JP2015502387A5 - - Google Patents
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- Publication number
- JP2015502387A5 JP2015502387A5 JP2014548061A JP2014548061A JP2015502387A5 JP 2015502387 A5 JP2015502387 A5 JP 2015502387A5 JP 2014548061 A JP2014548061 A JP 2014548061A JP 2014548061 A JP2014548061 A JP 2014548061A JP 2015502387 A5 JP2015502387 A5 JP 2015502387A5
- Authority
- JP
- Japan
- Prior art keywords
- hal
- formula
- alkyl
- independently
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579076P | 2011-12-22 | 2011-12-22 | |
| EP11195107 | 2011-12-22 | ||
| EP11195107.5 | 2011-12-22 | ||
| US61/579,076 | 2011-12-22 | ||
| PCT/EP2012/076595 WO2013092979A1 (en) | 2011-12-22 | 2012-12-21 | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502387A JP2015502387A (ja) | 2015-01-22 |
| JP2015502387A5 true JP2015502387A5 (https=) | 2016-02-18 |
| JP6129203B2 JP6129203B2 (ja) | 2017-05-17 |
Family
ID=48667763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548061A Expired - Fee Related JP6129203B2 (ja) | 2011-12-22 | 2012-12-21 | α−アミノボロン酸誘導体、選択性免疫プロテアソーム阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9688702B2 (https=) |
| EP (1) | EP2793900B1 (https=) |
| JP (1) | JP6129203B2 (https=) |
| KR (1) | KR20140114391A (https=) |
| CN (1) | CN104321060B (https=) |
| AU (1) | AU2012356890B2 (https=) |
| BR (1) | BR112014015363A2 (https=) |
| CA (1) | CA2860142C (https=) |
| EA (1) | EA201400735A1 (https=) |
| ES (1) | ES2699267T3 (https=) |
| HK (1) | HK1206261A1 (https=) |
| IL (1) | IL233200A (https=) |
| MX (1) | MX352652B (https=) |
| SG (2) | SG11201403254QA (https=) |
| WO (1) | WO2013092979A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS60310B1 (sr) | 2010-08-10 | 2020-07-31 | Rempex Pharmaceuticals Inc | Ciklični derivati estra boronske kiseline, postupak za pripremu injihove terapeutske upotrebe |
| US9012491B2 (en) | 2011-08-31 | 2015-04-21 | Rempex Pharmaceuticals, Inc. | Heterocyclic boronic acid ester derivatives and therapeutic uses thereof |
| US9156858B2 (en) | 2012-05-23 | 2015-10-13 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US10561675B2 (en) | 2012-06-06 | 2020-02-18 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| MX2015006715A (es) | 2012-12-03 | 2015-08-14 | Hoffmann La Roche | Compuestos de acido triazolboronico sustituido. |
| CN105026407B (zh) | 2012-12-07 | 2017-09-08 | 维纳拓尔斯制药公司 | β‑内酰胺酶抑制剂 |
| US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| KR20150103270A (ko) | 2013-01-04 | 2015-09-09 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
| US9101638B2 (en) | 2013-01-04 | 2015-08-11 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| KR20150103269A (ko) | 2013-01-04 | 2015-09-09 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
| EP2943204B1 (en) | 2013-01-10 | 2019-03-13 | Venatorx Pharmaceuticals Inc | Beta-lactamase inhibitors |
| WO2014151958A1 (en) | 2013-03-14 | 2014-09-25 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| EP3092244B1 (en) | 2014-01-10 | 2019-08-14 | Cornell University | Dipeptides as inhibitors of human immunoproteasomes |
| SI3140310T1 (sl) | 2014-05-05 | 2020-01-31 | Rempex Pharmaceuticals, Inc. | Sinteza boronatnih soli in njihova uporaba |
| EP3139930B1 (en) | 2014-05-05 | 2024-08-14 | Melinta Therapeutics, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
| WO2015179308A1 (en) | 2014-05-19 | 2015-11-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| PT3154989T (pt) | 2014-06-11 | 2021-05-18 | Venatorx Pharmaceuticals Inc | Inibidores de beta-lactamase |
| EA201692301A1 (ru) * | 2014-07-01 | 2017-06-30 | Ремпекс Фармасьютикалз, Инк. | Производные бороновой кислоты и их терапевтическое применение |
| CN107073069B (zh) | 2014-08-18 | 2022-03-08 | 康奈尔大学 | 作为人免疫蛋白酶体的抑制剂的二肽模拟物 |
| CN107001391B (zh) | 2014-10-01 | 2020-11-27 | 默克专利股份公司 | 硼酸衍生物 |
| EP3201205B1 (en) * | 2014-10-01 | 2020-05-13 | Merck Patent GmbH | Boronic acid derivatives |
| EP3201208B1 (en) * | 2014-10-01 | 2021-03-24 | Merck Patent GmbH | Boronic acid derivatives |
| US10294246B2 (en) * | 2014-10-01 | 2019-05-21 | Merck Patent Gmbh | Substituted boronic acids and boronate esters as immunoproteasome inhibitors |
| WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| US20180051041A1 (en) | 2015-03-17 | 2018-02-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| CN108472284A (zh) | 2015-09-11 | 2018-08-31 | 维纳拓尔斯制药公司 | β-内酰胺酶抑制剂 |
| WO2017066763A1 (en) | 2015-10-15 | 2017-04-20 | Cornell University | Proteasome inhibitors and uses thereof |
| WO2017100537A1 (en) | 2015-12-10 | 2017-06-15 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| CN107151255A (zh) * | 2016-03-06 | 2017-09-12 | 复旦大学 | 硼酸类化合物及其制备方法和用途 |
| ES2894251T3 (es) | 2016-06-30 | 2022-02-14 | Qpex Biopharma Inc | Derivados de ácido borónico y usos terapéuticos de los mismos |
| EP3630783A4 (en) | 2017-05-26 | 2021-03-03 | Venatorx Pharmaceuticals, Inc. | PENICILLIN-BINDING PROTEIN INHIBITORS |
| US11332485B2 (en) | 2017-05-26 | 2022-05-17 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| US11274109B2 (en) | 2017-08-24 | 2022-03-15 | Merck Patent Gmbh | Boronic acid derivatives |
| US11203613B2 (en) | 2017-10-11 | 2021-12-21 | Cornell University | Peptidomimetic proteasome inhibitors |
| MX2020003495A (es) | 2017-10-11 | 2020-09-18 | Qpex Biopharma Inc | Derivados de acido boronico y sintesis de los mismos. |
| CN107556336A (zh) * | 2017-10-16 | 2018-01-09 | 康化（上海）新药研发有限公司 | 一种呋喃‑2‑甲烷基硼酸频哪醇酯的合成方法 |
| EP3710458B1 (en) | 2017-11-16 | 2026-03-25 | Principia Biopharma Inc. | Immunoproteasome inhibitors |
| ES2928787T3 (es) | 2017-11-16 | 2022-11-22 | Principia Biopharma Inc | Inhibidores del inmunoproteasoma |
| CN108130370B (zh) * | 2018-01-05 | 2020-11-17 | 武汉惠康达科技有限公司 | Psmb8及其抑制剂在制备治疗脂肪肝及其相关疾病药物中的应用 |
| US12016868B2 (en) | 2018-04-20 | 2024-06-25 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| EP3802551A4 (en) | 2018-05-25 | 2022-03-02 | Venatorx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| IL280376B2 (en) | 2018-07-26 | 2024-08-01 | Merck Patent Gmbh | Boronic acid derivatives, their preparation and pharmaceutical compositions containing them |
| CN113382713A (zh) | 2018-11-29 | 2021-09-10 | 维纳拓尔斯制药公司 | 包含β-内酰胺酶抑制剂的组合式组合物及其用途 |
| CN113135944A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| BR112022022367A2 (pt) | 2020-05-05 | 2023-01-10 | Qpex Biopharma Inc | Derivados e síntese de ácido borônico, formas polimórficas e usos terapêuticos dos mesmos |
| CN114075227B (zh) | 2020-08-19 | 2023-07-04 | 北京嵩润医药科技有限责任公司 | 吡唑硼酸类化合物、包含其的药物组合物及它们的用途 |
| WO2022187362A1 (en) * | 2021-03-02 | 2022-09-09 | Case Western Reserve University | Β-lactamase inhibitors and uses thereof |
| CN116940580A (zh) * | 2021-03-05 | 2023-10-24 | Ａｇｃ株式会社 | 化合物、化合物的制造方法及表面处理剂的制造方法 |
| EP4377324A1 (en) | 2021-07-29 | 2024-06-05 | Merck Patent GmbH | Novel crystalline forms of [(1r)-2-(1-benzofuran-3-yl)-1-{[(1s,2r,4r)-7- oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid, adducts thereof, and processes to obtain |
| US20240425529A1 (en) * | 2021-10-14 | 2024-12-26 | Shouyao Holdings (beijing) Co., Ltd. | Boric acid derivative |
| WO2023232830A1 (en) | 2022-06-02 | 2023-12-07 | Merck Patent Gmbh | Boronic acid adducts |
| WO2025111328A1 (en) | 2023-11-21 | 2025-05-30 | VenatoRx Pharmaceuticals, Inc. | Citrate coordination complex of an orally-delivered beta-lactamase inhibitor and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111175A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
| US7271186B1 (en) | 2002-12-09 | 2007-09-18 | Northwestern University | Nanomolar β-lactamase inhibitors |
| US7332343B2 (en) * | 2004-01-16 | 2008-02-19 | Board Of Regents, The University Of Texas System | Determining enantiomeric excess using indicator-displacement assays |
| ME01975B (me) | 2004-03-30 | 2015-05-20 | Millennium Pharm Inc | Sinteza jedinjenja estra organoborne kiseline i organoborne kiseline |
| US7855206B2 (en) | 2006-11-14 | 2010-12-21 | Merck Sharp & Dohme Corp. | Tricyclic heteroaromatic compounds as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
| PL2178888T3 (pl) * | 2007-08-06 | 2012-11-30 | Millennium Pharm Inc | Inhibitory proteasomów |
| WO2009051581A1 (en) * | 2007-10-16 | 2009-04-23 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
| JP2011504468A (ja) | 2007-11-13 | 2011-02-10 | プロテズ・ファーマシューティカルズ・インコーポレイテッド | β−ラクタマーゼ阻害剤 |
| AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| MX2012011298A (es) | 2010-03-31 | 2012-11-06 | Millennium Pharm Inc | Derivados del acido 1-amino-2-ciclopropiletilboronico. |
| WO2011137049A1 (en) | 2010-04-30 | 2011-11-03 | Merck Sharp & Dohme Corp. | Heterocyclic quinolizine derived m1 receptor positive allosteric modulators |
-
2012
- 2012-12-21 SG SG11201403254QA patent/SG11201403254QA/en unknown
- 2012-12-21 CN CN201280063440.0A patent/CN104321060B/zh not_active Expired - Fee Related
- 2012-12-21 SG SG10201605152SA patent/SG10201605152SA/en unknown
- 2012-12-21 WO PCT/EP2012/076595 patent/WO2013092979A1/en not_active Ceased
- 2012-12-21 JP JP2014548061A patent/JP6129203B2/ja not_active Expired - Fee Related
- 2012-12-21 KR KR1020147020413A patent/KR20140114391A/ko not_active Ceased
- 2012-12-21 HK HK15106906.3A patent/HK1206261A1/xx unknown
- 2012-12-21 CA CA2860142A patent/CA2860142C/en active Active
- 2012-12-21 AU AU2012356890A patent/AU2012356890B2/en not_active Ceased
- 2012-12-21 EP EP12806491.2A patent/EP2793900B1/en active Active
- 2012-12-21 EA EA201400735A patent/EA201400735A1/ru unknown
- 2012-12-21 MX MX2014007362A patent/MX352652B/es active IP Right Grant
- 2012-12-21 US US14/366,949 patent/US9688702B2/en not_active Expired - Fee Related
- 2012-12-21 ES ES12806491T patent/ES2699267T3/es active Active
- 2012-12-21 BR BR112014015363A patent/BR112014015363A2/pt not_active Application Discontinuation
-
2014
- 2014-06-17 IL IL233200A patent/IL233200A/en active IP Right Grant
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