 (ja) | 2009-06-11 | 2015-01-21 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 1,3−オキサジナン−2−オン構造に基づく11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤 |
US8883778B2 (en) | 2009-07-01 | 2014-11-11 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
WO2011109324A1 (en) | 2010-03-05 | 2011-09-09 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the cb2 receptor |
US8933072B2 (en) | 2010-06-16 | 2015-01-13 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
EP2585444B1 (en) | 2010-06-25 | 2014-10-22 | Boehringer Ingelheim International GmbH | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
WO2012059416A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
KR102061743B1 (ko) | 2011-03-04 | 2020-01-03 | 뉴젠 세러퓨틱스 인코포레이티드 | 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법 |
WO2012155339A1 (zh) | 2011-05-17 | 2012-11-22 | 江苏康缘药业股份有限公司 | 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途 |
CN108699013B (zh) * | 2016-09-08 | 2022-05-06 | 嘉泉大学校校产学协力团 | 螺醌衍生物、其制备方法及含有其作为活性成分的用于预防或治疗神经疾患的药物组合物 |
CN109012748B (zh) * | 2018-07-27 | 2021-03-16 | 安徽师范大学 | 吡啶取代吡咯基稀土金属催化剂及其制备方法和应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL127065C (es) | 1964-04-22 | |||
HU204529B (en) | 1989-08-10 | 1992-01-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
AU713235B2 (en) | 1995-09-29 | 1999-11-25 | Cor Therapeutics, Inc. | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation |
US6689765B2 (en) | 1999-05-04 | 2004-02-10 | Schering Corporation | Piperazine derivatives useful as CCR5 antagonists |
TR200402496T2 (tr) | 1999-05-04 | 2005-01-24 | Schering Corporation | CCR5 antagonistleri olarak yararlı piperidin türevleri. |
US6391865B1 (en) | 1999-05-04 | 2002-05-21 | Schering Corporation | Piperazine derivatives useful as CCR5 antagonists |
AU780888B2 (en) | 1999-05-04 | 2005-04-21 | Merck Sharp & Dohme Corp. | Piperazine derivatives useful as CCR5 antagonists |
TWI224597B (en) | 1999-12-03 | 2004-12-01 | Ono Pharmaceutical Co | Triazaspiro[5.5]undecane derivatives and a medicine containing the derivatives as an active ingredient |
WO2001057044A1 (fr) | 2000-02-01 | 2001-08-09 | Daiichi Pharmaceutical Co., Ltd. | Derives de pyrido-oxazine |
WO2002092604A1 (en) | 2001-05-14 | 2002-11-21 | F. Hoffmann-La Roche Ag | 1-oxa-3,9-diaza-spiro'5,5!undecan-2-ones derivatives and its use as antagonist of the neurikinin receptor |
DE60236206D1 (de) | 2001-12-28 | 2010-06-10 | Acadia Pharm Inc | Spiroazacyclische verbindungen als monoaminrezeptormodulatoren |
BRPI0507586A (pt) * | 2004-02-10 | 2007-07-03 | Hoffmann La Roche | moduladores de receptor de quimiocina ccr5 |
EP1981911A2 (en) * | 2006-01-30 | 2008-10-22 | F.Hoffmann-La Roche Ag | Synergistic compositions for treating hiv |
-
2008
- 2008-03-18 AU AU2008233930A patent/AU2008233930A1/en not_active Abandoned
- 2008-03-18 MX MX2009010503A patent/MX2009010503A/es unknown
- 2008-03-18 BR BRPI0809646-5A patent/BRPI0809646A2/pt not_active Application Discontinuation
- 2008-03-18 KR KR1020097020226A patent/KR20090127298A/ko not_active Application Discontinuation
- 2008-03-18 WO PCT/EP2008/053238 patent/WO2008119663A1/en active Application Filing
- 2008-03-18 JP JP2010500218A patent/JP2010522707A/ja active Pending
- 2008-03-18 EP EP08717970A patent/EP2142555A1/en not_active Withdrawn
- 2008-03-18 CN CN200880010622A patent/CN101646679A/zh active Pending
- 2008-03-18 CA CA002682639A patent/CA2682639A1/en not_active Abandoned
- 2008-03-26 CL CL2008000863A patent/CL2008000863A1/es unknown
- 2008-03-26 PE PE2008000546A patent/PE20090183A1/es not_active Application Discontinuation
- 2008-03-26 TW TW097110847A patent/TW200902020A/zh unknown
- 2008-03-27 AR ARP080101248A patent/AR065854A1/es unknown
- 2008-03-28 US US12/079,746 patent/US7625891B2/en not_active Expired - Fee Related
-
2009
- 2009-09-01 IL IL200661A patent/IL200661A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CL2008000863A1 (es) | 2008-11-07 |
US20080249087A1 (en) | 2008-10-09 |
TW200902020A (en) | 2009-01-16 |
KR20090127298A (ko) | 2009-12-10 |
CN101646679A (zh) | 2010-02-10 |
JP2010522707A (ja) | 2010-07-08 |
EP2142555A1 (en) | 2010-01-13 |
US7625891B2 (en) | 2009-12-01 |
CA2682639A1 (en) | 2008-10-09 |
AR065854A1 (es) | 2009-07-08 |
AU2008233930A1 (en) | 2008-10-09 |
MX2009010503A (es) | 2009-10-19 |
WO2008119663A1 (en) | 2008-10-09 |
IL200661A0 (en) | 2010-05-17 |
BRPI0809646A2 (pt) | 2014-09-23 |
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Legal Events
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FD | Application declared void or lapsed |