PE20071232A1 - Derivados de piperidina o piperazina como inhibidores de 11-beta hsd1 - Google Patents

Derivados de piperidina o piperazina como inhibidores de 11-beta hsd1

Info

Publication number
PE20071232A1
PE20071232A1 PE2007000130A PE2007000130A PE20071232A1 PE 20071232 A1 PE20071232 A1 PE 20071232A1 PE 2007000130 A PE2007000130 A PE 2007000130A PE 2007000130 A PE2007000130 A PE 2007000130A PE 20071232 A1 PE20071232 A1 PE 20071232A1
Authority
PE
Peru
Prior art keywords
piperazine
alkyl
piperidine
inhibitors
beta
Prior art date
Application number
PE2007000130A
Other languages
English (en)
Inventor
Jason Shaoyun Xiang
Eddine Saiah
Steve Y Tam
John C Mckew
Lihren Chen
Manus Ipek
Katherine L Lee
Huan-Qiu Li
Jianchang Li
Wei Li
Tarek Suhayl Mansour
Vipin Suri
Richard Vargas
Yuchuan Wu
Zhao-Kui Wan
Jinbo Lee
Eva Binnun
Douglas P Wilson
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20071232A1 publication Critical patent/PE20071232A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96Sulfur atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE PIPERIDINA O PIPERAZINA DE FORMULA 8I), DONDE R1 ES ARILO C6-C18, HETEROARILO DE 5 A 20 ATOMOS, ARALQUILO C7-C20, ENTRE OTROS; R2 ES ARILO C6-C18 O HETEROARILO DE 5 A 20 ATOMOS OPCIONALMENTE SUSTITUIDOS CON 1 A 10 Rc; X ES S(O)n O S(O)nNR6; n ES 1 O 2; R6 ES H, ALQUILO C1-C12 O CICLOALQUILO C3-C16; V E Y SON CR7 O N; R7 ES H O ALQUILO C1-C12, CON LA CONDICION DE QUE Y Y V NO PUEDEN SER AMBOS CR7; W1, Z1, W2 Y Z2 SON ALQUILO C1-C12, OXO, ARILO C6-C18, ENTRE OTROS; Rc ES HALOGENO, NITRO, OH, ALQUILO C1-C12, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-[(3,4-DICLOROFENIL)SULFONIL]-4-(2-FLUOROFENIL)PIPERAZINA, 1-(2,6-DIMETILFENIL)-4-(2-NAFTILSULFONIL)PIPERAZINA, 1-(2,3-DICLOROFENIL)-4-(2-NAFTILSULFONIL)PIPERAZINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA 11-BETA-HIDROXIESTEROIDE DEHIDROGENASA (11-BETA-HSD1) Y SON UTILES EN EL TRATAMIENTO DE LA DIABETES, HIPERTRIGLICICERIDEMIA, ATEROESCLEROSIS, ENTRE OTRAS
PE2007000130A 2006-02-07 2007-02-07 Derivados de piperidina o piperazina como inhibidores de 11-beta hsd1 PE20071232A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77126206P 2006-02-07 2006-02-07

Publications (1)

Publication Number Publication Date
PE20071232A1 true PE20071232A1 (es) 2008-02-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000130A PE20071232A1 (es) 2006-02-07 2007-02-07 Derivados de piperidina o piperazina como inhibidores de 11-beta hsd1

Country Status (18)

Country Link
US (2) US7632838B2 (es)
EP (1) EP1981848A2 (es)
JP (1) JP2009526059A (es)
KR (1) KR20080093072A (es)
CN (1) CN101400653A (es)
AR (1) AR059355A1 (es)
AU (1) AU2007212429A1 (es)
BR (1) BRPI0707537A2 (es)
CA (1) CA2641609A1 (es)
CR (1) CR10186A (es)
GT (1) GT200800151A (es)
IL (1) IL193157A0 (es)
NO (1) NO20083492L (es)
PA (1) PA8713501A1 (es)
PE (1) PE20071232A1 (es)
RU (1) RU2008132333A (es)
TW (1) TW200800898A (es)
WO (1) WO2007092435A2 (es)

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US7632838B2 (en) 2009-12-15
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IL193157A0 (en) 2009-02-11
WO2007092435A3 (en) 2007-12-27
CN101400653A (zh) 2009-04-01
CR10186A (es) 2008-10-29
AR059355A1 (es) 2008-03-26
JP2009526059A (ja) 2009-07-16
NO20083492L (no) 2008-10-28
GT200800151A (es) 2008-11-03
WO2007092435A2 (en) 2007-08-16
US20070219198A1 (en) 2007-09-20
US20100029648A1 (en) 2010-02-04
AU2007212429A1 (en) 2007-08-16
KR20080093072A (ko) 2008-10-17
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TW200800898A (en) 2008-01-01
CA2641609A1 (en) 2007-08-16

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