PE20050121A1 - Acidos tienil-hidroxamicos, sustituidos referidos a la actividad enzimatica de la histona desacetilasa - Google Patents
Acidos tienil-hidroxamicos, sustituidos referidos a la actividad enzimatica de la histona desacetilasaInfo
- Publication number
- PE20050121A1 PE20050121A1 PE2003000764A PE2003000764A PE20050121A1 PE 20050121 A1 PE20050121 A1 PE 20050121A1 PE 2003000764 A PE2003000764 A PE 2003000764A PE 2003000764 A PE2003000764 A PE 2003000764A PE 20050121 A1 PE20050121 A1 PE 20050121A1
- Authority
- PE
- Peru
- Prior art keywords
- desacetilase
- histone
- tienyl
- substituted
- referred
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 ES ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS POR ALQUILENODIOXI, CARBOXI, CIANO, ENTRE OTROS; R2 ES H, CLORO, HETEROARILO, CICLOALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: HIDROXIAMIDA DEL ACIDO 5-(4- TRIFLUOROMETIL-1H-IMIDAZOL-2-IL)-TIOFENO-2-CARBOXILICO; HIDROXIAMIDA DEL ACIDO 5-(1-FENETIL-1H-PIRAZOL-3-IL)-TIOFENO-2-CARBOXILICO Y HIDROXIAMIDA DEL ACIDO 5-[1-(2,3-DIHIDRO-BENZO[1,4]DIOXIN-2-ILMETIL)-1H-PIRAZOL-3-IL]-TIOFENO-2-CARBOXILICO; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA EN LA QUE DICHOS COMPUESTOS SON INHIBIDORES DE HISTONA DESACETILASA UTILES EN EL TRATAMIENTO DE CANCER, PSORIASIS, TRASTORNOS FIBROPROLIFERATIVOS, ENTRE OTROS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0218040A GB0218040D0 (en) | 2002-08-02 | 2002-08-02 | Chemical compounds |
GB0310462A GB0310462D0 (en) | 2003-05-07 | 2003-05-07 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20050121A1 true PE20050121A1 (es) | 2005-03-12 |
Family
ID=31497256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000764A PE20050121A1 (es) | 2002-08-02 | 2003-08-01 | Acidos tienil-hidroxamicos, sustituidos referidos a la actividad enzimatica de la histona desacetilasa |
Country Status (18)
Country | Link |
---|---|
US (1) | US20060122234A1 (es) |
EP (1) | EP1525199A1 (es) |
JP (1) | JP2005539001A (es) |
KR (1) | KR20050034732A (es) |
CN (1) | CN1684957A (es) |
AR (1) | AR040765A1 (es) |
AU (1) | AU2003255724A1 (es) |
BR (1) | BR0313371A (es) |
CA (1) | CA2494114A1 (es) |
EC (1) | ECSP055636A (es) |
IL (1) | IL166603A0 (es) |
MX (1) | MXPA05001334A (es) |
NO (1) | NO20051107L (es) |
PE (1) | PE20050121A1 (es) |
PL (1) | PL374970A1 (es) |
RU (1) | RU2005105696A (es) |
UY (1) | UY27921A1 (es) |
WO (1) | WO2004013130A1 (es) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100519527C (zh) | 2002-03-13 | 2009-07-29 | 詹森药业有限公司 | 组织蛋白去乙酰酶抑制剂 |
KR20040093692A (ko) | 2002-03-13 | 2004-11-08 | 얀센 파마슈티카 엔.브이. | 히스톤 디아세틸라제의 신규한 저해제로서의 피페라지닐-,피페리디닐- 및 모르폴리닐-유도체 |
EA007099B1 (ru) | 2002-03-13 | 2006-06-30 | Янссен Фармацевтика Н. В. | Сульфонилпроизводные в качестве ингибиторов гистон-деацетилазы |
DE60321548D1 (de) | 2002-03-13 | 2008-07-24 | Janssen Pharmaceutica Nv | Carbonylamino- derivativate als neue inhibitoren von histone deacetylase |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
AU2003236500B9 (en) * | 2002-06-12 | 2009-07-02 | Chemocentryx, Inc. | 1-aryl-4-substituted piperazine derivatives for use as CCR1 antagonists for the treatment of inflammation and immune disorders |
BRPI0409227C1 (pt) | 2003-04-07 | 2021-05-25 | Axys Pharm Inc | composto, composição farmacêutica, uso de um composto e processo para a preparação de um composto de fórmula (i) |
WO2005014588A1 (en) * | 2003-08-01 | 2005-02-17 | Argenta Discovery Limited | Substituted thienyl-hydroxamic acids having histone deacetylase activity |
JP2007508318A (ja) * | 2003-10-09 | 2007-04-05 | エートン ファーマ インコーポレーティッド | チオフェンおよびベンゾチオフェンヒドロキサム酸誘導体 |
WO2005040161A1 (en) * | 2003-10-27 | 2005-05-06 | S*Bio Pte Ltd | Biaryl linked hydroxamates: preparation and pharmaceutical applications |
RU2006138036A (ru) | 2004-03-30 | 2008-05-10 | Чирон Корпорейшн (Us) | Производные замещенного тиофена в качестве противораковых средств |
WO2005118543A1 (ja) * | 2004-06-03 | 2005-12-15 | Ono Pharmaceutical Co., Ltd. | キナーゼ阻害薬およびその用途 |
PL1781639T3 (pl) | 2004-07-28 | 2012-07-31 | Janssen Pharmaceutica Nv | Podstawione pochodne indolilo-alkiloaminowe jako nowe inhibitory deacetylazy histonowej |
ME01058B (me) | 2004-07-28 | 2012-10-20 | Janssen Pharmaceutica Nv | Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze |
DE102004051277A1 (de) * | 2004-10-21 | 2006-04-27 | Merck Patent Gmbh | Heterocyclische Carbonylverbindungen |
EP2522395A1 (en) | 2005-02-03 | 2012-11-14 | TopoTarget UK Limited | Combination therapies using HDAC inhibitors |
WO2006088949A1 (en) | 2005-02-14 | 2006-08-24 | Miikana Therapeutics, Inc. | Fused heterocyclic compounds useful as inhibitors of histone deacetylase |
WO2006102645A1 (en) * | 2005-03-24 | 2006-09-28 | Janssen Pharmaceutica, N.V. | Biaryl derived amide modulators of vanilloid vr1 receptor |
GB0509223D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
GB0509225D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of enzymatic activity |
CN102579417B (zh) | 2005-05-13 | 2014-11-26 | 托波塔吉特英国有限公司 | Hdac抑制剂的药物制剂 |
US8138198B2 (en) | 2005-05-18 | 2012-03-20 | Angibaud Patrick Rene | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
WO2007011626A2 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
DK1943232T3 (da) | 2005-10-27 | 2011-08-29 | Janssen Pharmaceutica Nv | Kvadratsyrederivater som inhibitorer af histondeacetylase |
WO2007054719A2 (en) | 2005-11-10 | 2007-05-18 | Topotarget Uk Limited | Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer alone or in combination with chemotherapeutic agent |
US8114876B2 (en) | 2006-01-19 | 2012-02-14 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
EP1979327A1 (en) | 2006-01-19 | 2008-10-15 | Janssen Pharmaceutica, N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
EP1981875B1 (en) | 2006-01-19 | 2014-04-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
ES2327972T3 (es) | 2006-01-19 | 2009-11-05 | Janssen Pharmaceutica, N.V. | Derivados de aminofenil como nuevos inhibidores de histona deacetilasa. |
US7888360B2 (en) | 2006-01-19 | 2011-02-15 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
DK1981871T3 (da) | 2006-01-19 | 2012-02-13 | Janssen Pharmaceutica Nv | Heterocyclylalkylderivater som hidtil ukendte inhibitorer af histondeacetylase |
GB0603041D0 (en) * | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
EP1989188B1 (en) | 2006-02-28 | 2015-07-22 | Dart Neuroscience (Cayman) Ltd | Therapeutic piperazines as pde4 inhibitors |
EP2465850B1 (en) | 2006-02-28 | 2016-11-23 | Dart Neuroscience (Cayman) Ltd | Therapeutic compounds |
AU2013200480B2 (en) * | 2006-02-28 | 2016-06-09 | Dart Neuroscience (Cayman) Ltd. | Therapeutic compounds |
GB0613518D0 (en) * | 2006-07-06 | 2006-08-16 | Phytopharm Plc | Chemical compounds |
EP1878730A1 (en) * | 2006-07-12 | 2008-01-16 | Bayer Schering Pharma Aktiengesellschaft | Substituted isoxazolines, pharmaceutical compositions containing the same, methods of preparing the same, and uses of the same |
GB0619753D0 (en) | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
ES2509342T3 (es) | 2006-10-30 | 2014-10-17 | Chroma Therapeutics Limited | Hidroxamatos como inhibidores de histona desacetilasa |
WO2008062878A1 (fr) * | 2006-11-22 | 2008-05-29 | Nihon Nohyaku Co., Ltd. | Nouveau dérivé de pyrazole, agent de lutte contre des organismes nuisibles et utilisation de l'agent de lutte contre des organismes nuisibles |
JP2010513403A (ja) * | 2006-12-20 | 2010-04-30 | ノバルティス アーゲー | Scd阻害剤としての2−置換5員ヘテロ環 |
DK2099442T3 (en) | 2006-12-26 | 2015-02-16 | Pharmacyclics Inc | Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy |
EP2993473A1 (en) | 2007-01-30 | 2016-03-09 | Pharmacyclics, Inc. | Methods for determining cancer resistance to histone deacetylase inhibitors |
UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
WO2008101186A1 (en) * | 2007-02-15 | 2008-08-21 | The J. David Gladstone Institutes | Inhibitors for hdac8 |
JP2008266321A (ja) * | 2007-03-28 | 2008-11-06 | Santen Pharmaceut Co Ltd | フェニレンジアミン誘導体を有効成分とする眼圧下降剤 |
EP3311813B1 (en) | 2007-08-27 | 2019-08-07 | Dart Neuroscience (Cayman) Ltd | Therapeutic isoxazole compounds |
CA2700173C (en) | 2007-09-25 | 2016-10-11 | Topotarget Uk Limited | Methods of synthesis of certain hydroxamic acid compounds |
US20100249176A1 (en) * | 2007-10-24 | 2010-09-30 | Barrow James C | Heterocycle amide t-type calcium channel antagonists |
BRPI0817897A2 (pt) | 2007-11-02 | 2019-09-24 | Methylgene Inc | composto, composição, e, métodos de inibição da atividade hdac, e de tratamento de uma doença responsiva a um inibidor de atividade hdac |
AU2008338631A1 (en) * | 2007-12-14 | 2009-06-25 | Georgetown University | Histone deacetylase inhibitors |
DK2274301T3 (da) | 2008-03-27 | 2013-01-02 | Janssen Pharmaceutica Nv | Azabicyclohexylsubstituerede indolylalkylaminoderivater som hidtil ukendte inhibitorer af histondeacetylase |
US8703811B2 (en) * | 2008-05-07 | 2014-04-22 | Genzyme Corporation | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase |
GB0903480D0 (en) | 2009-02-27 | 2009-04-08 | Chroma Therapeutics Ltd | Enzyme Inhibitors |
US8603521B2 (en) | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
AR078793A1 (es) * | 2009-10-27 | 2011-12-07 | Orion Corp | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros |
WO2011089995A1 (ja) * | 2010-01-21 | 2011-07-28 | 公立大学法人名古屋市立大学 | ヒドロキサム酸誘導体及びそれを用いたhdac8阻害剤 |
ES2603032T3 (es) | 2010-07-15 | 2017-02-23 | Bayer Intellectual Property Gmbh | Compuestos de 3-piridil-heteroarilcarboxamida como pesticidas |
EP2630133A1 (de) | 2010-10-22 | 2013-08-28 | Bayer Intellectual Property GmbH | Neue heterocylische verbindungen als schädlingsbekämpfungsmittel |
WO2012112447A2 (en) * | 2011-02-14 | 2012-08-23 | Dana-Farber Cancer Institute, Inc. | Histone deacetylase inhibitors and methods of use thereof |
SG2014014419A (en) | 2011-09-13 | 2014-07-30 | Pharmacyclics Inc | Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof |
WO2013141362A1 (ja) * | 2012-03-23 | 2013-09-26 | 日本農薬株式会社 | チアゾールカルボキサミド誘導体及びその使用方法 |
JP6183053B2 (ja) * | 2012-08-22 | 2017-08-23 | 宇部興産株式会社 | テトラヒドロピラニルピリミジン化合物の製造方法 |
US9421208B2 (en) | 2013-08-02 | 2016-08-23 | Pharmacyclics Llc | Methods for the treatment of solid tumors |
EP3062783B1 (en) * | 2013-10-18 | 2020-08-12 | The General Hospital Corporation | Imaging histone deacetylases with a radiotracer using positron emission tomography |
WO2015172196A1 (en) * | 2014-05-13 | 2015-11-19 | Monash University | Heterocyclic compounds and use of same |
CN108379585B (zh) * | 2018-04-16 | 2020-10-16 | 复旦大学附属中山医院 | Hdac4抑制剂在制备治疗心力衰竭的药物中的应用 |
CN111072582A (zh) * | 2018-10-18 | 2020-04-28 | 中国药科大学 | 一种n-羟基芳杂环-2-甲酰胺化合物及其制备方法和用途 |
CN111100071A (zh) * | 2019-12-19 | 2020-05-05 | 西安近代化学研究所 | 一种合成2-氰基-5-芳基-1h-咪唑类化合物的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
WO2002026696A1 (en) * | 2000-09-29 | 2002-04-04 | Prolifix Limited | Carbamic acid compounds comprising an amide linkage as hdac inhibitors |
-
2003
- 2003-07-24 CA CA002494114A patent/CA2494114A1/en not_active Abandoned
- 2003-07-24 WO PCT/GB2003/003168 patent/WO2004013130A1/en not_active Application Discontinuation
- 2003-07-24 AU AU2003255724A patent/AU2003255724A1/en not_active Abandoned
- 2003-07-24 RU RU2005105696/04A patent/RU2005105696A/ru not_active Application Discontinuation
- 2003-07-24 PL PL03374970A patent/PL374970A1/xx not_active Application Discontinuation
- 2003-07-24 KR KR1020057001921A patent/KR20050034732A/ko not_active Application Discontinuation
- 2003-07-24 JP JP2004525525A patent/JP2005539001A/ja not_active Withdrawn
- 2003-07-24 BR BR0313371-0A patent/BR0313371A/pt not_active Application Discontinuation
- 2003-07-24 US US10/522,873 patent/US20060122234A1/en not_active Abandoned
- 2003-07-24 CN CNA038231549A patent/CN1684957A/zh active Pending
- 2003-07-24 EP EP03766437A patent/EP1525199A1/en not_active Withdrawn
- 2003-07-24 MX MXPA05001334A patent/MXPA05001334A/es not_active Application Discontinuation
- 2003-08-01 AR AR20030102776A patent/AR040765A1/es unknown
- 2003-08-01 PE PE2003000764A patent/PE20050121A1/es not_active Application Discontinuation
- 2003-08-01 UY UY27921A patent/UY27921A1/es not_active Application Discontinuation
-
2005
- 2005-01-31 IL IL16660305A patent/IL166603A0/xx unknown
- 2005-02-28 EC EC2005005636A patent/ECSP055636A/es unknown
- 2005-03-01 NO NO20051107A patent/NO20051107L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL374970A1 (en) | 2005-11-14 |
EP1525199A1 (en) | 2005-04-27 |
BR0313371A (pt) | 2005-07-05 |
AR040765A1 (es) | 2005-04-20 |
US20060122234A1 (en) | 2006-06-08 |
UY27921A1 (es) | 2004-02-27 |
RU2005105696A (ru) | 2005-11-10 |
NO20051107L (no) | 2005-04-20 |
WO2004013130A1 (en) | 2004-02-12 |
CA2494114A1 (en) | 2004-02-12 |
CN1684957A (zh) | 2005-10-19 |
JP2005539001A (ja) | 2005-12-22 |
KR20050034732A (ko) | 2005-04-14 |
ECSP055636A (es) | 2005-05-30 |
IL166603A0 (en) | 2006-01-15 |
MXPA05001334A (es) | 2005-09-08 |
AU2003255724A1 (en) | 2004-02-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20050121A1 (es) | Acidos tienil-hidroxamicos, sustituidos referidos a la actividad enzimatica de la histona desacetilasa | |
PE110899A1 (es) | Derivados de acidos ariloxiarilsulfonilamino hidroxamicos | |
CL2003002665A1 (es) | COMPUESTOS DERIVADOS DE ACIDOS CARBOXILICOS, SUS SALES; PROCEDIMIENTO DE PREPARACION; COMPOSICION FARMACEUTICA, Y SU USO EN EL TRATAMIENTO DE ENFERMEDADES DONDE ES NECESARIO UN INHIBIDORE DEL FACTOR Xa Y /O UN INHIBIDOR DE SERINA PROTEASA. | |
PE20081836A1 (es) | Derivados de piperidina como inhibidores de la sintasa de acido graso | |
PE20110854A1 (es) | DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1 | |
PE20080843A1 (es) | Inhibidores de renina y metodo para su utilizacion | |
PE20060937A1 (es) | Derivados de sulfonilbencimidazol como agonistas del receptor cannabinoide 2 (cb2) | |
PE20040589A1 (es) | Tiazolidinonas y su preparacion como medicamentos | |
PE20070138A1 (es) | Compuestos heterociclicos como inhibidores de aspartil proteasas | |
PE20040925A1 (es) | DERIVADOS DE PIRAZOL COMO INHIBIDORES DEL FACTOR Xa | |
PE20030612A1 (es) | Benzoimidazoles | |
CY1108744T1 (el) | 2-οξο-1,2,4,5-τετραϋδρo-1,3-βενζοδιαζεπιν-3-υλ-πιπεριδινες ως ανταγωνιστες της cgrp | |
BR0013041A (pt) | Composto heterociclico e composição farmacêutica para tratar e prevenir doenças mediadas por cgmp-pde, seu uso e método | |
PE20021006A1 (es) | Derivados de 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la proteinquinasa | |
PE20060488A1 (es) | Compuestos heterociclicos como inhibidores de aspartil proteasa | |
PE20060298A1 (es) | Derivados de acido carboxilico de bencimidazolona | |
PE20050229A1 (es) | Derivados de etinilprolina | |
NO20051965D0 (no) | Nye piperidinderivater for anvendelse ved behandling av kemokinmedierte sykdomstilstander. | |
BRPI0212775B8 (pt) | composto de 1,2,4-triazol e medicamento | |
PE20060481A1 (es) | N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas | |
PE20040864A1 (es) | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz | |
PE20040666A1 (es) | Derivados novedosos de piperidina | |
ATE553077T1 (de) | Peptidaseinhibitoren | |
ATE540928T1 (de) | Isochinolinverbindungen und ihre medizinische verwendung | |
PE20080364A1 (es) | Acido bifenilcarboxilicos substituidos y sus derivados como moduladores de la actividad de la gamma-secretasa |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |